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Programmed nanoparticle-loaded microparticles for effective antigen/adjuvant delivery

Particuology 2022年第1期20卷 77-89页

作者： Rong Xu Ying Dong Yajing zhang Xiaoli Wang Chuangnian zhang Yanjun Jiang Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences&1 Peking Union Medical CollegeTianjin 300192China School of Chemical Engineering and Technology.Hebei University of Technology.Tianjin.300130 China NHC Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic DiseasesChu Hsien-I Memorial Hospital&Tianjin Institute of EndocrinologyTianjin Medical UniversityTianjin 300134China

A microscale vaccine containing SiO_(2)nanoparticles loaded in CaC〇3 microparticles was constructed using the co-precipitation *** antigen ovalbumin(OVA)was covalently conjugated with SiO_(2)nanoparticles,and these nanoparticles and CpG were co-encapsulated into CaCO_(3)microparticles,generating a vaccine with a size of approximately 5.2μ*** electron microscopy(SEM),energy-dispersive X-ray(EDX),elemental mapping,and Fourier transform infrared(FTIR)analyses confirmed the successful preparation of the microscale vaccine;the vaccine had good storage stability without sustained antigen release,and negligible cytotoxicity to dendritic cells(DCs)and *** to SiO_(2)nanoparticles,the microscale vaccine can significantly improve antigen/adjuvant *** internalized the entire microscale vaccine into lysosomes via macropinocytosis,and an increase in antigen endo/lysosomal escape was observed by confocal User scanning microscopy(CLSM).Specifically,DCs pulsed with the vaccine were fully mature,expressing high levels of costimulatory molecules(CD40,CD80,and CD86),MHCⅡ,and MHCⅠand secreting high levels of proinflammatory cytokines(IL-12,TNF-α,IL-1β,and IL-6).In addition,the vaccine had good in vivo biocompatibility,could protect the antigen from rapid degradation,and increased the retention time in lymph ***_(2)nanoparticles-in-CaCO_(3)microparticles were an excellent carrier for antigen and adjuvant ***,this study can provide some information on the design of microscale carriers for vaccine delivery systems.

关键词： Antigen delivery Cross-presentation Microparticle Silica nanoparticle Bone marrow dendritic cell

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Enhancing effect of choline chloride-based deep eutectic solvents with polyols on the aqueous solubility of curcumin–insight from experiment and theoretical calculation

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Chinese Journal of Chemical Engineering 2023年第7期59卷 160-168页

作者： Wen Yu Yiyang Bo Yiling Luo Xiyan Huang Rixiang zhang Jiaheng zhang Research Centre of Printed Flexible Electronics School of Materials Science and EngineeringHarbin Institute of TechnologyShenzhen 518055China

The development of green solvents for enhancing aqueous solubility of drug curcumin remains a challenge. This study explores the enhancing effect of deep eutectic solvents(DESs) on the aqueous solubility of curcumin(CUR) via experiment and theoretical calculation. Choline chloride-based DESs with polyols 1,2-propanediol(1,2-PDO), 1,3-propanediol, ethylene glycol, and glycerol as hydrogen bond donors were prepared and used as co-solvents. The CUR aqueous solubility increased with increasing the DESs content at temperature of 303.15-318.15 K, especially in aqueous ChCl/1,2-PDO(mole ratio 1:4) solutions. The positive apparent molar volume values and reduced density gradient analysis confirmed the existence of strong interactions between CUR and solvent. The van der Waals interactions and hydrogen bonding coexisted in DESs monomer retained the stability of DESs structure after introducing CUR. Moreover,the lower interaction energy of DESs…CUR system than that of the counterpart DESs further proved the strong interaction between CUR and DESs. The lowest interaction energy of ChCl/1,2-PDO…CUR system indicated that this system was the most stable and ChCl/1,2-PDO was promising for CUR *** work provides efficient solvents for utilizing curcumin, contributing to a deep insight into the interactions between DES and CUR at the molecular level, and the role of DESs on enhancing drugs solubility.

