检索结果-南通市图书馆

Photothermal probiotics delivery of photodynamic agents for enhanced immunogenic cell death within hypoxia center of solid tumors

引用

Nano Research 2025年第1期18卷 642-652页

作者： Wen Luo Shiyu Du Yateng Jiang Bangshun He Jun Tang Jingjing Yang yujun song Jiangsu Key Laboratory of Artificial Functional Materials State Key Laboratory of Analytical Chemistry for Life ScienceNational Laboratory of Solid State MicrostructuresCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210023China Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Department of Anesthesiology Jinling HospitalMedical School of Nanjing UniversityNanjing 210000China Department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative MedicineJiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Resulting from harsh hypoxic environmental conditions,central cells in the core of solid tumors are usually more aggressive and malignant with a less stable ***,therapeutic agents with improved penetration for the activation of immunity in tumor centers exhibit promising potential in ***,polydopamine-coated Escherichia coli Nissle 1917(EcN)bearing chlorin e6(Ce6)-loaded and polyethyleneimine(PEI)-coated hollow manganese dioxide(shorted as EP-ChP)are applied for enhanced immunotherapy in deep *** accumulation in tumor center through hypoxia targeting,manganese dioxide is degradated under the tumor microenvironment with released Ce6 and thus generates reactive oxygen species(ROS)upon 660 nm laser irradiation,which can further lower thermalresistance of cancer cells via HSP90α*** to that,heating induced by polydopamine upon 808 nm laser irradiation can achieve effective tumor *** upon dual laser induces enhanced immunogenic cell death,while bacterial infections in tumor tissues also trigger innate *** bacteria-based approach provides enhanced antitumor immune responses in deep tumors with great potential in the reshaping of immunosuppression tumor microenvironment.

关键词： bacteria phototherapies immunotherapy hypoxia targeting tumor penetration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Shell-driven Fine Structure Transition of Core Materials in Co@Au Core-shell Nanoparticles

引用

Nano-Micro Letters 2012年第4期4卷 235-242页

作者： yujun song Yinghui Wang Shaoxia Ji Jie Ding School of Materials Science and Engineering Beihang University

Co@Au core shell nanoparticles(NPs) of different shell thicknesses were fabricated by a combination of the displacement process and the reduction-deposition process in a microfluidic reactor. The effect of the shell thickness on the fine structures(local atom arrangement) of core materials was investigated by X-ray Absorption Near Edge Structure(XANES) and Extended X-ray Absorption Fine Structure(EXAFS).The results indicate that the shell thickness affects the fine structure of the core materials by causing atomic re-arrangement between the hexagonal close pack(hcp) and the face centered cubic(fcc) structure, and forming Co-Au bonds in the core-shell interface.

关键词： Nanoparticle Core-shell Fine Structure Microfluidic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent advances of microneedles for biomedical applications: drug delivery and beyond

引用

Acta Pharmaceutica Sinica B 2019年第3期9卷 469-483页

作者： Jian Yang Xinli Liu Yunzhi Fu yujun song College of Materials Science and Chemical Engineering Hainan UniversityHaikou570228China College of Engineering and Applied Sciences Nanjing UniversityNanjing210093China

The microneedle(MN), a highly efficient and versatile device, has attracted extensive scientific and industrial interests in the past decades due to prominent properties including painless penetration, low cost, excellent therapeutic efficacy, and relative safety. The robust microneedle enabling transdermal delivery has a paramount potential to create advanced functional devices with superior nature for biomedical applications. In this review, a great effort has been made to summarize the advance of microneedles including their materials and latest fabrication method, such as three-dimensional printing(3DP). Importantly, a variety of representative biomedical applications of microneedles such as disease treatment, immunobiological administration, disease diagnosis and cosmetic field, are highlighted in detail. At last, conclusions and future perspectives for development of advanced microneedles in biomedical fields have been discussed systematically. Taken together, as an emerging tool, microneedles have showed profound promise for biomedical applications.

关键词： Microneedle patches Biomedical applications Microfabricated device Drug delivery Disease treatment Disease diagnosis Immunobiological administration 3D printing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SOX17-mediated immune evasion in early colorectal cancer:From pre-malignant adaptation to tumor progression

引用

Acta Pharmaceutica Sinica B 2024年第8期14卷 3780-3782页

作者： Yanfeng Gao Yanping Wang Jinsong Zhao yujun song School of Medical Imaging Wannan Medical CollegeWuhu 241002China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China

One of the hallmarks of cancer is its inherently immunosuppressive microenvironment,which strategically manipulates surrounding immune cells,signaling molecules,and structural components to shield cancer cells from immune attacks and foster tumor *** tumor microenvironment is characterized by the presence of immunosuppressive entities such as tumor-associated macrophages,T cells,tumor-associated neutrophils,and myeloid-derived suppressor cells(MDSCs),as well as metabolic alterations like hypoxia2 and elevated lactate levels3.

