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Science China(Life Sciences) 2021年第9期64卷 1522-1532页

作者： Xiao-Feng Zhang Tianbao Zeng Yunjie Xie yuemin zheng Huanqin Wang Hanbin Lin Zongwen Wang Taiyun Wei State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Institute of Plant VirologyFujian Agriculture and Forestry UniversityFuzhou 350002China

Intracellular polyamines(putrescine,spermidine,and spermine)have emerged as important molecules for viral infection;however,how viruses activate polyamines biosynthesis to promote viral infection remains *** decarboxylase 1(ODC1)and its antienzyme 1(OAZ1)are major regulators of polyamine biosynthesis in animal ***,we report that rice yellow stunt virus(RYSV),a plant rhabdovirus,could activate putrescine biosynthesis in leafhoppers to promote viral propagation by inhibiting OAZ1 *** observed that the reduction of putrescine biosynthesis by treatment with difluormethylornithine(DFMO),a specific nontoxic inhibitor of ODC1,or with in vitro synthesized dsRNAs targeting ODC1 mRNA could inhibit viral *** contrast,the supplement of putrescine or the increase of putrescine biosynthesis by treatment with ds RNAs targeting OAZ1 mRNA could facilitate viral *** further determined that both RYSV matrix protein M and ODC1 directly bind to the ODC-binding domain at the C-terminus of ***,viral propagation in leafhoppers would decrease the ability of OAZ1 to target and mediate the degradation of ODC1,which finally activates putrescine production to benefit viral *** work reveals that polyamine-metabolizing enzymes are directly exploited by a vector-borne virus to increase polyamine production,thereby facilitating viral infection in insect vectors.

关键词： rice yellow stunt virus leafhopper polyamines viral infection plant virus

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基于负荷电流的综合管廊电缆发热量计算

暖通空调 2024年第5期54卷 67-71,116页

作者：庄璐叶黎明尹力文郑月敏张娟徐昌鹏中冶京诚工程技术有限公司北京南开大学天津

综合管廊属于密闭型地下构筑物,廊内敷设的电缆是主要的发热源。准确估计入廊电缆的发热量有助于通风设备的合理选择和工艺的科学设计,避免造成资源和成本的浪费。本文提出了基于负荷电流的电缆发热量计算方法,通过对出变电站母线段电... 详细信息

综合管廊属于密闭型地下构筑物,廊内敷设的电缆是主要的发热源。准确估计入廊电缆的发热量有助于通风设备的合理选择和工艺的科学设计,避免造成资源和成本的浪费。本文提出了基于负荷电流的电缆发热量计算方法,通过对出变电站母线段电缆进行分析,得到了更为精确的电缆负荷电流。通过计算可知,使用负荷电流进行电缆发热量计算得到的结果比使用载流量进行电缆发热量计算的结果更为准确,且明显减小,可以实现在满足规范要求和功能需要的前提下降低能耗、节约成本。

关键词：电缆发热量综合管廊负荷电流载流量管廊温度

Towards Achieving Carbon Neutrality: The Role of Vegetation Restoration in Karst Regions of Southwest China

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Journal of Earth Science 2024年第3期35卷 1044-1048页

作者： yuemin Yue Lu Wang Xinbao Zhang Kelin Wang Guangxi Key Laboratory of Karst Ecological Processes and Services Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Huanjiang Observation and Research Station for Karst Ecosystem Chinese Academy of SciencesHuanjiang 547100China Chengdu Institute of Mountain Disasters and Environment Chinese Academy of Sciences&Ministry of Water ResourcesChengdu 610041China

Karst regions of Southwest China become a hotspot for global greening through large-scale vegetation restoration in recent two ***,the unique,fragile geological setting of carbonate rocks affects the sustainability of vegetation ***,we summarize and evaluate the impacts of the rock and soil compositions of karst landscapes on the types and quality of vegetation *** introduce the concept of“soil mass”and establish its relationship with aboveground vegetation biomass across varying degrees of rocky *** mineral nutrients and soil mass constrain the potential of vegetation carbon sequestration in karst *** enhance the sustainability of vegetation restoration and carbon sequestration under karst geological constraints,we suggest to push ecological intensification of tree plantations and optimize the zoning and classification of rocky desertification treatment,and these restoration initiatives will foster vegetation restoration to serve as a pivotal pathway towards carbon neutrality.

