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The investigation of the stability of DNA-b-PPO vesicles formed through frame guided assembly

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Science China Chemistry 2018年第12期61卷 1568-1571页

作者： Bo Bian Yi-Yang Zhang yuan-chen dong Fen Wu Chao Wang Shuo Wang Yun Xu dong-Sheng Liu Department of Chemistry Tsinghua University College of Chemistry and Materials Engineering Wenzhou University Center for Medical Device Evaluation China Food and Drug Administration (CFDA)

Frame-guided assembly is a novel assembly method which can control the shape and size of vesicles accurately. It has been reported that the DNA-b-PPO vesicles could be stable over two weeks. In this communication we have introduced restriction sites of EcoR1 in the interior DNA scaffold to the formed vesicles in order to further study their stability. Dynamic light scattering(DLS), transmission electron microscope(TEM) and fluorescence spectrum were used to characterize the digestion process. The final results revealed that the vesicles were still stable even after two weeks cultivated with EcoR1, which suggests potential in future biological applications.

关键词： frame-guided assembly vesicles stability restriction sites EcoR1

Hydrogen-rich surface of MoC catalysts for efficient CO_(2) hydrogenation induced by a coupled hydrogen donator

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Nano Research 2024年第8期17卷 7762-7767页

作者： dong Xu Si-yuan Xia Qi-yuan Li Jie-Sheng chen Xin-Hao Li School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China

Direct CO_(2) hydrogenation offers an important strategy for promoting the global carbon balance,but high thermodynamic and kinetic stability of CO_(2) has restricted its applicability to only a handful of industrial ***,we introduce a proof-of-concept application of the electron-rich Pt surface to promote hydrogen donation for electron-rich MoC particles acting as hydrogen acceptors,thereby constructing hydrogen-rich surface of MoC active ***,the formed hydrogen-rich and electronrich surface could greatly decrease reaction activation energy to boost the efficient CO_(2) hydrogenation into formic acid over the MoC *** optimized MoC@NC/Pt-0.1(NC:nitrogen-doped carbon)catalyst exhibits a high turnover frequency(TOF)value of 1.2 h^(−1) at a lower temperature of 60℃and a TOF of 24.2 h^(−1) under standard reaction conditions widely used in the literature,exceeding 7 times of MoC@NC catalyst and surpassing the benchmark classical non-noble metal active center-based heterogeneous catalyst.

关键词： electron-rich Pt nanoparticles hydrogen donation hydrogen-rich MoC nanoparticles CO_(2) hydrogenation formic acid

MULTIPHOTON MICROSCOPY:A NEW APPROACH IN PHYSIOLOGICAL STUDIES AND PATHOLOGICAL DIAGNOSIS FOR OPHTHALMOLOGY

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Journal of Innovative Optical Health Sciences 2009年第1期2卷 45-60页

作者： CHIU-MEI HSUEH WEN LO SUNG-JAN LIN TSUNG-JEN WANG FUNG-RUNG HU HSIN-yuan TAN chen-yuan dong Department of Physics National Taiwan University Taipei 106 Taiwan Institute of Biomedical Engineering National Taiwan University Taipei 106 Taiwan Department of Dermatology National Taiwan University Hospital Taipei 100 Taiwan Department of Ophthalmology Taipei Medical University Hospital Taipei 100 Taiwan Department of Ophthalmology National Taiwan University College of Medicine and Hospital Taipei 100Taiwan Department of Ophthalmology Chang-Gung University Linko 333 Taiwan Institute of Biomedical Engineering National Taiwan University Taipei 100 Taiwan

Multiphoton microscopy(MPM),with the advantages of improved penetration depth,decreased photo-damage,and optical sectioning capability,has become an indispensable tool for biomedical *** combination of multiphoton fluorescence(MF)and second-harmonic generation(SHG)microscopy is particularly effective in imaging tissue structures of the ocular *** work is intended to be a review of advances that MPM has made in ophthalmic *** MPM not only can be used for the label-free imaging of ocular structures,it can also be applied for investigating the morphological alterations in corneal pathologies,such as keratoconus,infected keratitis,and corneal ***,the corneal wound healing process after refractive surgical procedures such as conductive keratoplasty(CK)can also be studied with ***,qualitative and quantitative SHG microscopy is effective for characterizing corneal thermal *** additional development,multiphoton imaging has the potential to be developed into an effective imaging technique for in vivo studies and clinical diagnosis in ophthalmology.

