Copper-catalyzed conjugate addition of allene-derived nucleophiles to alkenyl-substituted carboxamides
作者机构：Jilin Province Key Laboratory of Organic Functional Molecular Design&SynthesisDepartment of ChemistryNortheast Normal UniversityChangchun 130024China State Key Laboratory of Organometallic ChemistryShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Chemistry and Environmental EngineeringChangchun University of Science and TechnologyChangchun 130012China
出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)
年 卷 期：2024年第35卷第3期
页 面：239-242页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：the financial support from the National Natural Science Foundation of China(NSFC,Nos.22171042,21831002,and 22193012) the Jilin Province Natural Science Foundation(No.20160520140JH) the Fundamental Research Funds for the Central Universities the Ten Thousand Talents Program for generous financial support
主 题：CuH catalysis Allenes Unsaturated amide Conjugate addition Regioselectivity
摘 要：Catalytic Michael addition reaction represents a fundamental importance in organic synthetic *** corresponding conversions toward intrinsically low reactive enamide remains an ongoing *** herein report a copper-catalyzed conjugate addition of allenes toβ-substituted alkenyl amides,one of the most challenging Michael *** present method utilizes readily available allenes as the latent carbon-based nucleophiles and simple,commonβ-substituted alkenyl amides as starting materials,unlike previous methods that usually preinstall an activating group to improve the reactivity of amide or uses highly reactive stoichiometric quantities of ***,this approach shows good functional group compatibility and can be implemented under mild reaction conditions with excellent level of chemo-and regioselectivities.
维普期刊数据库
同方期刊数据库