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Chinese Chemical Letters 2024年第2期35卷 415-419页

作者： yufen Lv Hongyu Ding Jinmao You Wei Wei Dong Yi Key Laboratory of Catalytic Conversion and Clean Energy in Universities of Shandong Province School of Chemistry and Chemical EngineeringQufu Normal UniversityQufu 273165China College of Chemistry and Chemical Engineering Shaoxing UniversityShaoxing 312000China School of Pharmacy Southwest Medical UniversityLuzhou 646000China

An additive-free and environmentally friendly strategy has been realized for the construction of S-substituted isothioureas through visible-light-induced multicomponent reaction starting fromα-diazoesters,aryl isothiocyanates,amines and cyclic *** methodology features simple operation,mild reaction conditions,favorable functional group tolerance,easily available starting materials and high efficiency.

关键词： Visible-light Additive-free Four-component reaction S-Substituted isothioureas

球坐标系六片网格下三维定态行星际太阳风模拟

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空间科学学报 2014年第6期34卷 773-784页

作者：张嫚周玉芬中国科学院空间科学与应用研究中心空间天气学国家重点实验室中国科学院大学

采用二阶MacCormack差分格式,利用稳态的磁流体(MHD)方程组在球坐标系六片网格下模拟研究了行星际太阳风.六片网格系统能有效避免极区奇性和网格收敛性.迭代按径向方向推进求解,很大程度上减少了计算量,节约了计算时间.内边界条件根据... 详细信息

采用二阶MacCormack差分格式,利用稳态的磁流体(MHD)方程组在球坐标系六片网格下模拟研究了行星际太阳风.六片网格系统能有效避免极区奇性和网格收敛性.迭代按径向方向推进求解,很大程度上减少了计算量,节约了计算时间.内边界条件根据太阳与行星际观测确定,比较测试了5种内边界条件,模拟给出了1922卡林顿周的背景太阳风结构.几种内边界条件所得模拟结果与行星际观测基本吻合.太阳风速度采用McGregor等的经验公式给出,磁场由水平电流片(HCCS)模型得到,密度和温度分别根据动量守恒和气压守恒得到,研究表明采用这样的边界条件模拟结果最佳.

关键词： MHD方程组六片网格系统行星际太阳风模拟

Knockdown of RCN1 contributes to the apoptosis of colorectal cancer via regulating IP3R1

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BIOCELL 2024年第5期48卷 835-845页

作者： XUAN SHI yufen WANG CHENYU LI WANGSHU FU XINYUE ZHANG AIXIA GONG Department of Gastroenterology The First Affiliated Hospital of Dalian Medical UniversityDalianChina Department of Gastroenterology The First Affiliated Hospital of Jinzhou Medical UniversityJinzhouChina The First Clinical College Dalian Medical UniversityDalianChina

Background:The incidence of colorectal cancer(CRC)has been increasing in recent ***,the discovery of factors that can assist in alleviating CRC is urgently ***:To identify a potential factor involved in the development of CRC,we screened the upregulated genes in tumor tissues through four datasets from an online *** expression of reticulocalbin 1(RCN1),a Ca2+-binding protein,was upregulated in the four *** on loss-offunction experiments,the effect of RCN1 on cell viability was assessed by Cell Counting Kit-8(CCK-8)*** regulatory effect of RCN1 on apoptosis was evaluated through Annexin V-fluorescein 5-isothiocyanate(FITC)/propidium iodide(PI)staining assay and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling(TUNEL)assay in RKO and SW480 *** of endoplasmic reticulum(ER)stress signaling pathways was confirmed by estimating the phosphorylation and expression of PRKR-like ER kinase(PERK),inositol-requiring kinase-1(IRE1),transcription factor 6(ACT6),and CCAAT/enhancer-binding protein-homologous protein(CHOP).The intracellular Ca2+homeostasis regulated by RCN1 was determined through the detection of Ca2+concentration and mitochondrial membrane potential(MMP)***,whether inositol 1,4,5-trisphosphate receptor type 1(IP3R1)was involved in the regulation of RCN1 in CRC was verified through the depletion of IP3R1 in RKO ***:Knockdown of RCN1 reduced cell viability and facilitated apoptosis in RKO and SW480 *** of PERK and IRE1,activation of ATF6,and upregulation of CHOP were induced by the absence of RCN1,suggesting that the unfolded protein response(UPR)was activated in CRC *** concentration of Ca2+in mitochondria was increased after RCN1 depletion,followed by reduction in the MMP and release of cytochrome c from mitochondria to the cytoplasm in RKO and SW480 ***,it was demonstrated that IP3R1 mediates the effect of RCN1 on apoptosis i