关键词： Multiphoton microscopy fluorescence second harmonic generation cornea sclera

Preparation of PVA/GO/h-BN Janus Film with High Thermal Conductivity and Excellent Flexibility via a Density Deposition Self-assembly Method

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Chinese Journal of Polymer Science 2024年第8期42卷 1217-1226页

作者： Fang-Hua Luo Zhi-Tao dong Guo-Hua chen chen Ma Huai-yuan Wang College of Chemistry and Chemical Engineering Northeast Petroleum UniversityDaqing 163318China College of Materials Science and Engineering Huaqiao UniversityXiamen 361000China School of Chemical Engineering and Technology and State Key Laboratory for Chemical Engineering Tianjin UniversityTianjin 300350China

Janus films with asymmetric physical/chemical properties have attracted con siderable attention due to their promising applications in personal thermal management,electronic skin s,sensors,actuators,***,traditional methods for fabricating Janus films conventionally need the assistance of an interface or auxiliary equipment,which are usually complex and ***,flexible poly(vinyl alcohol)(PVA)/graphene oxide(GO)/h-BN(recorded as PVA/GO/h-BN)Janus films with thermally,optically,and electrically anisotropic properties are fabricated by a simple density deposition self-assem bly method,which just utilizes the density difference between GO and h-BN during water *** results show that the two sides of the acquired Janus films have obvious asymmetric *** the original state of the PVA/GO/h-BN Janus films,the thermal conductivity of the GO side(10.06 W·m^(-1)·K^(-1))is generally lower than that of the h-BN side(10.48W·m^(-1)·K^(-1)).But after GO is reduced,the thermal conductivity of the rGO side reaches 12.17 W·m^(-1)·K^(-1),surpassing that of the h-BN *** addition,the relative reflectance of the h-BN side of Janus film is also significantly higher than that of the rGO side,and the su rface resistance difference between the two sides is about 4 orders of *** prepared PVA/GO/h-BN Janus films show great application potential in human thermal management,light conversion switches,and electronic *** study provides a simple and versatile strategy for fabricating Janus films with multifunctional(such as thermal,optical,and electrical)anisotropies.

关键词： Janus films PVA/GO/h-BN Density deposition self-assembly method

Molecular recognition of cyclophanes in water

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Chinese Chemical Letters 2024年第5期35卷 32-44页

作者： Fang-yuan chen Wen-Chao Geng Kang Cai dong-Sheng Guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer Materials(Ministry of Education)Frontiers Science Center for New Organic MatterCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China College of Chemistry Nankai UniversityTianjin 300071China

Molecular recognition in water,the biological solvent,always receives significant research focus in supramolecular *** mechanisms of molecular recognition in water is key to comprehending biological processes at the molecular *** the past five decades,supramolecular chemists have developed a vast array of synthetic receptors with highly diverse structures and recognition *** them,cyclophanes represent an important family of macrocyclic receptors that have been extensively *** aromatic moieties in cyclophanes not only facilitate chemical modifications to impart water solubility but also enable forming hydrophobic cavities for guest inclusion in aqueous *** by Koga et al.,who reported the first inclusion complex of cyclophanes in water and solid state,numerous water-soluble cyclophanes,including derivatives of blue box,calixarenes,resorcinarenes,pillararenes,octopusarenes,biphenarenes,coronarenes,and naphthotubes,etc.,have been synthesized and subjected to investigation of the recognition capabilities in aqueous *** review provides an overview of cyclophane receptors designed to bind organic guests in *** categorize them into two classes based on the modifications made to their hydrophobic cavities:those with“exo-functionalized hydrophobic cavities”and those with“endo-functionalized hydrophobic cavities”.We introduce their distinctive features and discuss strategies to enhance recognition affinity and *** review aims to inspire the development of novel synthetic receptors with intriguing properties and foster practical applications of cyclophanes.