关键词： Immune escape Tumor microenvironment Immunotherapy Immunosuppressive tumor microenvironment Transcription factor CD8^(+)T cell infiltration AKP organoids CRISPReCas9 genome editing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Highly biocompatible BSA-MnO_2 nanoparticles as an efficient near-infrared photothermal agent for cancer therapy

引用

Chinese Chemical Letters 2018年第11期29卷 1685-1688页

作者： Yuzhen Wang yujun song Guixian Zhu Dechen Zhang Xuewu Liu Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM)Nanjing Tech University (NanjingTech) Department of Biomedical Engineering College of Engineering and Applied SciencesNanjing University Department of Nanomedicine Houston Methodist Research Institute

More recently, the biomedical applications of MnO2 in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However, research on a near infrared （NIR） photothermal response of MnO2 was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin （BSA）-reduced and stabilized MnO2 nanoparticles （BSA-MnO2 NPs） with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO2 NPs displayed superior NIR photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent.

关键词： Bovine serum albumin Manganese dioxide Photothermal NIR Cancer therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Solid-phase sintering and vapor-liquid-solid growth of BP@MgO quantum dot crystals with a high piezoelectric response

引用

Journal of Advanced Ceramics 2022年第11期11卷 1725-1734页

作者： Qingwei LIAO Wei HOU Kexuan LIAO Liyin CHEN yujun song Guowei GAO Lei QIN Key Laboratory of Sensors Beijing Information Science&Technology UniversityBeijing 100192China Key Laboratory of Modern Measurement&Control Technology Ministry of EducationBeijing Information Science&Technology UniversityBeijing 100192China Key Laboratory of Photoelectric Testing Technology Beijing Information Science&Technology UniversityBeijing 100192China School of Chemical Science and Engineering Tongji UniversityShanghai 200092China Harvard John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridge 02138USA Center of Modern Physics Technology School of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing 100083China

Low-dimensional piezoelectric and quantum piezotronics are two important branches of low-dimensional materials,playing a significant role in the advancement of low-dimensional devices,circuits,and ***,we firstly propose a solid-phase sintering and vapor–liquid–solid growth(SS–VLS-like)method of preparing a quantum-sized oxide material,i.e.,black phosphorus(BP)@MgO quantum dot(QD)crystal with a strong piezoelectric ***-sized MgO was obtained by Mg slowly released from MgB_(2) within the confinement of a nanoflake BP *** the slow release of Mg only grows nanometer-sized MgO to hinder the further growth of MgO,we added a heterostructure matrix constraint:nanoflake *** the BP as the matrix confinement,MgO QDs embedded in the BP@MgO QD crystals were *** crystals have a layered two-dimensional(2D)structure with a thickness of 11 nm and are stable in the *** addition,piezoresponse force microscopy(PFM)images show that they have extremely strong *** strong polarity can also be proved by polarization reversal and a simple pressure sensor.

关键词： quantum dots(QDs) piezoelectric black phosphorus(BP) MgO

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gold nanoparticles doped metal-organic frameworks as near-infrared light-enhanced cascade nanozyme against hypoxic tumors

引用

Nano Research 2020年第3期13卷 653-660页

作者： Xinli Liu Yongchun Pan Jingjing Yang Yanfeng Gao Ting Huang Xiaowei Luan Yuzhen Wang yujun song Department of Biomedical Engineering and Jiangsu Key Laboratory of Artificial Functional Materials College of Engineering and Applied SciencesNanjing UniversityNanjing210093China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Jiangsu National Synergistic Innovation Center for Advanced Materials(SICAM)Nanjing Tech UniversityNanjing211816China

We report gold nanoparticles(AuNPs)doped iron-based metal-organic frameworks(GIM)which displays near-infrared light(NIR)-enhanced cascade nanozyme against hypoxic *** to the strong protein adsorption-induced surface passivation,AuNPs suffer from the loss of glucose oxidase(GOx)***,GIM could protect the GOx-like activity of AuNPs with the satisfactory shield *** addition,GIM exhibited excellent photothermal conversion ability and unique NIR light-enhanced GOx-like activity,which could efficiently increase the endogenous H2O2 ***,as the produced H2O2 is converted by GIM into O2 and highly toxic ***,GIM-catalyzed cascade reactions with NIR light irradiation not only offer the O2 but also promote the reactive oxygen species(ROS)generation at tumor *** produced O2 could be further applied to AuNPs catalytic oxidation of glucose and relieve hypoxic condition of tumor microenvironment(TME).As a proof-of-concept study,GIM demonstrates the admirable tumor ablation under NIR irradiation in vivo.