关键词： Choline chloride-polyol Deep eutectic solvents Curcumin Aqueous solubility Theoretical calculation

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Role of capillary adhesion in the friction peak during the tacky transition

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Friction 2022年第8期10卷 1208-1216页

作者： Tianyan GAO Jiaxin YE Kaisen zhang Xiaojun LIU Yan zhang Kun LIU Institute of Tribology School of Mechanical EngineeringHefei University of TechnologyHefei 230009China

The friction peak that occurs in tire–road sliding when the contact changes from wet to dry was previously attributed to capillary cohesion,van der Waals attraction,and surface roughness,but the detailed mechanisms have yet to be *** this study,friction and static contact experiments were conducted using a custom-built in situ optical microtribometer,which allowed us to investigate the evolution of the friction,normal load,and contact area between a polydimethylsiloxane(PDMS)film and a silicon nitride ball during water *** friction coefficient increased by 100%,and the normal force dropped by 30%relative to those in the dry condition during the wet-to-dry *** static contact experiments,the probe indentation depth increased,and the normal load decreased by~60%as the water *** the friction and static contact results,we propose that the large friction peak that appeared in this study can be attributed to the combined effects of increased adhesive capillary force and increased plowing during the wet-to-dry transition.

关键词： friction peak capillary adhesion tacky condition polydimethylsiloxane(PDMS)film silicon nitride

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Ion conduction path in composite solid electrolytes for lithium metal batteries: from polymer rich to ceramic rich

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Frontiers in Energy 2022年第5期16卷 706-733页

作者： Zhouyu zhang Hao CHEN Zhenglin HU Shoubin ZHOU Lan zhang Jiayan LUO Key Laboratory for Green Chemical Technology of the Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Shanghai Key Laboratory of Advanced High-Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Huafu High Technology Energy Storage Co. Ltd.Yangzhou 225600China CAS Key Laboratory of Green Process and Engineering Beijing Key Laboratory of Ionic Liquids Clean ProcessState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Solid-state electrolytes(SSEs)can address the safety issue of organic electrolyte in rechargeable lithium ***,neither polymer nor ceramic SSEs used alone can meet the demand although great progress has been made in the past few *** solid electrolytes(CSEs)composed of flexible polymers and brittle but more conducting ceramics can take advantage of the individual system for solid-state lithium metal batteries(SSLMBs).CSEs can be largely divided into two categories by the mass fraction of the components:“polymer rich”(PR)and“ceramic rich”(CR)systems with different internal structures and electrochemical *** review provides a comprehensive and in-depth understanding of recent advances and limitations of both PR and CR electrolytes,with a special focus on the ion conduction path based on polymer-ceramic interaction mechanisms and structural designs of ceramic fillers/*** addition,it highlights the PR and CR which bring the leverage between the electrochemical property and the mechanical ***,it further prospects the possible route for future development of CSEs according to their rational design,which is expected to accelerate the practical application of SSLMBs.

关键词： composite solid electrolytes active filler/framework ion conduction path interphase compatibility multilayer design

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Role of transition metal oxides in g-C_(3)N_(4)-based heterojunctions for photocatalysis and supercapacitors

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Journal of Energy Chemistry 2022年第1期31卷 214-235,I0007页

作者： Liqi Bai Hongwei Huang Shixin Yu Deyang zhang Haitao Huang Yihe zhang Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes.School of Materials Science and Technology China University of GeosciencesBeijing 100083China Department of Physics&Department of Materials Science and Engineering City University of Hong KongTat Chee AvenueKowloonHong KongChina Key Laboratory of Microelectronics and Energy of Henan Province Henan Joint International Research Laboratory of New Energy Storage TechnologySchool of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000HenanChina Department of Applied Physics and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

g-C_(3)N_(4) emerges as a star 2D photocatalyst due to its unique layered structure,suitable band structure and low ***,its photocatalytic application is limited by the fast charge recombination and low *** designing g-C_(3)N_(4)-based heterojunction is promising for improving photocatalytic ***,g-C_(3)N_(4) exhibits great potentials in electrochemical energy *** view of the excellent performance of typical transition metal oxides(TMOs)in photocatalysis and energy storage,this review summarized the advances of TMOs/g-C_(3)N_(4) heterojunctions in the above two ***,we introduce several typical TMOs based on their crystal structures and band ***,we summarize different kinds of TMOs/g-C_(3)N_(4) heterojunctions,including type Ⅰ/Ⅱ heterojunction,Z-scheme,p-n junction and Schottky junction,with diverse photocatalytic applications(pollutant degradation,water splitting,CO_(2) reduction and N_(2) fixation)and supercapacitive energy ***,some promising strategies for improving the performance of TMOs/g-C_(3)N_(4) were ***,the exploration of photocatalysis-assisted supercapacitors was discussed.

