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Asian Journal of Andrology 2015年第2期17卷 253-260,I0009页

作者： yu-Fei Zhang Kai-Ming yuan Yong liang Yan-Hui Chu Qing-Quan Lian yu-Fei Ge Wei Zhen Chantal M Sottas Zhi-Jian su Ren-Shan Ge Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy Mudanjiang Medical University Mudanjiang 157011 China The 2nd Affiliated Hospital Wenzhou Medical College Wenzhou 325000 China The Affiliated Taizhou Municipal Hospital Taizhou University Taizhou 318000 China The Population Council New York 10065 USA Department of Pathology Molecular Pathology Laboratory Montefiore Medical Centre Albert Einstein College of Medicine Bronx NY 10467 USA College of Life Science and Technology Jinan University Guangzhou 510632 China

成年睾丸间质细胞（ALC）是睾丸中产生雄激素的唯一内分泌细胞，只占有睾丸细胞的1％-5％。大鼠睾丸中的睾丸间质细胞被EDs去除后能够再生。本研究中，我们主要研究了大鼠睾丸经EDS处理后睾丸间质细胞再生及基因的变化图谱。EDS处理后7... 详细信息

成年睾丸间质细胞（ALC）是睾丸中产生雄激素的唯一内分泌细胞，只占有睾丸细胞的1％-5％。大鼠睾丸中的睾丸间质细胞被EDs去除后能够再生。本研究中，我们主要研究了大鼠睾丸经EDS处理后睾丸间质细胞再生及基因的变化图谱。EDS处理后7、21、35、90天后分析血清中睾酮、睾丸基因图谱和一些类固醇生成相关的蛋白变化情况。EDS处理后第7天睾丸中睾酮水平几乎检测不到，然后开始恢复。处理后7天，81个基因下调2倍或者更多，其中48个基因检测不到，包括类固醇合成通路中的蛋白Star、Scarbl、Cypllal、Cypl7al、Hsd3bl、CyplblICyp2al。这些基因在21天开始表达增多，到90天已经完全恢复到正常水平。89个基因上调2倍或者更高，nPkib。这些上调的基因到90天恢复正常；其中Cyp2al直到35天才开始恢复，表明这个基因只在成年睾丸间质细胞中表达，不在前体细胞中表达。qPCR，Westernblot、半定量免疫组织染色检测了随机抽取的基因和蛋白确认其变化情况。

关键词： EDS 基因分析睾丸间质细胞类固醇生成

Efficient scheme for realizing a multiplex-controlled phase gate with photonic qubits in circuit quantum electrodynamics

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Frontiers of physics 2022年第5期17卷 125-135页

作者： Qi-Ping su yu Zhang liang Bin Chui-Ping Yang School of Physics Hangzhou Normal UniversityHangzhou 311121China School of Physics Nanjing UniversityNanjing 210093China Quantum Information Research Center Shangrao Normal UniversityShangrao 334001China

We propose an efficient scheme to implement a multiplex-controlled phase gate with multiple photonic qubits simultaneously controlling one target photonic qubit based on circuit quantum electrodynamics(QED).For convenience,we denote this multiqubit gate as MCP *** gate is realized by using a two-level coupler to couple multiple *** coupler here is a superconducting *** scheme is simple because the gate implementation requires only one step of *** addition,this scheme is quite general because the two logic states of each photonic qubit can be encoded with a vacuum state and an arbitrary non-vacuum state|φ>(e.g.,a Fock state,a superposition of Fock states,a cat state,or a coherent state,etc.)which is orthogonal or quasi-orthogonal to the vacuum *** scheme has some additional advantages:because only two levels of the coupler are used,i.e.,no auxiliary levels are utilized,decoherence from higher energy levels of the coupler is avoided;the gate operation time does not depend on the number of qubits;and the gate is implemented deterministically because no measurement is *** an example,we numerically analyze the circuit-QED based experimental feasibility of implementing a three-qubit MCP gate with photonic qubits each encoded via a vacuum state and a cat *** scheme can be applied to accomplish the same task in a wide range of physical system,which consists of multiple microwave or optical cavities coupled to a two-level coupler such as a natural or artificial atom.

关键词： multiplex controlled phase gate circuit QED

Extracellular vesicles in anti-tumor drug resistance: Mechanisms and therapeutic prospects

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Journal of Pharmaceutical Analysis 2024年第7期14卷 940-954页

作者： Hao-Yang Cheng Guang-liang su yu-Xuan Wu Gang Chen Zi-Li yu State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhan430079China Department of Oral and Maxillofacial surgery School and Hospital of StomatologyWuhan UniversityWuhan430079China TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhan430071China Frontier Science Center for Immunology and Metabolism Wuhan UniversityWuhan430071China

Drug resistance presents a significant challenge to achieving positive clinical outcomes in anti-tumor *** research has illuminated reasons behind drug resistance,including increased drug efflux,alterations in drug targets,and abnormal activation of oncogenic ***,there's a need for deeper investigation into the impact of drug-resistant cells on parental tumor cells and intricate crosstalk between tumor cells and the malignant tumor microenvironment(TME).Recent studies on extracellular vesicles(EVs)have provided valuable *** are membrane-bound particles secreted by all cells,mediating cell-to-cell *** contain functional cargoes like DNA,RNA,lipids,proteins,and metabolites from mother cells,delivered to other ***,EVs are increasingly recognized as regulators in the resistance to anti-cancer *** review aims to summarize the mechanisms of EV-mediated anti-tumor drug resistance,covering therapeutic approaches like chemo-therapy,targeted therapy,immunotherapy and even *** Ev-based biomarkers to predict drug resistance assists in bypassing anti-tumor drug ***,targeted inhibition of EV biogenesis and secretion emerges as a promising approach to counter drug *** highlight the importance of conducting in-depth mechanistic research on EVs,their cargoes,and functional ap-proaches specifically focusing on EV *** efforts will significantly advance the devel-opment of strategies to overcome drug resistance in anti-tumor therapy.

关键词： Extracellular vesicle Anti-Tumor therapy Drug resistance Mechanisms Prospects

Three-dimensional porous electrodes for direct formate fuel cells

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Science China(Technological Sciences) 2021年第4期64卷 705-718页

作者： su Xiangyu PAN ZheFei AN liang Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SAR 999077China

The dual-layer electrode for fuel cells is typically prepared by binding discrete catalyst nanoparticles onto a diffusion *** a random packing forms a dense catalyst layer and thus creates a barrier for mass/ion transport,particularly for direct liquid fuel ***-dimensional porous electrodes,a thin nano-porous catalyst layer uniformly distributed on the matrix surface of a foam-like structure,are typically employed to improve the mass/ion *** a three-dimensional porous structure brings two critical advantages:(i)reduced mass/ion transport resistance for the delivery of the reactants via shortening the transport distance and(ii)enlarged electrochemical surface area,via reducing the dead pores,isolated particles and severe aggregations,for interfacial ***,the three-dimensional design is capable of fabricating binder-free electrodes,thereby eliminating the use of ionomers/binders and simplifying the fabrication *** this work,three types of three-dimensional porous electrode are fabricated,via different preparation methods,for direct formate fuel cells:(i)Pd/C nanoparticles coating on the nickel foam matrix surface(Pd-C/NF)via a dip-coating method,(ii)Pd nanoparticles depositing on the nickel foam matrix surface(Pd/NF)via reduction reaction deposition,and(iii)Pd nanoparticles embedding in the nickel foam matrix(Pd/(in)NF)via replacement reaction *** latter two are binder-free three-dimensional porous *** a comparison,a conventional dual-layer design,Pd/C nanoparticles painting on the nickel foam layer(Pd-C//NF),is also prepared via direct painting *** is shown that the use of the three-dimensional Pd-C/NF electrode as the anode in a direct formate fuel cell results in a peak power density of 45.0 mW cm^(-2)at 60℃,which is two times of that achieved by using a conventional dual-layer design(19.5 mW cm^(-2)).This performance improvement is mainly attributed to the unique three-dimensional structure

关键词： direct formate fuel cells dual-layer structure three-dimensional porous structure binder-free mass/ion transport electrochemical surface area

Deep eutectic solvents for separation and purification applications in critical metal metallurgy:Recent advances and perspectives

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 1-19页

作者： Shuo Chen Shengpeng su Yanfang Huang Bingbing Liu Hu sun Shuzhen Yang Guihong Han School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Henan ProvinceZhengzhou 450001China

Solvent extraction,a separation and purification technology,is crucial in critical metal *** solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental *** solvents have been recognized as potential alternatives to these harmful organic *** the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low *** this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically ***,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively ***,future opportunities and challenges of DESs were explored in the current research *** conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.

关键词： deep eutectic solvents preparations properties separation and purification critical metal metallurgy

Radical reduction of Passerini 3CR adducts by SmI_2/HMPA

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Chinese Chemical Letters 2011年第4期22卷 379-381页

作者： Hui yu Tao Gai Wen liang sun Mei su Zhang Department of Chemistry Tongji UniversityShanghai 200092China

The Passerini 3-CR adducts of substituted cinnamaldehydes,isocyanides and acetic acid were treated with SmI2/HMPA in dry tetrahydrofuran（THF） at room temperature,andβ,γ-unsaturated amides were obtained in moderate... 详细信息

关键词： Passerini Isocyanide Modification Amides Samarium diiodide

Preparation of maximally-entangled states with multiple cat-state qutrits in circuit QED

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Frontiers of physics 2024年第3期19卷 239-251页

作者： Chui-Ping Yang Jia-Heng Ni liang Bin yu Zhang Yang yu Qi-Ping su Department of Physics Hangzhou Normal UniversityHangzhou 311121China School of Physics Nanjing UniversityNanjing 210093China Institute for Quantum Science and Technology University of CalgaryAlberta T2N 1N4Canada

In recent years,cat-state encoding and high-dimensional entanglement have attracted much ***,previous works are limited to generation of entangled states of cat-state qubits(two-dimensional entanglement with cat-state encoding),while how to prepare entangled states of cat-state qutrits or qudits(high-dimensional entanglement with cat-state encoding)has not been *** here propose to generate a maximally-entangled state of multiple cat-state qutrits(three-dimensional entanglement by cat-state encoding)in circuit *** entangled state is prepared with multiple microwave cavities coupled to a superconducting flux ququart(a four-level quantum system).This proposal operates essentially by the cavity-qutrit dispersive *** circuit hardware resource is minimized because only a coupler ququart is *** higher intermediate level of the ququart is occupied only for a short time,thereby decoherence from this level is greatly suppressed during the state ***,the state preparation time does not depend on the number of the qutrits,thus it does not increase with the number of the *** an example,our numerical simulations demonstrate that,with the present circuit QED technology,the high-fidelity preparation is feasible for a maximally-entangled state of two cat-state ***,we numerically analyze the effect of the inter-cavity crosstalk on the scalability of this *** proposal is universal and can be extended to accomplish the same task with multiple microwave or optical cavities coupled to a natural or artificial four-level atom.

关键词： maximally-entangled states cat state qutrit circuit QED

Effects of cooling rate on the microstructure and properties of magnesium alloy-a review

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Journal of Magnesium and Alloys 2024年第8期12卷 3094-3114页

作者： Huisheng Cai Nannan Zhang liang Liu Juan su yuguang Li yu Kang Feng Guo Inner Mongolia Key Laboratory of Thin Film and Coatings School of Material Science and EngineeringInner Mongolia University of TechnologyHohhot 010051China School of Sino-German Engineering Shanghai Technical Institute of Electronics and InformationShanghai 201411China

Magnesium alloy is one of the most widely used lightweight structural materials,and the development of high strength-toughness magnesium alloy is an important research field at present and even in the *** preparation process parameters of magnesium alloy directly affect the microstructure of the magnesium alloy,and then determine the properties of the magnesium *** cooling rate has important effects on the microstructure and properties of the magnesium alloy,and is an important preparation process parameter that cannot be *** the cooling rate from liquid phase to solid phase and the cooling rate of the magnesium alloy after heat treatment will change the microstructure of the magnesium ***,the properties of magnesium alloy will be *** this paper,the effects of cooling rate on the solidification behavior,the rheological behavior,the change of microstructure(the solid solution of alloying elements in matrix,the composition,size,distribution and morphology of second phase,the diffusion and segregation of alloying elements,the grain size,the formation and morphology of dendrite,etc.),and the effects of cooling rate of magnesium alloy after heat treatment on the microstructure and stress distribution are *** reasons for the divergence about the influence of cooling rate on the microstructure of magnesium alloy are analyzed in *** effects of cooling rate on the mechanical properties,corrosion resistance and oxidation resistance of magnesium alloy are also analyzed and discussed ***,the new methods and approaches to study the effects of cooling rate on the microstructure and properties of magnesium alloy are prospected.

关键词： Magnesium alloy Cooling rate Microstructure Mechanical properties Corrosion resistance Oxidation resistance

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei Li Jian-Hong Shi Tan Li Wan-su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

Growth Mechanism and Characterization of Single-crystalline Ga-doped SnO2 Nanowires and Self-organized SnO2/Ga2O3 Heterogeneous Microcomb Structures

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Chinese Journal of Chemical Physics 2008年第2期21卷 181-186页

作者： Yong su liang Xu Xue-mei liang Yi-qing Chen School of Materials Science and Engineering Hefei University of Technology Hefei 230009 China Hefei General Machinery Research Institute Hefei 230031 China

Single-crystalline Ga-doped SnO2 nanowires and SnO2：Ga2O3 heterogeneous microcombs were synthesized by a simple one-step thermal evaporation and condensation method. They were characterized by means of X-ray powder diffraction （XRD）, field-emission scanning electron microscopy （FE-SEM）, energy-dispersive X-ray spectroscopy （EDS）, transmission electron microscopy （TEM） and selected-area electron diffraction （SAED）. FE-SEM images showed that the products consisted of nanowires and mierocombs that represent a novel morphology. XRD, SAED and EDS indicated that they were single-crystalline tetragonal SnO2. The influence of experimental conditions on the morphologies of the products is discussed. The morphology of the product showed a ribbon-like stem and nanoribbon array aligned evenly along one or both side of the nanoribbon. It was found that many Ga2O3 nanoparticles deposited on the surface of the microcombs. The major core nanoribbon grew mainly along the [110] direction and the self-organized branching nanoribbons grew epitaxially along [110] or [110] orientation from the （110） plane of the stem. A growth process was proposed for interpreting the growth of these remarkable SnO2：Ga2O3 heterogeneous microcombs. Due to the heavy doping of Ga, the emission peak in photoluminescence spectra has red-shifted as well as broadened significantly.

关键词： Microcomb Nanoribbon Photoluminescence