关键词： soil karst Restoration

A model for predicting the segregation directions of binary Geldart B particle mixtures in bubbling fluidized beds

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Particuology 2024年第7期90卷 340-349页

作者： Chenmin Liu yuemin Zhao Yanjiao Li Yuqing Feng Chenlong Duan Chenyang Zhou Liang Dong Key Laboratory of Coal Processing and Efficient Utilization Ministry of EducationChina University of Mining and TechnologyXuzhou221116China School of Chemical Engineering and Technology China University of Mining and TechnologyXuzhou221116China Mineral Resources Business Unit CSIROClaytonVIC 3169Australia

In gas fluidization processes involving different types of particles,the mixing or segregation behavior of the solid mixture is crucial to the overall outcome of the *** study develops a model to predict the segregation directions of binary mixtures of Geldart B particles with density and size differences in bubbling fluidized *** proposed model was established by combining the particle segregation model,a previous particle segregation model,with a derived bed voidage equation of the bubbling fluidization based on the two-phase *** model was then analyzed with different function graphs of the model equations under various *** results indicated that an increase in gas velocity or volume fraction of larger particles would strengthen size segregation,causing the larger and less dense components to *** validate the model,42 sets of data collected from 6 independent literature sources were compared with the predictions of the *** the gas velocities were below 3.2 times the minimum gas velocity,the predictions were consistent with experimental *** study has shed new light on the mechanisms of particle segregation in binary fluidized systems and provides a theoretical foundation for designing and manipulating gas-solid fluidized reactors.

关键词： Particle segregation Binary mixture Bubbling fluidization Geldart B particles Two-phase theory

Electricity-driven enantioselective cross-dehydrogenative coupling of two C(sp^(3))-H bonds enabled by organocatalysis

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Chinese Chemical Letters 2024年第9期35卷 130-134页

作者： yuemin Chen Yunqi Wu Guoao Wang Feihu Cui Haitao Tang Yingming Pan State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences of Guangxi Normal UniversityGuilin 541004China

An efficient and scalable electrochemical asymmetric protocol with metal-free catalysts and even without additional oxidants for the cross-dehydrogenative coupling reaction(CDC)of two C(sp^(3))-H bonds is reported.A series of aldehydes including natural products and various substrates containing C(sp^(3))-H bonds including xanthenes,acridines,cycloheptatrienes and even diarylmethane have been shown to undergo asymmetric CDC to afford a series of carbon-carbon bond coupling products with up to 94%yield and 98%*** studies such as radical clock experiment suggest that the reaction proceeds via nucleophilic attack by enamine under electrochemical conditions.

关键词： Aminocatalysis Electrochemistry Asymmetric catalysis CDC of C(sp^(3))-H bonds

阿托伐他汀治疗冠心病临床疗效及对患者心功能和血清炎症因子的影响

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首都食品与医药 2022年第13期29卷 56-58页

作者：郑月敏天津市静海区医院天津301600

目的探讨阿托伐他汀对冠心病(CHD)患者IL-18、TG、TC、CRP以及hs-CRP的作用.方法随机选取天津市静海区医院在2018年5月-2019年12月就诊的冠心病患者60例作为研究对象,按照双盲信封法将其分为对照组和观察组各30例.对照组给予常规治疗,... 详细信息

目的探讨阿托伐他汀对冠心病(CHD)患者IL-18、TG、TC、CRP以及hs-CRP的作用.方法随机选取天津市静海区医院在2018年5月-2019年12月就诊的冠心病患者60例作为研究对象,按照双盲信封法将其分为对照组和观察组各30例.对照组给予常规治疗,观察组给予阿托伐他汀治疗,观察两组患者的IL-18、TG、TC、CRP以及hs-CRP水平、心脏功能和内皮功能.结果治疗后对照组LVEF(%)和FMD(%)分别为(40.24±6.73)和(7.90±1.29),而观察组分别为(50.87±8.54)和(7.60±1.30),两组比较,差异显著(P<0.05).治疗后,两组患者的IL-18、TG、TC、CRP以及hs-CRP含量差异显著(P<0.05);两组患者用药后随访24个月,随访期间观察组心绞痛复发风险显著低于对照组(HR=0.56,95%CI:0.23-0.88,P<0.05).结论阿托伐他汀能够改善冠心病患者血清炎症水平和内皮功能,降低心绞痛发生风险.