关键词： Transition metal oxides Carbon nitride Heterojunction Photocatalysis Supercapacitors

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SAR performance-based fault diagnosis for electrohydraulic control system:A novel FDI framework for closed-loop system

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Chinese Journal of Aeronautics 2022年第10期35卷 381-392页

作者： Yang zhang Shaoping WANG Jian SHI Xinyu YANG Jiarui zhang Xi WANG School of Energy and Power Engineering Beihang UniversityBeijing 100191China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Institute for Automatic Control and Complex Systems(AKS) University of Duisburg-EssenDuisburg 47057Germany

Model-based fault diagnosis serves as an efficient and powerful technique in addressing fault detection and isolation(FDI)issues for control ***,the standard methods and their modifications still encounter some difficulties in algorithm design and application for complex higher-order *** avoid these difficulties,a novel fault diagnosis framework based on multiple performance indicators of closed-loop control system is *** this framework,a socalled performance residual vector is constructed to measure the differences between the real system and the nominal model in terms of system stability,accuracy,and rapidity(SAR)*** criteria for quantification,normalization of the SAR residuals and the explicit mappings between the thresholds and the required performance are *** can be easily achieved simultaneously by monitoring the normalized residual vector length and direction in the SAR performance residual space.A case study on electro-hydraulic servo control system of turbofan engine is adopted to demonstrate the effectiveness of the proposed method.

关键词： Electro-hydraulic servo valve(EHSV) Fault diagnosis Fuel metering unit Performance degradation Performance residual Stability,accuracy,and rapidity(SAR)

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Nickel-iron in the second coordination shell boost single-atomicsite iridium catalysts for high-performance urea electrooxidation

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Nano Research 2024年第5期17卷 3919-3926页

作者： Xiaoyu Chen Jiawei Wan Jing Chai Liang zhang Fang zhang Qinghua zhang Lin Gu Lirong Zheng Ranbo Yu Department of Physical Chemistry School of Metallurgical and Ecological EngineeringUniversity of Science and Technology BeijingBeijing 100083China State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and DeliveryChinese Academy of SciencesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Center for Combustion Energy School of Vehicle and MobilityState Key Laboratory of Intelligent Green Vehicle and MobilityTsinghua UniversityBeijing 100084China Analysis and Testing Center Beijing Institute of TechnologyBeijing 100081China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Beijing National Center for Electron Microscopy and Laboratory of Advanced Materials Department of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Single-atom catalysts(SACs)with high catalytic activity as well as great stability are demonstrating great promotion in electrocatalytic energy conversion,which is also a big challenge to ***,we proposed a facile synthetic strategy to construct nickel-iron bimetallic hydroxide nanoribbon stabilized single-atom iridium catalysts(Ir-NiFe-OH),where the nickel-iron hydroxide nanoribbon not only can serve as good electronic conductor,but also can well stabilize and fully expose single-atom *** as catalyst for urea oxidation reaction(UOR),it exhibited excellent UOR performance that it only needed a low operated potential of 1.38 V to achieve the current density of 100 mA·cm^(-2).In-situ Fourier transform infrared spectroscopy,X-ray absorption spectrum,and density functional theory calculations proved that Ir species are active centers and the existence of both Ni and Fe in the local structure of Ir atom can optimize the d-band center of Ir species,promoting the adsorption of intermediates and desorption of products for *** hydrogen evolution reaction(HER)/UOR electrocatalytic cell demanded voltages of 1.46 and 1.50 V to achieve 50 and 100 mA·cm^(-2),respectively,which demonstrated a higher activity and better stability than those of conventional *** work opens a new avenue to develop catalysts for UORs with boosted activity and stability.

关键词： single-atom iridium coordinate structure nanoribbon urea electrooxidation

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Machine learning enabled film pressure sensor to identify surface contacts:An application in surface transmission of infectious disease

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Building Simulation 2024年第6期17卷 1023-1036页

作者： Baotian Chang Jianchao zhang Yingying Geng Jiarui Li Doudou Miao Nan zhang Beijing Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing100124China

The global prevalence of infectious diseases has emerged as a significant challenge in recent *** transmission is a potential transmission route of most gastrointestinal and respiratory infectious diseases,which is related to surface touch *** observation,the traditional method of surface touching data collection,is characterized by limited accuracy and high labor *** this work,we proposed a methodology based on machine learning technologies aimed at obtaining high-accuracy and low-labor-cost surface touch behavioral data by means of sensor-based contact *** touch sensing device,primarily utilizing a film pressure sensor and Arduino board,is designed to automatically detect and collect surface contact data,encompassing pressure,duration and *** make certain the surface touch behavior and to describe the behavioral data more accurately,six classification algorithms(*** Vector Machine and Random Forest)have been trained and tested on an experimentally available dataset containing more than 500 surface *** classification results reported the accuracy of above 85%for all the six classifiers and indicated that Random Forest performed best in identifying surface touch behaviors,with 91.8%accuracy,91.9%precision and 0.98 *** study conclusively demonstrated the feasibility of identifying surface touch behaviors through film pressure sensor-based data,offering robust support for the calculation of viral load and exposure risk associated with surface transmission.

