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Biomedical and Environmental Sciences 2011年第3期24卷 315-320页

作者： SHEN YuJuan YIN JianHai yuan zhongying LU Weiyuan XU YuXin XIAO LiHua CAO JianPing National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention Laboratory of Parasite and Vector Biology MOH China WHO Collaborating Centre for Malaria Schistosomiasis and Filariasis Shanghai 200025 China Centers for Disease Control and Prevention Atlanta Georgia USA

Objective Cryptosporidium spp. are prevalent globally and sheep are an important zoonotic reservoir. Little data regarding the rates of Cryptosporidium infections in ovines in China are available. This study assessed the prevalence of Cryptosporidium spp. in pre-weaned ovines from Aba Tibetan and Qiang Autonomous Prefecture in the Sichuan province of China. Methods A total of 213 fecal samples were collected from pre-weaned ovines and were examined microscopically （following modified acid fast staining）. In addition, 18S rRNA genetic sequences were amplified from fecal samples by nested PCR and phylogenetically analyzed. Results The prevalence of Cryptosporidium in the collected samples was at 14.6% （31/213） and four isolates identified by PCR belonged to the Cryptosporidium cervine genotype （Cryptosporidium ubiquiturn） demonstrating that this species was the primary sheep species found in sheep in China. Conclusion The present study suggested that the high incidence of Cryptosporidium in sheep poses a significant public health threat and that surveillance practices must be established to prevent zoonotic disease of humans.

关键词： Cryptosporidium ubiquitum Ovines Aba China Cryptosporidium cervine genotype

Intestinal Protozoan Infections in Patients with Diarrhea—Shanghai Municipality,Zhenjiang City,and Danyang City,China,2011–2015 and 2019–2021

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China CDC weekly 2022年第8期4卷 143-147页

作者： Yanyan Jiang zhongying yuan Hua Liu Jianhai Yin yuan Qin Xiaofeng Jiang Jie Xu Jianping Cao Yujuan Shen National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)Key Laboratory of Parasite and Vector BiologyNational Health Commission of the People’s Republic of ChinaWorld Health Organization Collaborating Centre for Tropical DiseasesShanghaiChina School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina

Summary What is already known about this topic?Intestinal protozoa are common pathogens of diarrhea ***,the etiology of diarrhea due to intestinal protozoan infections in China is not *** is added by this report?Based on active syndromic surveillance in Shanghai,Zhenjiang,and Danyang during 2011–2015 and 2019–2021,89(1.67%)patients were infected with intestinal protozoa(Cryptosporidium spp.,Giardia duodenalis,Enterocytozoon bieneusi,and Cyclospora cayetanensis),and positivity rates statistically differed by region and *** are the implications for public health practice?This was the most comprehensive data collection in investigating parasitic diarrheal diseases in *** of these protozoa in diarrhea will provide new perspectives for detecting hidden etiological agents of diarrhea as early as possible.

关键词： globally ang detecting

Cyclospora cayetanensis infections among diarrheal outpatients in Shanghai： a retrospective case study

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Frontiers of Medicine 2018年第1期12卷 98-103页

作者： Yanyan Jiang zhongying yuan Guoqing Zang Dan Li Ying Wang Yi Zhang Hua Liu Jianping Cao Yujuan Shen National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention Key Laboratory of Parasite and VectorBiology Ministry of Health China WHO Collaborating Center for Tropical Diseases Shanghai 200025 China Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 China

Cyclospora cayetanensis is a foodborne and waterborne pathogen that causes endemic and epidemic human diarrhea worldwide. A few epidemiological studies regarding C. cayetanensis infections in China have been conducted. During 2013, a total of 291 stool specimens were collected from patients with diarrhea at a hospital in urban Shanghai. C. cayetanensis was not detected in any of the stool specimens by traditional microscopy, whereas five stool specimens （1.72%, 5/291） were positive by PCR. These positive cases confirmed by molecular technology were all in the adult group （mean age 27.8 years; 2.94%, 5/170） with watery diarrhea. Marked infection occurred in the rainy season of May and July. Sequence and phylogenetic analyses of the partial 18S rRNA genes of C. cayetanensis isolated showed intra-species diversity of this parasite. This study showed, for the first time, that C. cayetanensis is a pathogen in outpatients with diarrhea in Shanghai, albeit at a low level. However, the transmission dynamics of this parasite in these patients remain uncertain.

