检索结果-南通市图书馆

Pathogen-induced methylglyoxal negatively regulates rice bacterial blight resistance by inhibiting OsCDR1 protease activity

引用

Molecular Plant 2024年第2期17卷 325-341页

作者： Zheng-Wei fu Jian-Hui Li Xiang Gao Shi-Jia Wang Ting-Ting yuan Ying-Tang Lu State Key Laboratory of Hybrid Rice College of Life SciencesRenmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430072China Key Laboratory of Biology and Genetic Improvement of OilCrops Ministry of Agriculture and Rural AffairsOilCrops Research Institute of the Chinese Academy of Agricultural SciencesWuhan 430062China

Xanthomonas oryzae ***(Xoo)causes bacterial blight(BB),a globally devastating disease of rice(Oryza sativa)that is responsible for significant crop *** and sugar metabolites are important for pathogen infection,providing energy and regulating events associated with defense responses;howev-er,the mechanisms by which they regulate such events in BB are *** an inevitable sugar metabolite,methylglyoxal(MG)is involved in plant growth and responses to various abiotic stresses,but the underlying mechanisms remain *** and how MG functions in plant biotic stress responses is almost completely ***,we report that the Xoo strain PXO99 induces OsWRKY62.1 to repress transcrip-tion of OsGLY Il genes by directly binding to their promoters,resulting in overaccumulation of *** negatively regulates rice resistance against Pxo99:osglyll2 mutants with higher MG levels are more sus-ceptible to the pathogen,whereas OsGLYIl2-overexpressing plants with lower MG content show greater resistance than the wild *** of OsGLYll2 to prevent excessive MG accumulation confers broad-spectrum resistance against the biotrophic bacterial pathogens Xoo and Xanthomonas oryzae *** and the necrotrophic fungal pathogen Rhizoctonia solani,which causes rice sheath *** evidence shows that MG reduces rice resistance against PXO99 through CONSTITUTIVE DISEASE RESISTANCE 1(OsCDR1).MGmodifies the Arg97 residue of OsCDR1to inhibit its aspartic protease activ-ity,which is essential for OsCDR1-enhanced *** together,these findings illustrate how Xoo promotes infection by hijacking a sugar metabolite in the host plant.

关键词： Oryza sativa bacterial blight OsWRKY62.1 methylglyoxal OsCDR1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microstructure and properties of 35 kg large aluminum alloy flywheel housing components formed by squeeze casting with local pressure compensation

引用

China Foundry 2024年第5期21卷 563-576页

作者： Ju-fu Jiang Jing Yan Ying-ze Liu Ning Ge Ying Wang Chang-jie ding De-chao Zou School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China Dalian Innovation Die-casting Co. Ltd.Dalian 116600LiaoningChina

The squeeze casting method with local pressure compensation was proposed to form a flywheel housing component with a weight of 35 *** numerical simulation,microstructure observation and phase characterization were performed,and the influence of local pressure compensation on feeding of thick-wall position,microstructure and mechanical properties of the formed components were *** show that the molten metal keeps a good fluidity and the filling is complete during the filling *** the solidification at thick-wall positions of the mounting ports is slow,the local pressure compensation effectively realizes the local forced feeding,significantly eliminating the shrinkage cavity *** the microstructure of AlSi9Mg alloy,α-Al primarily consists of fragmented dendrites and rosette grains,while eutectic Si predominantly comprises needles and short *** impact of local pressure compensation on strength is relatively minimal,yet its influence on elongation is *** local pressure compensation,the average elongation at the compensated areas is 9.18%,which represents a 44.90%higher than that before *** average tensile strength is 209.1 MPa,and the average yield strength is 100.6 *** local pressure compensation can significantly reduce or even eliminate the internal defects in the 35 kg large-weight components formed by squeeze casting.

