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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng yujing huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Application of Ice Pigging in a Drinking Water Distribution System:Impacts on Pipes and Bulk Water Quality

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Engineering 2024年第9期40卷 122-130页

作者： yujing huang Zhiwei Chen Guilin He Yu Shao Shuang Song Feilong Dong Tuqiao Zhang College of Civil Engineering and Architecture Zhejiang UniversityHangzhou 310027China Suzhou Wuzhong Water Co. Ltd.Suzhou 215128China School of Municipal and Environmental Engineering Shandong Jianzhu UniversityJi’nan 250101China College of Environment Zhejiang University of TechnologyHangzhou 310014China

Ice pigging is an emerging technique for pipe cleaning in drinking water distribution ***,substantial confusion and controversy exist on the potential impacts of ice pigging on bulk water *** study monitored the microstructural features and composition of sediments and microbial community structures in bulk water in eight multimaterial Chinese *** concentration analysis demonstrated that separate cleaning of pipes with different materials in complex networks could mitigate the risk of losing ice pigs and degrading water *** microstructural and trace element characterization results showed that ice pigs would scarcely disturb the inner surfaces of long-used *** bacterial richness and diversity of bulk water decreased significantly after ice ***,correlations were established between pipe service age,temperature,and chloride and total iron concentrations,and the 15 most abundant taxa in bulk water,which could be used to guide practical ice pigging operations.

关键词： Ice pigging Pipe cleaning Drinking water distribution system Bacterial community Sediments

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Nanotechnology’s frontier in combatting infectious and inflammatory diseases:prevention and treatment

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Signal Transduction and Targeted Therapy 2024年第3期9卷 998-1047页

作者： yujing huang Xiaohan Guo Yi Wu Xingyu Chen Lixiang Feng Na Xie Guobo Shen Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China Hospitaland West China School of Basic Medical Sciences and Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China

Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases,which continuously pose one of the most serious threats to human health,attributed to factors such as the emergence of new pathogens,increasing drug resistance,changes in living environments and lifestyles,and the aging *** rapid advancements in mechanistic research and drug development for these diseases,current treatments often have limited efficacy and notable side effects,necessitating the development of more effective and targeted anti-inflammatory *** recent years,the rapid development of nanotechnology has provided crucial technological support for the prevention,treatment,and detection of inflammation-associated *** types of nanoparticles(NPs)play significant roles,serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and *** can also directly combat pathogens and *** addition,nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory *** review categorizes and characterizes different types of NPs,summarizes their applications in the prevention,treatment,and detection of infectious and inflammatory *** also discusses the challenges associated with clinical translation in this field and explores the latest developments and *** conclusion,nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

关键词： prevention inflammatory treatment

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Human Cytomegalovirus Influences Host circRNA Transcriptions during Productive Infection

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Virologica Sinica 2021年第2期36卷 241-253页

作者： Jingui Deng yujing huang Qing Wang Jianming Li Yanping Ma Ying Qi Zhongyang Liu Yibo Li Qiang Ruan Virology Laboratory The Affiliated Shengjing HospitalChina Medical UniversityShenyang 110004China Department of Laboratory Central Hospital Affiliated to Shenyang Medical CollegeShenyang 110024China Department of Gynecology and Obstetrics The Affiliated Shengjing HospitalChina Medical UniversityShenyang 110004China Department of Obstetrics Central Hospital Affiliated to Shenyang Medical CollegeShenyang 110024China