关键词： Reticulocalbin 1 Unfolded protein response IP3R1 Colorectal cancer

3D interlocked all-textile structured triboelectric pressure sensor for accurately measuring epidermal pulse waves in amphibious environments

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Nano Research 2024年第3期17卷 1923-1932页

作者： Shaobo Si Chenchen Sun yufen Wu Jingjing Li Han Wang Yinggang Lin Jin Yang Zhong Lin Wang Department of Optoelectronic Engineering Key Laboratory of Optoelectronic Technology and Systems Ministry of EducationChongqing UniversityChongqing 400044China College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 401331China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100083China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

The performance degradation and even damage of the e-textiles caused by sweat,water,or submersion during all-weather health monitoring are the main reasons that e-textiles have not been commercialized and routinized so ***,we developed an amphibious,high-performance,air-permeable,and comfortable all-textile triboelectric sensor for continuous and precise measurement of epidermal pulse waves during full-day *** on the principle of preparing gas by acid-base neutralization reaction,a one-piece preparation process of amphibious conductive yarn(ACY)with densely porous structures is *** innovative three-dimensional(3D)interlocking fabric knitted from ACYs(0.6 mm in diameter)and polytetrafluoroethylene yarns exhibit high sensitivity(0.433 V·kPa^(-1)),wide bandwidth(up to 10 Hz),and stability(>30,000 cycles).With these benefits,98.8%agreement was achieved between wrist pulse waves acquired by the sensor and a high-precision laser ***,the polytetrafluoroethylene yarn with good compression resilience provides sufficient mechanical support for the contact separation of the ***,the unique skeletonized design of the 3D interlocking structure can effectively relieve the water pressure on the sensor surface to obtain stable and accurate pulse waves(underwater depth of 5 cm).This achievement represents an important step in improving the practicality of e-textiles and early diagnosis of cardiovascular diseases.

关键词： triboelectric pressure sensor amphibious fabric interlocking fabric pulse wave measurement one-piece preparation method

Additive-free synthesis of β-keto phosphorodithioates via geminal hydro-phosphorodithiolation of sulfoxonium ylides with P_(4)S_(10)and alcohols

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Chinese Chemical Letters 2024年第9期35卷 165-168页

作者： Jindong Hao yufen Lv Shuyue Tian Chao Ma Wenxiu Cui Huilan Yue Wei Wei Dong Yi Key Laboratory of Catalytic Conversion and Clean Energy in Universities of Shandong Province School of Chemistry and Chemical EngineeringQufu Normal UniversityQufu 273165China Qinghai Provincial Key Laboratory of Tibetan Medicine Research and CAS Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau BiologyXining 810008China Green Pharmaceutical Technology Key Laboratory of Luzhou City School of PharmacySouthwest Medical UniversityLuzhou 646000China

A simple and additive-free protocol has been developed for the preparation ofβ-keto phosphorodithioates through the three-component reaction of easily available sulfoxonium ylides,P_(4)S_(10),and *** present geminal hydro-phosphorodithiolation reaction was performed at room temperature to construct a series ofβ-keto phosphorodithioates in the absence of any metal reagents,bases,or additives.

