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嵌入式机器学习方法在街区形态生成设计中的应用探索

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西部人居环境学刊 2024年第3期39卷 1-7页

作者：甘惟王元楷李翔同济大学建筑与城市规划学院自然资源部国土空间智能规划技术重点实验室同济大学建筑设计研究院(集团)有限公司浙江工业大学设计与建筑学院

城市街区的形态与空间品质关系密切。在城市设计中借助智能工具实现街区形态的生成是辅助设计决策的一项典型应用。既有的生成式方法主要采用参数化建模、形流推理以及图像生成算法实现,缺少对街区尺度形态规律学习的过程因而难以处理... 详细信息

城市街区的形态与空间品质关系密切。在城市设计中借助智能工具实现街区形态的生成是辅助设计决策的一项典型应用。既有的生成式方法主要采用参数化建模、形流推理以及图像生成算法实现,缺少对街区尺度形态规律学习的过程因而难以处理复杂、精细的空间形态关系,生成令人满意的形态结果。因此,本研究在既有生成式方法基础上借鉴嵌入式系统理论,提出一种通过嵌入机器学习训练模块优化街区形态生成结果的综合性方法(简称“嵌入式机器学习方法”)。该方法包含高质量的训练数据、平衡的模型复杂度与性能、特征工程与模型优化能力、独立运行的学习模块以及支持开放接口与部署五个要素,实现在传统生成规则中增加弹性并且可控的人工神经网络,可根据设计需求对训练样本及模型进行自由组合,改善了既有算法的生成效果。该方法也增加了设计流程的灵活性,设计师可根据场地需要配置合适的训练样本,并通过预训练的方法将结果嵌入生成式系统中,从而实现快速、便捷的三维形态生成,辅助街区形态设计过程。文章阐述了一个探索性的实践案例,从模型目标、数据、训练过程等方面进行阐述,并结合生成结果对比探讨了该方法对传统生成方法的改进,结果表明采用嵌入式机器学习方法可以有效改善三维形态的特征细节,生成更契合场地特质的设计方案,为设计师带来有益启示。最后文章提出了嵌入式机器学习方法的未来开发潜力,为城市街区设计中的人工智能技术应用提出了新的思路和可能性。

关键词：街区形态设计嵌入式方法生成式模型机器学习智能设计

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仁怀市酒用高粱虫害防治药剂筛选试验

南方农业 2024年第2期18卷 4-6页

作者：王元开仁怀市苍龙街道办事处贵州564500

高粱对化学药剂比较敏感,在防治病虫害时要特别注意。为了筛选出防治高粱虫害高效、低毒的药剂,选用苏云金杆菌、氯虫苯甲酰胺、印楝素和高效氯氟氰菊酯开展防治高粱虫害试验。结果表明,氯虫苯甲酰胺悬浮剂对玉米螟和蚜虫的防效都较高,... 详细信息

高粱对化学药剂比较敏感,在防治病虫害时要特别注意。为了筛选出防治高粱虫害高效、低毒的药剂,选用苏云金杆菌、氯虫苯甲酰胺、印楝素和高效氯氟氰菊酯开展防治高粱虫害试验。结果表明,氯虫苯甲酰胺悬浮剂对玉米螟和蚜虫的防效都较高,并且在一定程度上可以促进酒用高粱的生长,提高产量。苏云金杆菌可湿性粉剂和印楝素乳油这两种生物农药对玉米螟的防效较高,但对蚜虫稍差。高效氯氟氰菊酯乳油对蚜虫的防效最高,但对玉米螟防效稍差,在生产上可依据病虫害实际情况进行选择。

关键词：酒用高粱玉米螟蚜虫药剂筛选贵州省仁怀市

Zn-Sn共掺杂Mg_(2)TiO_(4)微波介电陶瓷的制备与表征

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化工技术与开发 2024年第5期53卷 1-5,72页

作者：何梦慈王元凯娄本浊陕西理工大学物理与电信工程学院陕西汉中723001

本研究分别用微量Zn^(2+)与Sn^(4+)取代Mg_(2)+与Ti^(4+),通过固相反应法制备了Zn-Sn共掺杂Mg_(2)TiO_(4)微波介电陶瓷,并采用阿基米德法、XRD、SEM、EDS及网络分析仪等手段,分析了材料的基本物性和介电特性。基本物性分析结果表明,烧... 详细信息

