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Green tea, epigallocatechin gallate and the prevention of Alzheimer’s disease: clinical evidence

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Food Science and Human Wellness 2022年第4期11卷 765-770页

作者： Klaus W.Lange Katharina M.Lange yukiko nakamura Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

Given its increasing global prevalence,Alzheimer’s disease(AD)has become a major public health challenge *** symptomatic treatments available for AD have shown no significant efficacy,and no disease-modifying interventions are capable of slowing the progression of the *** potential of lifestyle-related factors,including diet,is increasingly recognized as an important consideration in the primary prevention of *** mechanisms potentially underlying neuroprotective effects of bioactive components contained in tea,such as(-)-epigallocatechin-3-gallate,as well as their preventive efficacy against AD,have been elucidated in preclinical ***,in contrast to the abundance of mechanistic findings in animals,clinical results demonstrating efficacy in humans are *** epidemiological studies have provided some evidence indicating that green tea consumption is associated with a reduced risk of age-related cognitive decline and AD,a causal relationship cannot be established on the basis of these *** clinical evidence regarding preventive or therapeutic effects of green tea and its bioactive components is unsatisfactory.A role of green tea in the prevention of AD cannot be recommended until well-designed,randomized,placebo-controlled clinical trials using standardized formulations confirm the purported beneficial effects of green tea.

关键词： Green tea Epigallocatechin gallate Alzheimer’s disease Neurodegeneration Prevention

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Tea and depression

Food Science and Human Wellness 2022年第3期11卷 476-482页

作者： Klaus W.Lange yukiko nakamura Katharina M.Lange Hui Zhao Department of Experimental Psychology University of RegensburgRegensburg 93040Germany Tianjin Key Laboratory of Food and Biotechnology University of CommerceTianjin 300134China

The available evidence,which derives from studies investigating mechanistic effects of tea,research on animal models as well as epidemiological studies and intervention trials in humans,suggests that compounds contained in tea may have the potential to aid in the prevention of depression or in its treatment as an addition to established therapies.A wide range of potentially antidepressive biological activities of tea components have been ***,the mechanisms of tea phytochemicals possibly capable of decreasing the risk of depressive symptoms are complex,multifaceted and not well *** pharmacological effects on circumscribed neurobiological systems may be produced not by individual tea components but rather by the synergistic action of various compounds on multiple pathophysiological mechanisms involved in *** epidemiological studies have generally demonstrated beneficial effects of tea consumption on mood and depressive symptoms,cross-sectional studies are unable to prove a cause-effect *** positive effects on mood could be firmly established,tea drinking could support mental ***,the moderate antidepressive effects observed in healthy people are not necessarily indicative of possible clinical effects in major depressive *** controlled intervention studies are needed to establish a causal relationship between bioactive compounds in tea and depression.

关键词： Depression Tea L-theanine Prevention Treatment

Diet and food in attention-deficit hyperactivity disorder

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Journal of Future Foods 2022年第2期2卷 112-118页

作者： Klaus W.Lange yukiko nakamura Andreas Reissmann Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

Deficiencies of nutrients,including vitamins,minerals and polyunsaturated fatty acids,and surpluses of food items,such as sucrose and artificial food additives,have not convincingly been shown to be involved in the etiology of *** group level,there is no conclusive evidence supporting dietary interventions for the treatment of *** identification of a role of food compounds in ADHD is hindered by the complex and ill-defined nature of *** view of the heterogeneity of the disorder,potential therapeutic benefits of nutritional interventions could be confined to subpopulations of children with ADHD as yet *** cumulative benefits of the range of ingredients comprising healthy diets may result in better outcomes compared to a supplementation of individual *** and nutrition interact with other lifestyle factors,such as physical activity,and the interrelationship between nutrition and lifestyle should play a more prominent role in research on treatment approaches to *** few-foods or oligoallergenic diet allows the design of individually tailored diets and may offer treatment opportunities in subgroups of children diagnosed with *** research is required to demonstrate the utility of nutrition-related interventions alone or in combination with other treatment approaches in ADHD.