Human cytomegalovirus(HCMV)is a double-strand DNA virus widely infected in *** RNAs(circ RNAs)are non-coding RNAs with most functions of which keep unknown,and the effects of HCMV productive infection on host circ RNA transcriptions remain *** this study,we profiled 283 host circ RNAs that significantly altered by HCMV productive infection in human embryonic lung fibroblasts(HELF)by RNA deep sequencing and bioinformatics *** these,circ SP100,circ MAP3 K1,circ PLEKHM1,and circ TRIO were validated for their transcriptions and ***,characteristics of circ SP100 were investigated by RT-q PCR and northern *** was implied that circ SP100 was produced from the sense strand of the SP100 gene containing six *** of circ SP100 and SP100 m RNA were significantly different after infection:circ SP100 levels increased gradually along with infection,whereas SP100 m RNA levels increased in the beginning and dropped at 24 h post-infection(hpi).Meanwhile,a total number of 257 proteins,including 10 HCMV encoding proteins,were identified potentially binding to cytoplasmic circ SP100 by RNA antisense purification(RAP)and mass *** analysis showed these proteins were mainly involved in the spliceosome,protein processing,ribosome,and phagosome pathways,suggesting multiple functions of circ SP100 during HCMV infection.

关键词： Human cytomegalovirus(HCMV) Productive infection Circular RNA(circRNA) circ SP100 Transcription

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Human cytomegalovirus RNA2.7 inhibits RNA polymeraseⅡ(PolⅡ)Serine-2 phosphorylation by reducing the interaction between PolⅡand phosphorylated cyclin-dependent kinase 9(pCDK9)

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Virologica Sinica 2022年第3期37卷 358-369页

作者： yujing huang Xin Guo Jing Zhang Jianming Li Mingyi Xu Qing Wang Zhongyang Liu Yanping Ma Ying Qi Qiang Ruan Virology Laboratory Shengjing Hospital of China Medical UniversityShenyang110004China Department of Pediatrics Shengjing Hospital of China Medical UniversityShenyang110004China Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyang110004China Department of Pediatrics The Fourth Affiliated HospitalChina Medical UniversityShenyang110033China

Human cytomegalovirus(HCMV)is a ubiquitous pathogen belongs to betaherpesvirus ***2.7 is a highly conserved long non-coding RNA accounting for more than 20%of total viral *** our study,functions of HCMV RNA2.7 were investigated by comparison of host cellular transcriptomes between cells infected with HCMV clinical strain and RNA2.7 deleted *** was demonstrated that RNA polymeraseⅡ(PolⅡ)-dependent host gene transcriptions were significantly activated when RNA2.7 was removed during infection.A145 nt-in-length motif within RNA2.7 was identified to inhibit the phosphorylation of PolⅡSerine-2(PolⅡS2)by reducing the interaction between PolⅡand phosphorylated cyclin-dependent kinase 9(pCDK9).Due to the loss of PolⅡS2 phosphorylation,cellular DNA pre-replication complex(pre-RC)factors,including Cdt1 and Cdc6,were significantly decreased,which prevented more cells from entering into S phase and facilitated viral DNA *** results provide new insights of HCMV RNA2.7 functions in regulation of host cellular transcription.

关键词： Human cytomegalovirus(HCMV) RNA2.7 RNA polymeraseⅡ(PolⅡ) Cyclin-dependent kinase 9(CDK9) Phosphorylation

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Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA

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Virologica Sinica 2017年第5期32卷 431-439页

作者： Shujuan Jiang yujing huang Ying Qi Rong He Zhongyang Liu Yanping Ma Xin Guo Yaozhong Shao Zhengrong Sun Qiang Ruan Virus Laboratory the Affiliated Shengjing Hospital China Medical University Shenyang 110122 China Clinical Genetics the Affiliated Shengjing Hospital China Medical University Shenyang 110122 China

Viruses commonly create favorable cellular conditions for their survival through multiple mechanisms. Micro RNAs(mi RNAs), which function as post-transcriptional regulators, are utilized by human cytomegalovirus(HCMV) in its infection and pathogenesis. In the present study, the DNA replication inhibitor Geminin(GMNN) was identified to be a direct target of hcmv-mi R-US5-1. Overexpression of hcmv-mi R-US5-1 could block the accumulation of GMNN during HCMV infection, and the decrease of GMNN expression caused by hcmv-mi R-US5-1 or GMNN specific si RNA reduced HCMV DNA copies in U373 cells. Meanwhile, ectopic expression of hcmv-mi R-US5-1 and consequent lower expression of GMNN influenced host cell cycle and proliferation. These results imply that hcmv-mi R-US5-1 may affect viral replication and host cellular environment by regulating expression kinetics of GMNN during HCMV infection.

