Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance

作     者：Zhiyong Li Lu Zhang Lei Zhou Xin Li Yuancong Zhao Jin Wang 

作者机构：Institute of Biomedical EngineeringCollege of MedicineSouthwest Jiaotong UniversityChengduSichuanChina 

出 版 物：《Biosurface and Biotribology》 (生物表面与生物摩擦学（英文）)

年 卷 期：2023年第9卷第2期

页      面：45-57页

核心收录：

学科分类：0710[理学-生物学] 08[工学] 0806[工学-冶金工程] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 

基　　金：Department of Science and Technology of Sichuan Province,Grant/Award Numbers:2020YFH0103,2022NSFSC0809 National Natural Science Foundation of China,Grant/Award Number:NSFC Project 32071328。 

主　　题：copper ions in‐situ release nitric oxide titanium nanotubes 

摘      要：Severe lesions in vessels need to be treated with implantable interventional devices such as vascular stents,which should be anti‐coagulantion,anti‐proliferation and promoting endothelialisation.Nitric oxide(NO),as a physiological gas signalling molecule,play an important role in revascularisation.Catalysing the release of NO from endogenous do-nors has already been widely favoured to treatment strategy for lesioned vessels.In this work,a series of copper‐loaded coatings(titanium nanotube(TNT)/PDA‐Cu)was fabricated by TNTs combined with polydopamine and ions,which achieve controlled in situ catalytic release of NO.This strategy could effectively immobilised copper ions on TNTs,and promoted the proliferation of endothelial cells and inhibited growth of smooth muscle cells(SMCs)via the performance of NO,as well as restrain the platelet adhesion.With the multiple function,TNT/PDA‐Cu provides a promise approach for promoting endothelialisation,anti‐coagulation and inhibition of SMC proliferation via copper‐loaded coatings on TNTs.