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中国工业产业链现代化指数:区域差异及动态演进

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统计与决策 2024年第4期40卷 96-101页

作者：余姗张哲西安财经大学经济学院西安710100 西安财经大学西部能源经济与区域发展协同创新研究中心西安710100

文章基于工业产业链流通、盈利、数字化、创新、协同以及绿色化六个维度构建指标体系,采用熵值法测算2011—2022年中国31个省份工业产业链现代化指数,并运用Dagum基尼系数、Moran指数、核密度估计及马尔可夫链的方法分析区域差异及动态... 详细信息

文章基于工业产业链流通、盈利、数字化、创新、协同以及绿色化六个维度构建指标体系,采用熵值法测算2011—2022年中国31个省份工业产业链现代化指数,并运用Dagum基尼系数、Moran指数、核密度估计及马尔可夫链的方法分析区域差异及动态演进规律。结果表明:中国工业产业链现代化指数整体呈稳定上升趋势,且东部地区和中部地区相对较高,而区域差异则主要表现在各区域之间,但是长期来看高水平地区将会辐射和带动其他地区的发展,进而促进工业产业链现代化整体水平提升。

关键词：工业产业链现代化区域差异动态演进 Dagum基尼系数核密度估计马尔可夫链

Taming heat with tiny pressure

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The Innovation 2024年第2期5卷 70-78页

作者： Kun Zhang zhe Zhang Hailong Pan Haoyu Wang Xueting Zhao Ji Qi Zhao Zhang Ruiqi Song Chenyang yu Biaohong Huang Xujing Li Huaican Chen Wen Yin Changlong Tan Weijin Hu Michael Wüubbenhorst Jiangshui Luo Dehong yu Zhidong Zhang Bing Li Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Laboratory for Soft Matter and Biophysics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150080China Australian Nuclear Science and Technology Organisation Lucas HeightsNSW 2234Australia

Heat is almost *** electricity,which can be easily manipulated,the current ability to control heat is still highly limited owing to spontaneous thermal dissipation imposed by the second law of *** illumination and pressure have been used to switch endothermic/exothermic responses of materials via phase transitions;however,these strategies are less cost-effective and ***,we spectroscopically demonstrate the glassy crystal state of 2-amino-2-methyl-1,3-propanediol(AMP)to realize an affordable,easily manageable approach for thermal energy *** supercooled state of AMP is so sensitive to pressure that even several megapascals can induce crystallization to the ordered crystal,resulting in a substantial temperature increase of 48 K within 20 ***,we demonstrate a proof-of-concept device capable of programable heating with an extremely high work-to-heat conversion effi-ciency of*** delicate and efficient tuning of heat may remarkably facilitate rational utilization of waste heat.

关键词： illumination thermal rational

基于PLUS-InVEST模型吐哈盆地陆地生态系统碳储量时空变化及多情景模拟

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干旱区地理 2024年第2期47卷 260-269页

作者：韩楚翘郑江华王哲于雯婕新疆大学地理与遥感科学学院新疆乌鲁木齐830017 新疆绿洲生态重点实验室新疆乌鲁木齐830017

土地覆盖变化能够改变区域碳储存能力,从而引起全球气候变化。研究土地覆盖变化对碳储量的影响,预测未来不同土地覆盖情景下的碳储量,对实现区域“碳中和”战略目标具有重要意义,然而目前针对中国西部生态脆弱区的研究仍有待探究。以新... 详细信息

土地覆盖变化能够改变区域碳储存能力,从而引起全球气候变化。研究土地覆盖变化对碳储量的影响,预测未来不同土地覆盖情景下的碳储量,对实现区域“碳中和”战略目标具有重要意义,然而目前针对中国西部生态脆弱区的研究仍有待探究。以新疆吐哈盆地为研究区,基于土地覆盖产品数据,结合PLUS模型和InVEST模型,探讨了土地覆盖变化与区域碳储量的时空变化关系,预测和评估了2025、2030年可持续发展情景,维持现状发展情景,经济优先发展情景下土地覆盖和碳储量的时空动态特征。结果表明:(1)近20 a来,吐哈盆地耕地和裸土地面积增加最大,其次是建设用地,而草地表现出最大的减少趋势,草地转为耕地和建设用地是最主要的转移类型。(2)2000、2010年和2020年吐哈盆地平均碳储量分别为26.01 t·hm~(-2)、25.68 t·hm~(-2)、25.73 t·hm~(-2),呈现出先降低后增加的趋势,平均碳储量累计减少了0.28 t·hm~(-2),其中土壤有机质碳储量占比最高,约占总碳储量的94%,裸土地、草地贡献了最多的碳储量。(3)2030年3种情景下,森林、灌木林、湿地几乎无明显变化,裸土地呈现出减少的趋势,而建设用地呈现增加的趋势。(4)到2030年可持续发展情景下吐哈盆地总碳储量较2020年增加了0.18×10~6t,维持现状发展情景和经济优先发展情景下分别减少了0.30×10~6t、1.01×10~6t,经济优先发展情景下碳储量损失最大。研究结果可为吐哈盆地土地利用优化以及制定生态系统可持续发展措施提供依据。