关键词： β-Keto phosphorodithioates Phosphorodithiolation Sulfoxonium ylides P_(4)S_(10) Alcohols

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microRNAs与胰腺癌的研究进展

胃肠病学 2011年第8期16卷 493-495页

作者：周郁芬袁耀宗上海交通大学医学院附属瑞金医院消化内科 200025

胰腺癌是恶性程度较高的肿瘤,早期诊断困难。microRNAs(miRNAs)由19～23个核苷酸所组成的小分子单链RNA。miRNAs属基因负调控因子,可在转录后水平调控靶基因的表达,从而影响肿瘤细胞的发育、分化和凋亡等。近年研究发现,胰腺癌组织、细... 详细信息

胰腺癌是恶性程度较高的肿瘤,早期诊断困难。microRNAs(miRNAs)由19～23个核苷酸所组成的小分子单链RNA。miRNAs属基因负调控因子,可在转录后水平调控靶基因的表达,从而影响肿瘤细胞的发育、分化和凋亡等。近年研究发现,胰腺癌组织、细胞株、癌前病变和血浆中均存在miRNAs表达谱异常,提示miRNAs可能在胰腺癌发生和发展机制的研究、诊断、治疗和预后判断中具有一定应用价值。本文就相关研究进展作一综述。

关键词：胰腺肿瘤微RNAs 诊断预后治疗

Direct Synthesis of α-Aminophosphonates from Amines,Alcohols,and White Phosphorus

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CCS Chemistry 2024年第1期6卷 91-99页

作者： Mengpei Bai Yinwei Cao Junwei Huang Yan Liu Guo Tang yufen Zhao Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province College of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005

Developing practical strategies for the synthesis of organophosphorus compounds(OPCs)from white phosphorus(P_(4))without the use of Cl_(2) and PCl_(3) remains a significant *** first multicomponent oxidative α-phosphonylation of amines with P_(4) and alcohols has been *** the use of copper(Ⅱ)as the catalyst and air as the safe oxidant,structurally sophisticated α-aminophosphonates have been prepared in high ***,this method is also suitable for selective construction of P-O-P *** reaction is characterized by a complete conversion of P_(4).The activation of P_(4) with transition metals often leads to formation of complexes[M_(x)P_(y)]_(n) associated with the deactivation of transition *** breakthrough showcases the potential of transition-metal-catalyzed reactions in elemental phosphorus chemistry.

关键词： white phosphorus P-C bonds dialkyl phosphites aminophosphonates pyrophosphates

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大型双曲冷却塔气弹模型风洞试验和响应特性

建筑结构学报 2010年第2期31卷 61-68页

作者：柯世堂赵林葛耀君张军锋周玉芬同济大学土木工程防灾国家重点试验室上海200092

双曲薄壳冷却塔是典型的风敏感结构,气动弹性模型风洞试验是研究其风振响应的有效方法。根据某大型双曲冷却塔结构动力特性和风振响应的特点,按相似准则合理简化,成功设计和制作了这一复杂结构的气动弹性模型,并在大型边界层风洞中模拟... 详细信息

双曲薄壳冷却塔是典型的风敏感结构,气动弹性模型风洞试验是研究其风振响应的有效方法。根据某大型双曲冷却塔结构动力特性和风振响应的特点,按相似准则合理简化,成功设计和制作了这一复杂结构的气动弹性模型,并在大型边界层风洞中模拟的B类风场、7个工况共112个风向角下进行了试验。根据试验结果可得:结构的位移响应特征参数均和风速呈现线性关系,干扰作用减小了位移响应的均值,增大了其脉动量,并使其沿环向的变化趋势发生改变;8m/s风速下测压试验计算的结构响应值相比气弹试验结果均值偏小、均方差偏大;单塔工况下背景分量占据主导地位,而多塔干扰影响使背景分量不再居于主导地位,共振响应趋于显著;多塔干扰下以原型结构10cm位移为阈值计入风振系数贡献的测点数减少,但是响应根方差增大,其风振系数均值相比单塔下结果明显变大。