本研究分别用微量Zn^(2+)与Sn^(4+)取代Mg_(2)+与Ti^(4+),通过固相反应法制备了Zn-Sn共掺杂Mg_(2)TiO_(4)微波介电陶瓷,并采用阿基米德法、XRD、SEM、EDS及网络分析仪等手段,分析了材料的基本物性和介电特性。基本物性分析结果表明,烧结温度、Zn掺杂量x、Sn掺杂量y等因素对Mg_(2)TiO_(4)的晶体结构无明显影响,烧结致密性随烧结温度的升高呈先增大后减小的趋势,其中在1300℃下烧结所得的(Zn_(0.05)Mg_(0.95))2(Sn_(0.05)Ti_(0.95))O_(4),烧结致密性最佳,达到98%。微波介电特性分析结果表明,Zn-Sn共掺杂Mg_(2)TiO_(4)的介电常数εr与品质因数Q×f值,均随烧结温度的升高而呈先增大后减小的趋势,且其谐振频率温度系数τf具有较好的稳定性,其中在1300℃下烧结所得的(Zn_(0.05)Mg_(0.95))2(Sn_(0.05)Ti_(0.95))O4,εr≈15.55,Q×f≈319690GHz,此时τf≈-52.06×10^(-6)·℃^(-1)。与前人的研究结果比较后可知,本研究制备的(Zn_(0.05)Mg_(0.95))2(Sn_(0.05)Ti_(0.95))O_(4)不仅将烧结温度大幅下降至1300℃,还能将品质因子提升至319690GHz,使其微波介电性能得到有效改善。

关键词：微波介电陶瓷 Mg_(2)TiO_(4) Zn-Sn共掺杂固相反应法微波介电特性

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叶绿素对叶黄素生物可给率的影响

食品工业科技 2024年第5期45卷 108-117页

作者：黄千千陈丽君李韵唱陈雪寒陈乾睿王元楷蔡甜陈科伟西南大学食品科学学院重庆400715 西南大学食品科学与工程国家级实验教学示范中心重庆400715 西南大学化学化工学院重庆400715 西南大学中匈食品科学合作中心重庆400715 川渝共建特色食品重庆市重点实验室重庆400715 农业农村部农产品贮藏保鲜质量安全风险评估实验室(重庆) 重庆400715

叶黄素具有多种生理活性,它在人体内不能合成,只能从外界获取,但叶黄素因其脂溶性的特点导致生物可给率低,如何高效补充叶黄素成为研究热点。叶绿素常与叶黄素共同出现在人类饮食中,且二者均为脂溶性物质,会产生一定的相互作用。因此研... 详细信息

叶黄素具有多种生理活性,它在人体内不能合成,只能从外界获取,但叶黄素因其脂溶性的特点导致生物可给率低,如何高效补充叶黄素成为研究热点。叶绿素常与叶黄素共同出现在人类饮食中,且二者均为脂溶性物质,会产生一定的相互作用。因此研究膳食叶绿素及其结构变化对叶黄素生物可给率的影响具有重要意义。通过制备膳食中常见的8种不同结构的叶绿素(叶绿素a和b、脱镁叶绿素a和b、脱植基叶绿素a和b、脱镁叶绿酸a和b),采用体外静态消化模型和胶束化实验研究它们对叶黄素生物可给率的影响,并测定叶黄素和叶绿素形成的混合胶束粒径和电位的变化。结果表明,在共消化时不同结构的叶绿素能够显著提高叶黄素的回收率和生物可给率(P<0.05),其中脱镁叶绿素b的作用最为显著,所对应的叶黄素回收率和生物可给率分别为90.48%和80.44%。在消化过程中,未检测到明显的叶黄素降解产物,而叶绿素的结构则发生了明显的变化。通过消化物和胶束的平均粒径、荧光图像以及Zeta电位值可以确定胶束液体系比消化液体系更稳定,并且叶绿素可以通过与叶黄素形成复合物来保护叶黄素。本研究对如何提高叶黄素的生物可给率及消化利用性能具有一定的指导意义。

关键词：叶黄素叶绿素相互作用生物可给率体外消化胶束化

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Stem cell-based ischemic stroke therapy:Novel modifications and clinical challenges

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 18-34页

作者： yuankai Sun Xinchi Jiang Jianqing Gao Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058China Department of Pharmacy The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Ischemic stroke(IS)causes severe disability and high mortality *** cell(SC)therapy exhibits unique therapeutic potential for IS that differs from current ***’s cell homing,differentiation and paracrine abilities give hope for *** studies on SC modification have enhanced therapeutic effects for IS,including gene transfection,nanoparticle modification,biomaterial modification and *** improve survival rate,homing,neural differentiation,and paracrine abilities in ischemic ***,many problems must be resolved before SC therapy can be clinically *** issues include production quality and quantity,stability during transportation and storage,as well as usage ***,we reviewed the brief pathogenesis of IS,the“multi-mechanism”advantages of SCs for treating IS,various SC modification methods,and SC therapy *** aim to uncover the potential and overcome the challenges of using SCs for treating IS and convey innovative ideas for modifying SCs.