关键词：阿托伐他汀冠状动脉粥样硬化心脏病临床价值心功能

含发电速率约束的三区域互联电力系统自抗扰控制

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哈尔滨工程大学学报 2020年第9期41卷 1312-1319页

作者：陈增强郑月敏孙明玮孙青林南开大学人工智能学院天津300350 天津市智能机器人重点实验室天津300350

针对含有发电速率约束的负荷频率控制系统的线性自抗扰控制问题,首先通过仿真发现发电速率的存在会影响系统的控制性能,为此,本文将含有发电速率约束的汽轮机输出与理想地不含发电速率约束的输出误差反馈到线性自抗扰控制器的PD控制组合... 详细信息

针对含有发电速率约束的负荷频率控制系统的线性自抗扰控制问题,首先通过仿真发现发电速率的存在会影响系统的控制性能,为此,本文将含有发电速率约束的汽轮机输出与理想地不含发电速率约束的输出误差反馈到线性自抗扰控制器的PD控制组合中,从而减小发电速率约束对系统的影响;最后,将上述方法应用到三区域互联电力系统中,并利用仿真图与性能指标结果来体现所提方法的有效性。结果表明:改进的系统在不增加参数的情况下能够取得很好的控制效果,且具有较强的鲁棒性。

关键词：自抗扰控制线性自抗扰控制降阶自抗扰控制器三区域互联电力系统负荷频率控制发电速率约束区域控制误差再热汽轮机

Human disturbance exacerbated erosion and deposition in the karst peak-cluster depressions during the Ming and Qing dynasties

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Science China Earth Sciences 2024年第11期 3550-3561页

作者： Shuai YUAN yuemin YUE Xinbao ZHANG Lu WANG Lu ZHAI Kelin WANG Key Laboratory for Agro-Ecological Processes in Subtropical Region Institute of Subtropical Agriculture Chinese Academy of Sciences Huanjiang Observation and Research Station for Karst Ecosystems Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Mountain Hazards and Environment Ministry of Water Resources Chinese Academy of Sciences State Key Laboratory of Environmental Geochemistry Institute of Geochemistry Chinese Academy of Sciences

Under the background of large-scale ecological restoration, China's southwestern karst region has become a hotspot of global vegetation cover “greening” in the past 20 years. However, because of geological constraints, it is difficult to restore the forest landscapes in some areas. It is urgent to understand the impacts of human disturbances during the historical period on the difficult-to-forestation rocky-desertification areas of the karst region in order to guide future afforestation. In this study, we quantified the changes of specific sediment yield in typical karst depressions over the past 500 years by using137Cs,210Pb, and14C dating methods in karst depressions, and identified the main human disturbances related to historical erosion and sedimentation by combining with historical data. The results showed that the erosion and sedimentation of the three depressions in 1921–1963 were significantly higher than that in 1963–2021, and the sedimentation rate(0.64–1.33 cm a-1) and the specific sediment yield(2.51–13.11 t ha-1a-1) during Ming and Qing dynasties（1504–1812） were higher than the sedimentation rate(0.26–0.95 cm a-1) and specific sediment yield(0.95–6.99 t ha-1a-1) in the recent century（1921–2021）. Reconstruction data and literature from the Ming and Qing dynasties show an empirical link between changes in population, arable land, food, forest area,and deforestation events during the same period. It was found that the population and arable land in Guangxi increased more than three-fold and the forest area decreased significantly in the 17th century after the migration of the Yao ethnic group and the introduction of maize to the region, which may be the main reason for intensifying the erosion of depressions. This study is of great significance to understanding the evolution history of rocky desertification in this region and to answer the potential of afforestation.