关键词： squeeze casting local pressure compensation aluminum alloy microstructure mechanical properties large flywheel housing components

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeted metabolomics study of fatty-acid metabolism in lean metabolic-associated fatty liver disease patients

引用

World Journal of Gastroenterology 2024年第27期30卷 3290-3303页

作者： Pei-Qi Sun Yi-fu yuan Qin Cao Xiao-Yan Chen yuan-Ye Jiang Wen-Min Dong Li-Li Guo Department of Gastroenterology Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai 200062China Department of Pharmacy Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Central Laboratory Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China

BACKGROUND The annual incidence of metabolic-associated fatty liver disease(MAFLD)in China has been increasing and is often overlooked owing to its insidious *** 50%of the patients have a normal weight or are not *** are said to have lean-type MAFLD,and few studies of such patients are *** MAFLD is associated with abnormal lipid metabolism,lipid-targeted metabolomics was used in this study to provide experimental evidence for early diagnosis and *** and analyze metabolic ***-Q-Orbitrap/MS content determination was used to determine serum palmitic acid(PA),oleic acid(OA),linoleic acid(LA),and arachidonic acid(AA)levels in lean-type MAFLD *** Urea nitrogen and uric acid levels were higher in lean-type MAFLD patients than in healthy individuals(P*** levels of PA,OA,LA,and AA were significantly increased compared with healthy *** The metabolic profiles of lean-type MAFLD patients and healthy participants differed significantly,yielding 65 identified ***,OA,LA,and AA exhibited the most significant changes,offering valuable clinical guidance for prevention and treatment of lean-type MAFLD.

关键词： Lean-type metabolic-associated fatty liver disease Targeted serum metabolomics Fatty acids Principal component analysis Orthogonal partial least squares-discriminant analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predictive value of machine learning models for lymph node metastasis in gastric cancer: A two-center study

引用

World Journal of Gastrointestinal Surgery 2024年第1期16卷 85-94页

作者： Tong Lu Miao Lu Dong Wu yuan-yuan ding Hao-Nan Liu Tao-Tao Li Da-Qing Song Department of Emergency Medicine Jining No.1 People’s HospitalJining 272000Shandong ProvinceChina Wuxi Mental Health Center Wuxi 214000Jiangsu ProvinceChina Department of Gastroenterology Jining No.1 People’s HospitalJining 272000Shandong ProvinceChina Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

BACKGROUND Gastric cancer is one of the most common malignant tumors in the digestive system,ranking sixth in incidence and fourth in mortality *** 42.5%of metastatic lymph nodes in gastric cancer belong to nodule type and peripheral type,the application of imaging diagnosis is *** To establish models for predicting the risk of lymph node metastasis in gastric cancer patients using machine learning(ML)algorithms and to evaluate their pre-dictive performance in clinical *** Data of a total of 369 patients who underwent radical gastrectomy at the Depart-ment of General Surgery of Affiliated Hospital of Xuzhou Medical University(Xuzhou,China)from March 2016 to November 2019 were collected and retro-spectively analyzed as the training *** addition,data of 123 patients who underwent radical gastrectomy at the Department of General Surgery of Jining First People’s Hospital(Jining,China)were collected and analyzed as the verifi-cation *** ML models,including decision tree,random forest,support vector machine(SVM),gradient boosting machine,naive Bayes,neural network,and logistic regression,were developed to evaluate the occurrence of lymph node metastasis in patients with gastric *** ML models were established fo-llowing ten cross-validation iterations using the training dataset,and subsequently,each model was assessed using the test *** models’performance was evaluated by comparing the area under the receiver operating characteristic curve of each *** Among the seven ML models,except for SVM,the other ones exhibited higher accuracy and reliability,and the influences of various risk factors on the models are *** The ML models developed exhibit strong predictive capabilities for lymph node metastasis in gastric cancer,which can aid in personalized clinical diagnosis and treatment.

