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Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance

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Biosurface and Biotribology 2023年第2期9卷 45-57页

作者： Zhiyong Li Lu Zhang Lei Zhou Xin Li yuancong Zhao Jin wang Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduSichuanChina

Severe lesions in vessels need to be treated with implantable interventional devices such as vascular stents,which should be anti‐coagulantion,anti‐proliferation and promoting *** oxide(NO),as a physiological gas signalling molecule,play an important role in *** the release of NO from endogenous do-nors has already been widely favoured to treatment strategy for lesioned *** this work,a series of copper‐loaded coatings(titanium nanotube(TNT)/PDA‐Cu)was fabricated by TNTs combined with polydopamine and ions,which achieve controlled in situ catalytic release of *** strategy could effectively immobilised copper ions on TNTs,and promoted the proliferation of endothelial cells and inhibited growth of smooth muscle cells(SMCs)via the performance of NO,as well as restrain the platelet *** the multiple function,TNT/PDA‐Cu provides a promise approach for promoting endothelialisation,anti‐coagulation and inhibition of SMC proliferation via copper‐loaded coatings on TNTs.

关键词： copper ions in‐situ release nitric oxide titanium nanotubes

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松辽盆地古龙凹陷凝析气藏判断及其分布

新疆石油地质 1997年第4期18卷 313-318页

作者：陈义才李延均杨远聪王廷栋李永康文享范孔庆云西南石油学院四川南充637000

针对古龙凹陷地区缺乏高压PVT相图的情况,首先通过试油成果中气油比的特征区分出油藏和气藏两种类型,然后在油气配方合成井流物的摩尔组成基础上,借助于Φ值法、Z值法和PR状态方程计算PVT相图进行综合分析,判断出古109井区葡萄花油层是... 详细信息

针对古龙凹陷地区缺乏高压PVT相图的情况,首先通过试油成果中气油比的特征区分出油藏和气藏两种类型,然后在油气配方合成井流物的摩尔组成基础上,借助于Φ值法、Z值法和PR状态方程计算PVT相图进行综合分析,判断出古109井区葡萄花油层是一个带油环中等凝析油含量的凝析气藏.根据凝析气藏的成藏机理,预测了该区凝析气藏分布的有利区带.

关键词：松辽盆地凝析油气气油比成藏气藏分布

Investigation on baicalin‐loaded chitosan film crosslinked by graphene oxide and its biocompatibility

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Biosurface and Biotribology 2023年第2期9卷 35-44页

作者： Yu Zhu Lu Zhang Lei Zhou Xin Li yuancong Zhao Jin wang Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduSichuanChina

Chitosan has good biocompatibility,in vivo biodegradability and certain physiological activity,which can be used as a drug carrier to stabilise and protect drug components,causing the promotion of drug absorption and controlling drug *** graphene oxide(GO)as a cross‐linking agent,the functional groups in its lamellar structure can interact effectively with the functional groups in chitosan molecules,leading to enhanced mechanical properties and optimize the controlled drug‐release ***/chitosan composite films were prepared by the solution mixing method with various GO content and exhibit many hydrogen bonds between the GO and *** were no obvi-ously agglomerated GO particles in the surface of composite films,and the lamellar structure can be observed in the cross section of the composite *** thermal analysis(DTA)indicated that the addition of GO increased the stability of the chitosan *** baicalin‐loaded GO/Chitosan also exhibited pH dependent release behaviour,with an increasing release amount and rate at lower pH *** addition,the result of biological evaluations showed that the GO/Chitosan films had good cytocompatibility in vitro and histocompatibility at appropriate GO *** investigation offered a new pH‐dependent drug carrier potentially applied for tumour and atherosclerosis treatment.

关键词： biomaterials coatings graphene oxide

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泡沫铝夹芯结构抗冲击性能数值模拟

金属功能材料 2024年第4期31卷 24-30页

作者：胡钰彬游晓红王录才米渊聪太原科技大学材料科学与工程学院山西太原030024 山西顺源耐磨科技有限公司山西吕梁030599

采用ABAQUS软件创建了泡沫铝夹芯结构材料的Voronoi几何模型,研究了子弹冲头初始速度、泡沫铝夹芯层孔隙率、上下面板材料的选择对泡沫铝夹芯结构抗冲击性能的影响。模拟分析发现,随弹丸冲头初始速度升高泡沫铝夹芯结构的吸能会增加,整... 详细信息