关键词：土地覆盖变化情景模拟碳储量吐哈盆地

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“一带一路”倡议与国内居民主观福利

系统工程理论与实践 2024年第9期44卷 3062-3078页

作者：张军张哲于晓宇陈磊东北财经大学国际经济贸易学院大连116025 东北财经大学上海合作组织研究中心大连116025 东北财经大学马克思主义学院大连116025 东北财经大学经济学院大连116025

“一带一路”倡议的核心目标之一是让建设成果更好地惠及全体人民.本文基于2010–2018年中国家庭追踪调查(CFPS)数据,利用双重差分法评估“一带一路”倡议的主观福利效应.研究发现,“一带一路”倡议的实施显著提高了国内居民主观福利,... 详细信息

“一带一路”倡议的核心目标之一是让建设成果更好地惠及全体人民.本文基于2010–2018年中国家庭追踪调查(CFPS)数据,利用双重差分法评估“一带一路”倡议的主观福利效应.研究发现,“一带一路”倡议的实施显著提高了国内居民主观福利,上述促增效应主要来源于城市交通基础设施水平提升、居民消费规模扩张以及消费结构优化升级.进一步研究表明,“一带一路”倡议的主观福利效应具有“亲贫性”特征,在收入水平和社会地位较低的群体中更为突出.此外,本文还发现“一带一路”倡议对居民主观福利的促增作用在第三产业占比较高和“丝绸之路经济带”城市中体现得更为明显.本文为理解“一带一路”倡议的经济效应提供了新视角,同时强调,深度融入共建“一带一路”大格局、加快建设现代化交通基础设施网络体系、多措并举促进消费扩容升级对“一带一路”倡议背景下有效提升国内居民主观福利具有重要启示意义.

关键词： “一带一路”倡议居民主观福利消费升级双重差分法

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数字技术赋能学生心理危机的应对

清华大学教育研究 2024年第4期45卷 25-36页

作者：俞国良张哲中国人民大学心理研究所中国人民大学教育学院

数字技术为学生心理危机的高质量、高水平“应对”,注入了新动能、带来了新契机。本文紧紧围绕数字技术赋能学生心理危机的应对，从心理危机的预防与筛查、识别与诊断、治疗与干预等过程入手，多角度、多层面阐述了数字技术对学生心理... 详细信息

数字技术为学生心理危机的高质量、高水平“应对”,注入了新动能、带来了新契机。本文紧紧围绕数字技术赋能学生心理危机的应对，从心理危机的预防与筛查、识别与诊断、治疗与干预等过程入手，多角度、多层面阐述了数字技术对学生心理危机应对的赋能。在此基础上，进一步从“强基”“健体”“固本”三个方面，探讨了我国学生心理危机应对的实践路径，旨在为广大儿童青少年的健康成长和幸福人生，攻坚破难、保驾护航。

关键词：数字技术心理健康心理危机心理危机应对

Fanlian Huazhuo Formula alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway

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World Journal of Gastroenterology 2024年第30期30卷 3584-3608页

作者： Meng-yuan Niu Geng-Ting Dong Yi Li Qing Luo Liu Cao Xi-Min Wang Qi-Wen Wang Yi-Ting Wang zhe Zhang Xi-Wen Zhong Wei-Bo Dai Le-yu Li Pharmacology Laboratory Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina Department of Endocrinology Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina

BACKGROUND Fanlian Huazhuo Formula(FLHZF)has the functions of invigorating spleen and resolving phlegm,clearing heat and purging *** has been identified to have therapeutic effects on type 2 diabetes mellitus(T2DM)in clinical ***-alcoholic fatty liver disease(NAFLD)is frequently diagnosed in patients with ***,the therapeutic potential of FLHZF on NAFLD and the underlying mechanisms need further *** To elucidate the effects of FLHZF on NAFLD and explore the underlying hepatoprotective mechanisms in vivo and in *** HepG2 cells were treated with free fatty acid for 24 hours to induce lipid accumulation cell ***,experiments were conducted with the different concentrations of freeze-dried powder of FLHZF for 24 hours.C57BL/6 mice were fed a high-fat diet for 8-week to establish a mouse model of NAFLD,and then treated with the different concentrations of FLHZF for 10 *** FLHZF had therapeutic potential against lipid accumulation and abnormal changes in biochemical indicators in vivo and in *** experiments verified that FLHZF alleviated abnormal lipid metabolism might by reducing oxidative stress,regulating the AMPKα/SREBP-1C signaling pathway,activating autophagy,and inhibiting hepatocyte *** FLHZF alleviates abnormal lipid metabolism in NAFLD models by regulating reactive oxygen species,autophagy,apoptosis,and lipid synthesis signaling pathways,indicating its potential for clinical application in NAFLD.

关键词： Fanlian Huazhuo Formula Nonalcoholic fatty liver disease Autophagy Apoptosis AMPKα/SREBP-1C signal pathway Oxidative stress

Constructing a nomogram to predict overall survival of colon cancer based on computed tomography characteristics and clinicopathological factors

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4104-4114页

作者： zhe-Xing Hu Yin Li Xuan Yang yu-Xia Li Yao-Yao He Xiao-Hui Niu Ting-Ting Nie Xiao-Fang Guo Zi-Long yuan Department of Radiology Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079Hubei ProvinceChina Department of Radiology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina College of Informatics Huazhong Agriculture UniversityWuhan 430070Hubei ProvinceChina

BACKGROUND The colon cancer prognosis is influenced by multiple factors,including clinical,pathological,and non-biological ***,only a few studies have focused on computed tomography(CT)imaging ***,this study aims to predict the prognosis of patients with colon cancer by combining CT imaging features with clinical and pathological characteristics,and establishes a nomogram to provide critical guidance for the individualized *** To establish and validate a nomogram to predict the overall survival(OS)of patients with colon *** A retrospective analysis was conducted on the survival data of 249 patients with colon cancer confirmed by surgical pathology between January 2017 and December *** patients were randomly divided into training and testing groups at a 1:1 *** and multivariate logistic regression analyses were performed to identify the independent risk factors associated with OS,and a nomogram model was constructed for the training *** curves were calculated using the Kaplan–Meier *** concordance index(C-index)and calibration curve were used to evaluate the nomogram model in the training and testing *** Multivariate logistic regression analysis revealed that lymph node metastasis on CT,perineural invasion,and tumor classification were independent prognostic factors.A nomogram incorporating these variables was constructed,and the C-index of the training and testing groups was 0.804 and 0.692,*** calibration curves demonstrated good consistency between the actual values and predicted probabilities of *** A nomogram combining CT imaging characteristics and clinicopathological factors exhibited good discrimination and *** can aid clinicians in risk stratification and postoperative monitoring and provide important guidance for the individualized treatment of patients with colon cancer.

关键词： Colon cancer Nomogram Prognosis Overall survival Computed tomography Clinicopathology

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不确定切除对非小细胞肺癌预后的影响

中华外科杂志 2024年第8期62卷 764-770页

作者：张难张少为韩晶王哲容宇刘俊峰河北医科大学第四医院胸外科石家庄050011 河北医科大学第四医院肿瘤内科石家庄050011 河北北方学院附属第一医院胸外科张家口075061

目的探讨非小细胞肺癌不确定切除[R(un)]对术后生存的影响。方法本研究为回顾性队列研究。回顾性分析2012年12月至2013年12月在河北医科大学第四医院胸外科接受手术治疗的477例非小细胞肺癌患者的资料。男性302例,女性175例,年龄(59±8)... 详细信息