关键词： Attention-deficit hyperactivity disorder Dietary patterns Food Nutrition Oligoallergenic diet

Sport and physical exercise in sustainable mental health care of common mental disorders:Lessons from the COVID-19 pandemic

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Sports Medicine and Health Science 2023年第2期5卷 151-155页

作者： Klaus W.Lange yukiko nakamura Andreas Reissmann Faculty of Human Sciences(Psychology Education and Sport Science)University of RegensburgRegensburgBavariaGermany

The large-scale disruptions to physical activity during the coronavirus pandemic have been found to be a leading predictor of common mental *** addition,regular physical exercise has been found to alleviate anxiety,sadness and depression during the *** findings,together with numerous studies published before the pandemic on the effects of physical activity on mental health,should be considered in the provision of mental health care following the ***-sectional research has revealed that all types of exercise and sport are associated with a reduced mental health ***,the effectiveness of exercise and sport participation in sustainable mental health care as well as the causal relationship between exercise,psychosocial health and common mental disorders merit further *** activity and sport,with their global accessibility,significant and clinically meaningful efficacy as well as virtual absence of adverse effects,offer a promising option for the promotion of mental health,including the prevention and treatment of common mental *** exercise and sport are likely to become valuable public mental health resources in the future.

关键词： Anxiety Depression Mental health Physical exercise COVID-19

Food intolerance and oligoantigenic diet in children with attention-deficit hyperactivity disorder

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Food Science and Human Wellness 2023年

作者： Klaus W.Lange reas Reissmann yukiko nakamura Katharina M.Lange Faculty of Human Sciences University of Regensburg Department of Psychology University of Bath

The hypothesis that some children with attention-deficit hyperactivity disorder (ADHD) may show sensitivity or allergic reactions to various food items has led to the development of the oligoantigenic diet. The rationale of the diet is to eliminate certain foods from the diet in order to exclude potential allergens contained either naturally in food or in artificial ingredients with allergenic properties. The oligoantigenic diet attempts to identify individual foods to which a person might be sensitive. First， ADHD symptoms are monitored while multiple foods are excluded from the diet. Subsequently， if symptoms remit， foods are re-introduced， while observing the individual for the return of symptoms. An advantage of the oligoantigenic diet is that it can be tailored to the individual. A growing body of evidence suggests that behavioral symptoms of subgroups of children with ADHD may benefit from the elimination of certain foods. The effect sizes of an oligoantigenic diet regarding improvement of ADHD symptoms have been found to be medium to large. Available evidence suggests that the investigation of the role of food hypersensitivities in ADHD is a promising avenue worthy of further exploration. Further large-scale， randomized controlled studies including assessment of long-term outcome are therefore warranted.

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Edible insects as future food:chances and challenges

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Journal of Future Foods 2021年第1期1卷 38-46页

作者： Klaus W.Lange yukiko nakamura Department of Eperimental Psychologr University of RegensburgRegensburg.Gemmaory

The consumption of insects(entomophagy)has recently attracted global attention for health reasons as well as environmental and economic *** environmentally sustainable food security is currently one of the biggest global challenges.A wide range of edible insect species,with their high contents in protein,fat,minerals,vitamins and fiber,can play a significant role in addressing food *** of entomophagy include a high feed-conversion efficiency of insects and the rearing on organic side streams,adding value to waste and decreasing environmental *** to cattle raising,insects emit relatively few greenhouse gases and little ammonia and require significantly less land and *** nutritional quality of edible insects appears to be equivalent and sometimes superior to that of foods derived from birds and *** farming may offer a sustainable means of food *** edible insects are calorie dense and highly nutritious,their consumption has the potential to reduce famine *** presence of high-quality protein and various micronutrients as well as potential environmental and economic benefits render edible insects globally a major potential future ***,consumer acceptance remains a major obstacle to the adoption of insects as a food source in many Western countries.