关键词： nanozyme metal-organic frameworks gold nanoparticles near-infrared light reactive oxygen species

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome

引用

Acta Pharmaceutica Sinica B 2023年第5期13卷 2176-2187页

作者： Chuan Hu yujun song Yiwei Zhang Siqin He Xueying Liu Xiaotong Yang Tao Gong Yuan Huang Huile Gao Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan UniversityChengdu 610041China

Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination ***,a kind of tumor cascade-targeted responsive liposome(NLG919@Lip-pep1)is developed by conjugating polypeptide inhibitor of PD-1 signal pathway(AUNP-12),which is also a targeted peptide that conjugated with liposome carrier through matrix metalloproteinase-2(MMP-2)cleavable peptide(GPLGVRGD).This targeted liposome is prepared through a mature preparation process,and indoleamine-2,3-dioxygenase(IDO)inhibitor NLG919 was encapsulated into ***,mediated by the enhanced permeability and retention effect(EPR effect)and AUNP-12,NLG919@Lip-pep1 first targets the cells that highly express PD-L1 in tumor *** the same time,the over-expressed MMP-2 in the tumor site triggers the dissociation of AUNP-12,thus realizing the precise block of PD-1 signal pathway,and restoring the activity of T *** exposure of secondary targeting moduleⅡVRGDC-NLG919@Lip mediated tumor cells targeting,and further relieved the immunosuppressive ***,this study offers a potentially appealing paradigm of a high efficiency,low toxicity,and simple intelligent responsive drug delivery system for targeted drug delivery in breast cancer,which can effectively rescue and activate the body's anti-tumor immune response and furthermore achieve effective treatment of metastatic breast cancer.

关键词： Immunotherapy Cascade targeting Liposome MMP-2 responsive Breast cancer ICBs IDO inhibitors Immunosuppressive microenvironment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging trends in organ-on-a-chip systems for drug screening

引用

Acta Pharmaceutica Sinica B 2023年第6期13卷 2483-2509页

作者： Yanping Wang Yanfeng Gao Yongchun Pan Dongtao Zhou Yuta Liu Yi Yin Jingjing Yang Yuzhen Wang yujun song College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China Sino-French Engineer School Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Flexible Electronics&Institute of Advanced Materials Jiangsu National Synergistic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing 211816China

New drug discovery is under growing pressure to satisfy the demand from a wide range of domains, especially from the pharmaceutical industry and healthcare services. Assessment of drug efficacy and safety prior to human clinical trials is a crucial part of drug development, which deserves greater emphasis to reduce the cost and time in drug discovery. Recent advances in microfabrication and tissue engineering have given rise to organ-on-a-chip, an in vitro model capable of recapitulating human organ functions in vivo and providing insight into disease pathophysiology, which offers a potential alternative to animal models for more efficient pre-clinical screening of drug candidates. In this review, we first give a snapshot of general considerations for organ-on-a-chip device design. Then, we comprehensively review the recent advances in organ-on-a-chip for drug screening. Finally, we summarize some key challenges of the progress in this field and discuss future prospects of organ-on-a-chip development. Overall,this review highlights the new avenue that organ-on-a-chip opens for drug development, therapeutic innovation, and precision medicine.

关键词： Microfluidics Drug discovery In vitro models Microphysiological systems Toxicity assessment Bioprinting Drug safety Human-on-a-chip

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy

引用

Acta Pharmaceutica Sinica B 2022年第11期12卷 4224-4234页

作者： Zekun Li Yongchun Pan Shiyu Du Yayao Li Chao Chen Hongxiu song Yueyao Wu Xiaowei Luan Qin Xu Xiaoxiang Guan yujun song Xin Han Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of Medicine&Holistic Integrative MedicineJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative MedicineNanjing University of Chinese MedicineNanjing 210023China College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional MaterialsState Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNajing 210023China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

Near-infrared(NIR)-light-triggered nanomedicine, including photodynamic therapy(PDT)and photothermal therapy(PTT), is growing an attractive approach for cancer therapy due to its high spatiotemporal controllability and minimal invasion, but the tumor eradication is limited by the intrinsic anti-stress response of tumor cells. Herein, we fabricate a tumor-microenvironment responsive CRISPR nanoplatform based on oxygen-deficient titania(TiO_(2-x)) for mild NIR-phototherapy. In tumor microenvironment, the overexpressed hyaluronidase(HAase) and glutathione(GSH) can readily destroy hyaluronic acid(HA) and disulfide bond and releases the Cas9/sgRNA from TiO_(2-x) to target the stress alleviating regulators, i.e., nuclear factor E2-related factor 2(NRF2) and heat shock protein 90a(HSP90a), thereby reducing the stress tolerance of tumor cells. Under subsequent NIR light illumination, the TiO_(2-x) demonstrates a higher anticancer effect both in vitro and in vivo. This strategy not only provides a promising modality to kills cancer cells in a minimal side-effects manner by interrupting anti-stress pathways but also proposes a general approach to achieve controllable gene editing in tumor region without unwanted genetic mutation in normal environments.

关键词： Near infrared phototherapy Gene editing Nuclear factor E2-related factor 2 .Heat shock protein 90c TiO_(2-x) Sensitized phototherapy Nanoprodrug Tumor microenvironment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：