关键词： Machine learning Prediction model Gastric cancer Lymph node metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification and characterization of FpRco1 in regulating vegetative growth and pathogenicity based on T-DNA insertion in fusarium pseudograminearum

引用

Journal of Integrative Agriculture 2024年第9期23卷 3055-3065页

作者： Haiyang Li yuan Zhang Cancan Qin Zhifang Wang Lingjun Hao Panpan Zhang Yongqiang yuan Chaopu ding Mengxuan Wang Feifei Zan Jiaxing Meng Xunyu Zhuang Zheran Liu Limin Wang Haifeng Zhou Linlin Chen Min Wang Xiaoping Xing Hongxia yuan Honglian Li Shengli ding College of Plant Protection Henan Agricultural UniversityZhengzhou 450046China National Key Laboratory of Wheat and Maize Crop Science Zhengzhou 450046China Henan Plant Health Protection Technology Engineering Research Center Zhenzhou 450046China

fusarium pseudograminearum is a devastating pathogen that causes fusarium crown rot(FCR)in wheat and poses a significant threat to wheat production in terms of grain yield and ***,the mechanism by which *** infects wheat remains *** this study,we aimed to elucidate these mechanisms by constructing a T-DNA insertion mutant library for the highly virulent strain WZ-8A of *** screening this mutant library,we identified nine independent mutants that displayed impaired pathogenesis in barley *** these mutants,one possessed a disruption in the gene FpRCO1 that is an ortholog of Saccharomyces cerevisiae RCO1,encoding essential component of the Rpd3S histone deacetylase complex in *** further investigate the role of FpRCO1 in ***,we employed a split-marker approach to knock out FpRCO1 in *** ***1 deletion mutants exhibit reduced vegetative growth,conidium production,and virulence in wheat coleoptiles and barley leaves,whereas the complementary strain restores these ***,under stress conditions,the FpRCO1 deletion mutants exhibited increased sensitivity to NaCl,sorbitol,and SDS,but possessed reduced sensitivity to H_(2)O_(2)compared to these characteristics in the wild-type ***-seq analysis revealed that deletion of FpRCO1 affected gene expression(particularly the downregulation of TRI gene expression),thus resulting in significantly reduced deoxynivalenol(DON)*** summary,our findings highlight the pivotal role of FpRCO1 in regulating vegetative growth and development,asexual reproduction,DON production,and pathogenicity of *** study provides valuable insights into the molecular mechanisms underlying *** infection in wheat and may pave the way for the development of novel strategies to combat this devastating disease.

关键词： fusarium pseudograminearum T-DNA insertion Rpd3S complex FpRCO1 pathogenicity DON production

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Copper-catalyzed conjugate addition of allene-derived nucleophiles to alkenyl-substituted carboxamides

引用

Chinese Chemical Letters 2024年第3期35卷 239-242页

作者： Bin fu Yue Zhao Xiuping yuan Yanfei Li Jianjun Yin Simin Wang Tao Xiong Qian Zhang Jilin Province Key Laboratory of Organic functional Molecular Design&Synthesis Department of ChemistryNortheast Normal UniversityChangchun 130024China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Chemistry and Environmental Engineering Changchun University of Science and TechnologyChangchun 130012China

Catalytic Michael addition reaction represents a fundamental importance in organic synthetic *** corresponding conversions toward intrinsically low reactive enamide remains an ongoing *** herein report a copper-catalyzed conjugate addition of allenes toβ-substituted alkenyl amides,one of the most challenging Michael *** present method utilizes readily available allenes as the latent carbon-based nucleophiles and simple,commonβ-substituted alkenyl amides as starting materials,unlike previous methods that usually preinstall an activating group to improve the reactivity of amide or uses highly reactive stoichiometric quantities of ***,this approach shows good functional group compatibility and can be implemented under mild reaction conditions with excellent level of chemo-and regioselectivities.