关键词： Biomimetic receptor Cyclophane Molecular recognition Hydrophobic effect High-affinity Macrocycles

Excitonic optical properties in monolayer SnP_(2)S_(6)

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Chinese Physics B 2024年第10期33卷 371-375页

作者： Peng-yuan chen Zhen Quan Shu-dong Wang School of Physical Science and Technology Inner Mongolia UniversityHohhot 010021China

Quantum confinement effect and reduced dielectric screening in two-dimensional(2D)dramatically enhance theelectron-hole *** this work,we use many-body perturbation theory and Bethe-Salpeter equation(BSE)toinvestigate the electronic and excitonic optical properties of monolayer SnP_(2)S_(6).Our findings reveal that the excitoniceffect dominates the optical absorption spectra in the visible light range,and the lowest-energy exciton X0 in monolayerSnP_(2)S_(6)is optically bright with the binding energy of 0.87 eV and the radiative lifetime of~10^(-11)s,which is highly advantageousto the *** importantly,the absence of optically forbidden states below the bright statesX0 would give rise to a high quantum efficiency of 2D SnP_(2)S_(6).We also find that applied biaxial strain can further shortenthe radiative lifetime of the bright *** results imply that 2D SnP_(2)S_(6)is a promising candidate for the optoelectronicdevices.

关键词： excitons radiative lifetime SnP_(2)S_(6)

On the Characteristic Length Scale for the Synthetic Turbulence Based on the Spalart-Allmaras Model

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Advances in Applied Mathematics and Mechanics 2024年第1期16卷 122-145页

作者： Qilong Guo Pengxin Liu chen Li dong Sun Xianxu yuan State Key Laboratory of Aerodynamics MianyangSichuan 621000China

In the hybrid RANS-LES simulations,proper turbulent fluctuations should be added at the RANS-to-LES interface to drive the numerical solution restoring to a physically resolved turbulence as rapidly as *** turbulence generation methods mostly need to know the distribution of the characteristic length scale of the background RANS model,which is important for the recovery *** approximation of the length scale for the Spalart-Allmaras(S-A)model is not a trivial issue since the model’s one-equation *** a direct analogy,the approximations could be obtained from the definition of the Prandtl’s mixing ***,this paper proposes a new algebraic expression to approximate the intrinsic length scale of the S-A *** underlying transportation mechanism of S-A model are largely exploited in the derivation of this new *** new proposed expression is employed in the generation of synthetic turbulence to perform the hybrid RANS-LES simulation of canonical wall-bounded turbulent *** comparisons demonstrated the feasibility and improved performance of the new length scale on generating synthetic turbulence at the LES inlet.

关键词： Length scale synthetic turbulence hybrid RANS-LES Spalart-Allmaras model

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框架诱导组装策略研究进展

高分子学报 2022年第10期53卷 1204-1216页

作者：袁伟董原辰中国科学院化学研究所中国科学院胶体、界面与化学热力学重点实验室北京100190 中国科学院大学北京100049

近年来,两亲分子自组装在生物医药和材料科学领域受到愈加广泛的关注和研究.为了实现特定大小和形态的功能纳米结构的制备,研究者们先后发展了多种稳健的构筑方法.框架诱导组装策略作为一种新兴的有效构筑策略,在精确形貌和尺寸可控的... 详细信息

近年来,两亲分子自组装在生物医药和材料科学领域受到愈加广泛的关注和研究.为了实现特定大小和形态的功能纳米结构的制备,研究者们先后发展了多种稳健的构筑方法.框架诱导组装策略作为一种新兴的有效构筑策略,在精确形貌和尺寸可控的三维纳米囊泡和二维纳米膜方面都取得了一系列重要的研究成果.本文总结并评了述了框架诱导组装策略近十年来的重要研究进展,并展望了该策略在未来存在的挑战和应用前景.

关键词：两亲分子自组装组装方法框架诱导组装

Microglial Calcium Homeostasis Modulator 2:Novel Anti-neuroinflammation Target for the Treatment of Neurodegenerative Diseases

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Neuroscience Bulletin 2024年第4期40卷 553-556页

作者： yuan dong Li Tang Neuropsychiatry Research Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao266000China Qingdao Institute of Measurement Technology Qingdao266000China

Neurodegenerative diseases,including Alzheimer's disease(AD)and Parkinson's disease(PD),are the most common causes of *** drugs for such diseases can only provide temporary help with the symptoms,leaving the discovery of new drugs urgently in *** cells are the local immune cells in the nervous system and have been recognized as the key player in neuroinflammation that contributes to the process of neurodegeneration[1],raising the discussion of aiming microglia as the therapeutic target for clinical treatment of neurodegenerative diseases.

关键词： inflammation degenerative drugs