关键词： Human cytomegalovirus(HCMV) hcmv-mi R-US5-1 Geminin(GMNN) DNA replication cell cycle

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Study of Zonula occluden-1

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Neural Regeneration Research 2006年第6期1卷 553-556页

作者： yujing huang Jiachun Feng Department of Neurology First Hospital Jilin University Changchun 130021 Jilin Province China

OBJECTIVE： To investigate the structure, location, function and regulation of Zonula occluden-1 （ZO-1） as well as the correlation of ZO-1 with diseases for helping diagnosis, treatment and determining prognosis of correlative diseases. DATA SOURCES ： Using the terms ＂Zonula Occluden＂, we searched the Medline database to identify ZO-1 related articles published between May 1963 and December 2006 in English. STUDY SELECTION ： The articles were selected firstly, and those involved the structure, location, function and regulation of ZO-1 as well as the correlation of ZO-1 with diseases were chosen. The full texts of the left articles were searched. Inclusive cnteda： Studies associated with the structure, location, function and regulation of ZO-1 as well as those associated with the correlation of ZO-1 with diseases. Exclusive cnteria： Studies with repetitive or uncorrelated contents. DATA EXTRACTION ： Among 1 462 collected articles of ZO-1, 1 424 were excluded. Of the 38 articles, which met inclusive criteria, 11, 2, 10, 11 and 4 were associated with the structure, location, function and regulation of ZO-1 as well as the correlation of ZO-1 with diseases, respectively. DATA SYNTHESIS： ZO-1 is a member of membrane associated guarylate kinasellike proteins （MAGUKS）, can not form homooligomers and exists as ZO-1/ZO-2 and ZO-1/ZO-3 heterodimers. It is expressed in endothelial cells and epithelial cells and also in other types （except for tight junction） of cells. It exists not only in tight junction but also in adherens junction. ＂ Messenger＂ which contacts with various junctional complexes, interacts with tight junction, adherens junction and gap junction to maintain the structure and function of junctional complex. The structure and function of ZO-1 are regulated by many factors, such as Ca^2＋, phosphorylation, protein kinase C, G protein and so on. ZO-1 plays an important role in the treatment of ischemia/hypoxia, inflammation and tumors. CONCLUSION： ZO-1, whic

关键词：磷蛋白类/代谢膜蛋白质类/代谢综述人类

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Combined Effects of Dibutyl Phthalate (DBP) and Benzo(a)Pyrene on Fertility in Male Rats

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Journal of Geoscience and Environment Protection 2014年第2期2卷 167-172页

作者： yujing huang Ji’an Chen Weiqun Shu Department of Environmental Hygiene College of Preventive Medicine Third Military Medical University Chongqing China

Our previous studies revealed the polycyclic aromatic hydrocarbon and phthalic acid esters were the major organic pollutants in the Jialing River and Yangtze River in the Three Gorges area, and they might cause the toxicity in male fertility when combined. Thus we used di-n-butyl phthalate (DBP) and Benzo(a)pyrene (Bap) as their representatives respectively to explore their effects on the spermatogenesis in male rats. Male Sprague Dawley rats were randomly divided into 4 groups and respectively exposed to corn oil, Bap (5 mg/kg/d), DBP (250 mg/kg/d), and combined doses of Bap (5 mg/kg/d) and DBP (250 mg/kg/d) for 90 days. We observed a significant increase in the stillbirth rate after Bap and combined treatments, while the mean area of seminiferous tubules was reduced after Bap, DBP and combined treatments. Bap and combined treatment had a sup- pressing effect on meiosis in germ cells, which reduced the haploid contents and the ratio between haploid and diploid but increased the tetraploid and diploid contents and the ratio between hap- loid and tetraploid. These effects were more obvious in the combined group. Furthermore, the ex- pression of a number of proteins was changed, of which was associated with the oxidative stress and cAMP/PKA signaling pathway. Our results suggest that Bap has significant toxic effects on male fertility, while the combined treatment of Bap and DBP has more toxic effects.