关键词： Cyclospora cayetanensis outpatients with diarrhea stool specimens 18S rRNA gene

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新经济环境下我国第三方物流的发展对策

中国市场 2008年第15期 34-36页

作者：袁中英重庆三峡学院

中国按照加入世贸组织的承诺,于2005年12月底全面放开物流市场,针对新经济环境,本文从企业自身以及市场环境展开分析,结合当前国际第三方物流发展的新趋势,提出我国第三方物流相应的发展对策。

关键词：第三方物流发展对策

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高热效率稀燃发动机的产品开发

汽车工程 2023年第3期45卷 430-437页

作者：崔亚彬赖海鹏贾楠柳茂斌袁中营长城汽车股份有限公司蜂巢易创科技有限公司保定071000

混合动力汽车是降低整车CO_(2)排放和污染物排放的有效解决方案。提升混动发动机最高热效率,并扩大常用工况高热效率区可以有效降低整车燃油消耗。根据混动技术平台需求,开发了一款2.0T高效稀燃混动发动机。该发动机采用高压缩比,大程... 详细信息

混合动力汽车是降低整车CO_(2)排放和污染物排放的有效解决方案。提升混动发动机最高热效率,并扩大常用工况高热效率区可以有效降低整车燃油消耗。根据混动技术平台需求,开发了一款2.0T高效稀燃混动发动机。该发动机采用高压缩比,大程径比和深度米勒循环,使用高滚流气道设计实现了过量空气系数1.8的超稀薄燃烧。凭借先进的燃烧系统和降摩擦设计,该发动机实现了44%的有效热效率。同时,41%以上热效率区域覆盖了转速从1000到4000 r/min发动机混动常用工况点,确保了出色的整车燃油经济性。此外,高效稀燃发动机还实现了115 kW的最大功率和240 N•m的转矩平台,保证了混动系统的动力性需求。

关键词：稀燃发动机高热效率高压缩比混合动力

Transcriptome sequencing-based study on the mechanism of action of Jintiange capsules (金天格胶囊) in regulating Synovial mesenchymal stem cells exosomal miRNA and Articular chondrocytes mRNA for the treatment of osteoarthritis

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Journal of Traditional Chinese Medicine 2024年

作者： CHEN zhongying ZHANG Xue ZHANG Xiaofei ZOU Junbo yuan Puwei SHI Yajun Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research， Pharmacy College， Shaanxi University of Chinese Medicine The First Clinical Medical College， Shaanxi University of Chinese Medicine

OBJECTIVE: To corroborate the efficacy of Jintiange capsules (JTGs) (金天格胶囊) in the treatment of osteoarthritis (OA) by exploring the potential mechanism of action of synovial mesenchymal stem cell exosomes (SMSC-Exos) and articular chondrocytes (ACs) through transcriptome sequencing (RNA-seq).METHODS: Type II collagenase was used to induce OA in rats. The efficacy of JTGs was confirmed by macroscopic observation of articular cartilage， micro-CT observation， and safranin fast green staining. After SMSC-Exos and ACs were qualified， RNA-seq was used to screen differentially expressed miRNAs and mRNAs. The target genes of differentially expressed miRNAs in Synovial mesenchymal stem cells (SMSCs) were predicted based on the multiMiR R package. The co-differentially expressed genes of SMSC-Exos and ACs were obtained by venny 2.1.0. The miRNA-mRNA regulatory network was constructed by Cytoscape software. Based on the OmicShare platform， Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis was performed on the mRNA regulated by key miRNAs. Expression trend analysis was performed for co-differentially expressed genes. Correlation analysis was performed on micro-CT efficacy indicators， co-differentially expressed genes mRNA and ***: The efficacy of each administration group of JTGs was significant compared with the model group. SMSC-Exos and ACs were identified by their characteristics. The expression of rno-miR-23a-3p， rno-miR-342-3p， rno-miR-146b-5p， rno-miR-501-3p， rno-miR-214-3p was down-regulated in OA pathological state， and the expression of rno-miR-222-3p， rno-miR-30e-3p， rno-miR-676， and rno-miR-192-5p expression was up-regulated， and the expression of all these miRNAs was reversed after the intervention with JTGs containing serum. The co-differentially expressed genes were enriched in the interleukin 17 signaling pathway， tumor necrosis factor signaling pathway， transforming growth factor-β signaling pathway， etc. The expression tr

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电动汽车无线充电系统电磁屏蔽结构设计理论与试验研究

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汽车技术 2024年第9期 51-56页

作者：田忠莹祝丽花李元天津工业大学天津300387 天津市新能源电力变换传输与智能控制重点实验室天津300384

为研究屏蔽结构对电动汽车无线充电系统的影响,基于屏蔽效能理论建立屏蔽体厚度与屏蔽体材料参数的关系模型。根据不同厚度、不同屏蔽材料的单层屏蔽体对磁场的屏蔽效果,对比数值解与解析解,初步验证了所建立的屏蔽体厚度模型的适用性,... 详细信息