关键词：双曲冷却塔气动弹性模型等效梁格设计法风洞试验风致响应

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醇酸树脂酸值测定的溶剂绿色化研究

涂料工业 2010年第8期40卷 73-75页

作者：郑绍成周玉芬陈晓浙江师范大学化学与生命科学学院浙江金华321004 金华职业技术学院材化学院浙江金华321017

醇酸树脂的生产控制中酸值是关键,目前大都采用中和法测定酸值,在酸值测定中一般所使用的溶剂为甲苯和乙醇混合物,由于甲苯对人体具有较大毒害性,本研究对醇酸树脂酸值测定中的溶剂进行了绿色化研究,比较了8种溶剂的毒性和挥发性,考察... 详细信息

醇酸树脂的生产控制中酸值是关键,目前大都采用中和法测定酸值,在酸值测定中一般所使用的溶剂为甲苯和乙醇混合物,由于甲苯对人体具有较大毒害性,本研究对醇酸树脂酸值测定中的溶剂进行了绿色化研究,比较了8种溶剂的毒性和挥发性,考察了柠檬烯与乙醇不同体积的混合比例对溶解醇酸树脂的影响,结果表明柠檬烯与乙醇混合的体积比为1∶1.5的互溶效果较好。并进行了修正,修正后的酸值测定的酸值之间最大相对误差小于0.36%。根据醇酸树脂的性质认为柠檬烯可以作为其酸值测定的溶剂,是较佳替代品。

关键词：醇酸树脂酸值柠檬烯溶剂绿色化

Peracetic acid(PAA)-based pretreatment effectively improves medium-chain fatty acids(MCFAs)production from sewage sludge

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Environmental Science and Ecotechnology 2024年第4期20卷 154-166页

作者： yufen Wang Haixiao Guo Xuecheng Li Xueming Chen Lai Peng Tingting Zhu Peizhe Sun Yiwen Liu School of Environmental Science and Engineering Tianjin UniversityTianjin300072China Fujian Provincial Engineering Research Center of Rural Waste Recycling Technology College of Environment and Safety EngineeringFuzhou UniversityFujian350116China Hubei Key Laboratory of Mineral Resources Processing and Environment Wuhan University of TechnologyLuoshi Road 122WuhanHubei430070China School of Resources and Environmental Engineering Wuhan University of TechnologyLuoshi Road 122WuhanHubei430070China

Peracetic acid(PAA),known for its environmentally friendly properties as a oxidant and bactericide,is gaining prominence in decontamination and disinfection *** primary product of PAA oxidation is acetate that can serve as an electron acceptor(EA)for the biosynthesis of medium-chain fatty acids(MCFAs)via chain elongation(CE)***,PAA-based pretreatment is supposed to be beneficial for MCFAs production from anaerobic sludge fermentation,as it could enhance organic matter availability,suppress competing microorganisms and furnish EA by providing ***,such a hypothesis has rarely been *** we reveal that PAA-based pretreatment leads to significant exfoliation of extracellular polymeric substances(EPS)from sludge flocs and disruption of proteinic secondary structures,through inducing highly active free radicals and singlet *** production of MCFAs increases substantially to 11,265.6 mg COD L^(-1),while the undesired byproducts,specifically long-chain alcohols(LCAs),decrease to 723.5 mg COD L^(-1).Microbial activity tests further demonstrate that PAA pretreatment stimulates the CE process,attributed to the up-regulation of functional genes involved in fatty acid biosynthesis *** comprehensive findings provide insights into the effectiveness and mechanisms behind enhanced MCFAs production through PAA-based technology,advancing our understanding of sustainable resource recovery from sewage sludge.

关键词： Sewage sludge Medium-chain fatty acids(MCFAs) Extracellular polymeric substances(EPS) Peracetic acid(PAA) Metabolic activity