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血红素加氧酶1调控铁死亡对非酒精性脂肪性肝病的作用机制研究进展

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中华肝脏病杂志 2024年第3期32卷 262-267页

作者：苑喜微南月敏河北医科大学第三医院中西医结合肝病科河北省慢性肝病肝纤维化机制研究重点实验室石家庄050051

非酒精性脂肪性肝病(NAFLD),已逐渐成为世界上流行率最高的慢性肝病,但其发病机制尚未完全阐明。铁死亡是一种由铁依赖性脂质过氧化引起的程序性细胞死亡新形式。血红素加氧酶1为公认的抗氧化酶,亦为铁死亡中重要的调节因子,可通过多种... 详细信息

非酒精性脂肪性肝病(NAFLD),已逐渐成为世界上流行率最高的慢性肝病,但其发病机制尚未完全阐明。铁死亡是一种由铁依赖性脂质过氧化引起的程序性细胞死亡新形式。血红素加氧酶1为公认的抗氧化酶,亦为铁死亡中重要的调节因子,可通过多种途径调节铁死亡进而调控NAFLD。现就血红素加氧酶1在铁死亡途径中对NAFLD的调控作用机制进行综述,以期探明NAFLD发生和发展机制,并为其防治问题提供新视野、新靶点。

关键词：非酒精性脂肪性肝病血红素加氧酶1 铁死亡

Intermittent fasting boosts antitumor immunity by restricting CD11b^(+)Ly6C^(low)Ly6G^(low) cell viability through glucose metabolism in murine breast tumor model

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Food Science and Human Wellness 2024年第4期13卷 2327-2345页

作者： Chenghao Fu Zhehao Liang Zemiao Niu Ning Chen yuemin Li Zhenhua Liang Yanwei Huo Hao Xi Rong Wang Yonghuan Yan Xiaoruo Gan Mengtian Wang Yun Huang Yan Zhang Mingming Gao Pin Lü Postdoctoral Station for Basic Medicine Cardiovascular Medical Science CenterDepartment of Cell BiologyKey Laboratory of Neural and Vascular Biology of Ministry of EducationHebei Medical UniversityShijiazhuang 050017China Hebei Key Laboratory of Forensic Medicine College of Forensic MedicineHebei Medical UniversityShijiazhuang 050017China Hebei Food Safety Key Laboratory Hebei Food Inspection and Research InstituteShijiazhuang 050091China Laboratory of Lipid Metabolism Department of Biochemistry and Molecular BiologyKey Laboratory of Medical Biotechnology of Hebei ProvinceShijiazhuang 050017China

Intermittent fasting can benefit breast cancer patients undergoing chemotherapy or ***,it is still uncertain how to select immunotherapy drugs to combine with intermittent *** we observed that two cycles of fasting treatment significantly inhibited breast tumor growth and lung tissue metastasis,as well as prolonged overall survival in mice bearing 4T1 and 4T07 breast *** this process,both the immunosuppressive monocytic-(M-)and granulocytic-(G-)myeloid-derived suppressor cell(MDSC)decreased,accompanied by an increase in interleukin(IL)7R^(+)and granzyme B^(+)T cells in the tumor ***,we observed that Ly6G^(low)G-MDSC sharply decreased after fasting treatment,and the cell surface markers and protein mass spectrometry data showed potential therapeutic *** investigation revealed that glucose metabolism restriction suppressed the splenic granulocytemonocyte progenitor and the generation of colony-stimulating factors and IL-6,which both contributed to the accumulation of *** the other hand,glucose metabolism restriction can directly induce the apoptosis of Ly6G^(low)G-MDSC,but not Ly6G^(high)*** summary,these results suggest that glucose metabolism restriction induced by fasting treatment attenuates the immune-suppressive milieu and enhances the activation of CD3^(+)T cells,providing potential solutions for enhancing immune-based cancer interventions.

关键词： Intermittent fasting Ly6G^(low)myeloid-derived suppressor cell apoptosis Extramedullary hematopoiesis Colony stimulating factor Glucose metabolism restriction