Extracellular vesicles in anti-tumor drug resistance: Mechanisms and therapeutic prospects
作者机构：State Key Laboratory of Oral&Maxillofacial Reconstruction and RegenerationKey Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhan430079China Department of Oral and Maxillofacial SurgerySchool and Hospital of StomatologyWuhan UniversityWuhan430079China TaiKang Center for Life and Medical SciencesWuhan UniversityWuhan430071China Frontier Science Center for Immunology and MetabolismWuhan UniversityWuhan430071China
出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)
年 卷 期：2024年第14卷第7期
页 面：940-954页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100214[医学-肿瘤学] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by the National Natural Science Foundation of China(Grant No.:82341023) the Interdisciplinary Research Project of School of Stomatology,Wuhan University,China(Grant No.:XNJC202305) the Innovative Research Team of Highlevel Local Universities in Shanghai,China(Grant No.:SHSMUZLCX20212300) Planning Project of Innovation and Entrepreneurship Training of National Undergraduate of Wuhan University,China(Grant No.:202310486122)
主 题：Extracellular vesicle Anti-Tumor therapy Drug resistance Mechanisms Prospects
摘 要：Drug resistance presents a significant challenge to achieving positive clinical outcomes in anti-tumor *** research has illuminated reasons behind drug resistance,including increased drug efflux,alterations in drug targets,and abnormal activation of oncogenic ***,there s a need for deeper investigation into the impact of drug-resistant cells on parental tumor cells and intricate crosstalk between tumor cells and the malignant tumor microenvironment(TME).Recent studies on extracellular vesicles(EVs)have provided valuable *** are membrane-bound particles secreted by all cells,mediating cell-to-cell *** contain functional cargoes like DNA,RNA,lipids,proteins,and metabolites from mother cells,delivered to other ***,EVs are increasingly recognized as regulators in the resistance to anti-cancer *** review aims to summarize the mechanisms of EV-mediated anti-tumor drug resistance,covering therapeutic approaches like chemo-therapy,targeted therapy,immunotherapy and even *** Ev-based biomarkers to predict drug resistance assists in bypassing anti-tumor drug ***,targeted inhibition of EV biogenesis and secretion emerges as a promising approach to counter drug *** highlight the importance of conducting in-depth mechanistic research on EVs,their cargoes,and functional ap-proaches specifically focusing on EV *** efforts will significantly advance the devel-opment of strategies to overcome drug resistance in anti-tumor therapy.
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