关键词： surface transmission touch behavior film pressure sensor random forest infectious disease

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Backdoor Attacks on Image Classification Models in Deep Neural Networks

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Chinese Journal of Electronics 2022年第2期31卷 199-212页

作者： zhang Quanxin MA Wencong WANG Yajie zhang Yaoyuan SHI Zhiwei LI Yuanzhang Beijing Institute of Technology China Information Technology Security Evaluation Center

Deep neural network(DNN) is applied widely in many applications and achieves state-of-the-art performance. However, DNN lacks transparency and interpretability for users in structure. Attackers can use this feature to embed trojan horses in the DNN structure,such as inserting a backdoor into the DNN, so that DNN can learn both the normal main task and additional malicious tasks at the same time. Besides, DNN relies on data set for training. Attackers can tamper with training data to interfere with DNN training process, such as attaching a trigger on input data. Because of defects in DNN structure and data, the backdoor attack can be a serious threat to the security of DNN. The DNN attacked by backdoor performs well on benign inputs while it outputs an attacker-specified label on trigger attached inputs. Backdoor attack can be conducted in almost every stage of the machine learning pipeline. Although there are a few researches in the backdoor attack on image classification, a systematic review is still rare in this field. This paper is a comprehensive review of backdoor attacks. According to whether attackers have access to the training data, we divide various backdoor attacks into two types: poisoning-based attacks and non-poisoning-based attacks. We go through the details of each work in the timeline, discussing its contribution and deficiencies. We propose a detailed mathematical backdoor model to summary all kinds of backdoor attacks. In the end, we provide some insights about future studies.

关键词： nonpoisoning-based attacks image classification mathematical backdoor model machine learning pipeline backdoor attack deep learning (artificial intelligence) DNN training process image classification models trojan horses deep neural network invasive software computer network security

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Characteristics,sources and health risks assessment of VOCs in Zhengzhou,China during haze pollution season

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Journal of Environmental Sciences 2021年第10期33卷 44-57页

作者： Dong zhang Bing He Minghao Yuan Shijie Yu Shasha Yin Ruiqin zhang College of Chemistry Zhengzhou UniversityZhengzhou 450001China Institute of Environmental Sciences Zhengzhou UniversityZhengzhou 450001China School of Ecology and Environment Zhengzhou UniversityZhengzhou 450001China Environmental Protection Monitoring Center Station of Zhengzhou Zhengzhou 450007China

Zhengzhou is one of the most haze-polluted cities in Central China with high organic carbon emission,which accounts for 15%-20%of particulate matter(PM_(2.5))in winter and causes significantly adverse health *** organic compounds(VOCs)are the precursors of secondary PM_(2.5)and O_(3)*** investigation of characteristics,sources and health risks assessment of VOCs was carried out at the urban area of Zhengzhou from 1^(st) to 31^(st) December,*** mean concentrations of total detected VOCs were 48.8±23.0 ***(22.0±10.4 ppbv),halocarbons(8.1±3.9 ppbv)and aromatics(6.5±3.9 ppbv)were the predominant VOC species,followed by alkenes(5.1±3.3 ppbv),oxygenated VOCs(3.6±1.8 ppbv),alkyne(3.5±1.9,ppbv)and sulfide(0.5±0.9 ppbv).The Positive Matrix Factorization model was used to identify and apportion VOCs *** major sources of VOCs were identified as vehicular exhaust,industrial processes,combustion,fuel evaporation,and solvent *** carcinogenic and non-carcinogenic risk values of species were *** carcinogenic and non-carcinogenic risks of almost all air toxics increased during haze *** total non-carcinogenic risks exceeded the acceptable *** VOC species posed no non-carcinogenic risk during three haze *** carcinogenic risks of chloroform,1,2-dichloroethane,1,2-dibromoethane,benzyl chloride,hexachloro-1,3-butadiene,benzene and naphthalene were above the acceptable level(1.0×10^(-6))but below the tolerable risk level(1.0×10^(-4)).Industrial emission was the major contributor to non-carcinogenic,and solvent use was the major contributor to carcinogenic risks.

关键词： Zhengzhou Positive Matrix Factorization Health risks VOC profiles

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