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Deep Transcranial Magnetic Stimulation as a Potential Approach for Digital Pain Management in Patients with Psychotic Disorder

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Neuroscience Bulletin 2023年第1期39卷 89-93页

作者： Peijun Ju Di Zhao Cuizhen Zhu Yongjun Zheng Shiyu Peng Haisu Wu Beibei Yang Zhenghui Yi Tifei yuan Jinghong Chen Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 201108China

Dear Editor,Pain is a common and complex clinical problem which affects 28%-50%of the general population and is responsible for large health-related *** with chronic pain often develop nociceptive sensitization,having mood and anxiety disorders as *** pain may alter the processing of affective information in the brain,thereby inducing anxio-depressive disorders.

关键词： Pain pain clinical

甘薯番茄红素β-环化酶基因的克隆与转化烟草的研究

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作物学报 2007年第10期33卷 1724-1728页

作者：陈选阳袁照年张招娟王松良郑金贵福建农林大学农产品品质研究所福建农林大学作物科学学院福建福州350002

番茄红素β-环化酶(LYC-B)催化番茄红素形成β-胡萝卜素,是β-胡萝卜素生物合成的关键酶之一。从甘薯块根总RNA逆转录的cDNA中扩增出lyc-b的保守序列后,用cDNA末端快速扩增方法(RACE)获得了该基因全长cDNA,共1844bp,开放阅读框1503bp,编... 详细信息

番茄红素β-环化酶(LYC-B)催化番茄红素形成β-胡萝卜素,是β-胡萝卜素生物合成的关键酶之一。从甘薯块根总RNA逆转录的cDNA中扩增出lyc-b的保守序列后,用cDNA末端快速扩增方法(RACE)获得了该基因全长cDNA,共1844bp,开放阅读框1503bp,编码501个氨基酸。构建了lyc-b植物表达载体p23-lyc-b,通过农杆菌介导法转化烟草,经PCR及Southern杂交表明该基因已整合到烟草的基因组中。

关键词：甘薯 lyc-b 基因克隆载体构建转化

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预估带法搜寻丢失放射源模拟研究

核电子学与探测技术 2017年第2期37卷 221-224页

作者：李远辉赵奎杨年程锋王鹏飞张庆贤中国中核宝原资产控股公司北京100097 成都理工大学成都610059 四川省核工业地质局成都610061

为了能快速高效的搜寻丢失的放射源,本文提出了一种预估带法丢失放射源搜寻方案,该方案具有操作简单,定位准确性高,实用性强,用时短,搜寻人员所受剂量低的优点。实验模拟了226Ra丢失情况下,采用BH3013B环境辐射剂量率仪进行搜寻,验证了... 详细信息

为了能快速高效的搜寻丢失的放射源,本文提出了一种预估带法丢失放射源搜寻方案,该方案具有操作简单,定位准确性高,实用性强,用时短,搜寻人员所受剂量低的优点。实验模拟了226Ra丢失情况下,采用BH3013B环境辐射剂量率仪进行搜寻,验证了该方案在无遮挡、单面遮挡和掩埋三种情况下搜寻丢失放射源的效率与定位准确性。实验结果表明,此搜寻方案能有效、快速、准确的确定丢失放射源的位置,为搜寻人员提供了依据,从而尽可能的减少损失。

关键词：丢失放射源快速定位辐射安全

外源抗坏血酸对香蕉常温后熟期果实品质的影响

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中国南方果树 2020年第1期49卷 56-60页

作者：陈娇李芬芳李奕星袁德保中国热带农业科学院海口实验站/海南省香蕉遗传改良重点实验室

为探究外源抗坏血酸对香蕉果实常温后熟期品质变化的影响,本研究以"巴西"香蕉为材料,用0.5%(质量体积百分比W/V)的抗坏血酸浸泡处理,以清水为对照,0.03 mm厚聚乙烯打孔薄膜袋包装后,于常温(25±2)℃、相对湿度85%~95%的环境中贮藏。研... 详细信息

为探究外源抗坏血酸对香蕉果实常温后熟期品质变化的影响,本研究以"巴西"香蕉为材料,用0.5%(质量体积百分比W/V)的抗坏血酸浸泡处理,以清水为对照,0.03 mm厚聚乙烯打孔薄膜袋包装后,于常温(25±2)℃、相对湿度85%~95%的环境中贮藏。研究结果表明,抗坏血酸处理有效抑制了香蕉果实常温后熟期呼吸和乙烯释放速率,保持果实的硬度和色度,抑制可溶性固形物和维生素C含量的减少,同时有效抑制电导率的上升和丙二醛的积累。可见,抗坏血酸能够有效延缓香蕉的衰老进程,保持香蕉果实品质,抑制采后香蕉果实膜脂过氧化的发生,从而延长香蕉果实贮藏期。