关键词： Ischemic stroke Stem cell therapy Stem cell modification Cell therapy challenge

Prediction of mechanical ventilation outcome by early abdominal-visceral-blood-flow-and-function score in critically ill patients after cardiopulmonary bypass in the ICU: A prospective observational study

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Journal of Intensive Medicine 2024年第1期4卷 101-107页

作者： Chaofu Yue Longxiang Su Jun wang Na Cui yuankai Zhou Wei Cheng Bo Tang Xi Rui Huaiwu He Yun Long Department of Intensive Care Unit Peking Union Medical College HospitalBeijingChina Department of Intensive Care Unit Qujing First People’s HospitalQujingYunnanChina Department of Intensive Care Unit Shiyan People’s Hospital of Bao’an DistrictShenzhenGuangdongChina

Background:Abdominal organs are important organs that sense and respond to ischemia and hypoxia,but there are few evaluation *** use ultrasonography to evaluate abdominal organ function and blood flow in patients with mechanical ventilation(MV)after cardiopulmonary bypass and to obtain a semiquantitative score for abdominal organ function and blood ***:Patients with cardiopulmonary bypass in the Critical Care Department of Peking Union Medical College Hospital in China from March to July 2021 were enrolled in this prospective observational *** correlation of the abdominal-visceral-blood-flow-and-function score(AVBFS)with the duration of MV,number of days spent in the intensive care unit(ICU),acute physiology and chronic health evaluation II(APACHE-II),sequential organ failure assessment(SOFA),lactate,epinephrine,and norepinephrine use was analyzed,and the results were used to assess the predictive value of the receiver operating characteristic curve(ROC)regression analysis score for the duration of ***:Of the 92 patients who underwent cardiopulmonary bypass,41 were finally *** AVBFS were significantly correlated with the duration of MV,number of days spent in the ICU,APACHE-II score,SOFA score,and norepinephrine use *** AVBFS in a group of patients using ventilators≥36 h were significantly higher than those obtained for a group of patients using ventilators<36 h(P<0.05).The evaluation results for the AVBFS at 0-12 h after ICU admission were as follows:area under the ROC curve(AUC)=0.876(95%confidence interval[CI]:0.767 to 0.984),cut-off value=2.5,specificity=0.842,and sensitivity=***:Abdominal visceral organ function and blood perfusion can be used to evaluate gastrointestinal *** is related to early and late extubation after cardiac surgery.

关键词： Ultrasonic evaluation Abdominal-visceral-blood-flow-and-function score(AVBFS) Gastrointestinal dysfunction Mechanical ventilation Cardiopulmonary bypass

Efficacy and safety of utidelone for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer who have failed standard second-line treatment:A phase 2 clinical trial(BG01-1801)

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Cancer Pathogenesis and Therapy 2024年第2期2卷 103-111页

作者： yuankai Shi Gongyan Chen Yanqiu Zhao Jing Zhao Lin Lin Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study On Anticancer Molecular Targeted DrugsBeijing 100021China Department of Respiration Harbin Medical University Cancer HospitalHarbinHeilongjiang 150040China Respiratory Department of Internal Medicine Henan Provincial Cancer HospitalZhengzhouHenan 450003China Department of Pulmonary and Critcal Care Medicine Peking Union Medical College HospitaChinese Academy of Medical Sciences&Peking Union Medical College Beijing100021China

