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Current research progress on cell membrane decorated macroscopic biomaterials

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Medicine in Novel Technology and Devices 2024年第1期21卷 23-30页

作者： Lingbing Yang Linhao Li yubo fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China

The cell membranes,derived from natural sources,possesses unique physicochemical properties of phospholipid bilayers and biological functionalities of membrane *** makes it an ideal biomimetic coating to enhance the in vivo circulation and retention time of micro/nanodrug carriers,provide targeted drug delivery effects,and neutralize bacterial ***,recent studies have successfully coated various types of cell membranes onto the surfaces of macroscopic materials,such as electrospun fiber scaffolds and decellularized matrices,to promote tissue repair,modulate host responses to foreign materials,and alleviate *** review comprehensively summarizes the latest research progress in the modification of macroscopic biomaterials with cell *** insights provided aim to serve as a valuable reference for the preparation of cell membrane biomimetic coatings and their applications in the field of tissue repair.

关键词： Cell membrane coating Macroscopic biomaterials Tissue repair Foreign body reactions

Biophysical cues involved in the stem cell niche for stemness maintenance

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Medicine in Novel Technology and Devices 2024年第2期22卷 80-89页

作者： Chiyu Li Lisha Zheng yubo fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China

The characteristics of stem cells are self-renewal ability and differentiation *** properties are defined as stemness,offering them application in tissue repair and regeneration based on stem cells with great ***,stem cells undergo functional deterioration and gradually lose stemness with long-term *** evidence implies that the regulation of stemness is primarily orchestrated by the niche,which comprises the connection between stem cells and niche cells,extracellular matrix(ECM)proteins,and secreted ***,physical signals are being acknowledged as paramount regulators of cellular behavior,governing stem cell stemness,tissue development,and *** review outlines current approaches for stemness maintenance and the important biophysical cues involved in the stem *** first encompass the latest discoveries regarding the sources and transduction pathways of these biophysical ***,the specific biophysical factors for regulating stemness have been ***,we summarize existing challenges and prospect future research in this field.

关键词： Stemness Stem cell Biophysical Niche

Multi-objective structural optimization and degradation model of magnesium alloy ureteral stent

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Medicine in Novel Technology and Devices 2024年第2期22卷 19-28页

作者： Lin Zhu Qiao Li Yuanming Gao Lizhen Wang yubo fan Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China School of Engineering Medicine Beihang UniversityBeijing100191China

Background:Mg alloys have attractive properties,including biocompatibility,biodegradability,and ideal mechanical ***,Mg alloys are regarded as one of the promising candidates for manufacturing ureteral *** study proposed a multi-objective optimization method based on the Kriging surrogate model,NSGA-III,and finite element analysis to improve the degradation performance of Mg alloy ureteral ***:The finite element model for the degradation of Mg alloy ureteral stents has been established to compare the degradation performance of the stents under different *** hypercube sampling was adopted to generate train sample points in the design ***,the Kriging surrogate model was constructed between strut parameters and stent degradation *** NSGA-III was utilized to determine the optimal solution in the global design ***:The optimized stent achieved 5.52degradation uniformity(M),10degradation time(DT),and 4work time(FT).The errors between the Kriging surrogate model and the finite element calculation results were less than 6%.Conclusion:The optimized stent achieved better degradation *** degradation behavior of stents was dependent on the design *** multi-objective optimization method based on the Kriging surrogate model and finite element analysis was effective in stent design optimization problems.

关键词： Mg alloys ureteral stent Kriging surrogate model NSGA-III Multi-objective optimization Degradation model

Wireless measurement of orthodontic forces in invisible aligners

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Medicine in Novel Technology and Devices 2024年第1期21卷 64-70页

作者： Siyu Wang Bingxin Xu Xiaokang Wang Xinfang Li Bangzheng Pu Gui Chen Jianmin Han Shengzhao Xiao yubo fan Jiebo Li Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationInstitute of Medical PhotonicsBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100191China Department of Orthodontics Peking University School and Hospital of Stomatology&.National Clinical Research Center for Oral Diseases&.National Engineering Laboratory for Digital and Material Technology of Stomatology&.Beijing Key Laboratory of Digital Stomatology&.Research Center of Engineering and Technology for Computerized Dentistry Ministry of HealthBeijing100081China Department of Dental Materials Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijing100081China Department of Orthodontics Shanghai Ninth People's HospitalCollage of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghaiChina

Invisible orthodontic treatment is an effective form of malocclusion treatment favored in recent *** magnitude of its orthodontic force has a crucial impact on the outcome of the treatment and has gained a high level of clinical ***,there are very few explorations of in vivo measurements of orthodontic force,and existing studies are limited to a large number of couplings,which are inconvenient for clinical *** this work,we developed a wireless flexible measurement system that allows quantitative measurement of the orthodontic force of an invisible aligner on a dental *** system is wireless,tiny,flexible,fast responding,and has a range suitable for the range of orthodontic *** show the difference in the orthodontic force applied to different tooth positions and the difference in the orthodontic force applied to different positions of the same *** addition,the system can evaluate the mechanical differences between aligners of different brands and materials as well as the deviation of fabrication *** system provides a test tool and evaluation method for future real-time assessment of clinical orthodontic forces.

关键词： Orthodontic forces Wireless measurement systems Flexible sensors Invisible orthodontics Performance evaluation Quantitative measurements

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线粒体的力学生物学研究进展

医用生物力学 2024年第3期39卷 545-551页

作者：纳静郑丽沙樊瑜波北京航空航天大学生物与医学工程学院生物力学与力生物学教育部重点实验室北京市生物医学工程高精尖创新中心北京100083

线粒体是高度动态的细胞器,不仅为细胞提供能量和物质基础,同时参与调控细胞的增殖、迁移、分化和凋亡等。细胞命运受来自微环境的力学信号调节。近年来的研究表明,力学因素对细胞的能量代谢具有调控作用。线粒体作为一个力学感受器和枢... 详细信息

线粒体是高度动态的细胞器,不仅为细胞提供能量和物质基础,同时参与调控细胞的增殖、迁移、分化和凋亡等。细胞命运受来自微环境的力学信号调节。近年来的研究表明,力学因素对细胞的能量代谢具有调控作用。线粒体作为一个力学感受器和枢纽,连接力学和代谢来调控细胞的命运。深入理解力学微环境和线粒体代谢的关系,为促进组织再生和疾病治疗提供有力的指导。本文主要介绍线粒体力学生物学研究进展,并探讨其在组织再生和疾病治疗中的潜在应用。

关键词：线粒体力学微环境力学转导组织再生癌症

基于脉冲序列标识的深度脉冲神经网络时空反向传播算法

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电子与信息学报 2024年第6期46卷 2596-2604页

作者：王子华叶莹刘洪运许燕樊瑜波王卫东北京航空航天大学生物与医学工程学院北京100191 中国人民解放军总医院医学创新研究部生物工程研究中心北京100853 工业和信息化部生物医学工程与转化医学重点实验室北京100853 华北计算技术研究所北京100083

尖峰放电的脉冲神经网络(SNN)具有接近大脑皮层的信号处理模式,被认为是实现大脑启发计算的重要途径。但是,目前对于深度脉冲神经网络的学习仍缺乏有效的监督学习算法。受尖峰放电速率标识的时空反向传播算法的启发,该文提出一种面向深... 详细信息

尖峰放电的脉冲神经网络(SNN)具有接近大脑皮层的信号处理模式,被认为是实现大脑启发计算的重要途径。但是,目前对于深度脉冲神经网络的学习仍缺乏有效的监督学习算法。受尖峰放电速率标识的时空反向传播算法的启发,该文提出一种面向深度脉冲神经网络训练的基于时间脉冲序列标识的监督学习算法,通过定义突触后电位和膜电位反传迭代因子分别分析脉冲神经元的空间和时间依赖关系,使用替代梯度的方法解决反传过程中不连续可微的问题。不同于现有基于尖峰放电速率标识的学习算法,该算法能够充分反映脉冲神经网络输出的时间脉冲序列的动态特性。因此,所提算法非常适合应用于需要较长时间序列标识的计算任务,例如行为的时间脉冲序列控制。该文在静态图像数据集CIFAR10和神经形态数据集NMNIST上验证了所提算法的有效性,在所有这些数据集上都显示出良好的性能,这有助于进一步研究基于时间脉冲序列应用的大脑启发计算。

关键词：脉冲神经网络监督学习误差反向传播时间脉冲序列标识替代梯度

连续疲劳干预对膝关节主被动生物力学特性的影响

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医用生物力学 2024年第3期39卷 457-462,468页

作者：孔祥飞王洪丹连子瞻姚杰樊瑜波北京航空航天大学生物与医学工程学院北京100083 吉林体育学院长春130022

目的探究连续疲劳干预对膝关节主被动生物力学特性的影响。方法招募27位健康大学生在等速力量测试系统上进行疲劳实验。疲劳实验包括3个疲劳周期,每个疲劳周期至少30次股四头肌连续等长收缩。对比不同疲劳周期的最大被动力矩、平均最... 详细信息