关键词： Edible insects Food security Environmenta1 sustainability Food Safety Consumer acceptance

Behavioral assessment of hippocampal function following dietary intervention

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Food Science and Human Wellness 2018年第3期7卷 229-233页

作者： Klaus W.Lange Ewelina Stollberg yukiko nakamura Joachim Hauser Department of Experimental Psychology University of Regensburg93040 RegensburgGermany

Pattern separation keeps items distinct in memory and is mediated by the hippocampus.A relationship between hippocampal function and diet quality has been suggested by findings in both humans and *** the present study,rats were fed over seven generations a diet containing increased amounts of sugar and saturated fatty acids,reduced levels of polyunsaturated fatty acids and an increased ratio of omega-6/omega-3 fatty acids(“Western”diet).Spatial pattern separation(or local discrimination)performance of these animals was compared with that of rats fed a standard diet.A separation-dependent difference between the standard and Western diet groups was found in the number of discriminations performed in the pattern separation task,with rats of the“Western”group performing fewer *** present results suggest that behavioral assessment of spatial pattern separation can detect effects of dietary interventions in rats and that pattern separation can be impaired by transgenerational administration of a“Western”*** studies should determine which components of this diet induce the memory impairments related to the *** translational relevance of these findings in regard to mental disorders such as dementia and depression needs to be investigated.

关键词： Memory Hippocampus Western diet Fatty acids Sugar

Sarcomatoid malignant pleural mesothelioma confirmed by full-thickness biopsy

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Chinese Medical Journal 2013年第17期126卷 3391-3392页

作者： DENG Chao-sheng Shinji Sasada Takehiro Izumo yukiko nakamura Koji Tsuta TakaakiTsuchida Department of Respiratory Disease First Affiliated Hospital of Fujian Medical University Fuzhou Fujian 350005 China Department of Endoscopy Respiratory Endoscopy Division National Cancer Center Hospital Tokyo Japan Pathology and Clinical Laboratory Division National Cancer Center Hospital Tokyo Japan

Diffuse malignant pleural mesothelioma （DMPM） is a rare thoracic malignancy, but its incidence isdramatically increasing worldwide as a result ot widespread use of asbestos. The World Health Organization classifies DMPM into three types： epithelioid, sarcomatoid, and biphasic types. DMPM remains suffering poor prognosis and the diagnosis should always be based on adequate, representative tissue samples. There still remains a considerable number of patients with DMPM who are misdiagnosed after a complete investigation including thoracoscopic biopsies.

关键词： malignant pleural mesothelioma adequate biopsy specimens encapsulated effusion conventional forceps biopsy necrotic atypical cells insulated-tip diathermic knife

Medical foods in Alzheimer’s disease

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Food Science and Human Wellness 2019年第1期8卷 1-7页

作者： Klaus W.Lange Jianjun Guo Shigehiko Kanaya Katharina M.Lange yukiko nakamura Shiming Li Department of Experimental Psychology University of Regensburg93040 RegensburgGermany China Institute of Sport Science BeijingChina Graduate School of Information Science Nara Institute of Science and TechnologyIkomaJapan Department of Psychology University of WinchesterWinchesterUnited Kingdom Department of Food Science Rutgers UniversityNew BrunswickNJUSA

Alzheimer’s disease(AD)is the most prevalent cause of dementia *** achieving a marked improvement in symptoms or preventing or delaying the progression of the disease are not *** diet-related risk factors for AD have been *** for a protective effect of the Mediterranean diet on AD risk is *** foods are designed to meet specific dietary needs for certain *** in symptomatology and regional brain atrophy in AD have been claimed for several medical foods,for example,those providing ketone bodies as alternative energy supply to neurons,those containing precursors believed to improve synaptic function,and those addressing oxidative stress related to memory *** methodological shortcomings render the interpretation of the available findings of medical food trials in AD *** results of medical foods in AD may be expected when administered in presymptomatic or early stages of the *** requires the reliable identification of minimal neuropathological changes related to *** outcome measures currently used may not be able to detect subtle changes in cognition and function in early ***-scale clinical studies using valid,sensitive,and reliable assessment tools are needed to establish the efficacy of medical foods in AD.

关键词： Alzheimer’s disease Ketogenic diet Medical foods Mediterranean diet Nutrition