Highly biocompatible BSA-MnO_2 nanoparticles as an efficient near-infrared photothermal agent for cancer therapy

作     者：Yuzhen Wang Yujun Song Guixian Zhu Dechen Zhang Xuewu Liu 

作者机构：Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM)Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM)Nanjing Tech University (NanjingTech) Department of Biomedical EngineeringCollege of Engineering and Applied SciencesNanjing University Department of NanomedicineHouston Methodist Research Institute 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2018年第29卷第11期

页      面：1685-1688页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学] 

基　　金：financial support from the following sources: National Natural Science Foundation of China (No. 81601632) the Natural Science Foundation of Jiangsu Province (No. SBK2016041233) the Fundamental Research Funds for Central Universities(No. 021314380067) Thousand Talents Program for Young Researchers, NIH (No. 1R21CA190024-01) DOD (No. W81XWH-12-1-0414) Houston Methodist Research Institute 

主　　题：Bovine serum albumin Manganese dioxide Photothermal NIR Cancer therapy 

摘      要：More recently, the biomedical applications of MnO2 in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However, research on a near infrared （NIR） photothermal response of MnO2 was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin （BSA）-reduced and stabilized MnO2 nanoparticles （BSA-MnO2 NPs） with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO2 NPs displayed superior NIR photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent.