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Kinetic Resolution of 1,2-Diamines via Organocatalyzed Asymmetric Electrophilic Aminations of Anilines

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Chinese Journal of Chemistry 2022年第24期40卷 1674-1680页

作者： Jinglei Xie Zheng Guo Wei Liu Dekun Zhang yu-peng he Xiaoyu Yang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Petrochemical Catalytic Science and Technology Liaoning Shihua UniversityFushunLiaoning 113001China Universityof Chinese Academy of Sciences Bejing 100049China State Key Laboratory of Fine Chemicals Ningbo Institute of Dalian University of TechnologyNingboZhejiang 315016China

An efficient kinetic resolution(KR)protocol for 1,2-diamines has been developed through asymmetric electrophilic aminations of anilines enabled by chiral phosphoric acid catalysis.A wide array of substituted 1,2-diamines were compatible with this method,generating both the recovered staring materials and the amination products with high enantioselectivities(with s-factor up to 218).Notably,this method is amenable to the kinetic resolution of 1,2-diamines bearingα-tertiary amine moieties,which represents the first KR of this type of 1,*** removal of the introduced hydrazine group and oxidative cleavage of the N-aryl group to release the free primary amine demonstrate the value of this method.

关键词： Asymmetric catalysis 1,2-Diamines Kinetic resolution Chiral phosphoric acids Amination

Implantable versatile oxidized bacterial cellulose membrane for postoperative HNSCC treatment via photothermal-boosted immunotherapy

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Nano Research 2023年第1期16卷 951-963页

作者： Jun-Jie Zhou Xiao-Hong Li peng-yu he Fu-yu Qi Muhammad Wajid Ullah Shu-Jin Li yuan-Tong Liu Lin-Lin Bu Guang Yang Zhi-Jun Sun The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Oral Maxillofacial head Neck Oncology School&Hospital of StomatologyWuhan UniversityWuhan 430079China Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education School of Physics and Technology Wuhan UniversityWuhan 430079China Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Biofuels Institute School of the Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China

The recurrence of head and neck squamous cell carcinoma(HNSCC)after surgical resection continues to pose a major challenge to cancer *** HNSCC exhibits a low response rate to immune checkpoint blockade(ICB),while photothermal therapy(PTT)can increase the infiltration of immune cells to make tumors more susceptible to cancer *** this regard,we designed and constructed a novel multifunctional nanocomposite comprised of oxidized bacterial cellulose(OBC),thrombin(TB),and gold nanocages(AuNCs)containing anti-programmed death 1(PD-1)antibody(αPD-1@AuNCs),which allows the combination of therapies with remarkable postoperative antitumor immunity to control local tumor ***αPD-1@AuNCs displayed high light-to-heat conversion efficiency and induced pyroptosis under near infrared(NIR)irradiation,which activated a potent antitumor immune *** importantly,the therapeutic system could induce tumor pyroptosis and enhance antitumor immune response by increasing T-cell infiltration and reducing the immune suppressive cells,when combined with local ICB therapy,which effectively avoided the tumor recurrence in a HNSCC postoperative mice ***,the newly developed multifunctional nanocomposites could be a promising candidate for the treatment of postoperative HNSCC.

关键词： head and neck squamous cell carcinoma(HNSCC) oxidized bacterial cellulose pyroptosis immunotherapy postoperative treatment

BiDMAP - A Biological Data Management and Analysis Platform

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计算机工程 2002年第S1期28卷 145-153页

作者： GAO Ge, yu peng, LIU Di, he Kuan , WU Xin , LUO Jingchu (Centre of Bioinformatics, Peking University, Beijing 100871,China, luojc @ ***) Centre of Bioinformatics Peking University Beijing 100871China luojc ***

With the rapid development of biotechnology, more and more genomic and associated functional data are available. Itis necessary and possible for biologists and bioinformaticians to integrate various databases in order to mine biological ***, the complexity of huge amount of biological data and their complicated structure need an advanced management systemwhich can store and manage data efficiently, and provide subject-oriented analysis tools for further study. BiDMAP is a platform designed to meet these needs. The core of BiDMAP is based on an Object Relational Database Management System (ORDBMS) which makes it possible not only to store and manage biological data but also to implement analysis tools on a single platform. Thegoal of BiDMAP is to integrate different datasets on specific subjects into one platform and provides a unified, easy-to-learn, easy-to-use interface to access those data. Complicated data structures are viewed as objects, stored in the database and manipulated via standard SQL. BiDMAP presents an intuitive approach for biologists with little computational skills and leaves the flexibility for further development. This paper gives an overview of the design and implementation of BiDMAP and gives a simple analysis example - finding interleukin candidates with implemented analysis tool of pattern scan.

关键词： ORDBMS Biological data BiDMAP

A DDoS Attack Detection Scheme Based on Entropy and PSO-BP Neural Network in SDN

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A DDoS Attack Detection Scheme Based on Entropy and PSO-BP N...

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

2018中国信息通信大会(CICC2018)

作者： Zheng-peng Liu yu-peng he Wen-Sheng Wang Bin Zhang School of Cyberspace Security and Computer Hebei University Information Technology Center Hebei University School of Electronic Information Engineering Hebei University

SDN（Software Defined Network）has many security problems,and DDoS attack is undoubtedly the most serious harm to SDN architecture *** to accurately and effectively detect DDoS attacks has always been a difficult point and focus of SDN security *** on the characteristics of SDN,a DDoS attack detection method combining generalized entropy and PSO-BP neural network is *** traffic is pre-detected by the generalized entropy method deployed on the switch,and the detection result is divided into normal and *** the switch that issued the abnormal *** controller uses the PSO-BP neural network to detect whether a DDoS attack occurs by further extracting the flow features of the abnormal *** show that compared with other methods,the detection accurate rate is guaranteed while the CPU load of the controller is reduced,and the detection capability is better.

关键词： software-defined networking Distributed Denial of Service attacks generalized information entropy Particle swarm optimization Back propagation neural network attack detection

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao yu-Gui peng peng Wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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基于迁移学习的跨域异常流量检测

北京邮电大学学报 2021年第2期44卷 33-39页

作者：彭雨荷陈翔陈双武杨坚中国科学技术大学信息科学技术学院合肥230026

基于已知数据的机器学习模型在实际异常流量检测任务中不完全可靠,为此,将不同分布的流量分别作为源域和目标域,建立跨域网络异常流量检测框架,提出了基于联合分布适配的迁移学习方法.通过寻找最优变换矩阵、适配源域与目标域之间的条... 详细信息

基于已知数据的机器学习模型在实际异常流量检测任务中不完全可靠,为此,将不同分布的流量分别作为源域和目标域,建立跨域网络异常流量检测框架,提出了基于联合分布适配的迁移学习方法.通过寻找最优变换矩阵、适配源域与目标域之间的条件概率和边缘概率,实现源域与目标域间的特征迁移,从而解决由于源域与目标域分布差异大所引起的检测准确率下降等问题.实验结果表明,所提方法可以显著提升跨域流量的检测准确率.

关键词：异常流量检测跨域迁移联合分布适配机器学习

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Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： Lin peng yu Bai Hang Li Meixiu Qu Zhenhua Wang Kening Sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

Lithium-sulfur （Li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （LiPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： Lithium sulfur batteries

High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong peng Xinyi Huang Mingwei Zhao Shuling Liao Quanhong Yang Nianjun Yang Siyu yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Flexible supercapacitors High-temperature tolerance Gel polymer electrolytes Electrode materials

Low-cost and fluoride-free synthesis of MFI zeolite nanosheets with enhanced stability for benzene alkylation with ethanol

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Journal of Energy Chemistry 2025年第1期100卷 458-468页

作者： peng Zhu Cun Liu Yiren yu Guoshu Gao yumeng Zhao Xiongfu Zhang Guodong Liu Guohui Yang State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

Zeolite nanosheets with a short b-axis thickness are highly desirable in lots of catalytic reactions due to their reduced diffusion resistance. Nevertheless, conventional synthesis methods usually require expensive structure-directing agents(SDAs), pricey raw materials, and eco-unfriendly fluorine-containing additives. here, we contributed a cost-effective and fluoride-free synthesis method for synthesizing high-quality MFI zeolite nanosheets through a Silicalite-1(Sil-1) seed suspension and urea cooperative strategy, only with inexpensive colloidal silica as the Si source. Our approach was effective for synthesizing both Sil-1 and aluminum-containing ZSM-5 nanosheets. By optimizing key synthesis parameters,including seed aging time, seed quantity, and urea concentration, we achieved precise control over the crystal face aspect ratio and b-axis thickness. We also revealed a non-classical oriented nanosheet growth mechanism, where Sil-1 seeds induced the formation of quasi-ordered precursor particles, and the(010)crystal planes of these particles facilitated urea adsorption, thereby promoting c-axis-oriented *** obtained ZSM-5 nanosheets exhibited exceptional catalytic performance in the benzene alkylation with ethanol, maintaining stability for over 500 h, which is 5 times longer than traditional ZSM-5 catalysts. Furthermore, large-scale production of ZSM-5 nanosheets was successfully carried out in a 3 L highpressure autoclave, yielding samples consistent with those from laboratory-scale synthesis. This work marks a significant step forward in the sustainable and efficient production of MFI nanosheets using inexpensive and environmentally friendly raw materials, offering the broad applicability in catalysis.

关键词： MFI zeolite ZSM-5 Nanosheets Scale-up synthesis Aromatic alkylation