关键词：香蕉抗坏血酸后熟衰老品质

基于宽窄带功率比值法的GNSS载噪比估计改进方法

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电讯技术 2018年第5期58卷 514-518页

作者：袁建国王姣陈忠平刘书涵重庆邮电大学光电信息感测与传输技术重庆市重点实验室重庆400065

为了降低载噪比估计算法的实现复杂度,提出了一种改进的宽窄带载噪比估计方法。该方法利用接收机良好跟踪信号时信号能量主要分布在I支路这一特点,将传统的宽窄带功率比值法中的宽带进行简化变为仅取I支路信号,而窄带保持不变来进行载... 详细信息

为了降低载噪比估计算法的实现复杂度,提出了一种改进的宽窄带载噪比估计方法。该方法利用接收机良好跟踪信号时信号能量主要分布在I支路这一特点,将传统的宽窄带功率比值法中的宽带进行简化变为仅取I支路信号,而窄带保持不变来进行载噪比估计。在详细推导了改进后算法的载噪比估计的理论表达式后,通过仿真测试进行了验证与分析,最后对K值的选取进行了讨论。测试结果表明,改进后的算法与传统算法的性能基本相当,但相比传统的宽窄带功率比值法而言,在算法复杂度方面加法和乘法次数都减少了1 000次左右,约为传统算法的60%,使算法复杂度得到了有效降低。

关键词：全球卫星导航系统载噪比估计宽窄带功率比值低复杂度

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贝壳对生物质气化的催化作用研究

热力发电 2014年第2期43卷 41-46,50页

作者：李建新余维高郑皎王永川袁镇福浙江大学宁波理工学院浙江宁波315100 浙江大学能源清洁利用国家重点实验室浙江杭州310027

贝壳的主要成分为CaCO3，以贝壳为催化剂考察其对木屑生物质气化的催化效果。通过在不同剂料比及温度条件下生物质的的产气特性实验发现：水蒸气气氛中贝壳对木屑生物质最佳催化温度在750～950℃之间；贝壳主要加快催化含碳大分子裂解... 详细信息

贝壳的主要成分为CaCO3，以贝壳为催化剂考察其对木屑生物质气化的催化效果。通过在不同剂料比及温度条件下生物质的的产气特性实验发现：水蒸气气氛中贝壳对木屑生物质最佳催化温度在750～950℃之间；贝壳主要加快催化含碳大分子裂解，气化效率与产气中H2＋CO总含量以及H2／c0比有关；水蒸气气氛下，当温度为950℃、剂料比为20％时，碳转化率为94％，物料能量转化率为81％，比同温度下纯生物质的碳转化率和能量转化率分别提高了10．3％和6％。

关键词：水蒸气贝壳生物质催化气化能量转化率

Patient-derived organoids potentiate precision medicine in advanced clear cell renal cell carcinoma

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Precision Clinical Medicine 2022年第4期5卷 215-221页

作者： Yizheng Xue Bingran Wang Yiying Tao Jun Xia Kedi yuan Junhua Zheng Wei Zhai Wei Xue Department of Urology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Ottawa-Shanghai Joint School of Medicine Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Pathology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China

To investigate the role of patient-derived organoid(PDO)model in the precision medicine of advanced clear cell renal cell carcinoma(ccRCC),we retrospectively analyzed the clinical data of seven cases of ccRCC diagnosed by operation and pathology in Renji Hospital from September 2021 to September *** seven patients were diagnosed with advanced ccRCC with or without remote *** and radical nephrectomy was performed *** predict the response to immunotherapy and provide personalized medicine recommendation,a PDO model based on air-liquid interface system was established from the surgical resected tumor and subsequent drug screening was *** and eosin(H&E)staining and immunohistochemistry revealed that the PDO recapitulated the histological feature of parent *** staining identified that CD3^(+)T cells,SMA^(+)cancer associated fibroblasts,and CD31^(+)endothelial cells were preserved in PDO *** activated cell sorter(FACS)revealed an evidently increased ratio of CD8^(+)/CD4^(+)T cells and apoptotic tumor cells in PDO treated with toripalimab than those treated with *** results showed that toripalimab is able to rescue the excessive death of CD8^(+)T cells by critically reversing the immune exhaustion state of ccRCC in PDO *** research validated that PDO is a promising and faithful preclinical model for prediction of immunotherapy response in patients with ccRCC.