目的探究连续疲劳干预对膝关节主被动生物力学特性的影响。方法招募27位健康大学生在等速力量测试系统上进行疲劳实验。疲劳实验包括3个疲劳周期,每个疲劳周期至少30次股四头肌连续等长收缩。对比不同疲劳周期的最大被动力矩、平均最大自主收缩(maximum voluntary contraction, MVC)力矩、股外侧肌和股二头肌肌电积分值以及协同收缩指数(co-contraction index, CI)。结果疲劳周期3后,最大被动力矩显著下降(P0.05)。结论股四头肌等长收缩训练剂量为90次的连续疲劳干预会显著影响膝关节主被动生物力学特性。疲劳干预后,膝关节抵抗被动屈伸能力下降。并且随着疲劳干预进程,股四头肌主动收缩能力下降,股四头肌和腘绳肌肌肉激活也下降,但二者肌群协同收缩水平不变。这种温和的肌群协同收缩模式有益于保持良性膝关节力学加载环境。研究结果有助于理解疲劳后膝关节主被动生物力学特性。

关键词：连续疲劳膝关节协同收缩等长收缩生物力学特性

软骨终板退化对颈椎椎间盘物质运输和力学响应的影响

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应用数学和力学 2024年第6期45卷 763-774页

作者：刘景龙徐鹏李侨王丽珍樊瑜波北京航空航天大学生物力学与力生物学教育部重点实验室北京市生物医学工程高精尖创新中心生物与医学工程学院北京100191 杭州市北京航空航天大学国际创新研究院(北京航空航天大学国际创新研究院) 杭州311115 北京航空航天大学医学科学与工程学院北京100191 北京航空航天大学虚拟现实技术与系统全国重点实验室北京100191

软骨终板内的液体流动是椎间盘营养供给和代谢废物运输的主要途径.退化的终板刚度增加、渗透性和含水量下降,会影响椎间盘内物质运输和力学响应.基于人体颈椎计算机断层扫描数据建立了C5-C6节段的多孔介质有限元模型.对验证后的模型施... 详细信息

软骨终板内的液体流动是椎间盘营养供给和代谢废物运输的主要途径.退化的终板刚度增加、渗透性和含水量下降,会影响椎间盘内物质运输和力学响应.基于人体颈椎计算机断层扫描数据建立了C5-C6节段的多孔介质有限元模型.对验证后的模型施加压缩、前屈、后伸、轴向旋转和侧弯五种载荷,通过改变终板渗透性、孔隙比和模量,分析了正常、钙化和硬化三种状态下椎间盘的响应.结果表明:软骨终板退化增加了软骨终板和髓核的多孔压力,降低了软骨终板的流体速度.前屈载荷下,与正常终板对比,钙化和硬化终板导致髓核内流体的多孔压力分别增加了50.8%和88.9%.退化终板渗透率和含水量的降低导致髓核内液体不易流动,增加了髓核基体的应力,在压缩和轴向旋转载荷下,硬化终板导致髓核基体的最大主应力分别增加了122.2%和100.0%.

关键词：软骨终板退化多孔介质建模流体多孔压力数值计算

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials:Based on the mechanisms of occurrence and development of adhesions

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Bioactive Materials 2023年第8期26卷 387-412页

作者： Jie Liao Xiaoming Li yubo fan Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China

Postoperative adhesion(POA)widely occurs in soft tissues and usually leads to chronic pain,dysfunction of adjacent organs and some acute complications,seriously reducing patients’quality of life and even being *** for adhesiolysis,there are few effective methods to release existing ***,it requires a second operation and inpatient care and usually triggers recurrent adhesion in a great ***,preventing POA formation has been regarded as the most effective clinical *** have attracted great attention in preventing POA because they can act as both barriers and drug ***,even though much reported research has been demonstrated their efficacy on POA inhibition to a certain extent,thoroughly preventing POA formation is still ***,most biomaterials for POA prevention were designed based on limited experiences,not a solid theoretical basis,showing ***,we aimed to provide guidance for designing anti-adhesion materials applied in different soft tissues based on the mechanisms of POA occurrence and *** first classified the postoperative adhesions into four categories according to the different components of diverse adhesion tissues,and named them as“membranous adhesion”,“vascular adhesion”,“adhesive adhesion”and“scarred adhesion”,***,the process of the occurrence and development of POA were analyzed,and the main influencing factors in different stages were ***,we proposed seven strategies for POA prevention by using biomaterials according to these influencing ***,the relevant practices were summarized according to the corresponding strategies and the future perspectives were analyzed.

关键词： Prevention of postoperative adhesions(POA) Soft tissues Mechanisms of occurrence and development Biomaterials