关键词： CuH catalysis Allenes Unsaturated amide Conjugate addition Regioselectivity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An Innovative Finite Element Geometric Modeling of Single-Layer Multi-Bead WAAMed Part

引用

Computer Modeling in Engineering & Sciences 2024年第3期138卷 2383-2401页

作者： Xiangman Zhou Jingping Qin Zichuan fu Min Wang Youlu yuan Junjian fu Haiou Zhang Seyed Reza Elmi Hosseini College of Mechanical and Power Engineering China Three Gorges UniversityYichang443002China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan430074China School of Metallurgy and Materials Engineering Iran University of Science and TechnologyNarmakIran

Finite element (FE) coupled thermal-mechanical analysis is widely used to predict the deformation and residualstress of wire arc additive manufacturing (WAAM) parts. In this study, an innovative single-layermulti-bead profilegeometric modeling method through the isosceles trapezoid function is proposed to build the FE model of theWAAMprocess. Firstly, a straight-line model for overlapping beads based on the parabola function was establishedto calculate the optimal center distance. Then, the isosceles trapezoid-based profile was employed to replace theparabola profiles of the parabola-based overlapping model to establish an innovative isosceles trapezoid-basedmulti-bead overlapping geometric model. The rationality of the isosceles trapezoid-based overlapping model wasconfirmed by comparing the geometric deviation and the heat dissipation performance index of the two overlappingmodels. In addition, the FE-coupled thermal-mechanical analysis, as well as a comparative experiment of thesingle-layer eight-bead deposition process show that the simulation results of the above two models agree with theexperimental results. At the same time, the proposed isosceles trapezoid-based overlappingmodels are all straightlineprofiles, which can be divided into high-quality FE elements. It can improve the modeling efficiency andshorten the simulation calculation time. The innovative modeling method proposed in this study can provide anefficient and high-precision geometricmodelingmethod forWAAMpart FE coupled thermal-mechanical analysis.

关键词： WAAM FE coupled thermal-mechanical analysis the isosceles trapezoid-based model residual stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Establishment and Application of a Radiation Dose Rate Model for Nuclear Medicine Examinees

引用

China CDC weekly 2024年第23期6卷 553-557,I0019-I0025页

作者： Yuehua Hu Xinyu He Wenjia Zhao Lixin ding Meiying You Zihan Li Xinyu Liu Miaomiao Wang Siyi Chen Ziwei Lu Lei Qu Kuke ding Li Zhang Qiuxian fu Office of Epidemiology Chinese Center for Disease Control and PreventionBeijingChina Department of Oncology Central Hospital Affiliated to Shandong First Medical UniversityJinan CityShandong ProvinceChina National Institute for Radiological Protection Chinese Center for Disease Control and PreventionBeijingChina National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Laboratory Animal Center Chinese Center for Disease Control and PreventionBeijingChina National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionShanghaiChina Office of Public Health Management Chinese Center for Disease Control and PreventionBeijingChina Hainan Medical University Haikou CityHainan ProvinceChina

Introduction:Traditional methods for determining radiation dose in nuclear medicine include the Monte Carlo method,the discrete ordinate method,and the point kernel integration *** study presents a new mathematical model for predicting the radiation dose rate in the vicinity of nuclear medicine ***:A new algorithm was created by combining the physical model of“cylinder superposition”of the human body with integral analysis to assess the radiation dose rate in the vicinity of nuclear medicine ***:The model accurately predicted radiation dose rates within distances of 0.1–3.0 m,with a deviation of less than 11%compared to observed *** model demonstrated greater accuracy at shorter distances from the radiation source,with a deviation of only 1.55%from observed values at 0.1 ***:The model proposed in this study effectively represents the spatial and temporal distribution of the radiation field around nuclear medicine patients and demonstrates good agreement with actual *** model has the potential to serve as a radiation dose rate alert system in hospital environments.