目的探讨非小细胞肺癌不确定切除[R(un)]对术后生存的影响。方法本研究为回顾性队列研究。回顾性分析2012年12月至2013年12月在河北医科大学第四医院胸外科接受手术治疗的477例非小细胞肺癌患者的资料。男性302例,女性175例,年龄(59±8)岁(范围:27~79岁)。依据国际肺癌协会颁布的手术切除标准将患者分为完整性切除(R0)组(286例)和R(un)组(191例)。采用χ2检验比较两组间的临床资料,以性别、年龄、吸烟史、辅助治疗、TNM分期、病理学类型及肿瘤部位为协变量进行倾向性评分匹配,采用最近邻法1∶3匹配,卡钳值为0.02。通过Kaplan-Meier法绘制生存曲线,Log-rank检验进行单因素生存分析,Cox比例风险模型分析总体生存的预后因素,对TNM分期、纵隔淋巴结转移状态进行亚组分层分析。结果R(un)组中最高组淋巴结阳性68例,纵隔淋巴结未达到清扫范围129例。倾向性评分匹配后,R0组227例,R(un)组142例。匹配后R0组和R(un)组5年总体生存率分别为64.3%和52.1%(P=0.021),Ⅰ、Ⅱ、Ⅲ期患者的5年总体生存率分别为85.2%、65.9%、34.8%(P<0.01),TNM分期(χ^(2)=46.913,P<0.01)、病理学分型为腺鳞癌(HR=5.970,95%CI:3.117~11.431,P<0.01)及R(un)(HR=1.512,95%CI:1.065~2.147,P=0.021)是总体生存的预后因素。亚组分析结果显示,Ⅲ期患者中,R0组和R(un)组5年总体生存率分别为45.8%和9.5%(P=0.002);纵隔淋巴结转移患者中,R0组和R(un)组5年总体生存率分别为50.6%和7.1%(P<0.01)。结论TNM分期、病理学类型及是否为R(un)是非小细胞肺癌术后总体生存的预后因素。在Ⅰ~Ⅱ期非小细胞肺癌患者中,R(un)不影响术后总体生存;在Ⅲ期及有纵隔淋巴结转移的患者中,R(un)患者的总体生存较R0患者更差。

关键词：癌,非小细胞肺淋巴结切除术预后不确定性切除病理学分型

Beyond clinical trials:CDK4/6 inhibitor efficacy predictors and nomogram model from real‐world evidence in metastatic breast cancer

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Cancer Innovation 2024年第6期3卷 58-75页

作者： Binliang Liu zhe‐yu Hu Ning Xie Liping Liu Jing Li Xiaohong Yang Huawu Xiao Xuran Zhao Can Tian Hui Wu Jun Lu Jianxiang Gao Xuming Hu Min Cao zhengrong Shui yu Tang Quchang Ouyang Department of Breast Cancer Medical Oncology Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanChina Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Gastroenterology The Third Xiangya Hospital of Central South UniversityChangshaHunanChina

Background:CDK4/6 inhibitors(CDK4/6i)have shown promising results in the treatment of hormone receptor‐positive(HR+)metastatic breast cancer(MBC)when combined with endocrine therapy(ET).It is crucial to evaluate the actual effectiveness and safety of CDK4/6i in clinical practice,as well as to analyze the factors that can predict their ***:Patients with HR+MBC who received CDK4/6i‐based therapy between May 2016 and May 2023 at Hunan Cancer Hospital were evaluated for progression‐free survival(PFS).Adverse reactions were assessed based on the National Cancer Institute Common Toxicity Criteria(version 5.0).Results:This study included 344 patients,with a median PFS(mPFS)of 12.8 months(range:10.4–15.2 months).After adjustment,Cox multivariate regression analysis revealed that visceral metastasis(specifically liver and brain metastases),Eastern Cooperative Oncology Group Performance Status(ECOG PS)≥1,estrogen receptor≤80%,progesterone receptor≤10%,Ki‐67>30%,and treatment in later stages were significant factors associated with reduced *** on this,we created a prognostic nomogram and validated its performance,obtaining a C‐index of 0.714(95%confidence interval:0.640–0.787)as well as reliable calibration and clinical *** mPFS of CDK4/6i rechallenge was 7.7 months;for patients who initially discontinued CDK4/6i for reasons other than disease progression,CDK4/6i rechallenge still provided a mPFS of 11.4 *** tolerability and safety of combining CDK4/6is with ET were *** events led to treatment discontinuation in 3.8%of ***(29.1%),leukopenia(13.7%),and anemia(4.1%)were the primary grade 3/4 adverse ***:This real‐world study highlights the ample efficacy and reasonable safety of combined CDK4/6i and ET in patients with HR+*** treatment decisions and ongoing safety monitoring are important to optimize the therapeutic benefit of CDK4/6i treatment.

关键词： breast cancer CDK4/6 inhibitor efficacy predictive factors real‐word study