为研究屏蔽结构对电动汽车无线充电系统的影响,基于屏蔽效能理论建立屏蔽体厚度与屏蔽体材料参数的关系模型。根据不同厚度、不同屏蔽材料的单层屏蔽体对磁场的屏蔽效果,对比数值解与解析解,初步验证了所建立的屏蔽体厚度模型的适用性,在此基础上,提出安全电磁环境下厚度最小的复合无线充电屏蔽体结构,并通过电磁试验进行了验证。结果表明,以0.05 mm的超薄硅钢和2.52 mm的铁氧体作为双层屏蔽结构时,磁场强度达到安全限值,且传输效率达到90.92%,相较于传统铁氧体和铝板复合屏蔽结构,该结构厚度减小了1.95 mm。

关键词：电动汽车无线充电电磁屏蔽屏蔽体厚度设计理论

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进气道喷水对增压直喷汽油机性能的影响

中南大学学报（自然科学版） 2020年第9期51卷 2595-2603页

作者：彭忠秦静裴毅强张启锐宋东先崔亚彬左坤峰袁中营吴慎超天津大学内燃机燃烧学国家重点实验室天津300072 天津大学内燃机研究所天津300072 长城汽车股份有限公司河北保定071000

基于1台缸内直喷增压汽油机,试验研究不同水油比对加浓和当量比混合气燃烧时的发动机燃烧和排放性能的影响。研究结果表明:在满负荷工况下,当过量空气系数λ为1时,随着水油比增加,燃烧相位推迟,燃烧持续期延长,同时喷水后空气质量流量下... 详细信息

基于1台缸内直喷增压汽油机,试验研究不同水油比对加浓和当量比混合气燃烧时的发动机燃烧和排放性能的影响。研究结果表明:在满负荷工况下,当过量空气系数λ为1时,随着水油比增加,燃烧相位推迟,燃烧持续期延长,同时喷水后空气质量流量下降,两者共同导致发动机平均有效压力降低;采用当量比混合气燃烧时,λ为1时的CO,HC和排气烟度与λ为0.88时相比明显降低,而NOx排放量升高;CO,排气烟度和NOx排放量随着水油比增加而降低,而HC排放量升高。在满负荷工况下采用当量比混合气燃烧时,通过喷水能够使发动机抗爆能力提高,点火时刻进一步提前,燃烧相位提前;燃烧相位提前使发动机平均有效压力与未优化点火时刻相比提升0.9%~2.9%,有效燃油消耗率降低2.2%~3.9%。

关键词：进气道喷水汽油机燃烧特性排放

催化柴油加氢裂化生产汽油和BTX技术相关专利分析炼油

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当代石油石化 2018年第5期26卷 28-32,36页

作者：任金晨柳伟袁长富张忠营中国石油化工股份有限公司大连石油化工研究院辽宁大连116045

通过INNOGRAPHY专利检索分析数据库对国内外公开申请的催化柴油加氢裂化生产汽油和BTX技术领域的相关专利进行检索,重点分析了催化柴油加氢裂化生产汽油和BTX技术在全球及中国的专利技术现状,以掌握催化柴油加氢裂化生产汽油和BTX技术... 详细信息

通过INNOGRAPHY专利检索分析数据库对国内外公开申请的催化柴油加氢裂化生产汽油和BTX技术领域的相关专利进行检索,重点分析了催化柴油加氢裂化生产汽油和BTX技术在全球及中国的专利技术现状,以掌握催化柴油加氢裂化生产汽油和BTX技术在国内外的研究发展趋势,为该项技术的研究发展提供了有利支撑。

关键词：催化柴油汽油 BTX 专利

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连续可变气门升程技术在汽油机上的应用研究

车用发动机 2019年第5期 35-40页

作者：崔亚彬袁中营郭峰王阔吴慎超宋东先高定伟长城汽车股份有限公司河北保定071000 河北省汽车工程技术研究中心河北保定071000

通过台架试验的方法,基于一台1.5L涡轮增压直喷汽油机,应用连续可变气门升程(CVVL)技术,在一定程度上实现米勒循环效果。在此基础上,对泵气损失、机械损失、理论热效率、米勒循环与LP-EGR的关系进行研究,提出优化方案并进行分析。试验... 详细信息

通过台架试验的方法,基于一台1.5L涡轮增压直喷汽油机,应用连续可变气门升程(CVVL)技术,在一定程度上实现米勒循环效果。在此基础上,对泵气损失、机械损失、理论热效率、米勒循环与LP-EGR的关系进行研究,提出优化方案并进行分析。试验结果显示,使用CVVL技术实现了米勒循环效果,泵气损失及机械损失均有一定降低,燃烧效率提高,但油耗降幅不明显。增大发动机压缩比,匹配LP-EGR系统,EGR降低油耗的作用非常明显,米勒循环的作用相对弱化,EGR对发动机的充气能力要求增强,导致米勒度有一定的降低。

关键词：连续可变气门升程泵气损失热效率米勒度废气再循环