关键词： patient-derived organoid air-liquid interface tumor microenvironment immunotherapy renal cell carcinoma

严重急性呼吸综合征后骨坏死的血液学改变及相关基因检测

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中华医学杂志 2006年第7期86卷 442-445页

作者：孙伟李子荣史振才张念非韩呈武丛笑张远春中日友好医院骨坏死与关节保留重建中心北京100029 中日友好医院检验科北京100029

目的探讨严重急性呼吸综合征(SARS)后骨坏死的病因学,以便用于非创伤性骨坏死的早期诊断和易感人群的筛选。方法取61例SARS后骨坏死患者空腹肘静脉血。另取健康人群52名为对照,应用酶联免疫吸附法等试验定凝血、纤溶指标,应用实时聚合... 详细信息

目的探讨严重急性呼吸综合征(SARS)后骨坏死的病因学,以便用于非创伤性骨坏死的早期诊断和易感人群的筛选。方法取61例SARS后骨坏死患者空腹肘静脉血。另取健康人群52名为对照,应用酶联免疫吸附法等试验定凝血、纤溶指标,应用实时聚合酶链反应(PCR)仪测定因子V G1691A(FV Le iden)变、凝血酶原G20210A突变。结果SARS后骨坏死患者血液学因素改变明显,其中蛋白C(PC)、活化蛋白C抵抗(APC-R)、抗凝血酶Ⅲ(AT-Ⅲ)、纤溶酶原激活抑制物(PAI)、纤溶酶原(PLG)。两组比较,差异有统计学意义(109%±20%vs 85%±34%、8.0 U/m l±4.3U/m l、16 U/m l±14 U/m l、197 s±46 s vs 192 s±63 s、104%±14%vs 84%±29%、94%±15%vs69μ/m l±23μ/m l,P<0.01)。骨坏死组和对照组均未发现因子V Le iden突变和凝血酶原G20210A的突变。结论SARS后骨坏死患者存在高凝低纤溶倾向,对骨坏死易感人群可以进行高凝和低纤溶指标的筛选,PC、AT-Ⅲ、PAI、APC-R、PLG可作为骨坏死易感因素的筛选指标。SARS后骨坏死与因子V Le iden和凝血酶原G20210A突变无关。

关键词：骨坏死肺炎血液凝固

Characterization of rapidly and naturally quenched skeletal iron catalysts for FT synthesis

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合成化学 2004年第Z1期12卷 135-135页

作者： YAN Shi-run QIAO Ming-hua ZHU yuan-long FAN Kang-nian Laboratory of molecular catalysis and innovative materials Department of Chemistry Fudan University Shanghai 200433 China

The slurry phase is a promising system for Fischer-Tropsch (FT) synthesis. Since the liquid medium efficiently removes the heat of reaction so that the steady-state reaction is easily achieved. High catalytic activity is maintained due to removal of waxy products from the catalyst surface by the action of solvent. In addition, CO-rich syngas from coal gasification can be directly used in FT synthesis which may increase the thermal efficiency of the indirect coal liquefaction. One of the important problems to be solved for slurry phase FT is the catalyst attrition and separation from wax residue. Fused iron and Raney iron were found to have high attrition resistance and easy to separate from wax in slurry phase FT synthesis, but their activity is relatively low. Amorphous alloys made by rapid quenching techniques have drawn increasing interest due to their superior mechanical,chemical and magnetic properties compared to the thermodynamically stable crystalline alloys of the same compositions. It is reported that rapidly quenched skeletal Ni catalyst showed higher catalytic activity than Raney Ni in selective hydrogenation of unsaturated organic functional *** this paper, Fe50Al50 (by weight) alloys with different quenching rates, rapid quenching (RQ) and natural quenching (NQ) were prepared for FT synthesis. The phase composition of alloys was characterized by XRD. The physical properties, thermal-stability and adsorption properties of skeletal Fe that was prepared by leaching aluminum of the corresponding alloy with aqueous solution of NaOH were also studied by BET, in situ XRD and H2- and CO-TPD. It is found from XRD patterns of the alloys that RQ Fe50Al50 is composed of orthorhombic phase, and NQ Fe50Al50 alloy is mainly composed of monoclinic phase. Meanwhile, diffraction peaks of the RQ alloy are seriously broadened. After leaching aluminum by aqueous solution of NaOH at the same conditions,skeletal Fe from the RQ alloy give the higher specific surface are

关键词： Skeletal Fe catalyst rapidly quenched alloy phase composition H2 and CO adsorption