检索结果-南通市图书馆

Challenges and exploration for immunotherapies targeting cold colorectal cancer

World Journal of Gastrointestinal Oncology 2023年第1期15卷 55-68页

作者： Dan-Dan Li yuan-ling tang Xin Wang Department of Abdominal Oncology/Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

In recent years,immune checkpoint inhibitors(ICIs)have made significant breakthroughs in the treatment of various tumors,greatly improving clinical *** the fifth most common antitumor treatment strategy for patients with solid tumors after surgery,chemotherapy,radiotherapy and targeted therapy,the therapeutic response to ICIs largely depends on the number and spatial distribution of effector T cells that can effectively identify and kill tumor cells,features that are also important when distinguishing malignant tumors from“cold tumors”or“hot tumors”.At present,only a small proportion of colorectal cancer(CRC)patients with deficient mismatch repair(dMMR)or who are microsatellite instability-high(MSI-H)can benefit from ICI treatments because these patients have the characteristics of a“hot tumor”,with a high tumor mutational burden(TMB)and massive immune cell infiltration,making the tumor more easily recognized by the immune *** contrast,a majority of CRC patients with proficient MMR(pMMR)or who are microsatellite stable(MSS)have a low TMB,lack immune cell infiltration,and have almost no response to immune monotherapy;thus,these tumors are“cold”.The greatest challenge today is how to improve the immunotherapy response of“cold tumor”*** the development of clinical research,immunotherapies combined with other treatment strategies(such as targeted therapy,chemotherapy,and radiotherapy)have now become potentially effective clinical strategies and research ***,the question of how to promote the transformation of“cold tumors”to“hot tumors”and break through the bottleneck of immunotherapy for cold tumors in CRC patients urgently requires *** by developing an in-depth understanding of the immunotherapy mechanisms of cold CRCs can we screen out the immunotherapy-dominant groups and explore the most suitable treatment options for individuals to improve therapeutic efficacy.

关键词： Colorectal cancer Immune checkpoint inhibitors Cold tumors Immunotherapy mechanism Combination therapy Effector T cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Resistance to targeted therapy in metastatic colorectal cancer:Current status and new developments

引用

World Journal of Gastroenterology 2023年第6期29卷 926-948页

作者： yuan-ling tang Dan-Dan Li Jia-Yu Duan Lei-Ming Sheng Xin Wang Department of Radiation Oncology Cancer CenterWest China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Abdominal Cancer Cancer CenterWest China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

Colorectal cancer(CRC)is one of the most lethal and common malignancies in the *** has been the conventional treatment for metastatic CRC(mCRC)***,the effects of chemotherapy have been *** the advent of targeted therapy,the survival of patients with CRC have been *** the past 20 years,targeted therapy for CRC has achieved substantial ***,targeted therapy has the same challenge of drug resistance as ***,exploring the resistance mechanism and finding strategies to address the resistance to targeted therapy,along with searching for novel effective regimens,is a constant challenge in the mCRC treatment,and it is also a hot research *** this review,we focus on the current status on resistance to existing targeted therapies in mCRC and discuss future developments.

关键词： Colorectal cancer Targeted treatment Resistance New development

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

前庭康复训练联合认知行为疗法治疗慢性主观性头晕伴发焦虑的疗效观察

引用

中华物理医学与康复杂志 2016年第12期38卷 938-941页

作者：袁天懿秦玲唐建良唐潮浪赵金龙武警浙江总队嘉兴医院心理科嘉兴314000 浙江省桐乡市第一人民医院心理科

目的观察前庭康复训练（VR）联合认知行为疗法（CBT）对慢性主观性头晕（CSD）伴发焦虑的疗效。方法将98例CSD伴发焦虑症状的患者，按照随机数字表法分为试验组（50例）和对照组（48例），所有人组患者汉密尔顿焦虑量表（HAMA）评分≥1... 详细信息

目的观察前庭康复训练（VR）联合认知行为疗法（CBT）对慢性主观性头晕（CSD）伴发焦虑的疗效。方法将98例CSD伴发焦虑症状的患者，按照随机数字表法分为试验组（50例）和对照组（48例），所有人组患者汉密尔顿焦虑量表（HAMA）评分≥14分、汉密尔顿抑郁量表（HAMD）〈18分。2组患者均给予常规的前庭功能康复训练，试验组在此基础上给予CBT。在治疗前和治疗第4周、第8周，采用眩晕残障程度评定量表（DHI）、HAMA对2组患者进行疾病严重程度及焦虑状态评定。结果治疗前，2组患者各项指标间比较，差异均无统计学意义（P〉O．05）。治疗第4周，2组HAMA、DHI及DHI各因子评分较治疗前均明显下降，差异有统计学意义（P〈0．05）。治疗8周，试验组HAMA评分[（8．71±3．64）分]、DHI总分[（28．83±12．80）分]、DHI各因子[躯体因子（9．04±4．15）分、情感因子（8．96±4．30）分和功能因子（10.83±4．65）分]及对照组各项评分[HAMA评分（11．24±3．15）分、DHI总分（38．40±11．59）分和DHI躯体因子（12．31±3．88）分、情感因子（12．31±3．86）分、功能因子（13．78±4．07）分]较治疗前、治疗4周均有明显改善，差异有统计学意义（P〈0．05）。治疗第4、8周，试验组HAMA、DHI及DHI各因子评分明显低于对照组，差异有统计学意义（P〈0．05）。结论VR联合CBT有利于CSD患者的功能恢复，显著改善其所伴发的焦虑症状。