采用ABAQUS软件创建了泡沫铝夹芯结构材料的Voronoi几何模型,研究了子弹冲头初始速度、泡沫铝夹芯层孔隙率、上下面板材料的选择对泡沫铝夹芯结构抗冲击性能的影响。模拟分析发现,随弹丸冲头初始速度升高泡沫铝夹芯结构的吸能会增加,整体的峰值承载力也会变高,在抗冲击的选择上,上板薄下板厚的结构是更加科学的;弹丸冲头冲击能量不变的情况下,不同孔隙率的夹芯结构呈现出承载力与吸能状况都与孔隙率成反比的情况;使用纯铝作为夹芯面板时,夹芯层的吸能占比会高于使用铝合金作为夹芯面板。

关键词：泡沫铝夹芯结构弹丸有限元模拟吸能

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Nerve growth factor activity of several immunal related serine proteases

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Chinese Science Bulletin 1998年第22期43卷 1886-1891页

作者： Liying Guo Hong Zhu yuancong Zhou Chinese Acad Sci Shanghai Inst Biochem Shanghai 200031 Peoples R China

Rabbit was immuned by the previously purified protein with high nerve growth factor (NGF) bioactivity (NGF_like protease) from \%Agkistrodon halys Pallas\% and the antisera were collected. The polyclonal antibodies were tentatively purified and then used as ligands of an affinity column. The \%***\% crude venom was fractionated by this affinity column and then by Mono Q on fast protein liquid chromatography (FPLC). As a result, fraction Ⅱ and fraction Ⅲ were purified respectively, whose N_terminal amino acid sequences show high homology with the serine proteases in snake venoms, as well as the previous NGF_like protease. However, they possessed different levels of NGF bioactivity. The NGF activity of the previous NGF_like protease is equivalent to that of NGF, while the activity of fraction Ⅱ seems relatively low in contrast to fraction Ⅲ which had no NGF activity.

关键词： nerve growth factor neurotrophic factor serine protease affinity chromatography.

Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants

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Regenerative Biomaterials 2020年第5期7卷 491-504页

作者： Peichuang Li Wanhao Cai Xin Li Kebing wang Lei Zhou Tianxue You Rui wang Hang Chen yuancong Zhao Jin wang Nan Huang Key Lab.of Advanced Technology for Materials of Education Ministry Southwest Jiaotong UniversityChengdu 610031China School of Materials Science and Engineering Southwest Jiaotong UniversityChengdu 610031China Institute of Physical Chemistry University of FreiburgAlbertstraße 21aFreiburg 79104Germany

Polyurethanes are widely used in interventional devices due to the excellent physicochemical ***,non-specific adhesion and severe inflammatory response of ordinary polyurethanes may lead to severe complications of intravenous ***,a novel phospholipid-based polycarbonate urethanes(PCUs)were developed via two-step solution polymerization by direct synthesis based on functional raw ***,PCUs were coated on biomedical metal sheets to construct biomimetic anti-fouling *** results of stress–strain curves exhibited excellent tensile properties of PCUs *** scanning calorimetry results indicated that the microphase separation of such PCUs polymers could be well regulated by adjusting the formulation of chain extender,leading to different biological *** vitro blood compatibility tests including bovine serum albumin adsorption,fibrinogen adsorption and denaturation,platelet adhesion and whole-blood experiment showed superior performance in inhibition non-specific adhesion of PCUs *** cells and smooth muscle cells culture tests further revealed a good anti-cell adhesion ***,animal experiments including ex vivo blood circulation and subcutaneous inflammation animal experiments indicated a strong ability in anti-thrombosis and *** results high light the strong anti-adhesion property of phospholipid-based PCUs films,which may be applied to the blood-contacting implants such as intravenous catheter or antithrombotic surface in the future.