关键词： Di-n-Butyl Phthalate Benzo(a)Pyrene Male Reproductive Protein Expression Tubules Structure Spermatogenesis

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虚弱与癫痫发生风险的因果关系:孟德尔随机化分析

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实用心脑肺血管病杂志 2025年第1期33卷 67-70页

作者：张帅帅黄宇靖贾肖扬彭阳阳李良宇王桂华杜爱玲新乡医学院第二附属医院神经内科河南省新乡市453000

目的采用孟德尔随机化(MR)分析方法探究虚弱与癫痫发生风险的因果关系。方法虚弱指数的全基因组关联分析(GWAS)汇总数据来源于Gwas Catalog数据库,包括175226例患者,7589717个单核苷酸多态性(SNP);癫痫的GWAS汇总数据来源于Finn Gen数据... 详细信息

目的采用孟德尔随机化(MR)分析方法探究虚弱与癫痫发生风险的因果关系。方法虚弱指数的全基因组关联分析(GWAS)汇总数据来源于Gwas Catalog数据库,包括175226例患者,7589717个单核苷酸多态性(SNP);癫痫的GWAS汇总数据来源于Finn Gen数据库,包括6260例癫痫患者和176107例健康对照者,16380349个SNP。本研究主要采用逆方差加权法(IVW)分析衰弱指数与癫痫发生风险的因果关系,采用MR-Egger回归、加权中位数法及加权模式法作为IVW的补充方法。采用Cochran'sQ检验、漏斗图分析SNP的统计学异质性,采用MR-Egger回归的截距项评估SNP的水平多效性,采用留一法分析单个SNP对MR分析结果的影响。结果IVW分析结果显示,衰弱指数与癫痫发生风险呈正相关[OR=1.584,95%CI(1.086~2.312)];MR-Egger回归、加权模式法分析结果显示,衰弱指数与癫痫发生风险之间无因果关系(P>0.05),但其β值与IVW的β值方向一致;加权中位数法分析结果显示,衰弱指数与癫痫发生风险呈正相关[OR=1.642,95%CI(1.036~2.603)]。Cochran'sQ检验、漏斗图分析结果显示,与衰弱指数强相关的SNP间无统计学异质性。MR-Egger回归的截距项分析结果显示,与衰弱指数强相关的SNP无水平多效性(P=0.987);留一法分析结果显示,逐一剔除单个SNP后,IVW分析结果无明显改变。结论虚弱与癫痫发生风险存在正向因果关系。

关键词：癫痫虚弱因果关系孟德尔随机化分析

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论爱国主义法治教育的价值意蕴及其实践路径

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思想理论教育 2023年第2期 56-61页

作者：黄钰晶华东师范大学马克思主义学院上海200241

针对当下爱国主义所面临的新挑战,通过法治引导爱国价值观和规范爱国行为十分必要和迫切,这就要实施爱国主义法治教育。爱国主义与法治的融通关系是爱国主义教育的理论前提,它表明以法治规范爱国行为具有可行性,而法律也势必要体现爱国... 详细信息

针对当下爱国主义所面临的新挑战,通过法治引导爱国价值观和规范爱国行为十分必要和迫切,这就要实施爱国主义法治教育。爱国主义与法治的融通关系是爱国主义教育的理论前提,它表明以法治规范爱国行为具有可行性,而法律也势必要体现爱国精神,并要求在法治和道德的共同作用下实施爱国主义教育。爱国主义法治教育以培育社会主义核心价值观为目标,具有以人为本、促进人的全面发展的育人特征,它能够实现以法治规范爱国行为、以法治维护国家安全以及培育青少年爱国法治意识的现实目标。通过构建爱国主义法治知识体系、建立以学校为主导的多部门协作教育模式、打造融媒体宣传学习平台等路径,切实推动爱国主义法治教育的实施。

关键词：爱国主义法治教育爱国主义法治

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