Background:Chemotherapy remains the standard-of-care for many patients with locally advanced or metastatic non-small-cell lung cancer(NSCLC),but acquired resistance presents *** aim of this open-label,multicenter phase 2 clinical trial was to determine the efficacy and safety of utidelone,a novel genetically engineered epothilone analog and microtubule-stabilizing agent,as a third-or later-line treatment for locally advanced ormetastatic ***:Patients who had failed standard second-line treatment(including platinum-containing chemotherapy or targeted therapy)received utidelone(40 mg/m?via intravenous injection daily,day 1-5)every 21 *** primary endpoint was the objective response rate(ORR).Secondary endpoints were the duration of response(DoR),progression-free survival(PFS),overall survival(OS),and ***:From March 12,2019 to January 18,2021,26 pretreated patients with locally advanced or metastatic NSCLC(100%of patients had received prior platinum and 65.4%patients had received prior taxane treatment)were enrolled(80.8%of patients had adenocarcinoma).At baseline,nine(34.6%)patients had received secondline treatment,10(38.5%)patients had received third-line treatment,and seven(26.9%)patients had received fourth-or later-line *** the data cut-off date of August 10,2021,the median follow-up was 7.49 months(range,1.4-26.7 months).The ORR was 15.4%(95%confidence interval[CI],4.4%-34.9%)in the intention-totreat(ITT)cohort(N=26)and 19.0%(95%CI,5.4%-41.9%)in the per-protocol(PP)cohort(N=21).The disease control rate was 69.2%(95%CI,48.2%-85.7%)and 81.0%(95%CI,58.1%-94.6%)in the ITT and PP cohorts,*** median DoR was 4.1 months(95%CI,3.1-5.1 months)in the ITT *** median PFS was 4.37 months(95%CI,2.50-5.29 months)in the ITT cohort and 4.37 months(95%CI,2.50-9.76 months)in the PP *** median OS was not reached,and the 12-month OS rate was 69%(95%CI,45.1%-84.1%).Grade 3/4 treatment-emergent adverse events occur

关键词： Utidelone Locally advanced or metastatic non-small-cell lung cancer Efficacy Platinum-and taxane-refractory

Chinese SPECT semi-quantitative analysis of striatum

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Nuclear Science and Techniques 2012年第6期23卷 355-360页

作者： wang yuankai LIU Xingdang ZUO Chuantao LIU Congjin LIU Miao ZHANG Guangming CHEN Zhengping TANG Jie Department of Nuclear Medicine Huashan Hospital affiliated to Fudan University Shanghai 200040 China PET Center Huashan Hospital affiliated to Fudan University Shanghai 200040 China

To study and analyze reconstruction parameters in 99mTc-Trodat-l SPECT（Tomography EmissionComputed Single-Photon） brain semi-quantitative analysis,and the outlined methods of ROIs（regions of interests）. The 99mTc-trodat-l SPECT brain imaging was processed,and the ROIs were outlined four times from December 2009 to July *** results for each method were analyzed and compared to improve our *** was no statistically significance between the outlined number of pixel in both sides of the cerebellum and the ratio of the radioactive *** LEHR and FAN beam collimator,the average ratio became better with increasing the outlining method,especially the fourth *** could be estimated that striatum mean volume（±SD） was（39.51±9.54 ml,in the range of 19.97-51.98 mL） and mean weight（±SD） was（44.09±10.64 g in the range of 22.28-58.01 g）.The details of image processing and data analysis should not be ignored to outline appropriate methods,and withstand the repetitive *** total striatum was outlined and its volume and weight was analyzed.

关键词：半定量分析 SPECT 纹状体投资回报率中国平均体重断层扫描成像处理

A visual analysis approach for data imputation via multi-party tabular data correlation strategies

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Frontiers of Information Technology & Electronic Engineering 2024年第3期25卷 398-414页

作者： Haiyang ZHU Dongming HAN Jiacheng PAN Yating WEI Yingchaojie FENG Luoxuan WENG Ketian MAO yuankai XING Jianshu LV Qiucheng WAN Wei CHEN The State Key Lab of CAD&CG Zhejiang UniversityHangzhou 310058China Wuchan Zhongda Digital Technology Co. Ltd.Hangzhou 310020China Zhejiang Metals and Materials Co. Ltd.Hangzhou 310005China

Data imputation is an essential pre-processing task for data governance,aimed at filling in incomplete ***,conventional data imputation methods can only partly alleviate data incompleteness using isolated tabular data,and they fail to achieve the best balance between accuracy and *** this paper,we present a novel visual analysis approach for data *** develop a multi-party tabular data association strategy that uses intelligent algorithms to identify similar columns and establish column correlations across multiple ***,we perform the initial imputation of incomplete data using correlated data entries from other ***,we develop a visual analysis system to refine data imputation *** interactive system combines the multi-party data imputation approach with expert knowledge,allowing for a better understanding of the relational structure of the *** significantly enhances the accuracy and eficiency of data imputation,thereby enhancing the quality of data governance and the intrinsic value of data *** validation and user surveys demonstrate that this method supports users in verifying and judging the associated columns and similar rows using theirdomain knowledge.

关键词： Data governance Data incompleteness Data imputation Data visualization Interactive visual analysis