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Family case of achalasia cardia: Case report and review of literature

World Journal of Gastroenterology 2014年第4期20卷 1114-1118页

作者： yulia Viktorovna evsyutina Alexander Sergeevich Trukhmanov Vladimir Trophimovich Ivashkin Department of Internal Disease Propaedeutics Gastroenterology and Hepatology Sechenov First Moscow State Medical University

Achalasia cardia is an idiopathic disease that occurs as a result of inflammation and degeneration of myenteric plexi leading to the loss of postganglionic inhibitory neurons required for relaxation of the lower esophageal sphincter and peristalsis of the *** main symptoms of achalasia are dysphagia,regurgitation,chest pain and weight *** present,there are three main hypotheses regarding etiology of achalasia cardia which are under consideration,these are genetic,infectious and *** theory is one of the most widely *** report given below represents an inheritable case of achalasia cardia which was not diagnosed for a long time in an 81-year-old woman and her 58-year-old daughter.

关键词： Achalasia cardia Dysphagia Regurgitation Gene poly

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Case report of Graves' disease manifesting with odynophagia and heartburn

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World Journal of Gastroenterology 2015年第48期21卷 13582-13586页

作者： yulia evsyutina Alexander Trukhmanov Vladimir Ivashkin Olga Storonova Elina Godjello Department of Internal Disease Propaedeutics Gastroenterology and HepatologySechenov First Moscow State Medical University Department of Endoscopy Russian National Center of Surgery named after B.V. Petrovsky

Graves' disease is an autoimmune disease, which can manifest with a variety of extrathyroidal clinical syndromes like ophthalmopathy, pretibial myxedema(dermopathy), acropathy, cardiomyopathy, and encephalopathy. Though quite rare, this disease can also manifest with gastrointestinal symptoms such as dysphagia, heartburn, nausea, vomiting and diarrhea. We report a clinical case of Graves' disease manifesting with dysfunction of the esophagus and heartburn in a 61-year-old man. In the muscular layer of the esophagus we found dystrophic changes led to its atony, which was documented by endoscopy and high-resolution manometry. The pathology features of esophageal symptoms were: focal proliferation of the basal cells, vascular distension, and dystrophy of the epithelial cells. Antithyroid treatment led to decrease of all clinical symptoms after 5 d of Thiamazole administration. Complete restoration of peristalsis in the esophagus, according to manometry, was observed in 1 mo after initiation of treatment.

关键词： Graves' disease Heartburn Odynophagia Esophagopathy Dysfunction

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Lung microbiome in healthy and diseased individuals

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World Journal of Respirology 2017年第2期7卷 39-47页

作者： yulia evsyutina Inna Komkova Oksana Zolnikova Petr Tkachenko Vladimir Ivashkin Department of Gastroenterology First Moscow State Medical University Department of Pulmonology First Moscow State Medical University Department of Hepatology First Moscow State Medical University University Clinical Hospital 2 First Moscow State Medical University

The data on quantitative and qualitative microbial composition of the respiratory tract of healthy individuals revealed significant differences when compared with the microbiota of patients suffering from respiratory diseases. Possible etiological role of microbiota in pulmonary diseases as well as drug resistance development is of profound interest nowadays. Numerous studies have provided evidence confirming the relationship between gut microbiome and those of lungs. This relationship could explain how changes in the microbial communities in one organ may lead to pathological changes in the other. Till date, some progress has been made in the study of the biological properties of probiotic bacteria, considering their modulating effect on inflammatory immune response. The use of probiotics which exhibits an immunomodulatory potential looks promising.

关键词： Microbiome Respiratory diseases Probiotics Prebiotics Gut-lung axis Synbiotics

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