关键词：前庭康复认知行为疗法慢性主观性头晕焦虑

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

引用

World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian tang yuan-Ming Pan Wei Li Rui-Qiong Ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Numerical simulation of micromixing effect on the reactive flow in a co-rotating twin screw extruder

引用

Chinese Journal of Chemical Engineering 2016年第9期24卷 1135-1146页

作者： Hao tang yuan Zong ling Zhao State Key Laboratory of Chemical Engineering East China University of Science and Technology

To control the multicomponent reactions in extrusion, reactive-mixing flow in a co-rotating twin screw extruder was numerically studied in the present paper. Effects of initial species distribution, rotating speed and flow rate on a competitive-parallel reaction were investigated and the relationship between mixing and reactions was discussed from the view of chemical reaction engineering. The simulation results show the studied operational parameters, which determine residence time distribution, earliness of mixing and segregation degree of reactive-mixing flows, affect the local species concentration and reaction time and hence have significant influences on the reaction extent. Orthogonal test was adopted to clarify the significance of operational *** analysis shows that initial species distribution and flow rate are the most important factors in the control of reaction extent, and effect of rotating speed is conditional depending on the micro-mixing status of the fluid.

关键词： Multicomponent reaction Mixing Numerical simulation Extrusion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of ocean data assimilation on the seasonal forecast of the 2014/15 marine heatwave in the Northeast Pacific Ocean

引用

Atmospheric and Oceanic Science Letters 2025年第1期18卷 24-31页

作者： Tiantian tang Jiaying He Huihang Sun Jingjia Luo Institute for Climate and Application Research(ICAR)/Key Laboratory of Meteorological Disaster Nanjing University of Information Science and TechnologyNanjingChina

A remarkable marine heatwave,known as the“Blob”,occurred in the Northeast Pacific Ocean from late 2013 to early 2016,which displayed strong warm anomalies extending from the surface to a depth of 300 *** study employed two assimilation schemes based on the global Climate Forecast System of Nanjing University of Information Science(NUIST-CFS 1.0)to investigate the impact of ocean data assimilation on the seasonal prediction of this extreme marine *** sea surface temperature(SST)nudging scheme assimilates SST only,while the deterministic ensemble Kalman filter(EnKF)scheme assimilates observations from the surface to the deep *** latter notably improves the forecasting skill for subsurface temperature anomalies,especially at the depth of 100-300 m(the lower layer),outperforming the SST nudging *** excels in predicting both horizontal and vertical heat transport in the lower layer,contributing to improved forecasts of the lower-layer warming during the *** improvements stem from the assimilation of subsurface observational data,which are important in predicting the upper-ocean *** results suggest that assimilating ocean data with the EnKF scheme significantly enhances the accuracy in predicting subsurface temperature anomalies during the Blob and offers better understanding of its underlying mechanisms.

关键词： Seasonal forecast Ocean data assimilation Marine heatwave Subsurface temperature

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

引用

Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li Xu Huiming Xu Changyong tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

引用

Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

引用

Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu tang Chun-Mao yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

臀位阴道分娩92例临床分析

引用

疾病监测与控制 2017年第3期11卷 193-193,192页

作者：刘丽园唐玲李海英周俐琼深圳市龙华新区中心医院广东深圳518110

目的探讨臀位阴道分娩的效果及安全性。方法回顾性分析2014年1月~2016年6月期间我院产科收治的92例臀位阴道分娩产妇的临床资料,并选择同期剖宫产分娩的92例臀位分娩产妇纳入剖宫产组,比较两组新生儿结局包括吸入性肺炎、新生儿窒息、... 详细信息

目的探讨臀位阴道分娩的效果及安全性。方法回顾性分析2014年1月~2016年6月期间我院产科收治的92例臀位阴道分娩产妇的临床资料,并选择同期剖宫产分娩的92例臀位分娩产妇纳入剖宫产组,比较两组新生儿结局包括吸入性肺炎、新生儿窒息、颅内出血及新生儿死亡等并发症发生情况。结果两组产妇均无新生儿死亡发生,阴道分娩组在吸入性肺炎、新生儿窒息及颅内出血发生率分别为9.78%、8.70%、3.26%,均略高于剖宫产组的4.35%、2.14%及0,但是差异无统计学意义(P﹥0.05);阴道分娩组与剖宫产组比较新生儿Apgar评分分别为(7.6±2.1)分、(8.4±2.9)分,差异均无统计学意义(P﹥0.05)。结论臀位阴道分娩在严格把握适应症的前提下具有较好的安全性,并且有利于降低剖宫产率。

关键词：臀位分娩新生儿窒息剖宫产阴道分娩

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：