关键词： phospholipid polycarbonate urethanes non-specific adhesion anti-thrombosis histocompatibility

Improved corrosion resistance and biocompatibility of biomedical magnesium alloy with polypeptide TK14 functionalised hydrophobic coating

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Biosurface and Biotribology 2021年第1期7卷 12-22页

作者： Yang Shen Xiaolong Shen Hao Zhang Xin Li Tengda Shang yuancong Zhao Jin wang Nan Huang Key Laboratories of Advanced Technology for Materials of Education Ministry School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuanChina Panzhihua University PanzhihuaSichuanChina

Magnesium(Mg)and its alloys can be used as biomedical materials because of their excellent mechanical properties and ***,the rapid degradation rate of Mg-based materials limits their application in biodegradable intravascular *** overcome this issue,we constructed a hydrophobic coating on *** pre-treatments with alkali and a silane coupling agent of pure magnesium,4,4’-diphenyl-methane-diisocyanate(MDI)and amino-terminated polydimethylsiloxane(H_(2)N-PDMS-NH_(2))were stepwise deposited on the surface,forming an amino-containing hydrophobic coating(-(M/P)_(3))to enhance the corrosion ***,polypeptide TK14 was immobilised on the hydrophobic coating to promote vascular endothelial cell adhesion and *** electrochemical results revealed that the self-corrosion current density(i_(corr))of-(M/P)_(3) decreased by approximately 4.5 orders of magnitude compared with that of pure *** TK14 immobilisation,the number of endothelial cells adhering to the surface of-(M/P)_(3)-T increased *** the corrosion resistance of-(M/P)_(3)-T was slightly reduced,the subcutaneous implantation inflam-matory response of the surrounding tissues was lower,showing suitable ***,the polypeptide TK14 functionalised hydrophobic coating may be a promising candidate material for the interface of magnesium-based cardiovascular implants.

关键词： coating corrosion resistance

Copper-mediated polyurethane materials with enzyme-like catalysis for biocompatibility improvement in blood environments

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Biosurface and Biotribology 2021年第1期7卷 30-41页

作者： Jiaxin Dou Peichuang Li yuancong Zhao Lei Zhou Xin Li Jin wang Nan Huang Key Lab of Advanced Technology for Materials of Education Ministry Southwest Jiaotong UniversityChengduChina Heze Branch Qilu University of Technology(Shandong Academy of Sciences)Biological Engineering Technology Innovation Center of Shandong ProvinceHezeChina

Because of their good performance,including biocompatibility and mechanical proper-ties,polyurethanes(PUs)are widely used in medical ***,undesired compatibility troubles,including thrombus,inflammation,and hyperplasia,still limit the applications of *** this study,copper-mediated polyurethane(PU-Cu)materials with enzyme-like catalysis were *** PU-Cu materials effectively catalysed the nitric oxide(NO)released from endogenous NO donors because of the glutathione peroxidase(GPx)-like function of copper *** PU‐Cu materials were respectively evaluated via platelet adhesion and endothelial cell(EC),smooth muscle cell(SMC),and macrophage(MA)*** electron microscopy results showed that PU-Cu materials significantly inhibited platelet adhesion and ***,PU-Cu materials not only promote the proliferation of EC but also inhibit SMC ***,MA culture results intuitively stated the anti-inflammatory ability of *** addition,experimental samples were implanted into the subcutaneous tissue of Sprague Dawley *** anti-inflammatory function of PU-Cu was further confirmed by haematoxylin-eosin staining *** regard to their excellent biological performance,PU-Cu materials are proposed for biocompatibility improvement of blood-contacting mate-rials,which should in turn provide new ideas for advanced medical devices.

关键词： polyurethane copper Copper

Influence of microgravity on protein crystal structures

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Chinese Science Bulletin 2000年第11期45卷 1002-1006页

作者： DONG Jun PAN Jisen NIU Xiutian ZHOU yuancong BI Ruchang Institute of Biophysics Chinese Academy of SciencesBeijing 100101China Institute of Biochemistry Chinese Academy of SciencesShanghai 200031China

Structural determination and comparison of microgravity and ground grown protein crystals have been carried out in order to investigate the effect of microgravity on the structure of protein crystals. Following the structural studies on the hen egg-white lysozyme cystals grown in space and on the ground, the same kind of comparative studies was performed with acidic phospholipase A2 crystals grown in different gravities. Based on the results obtained so far, a conclusion could be made that microgravity might not be strong enough to change the conformation of polypeptide chain of proteins, but it may improve the bound waters’ structure, and this might be an important factor for microgravity to improve the protein crystal quality. In addition, the difference in the improvement between the two kinds of protein crystals may imply that the degree of improvement of a protein crystal in microgravity may be related to the solvent content in the protein crystal.

关键词： microgravity protein crystal structure solvent structure phospholipase A2.