关键词： method. deviation cylinder

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structural Isomers:Small Change with Big Difference in Anion Storage

引用

Nano-Micro Letters 2024年第1期16卷 222-234页

作者： Huichao Dai yuan Chen Yueyue Cao Manli fu Linnan Guan Guoqun Zhang Lei Gong Mi Tang Kun Fan Chengliang Wang School of Integrated Circuits Wuhan National Laboratory for Optoelectronics(WNLO)Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Wenzhou Advanced Manufacturing Institute Huazhong University of Science and TechnologyWenzhou 325035People’s Republic of China Hubei Key Laboratory of Polymer Materials School of Materials Science and EngineeringHubei UniversityWuhan 430062People’s Republic of China School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430073People’s Republic of China

Organic electrode materials are promising for ***,the reported organic electrodes are often facing the challenges of low specific capacity,low voltage,poor rate capability and vague charge storage mechanisms,*** are good platform to investigate the charge storage mechanisms and enhance the performance of batteries,which,however,have not been focused in ***,two isomers are reported for *** a result,the isomer tetrathiafulvalene(TTF)could store two monovalent anions reversibly,deriving an average discharge voltage of 1.05 V and a specific capacity of 220 mAh g−1 at a current density of 2 *** the other hand,the other isomer tetrathianaphthalene could only reversibly store one monovalent anion and upon further oxidation,it would undergo an irreversible solid-state molecular rearrangement to *** molecular rearrangement was confirmed by electrochemical performances,X-ray diffraction patterns,nuclear magnetic resonance spectra,and 1H detected heteronuclear multiple bond correlation *** results suggested the small structural change could lead to a big difference in anion storage,and we hope this work will stimulate more attention to the structural design for boosting the performance of organic batteries.

关键词： Zinc-organic batteries Isomers Solid-state molecular rearrangement Anion storage P-type organic electrode materials

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rapid and stable calcium-looping solar thermochemical energy storage via co-doping binary sulfate and Al±Mn±Fe oxides

引用

Green Energy & Environment 2024年第8期9卷 1290-1305页

作者： Changjian yuan Xianglei Liu Xinrui Wang Chao Song Hangbin Zheng Cheng Tian Ke Gao Nan Sun Zhixing Jiang Yimin Xuan Yulong ding School of Energy and Power Engineering Nanjing University of Aeronautics and Astronautics Key Laboratory of Thermal Management and Energy Utilization of Aviation Vehicles Ministry of Industry and Information Technology Birmingham Centre for Energy Storage School of Chemical Engineering University of Birmingham

Solar thermochemical energy storage based on calcium looping（CaL） process is a promising technology for next-generation concentrated solar power（CSP） systems. However, conventional calcium carbonate（CaCO3） pellets suffer from slow reaction kinetics, poor stability, and low solar absorptance. Here, we successfully realized high power density and highly stable solar thermochemical energy storage/release by synergistically accelerating energy storage/release via binary sulfate and promoting cycle stability, mechanical strength, and solar absorptance via Al±Mn±Fe oxides. The energy storage density of proposed CaCO3pellets is still as high as 1455 kJ kg-1with only a slight decay rate of 4.91% over 100 cycles, which is higher than that of state-of-the-art pellets in the literature, in stark contrast to 69.9% of pure CaCO3pellets over 35cycles. Compared with pure CaCO3, the energy storage power density or decomposition rate is improved by 120% due to lower activation energy and promotion of Ca2+diffusion by binary sulfate. The energy release or carbonation rate rises by 10% because of high O2-transport ability of molten binary sulfate. Benefiting from fast energy storage/release rate and high solar absorptance, thermochemical energy storage efficiency is enhanced by more than 50% under direct solar irradiation. This work paves the way for application of direct solar thermochemical energy storage techniques via achieving fast energy storage/release rate, high energy density, good cyclic stability, and high solar absorptance simultaneously.

关键词： Calcium looping (CaL) Solar thermochemical Energy storage Binary sulfate Fast reaction kinetics

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：