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Advances in neuroimaging studies of alcohol use disorder(AUD)

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Psychoradiology 2022年第4期2卷 146-155页

作者： Ji-yu Xie Rui-Hua Li Wei yuan Jiang Du Dong-Sheng Zhou yu-qi cheng Xue-Ming Xu Heng Liu Ti-Fei yuan School of Mental Health Wenzhou Medical UniversityWenzho 325000ZhejianguChina Shandong Mental Health Center Shandong UniversityJinan 250014ShandongChina Shanghai Mental Health Center Shanghai Jiaotong University School of MedicineShanghai 200030China Department of Psychiatry Ningbo Kangning HospitalNingbo 315000ZhejiangChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunming 650000YunnanChina Department of Psychiatry Taizhou Second People’s HospitalTaizhou 318000ZhejiangChina Department of Radiology the Affiliated Hospital of Zunyi Medical UniversityMedical Imaging Center of Guizhou ProvinceZunyi 563000GuizhouChina

Alcohol use disorder(AUD)is a worldwide problem and themost common substance use *** alcohol consumptionmay have negative effects on the body,the mind,the family,and even *** the progress of current neuroimaging methods,an increasing number of imaging techniques are being used to objectively detect brain impairment induced by alcoholism and serve a vital role in the diagnosis,prognosis,and treatment assessment of *** article organizes and analyzes the research on alcohol dependence concerning the main noninvasive neuroimaging methods,structural magnetic resonance imaging,functional magnetic resonance imaging,and electroencephalography,as well as the most common noninvasive brain stimulation-transcranial magnetic stimulation,and intersperses the article with joint intra-and intergroup studies,providing an outlook on future research directions.

关键词： alcohol use disorder structural magnetic resonance imaging functionalmagnetic resonance imaging electroencephalography transcranial magnetic stimulation prefrontal cortex

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基于DSP的快速控制原型系统

东北大学学报（自然科学版） 2009年第8期30卷 1069-1073页

作者：方正张淇淳齐玉成东北大学流程工业综合自动化教育部重点实验室辽宁沈阳110004

为了在实际控制系统开发中缩短控制算法的设计周期,提高控制器的可靠性,并简化在调试过程中对控制算法的修改,设计与开发了基于DSP的快速原型控制系统.该系统包括基于TI F2812DSP的硬件控制器和基于MATLAB/Simulink的软件开发环境.用户... 详细信息

为了在实际控制系统开发中缩短控制算法的设计周期,提高控制器的可靠性,并简化在调试过程中对控制算法的修改,设计与开发了基于DSP的快速原型控制系统.该系统包括基于TI F2812DSP的硬件控制器和基于MATLAB/Simulink的软件开发环境.用户可以在Simulink环境中利用RTW功能直接从Simulink模型自动生成可执行代码,并下载到DSP控制器中进行实时控制,从而降低了开发人员繁重的编程任务,提高了控制系统开发的效率.通过带有神经网络补偿和前馈补偿的智能PD控制器的实时控制实验,验证了系统的有效性.

关键词：快速控制原型 TIDSP Simulink 自动代码生成 PD控制器

Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis

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World Journal of Gastroenterology 2024年第10期30卷 1405-1419页

作者： Ye Tian Xin Li Xu Wang Si-Ting Pei Hong-Xin Pan yu-qi cheng Yi-Chen Li Wen-Ting Cao Jin-Dong Ding Petersen Ping Zhang International School of Public Health and One Health Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Medical Laboratory Science and Technology College Harbin Medical University-Daqing CampusDaqing 163000Heilongjiang ProvinceChina Department of Laboratory Diagnosis Qiqihar Tuberculosis Control CenterQiqihar 161000Heilongjiang ProvinceChina Department of Public Health University of CopenhagenCopenhagen 1353Denmark Department of Public Health University of Southern DenmarkOdense 5000Denmark

BACKGROUND Ulcerative colitis is a chronic inflammatory disease of the colon with an unknown *** sphingomyelinase(alk-SMase)is specifically expressed by intestinal epithelial cells,and has been reported to play an anti-inflammatory ***,the underlying mechanism is still *** To explore the mechanism of alk-SMase anti-inflammatory effects on intestinal barrier function and oxidative stress in dextran sulfate sodium(DSS)-induced *** Mice were administered 3%DSS drinking water,and disease activity index was determined to evaluate the status of *** permeability was evaluated by gavage administration of fluorescein isothiocyanate dextran,and bacterial translocation was evaluated by measuring serum *** epithelial cell ultrastructure was observed by electron *** blotting and quantitative real-time reverse transcription-polymerase chain reaction were used to detect the expression of intestinal barrier proteins and mRNA,*** oxidant and antioxidant marker levels were analyzed using commercial kits to assess oxidative stress *** Compared to wild-type(WT)mice,inflammation and intestinal permeability in alk-SMase knockout(KO)mice were more severe beginning 4 d after DSS *** mRNA and protein levels of intestinal barrier proteins,including zonula occludens-1,occludin,claudin-3,claudin-5,claudin-8,mucin 2,and secretory immunoglobulin A,were significantly reduced on 4 d after DSS *** observations revealed progressive damage to the tight junctions of intestinal epithelial ***,by day 4,mitochondria appeared swollen and ***,compared to WT mice,serum malondialdehyde levels in KO mice were higher,and the antioxidant capacity was significantly *** expression of the transcription factor nuclear factor erythroid 2-related factor 2(Nrf2)in the colonic mucosal tissue of KO mice was significantly decr

关键词： Alkaline sphingomyelinase Intestinal mucosal barrier Antioxidant capacity Dextran sulfate sodium-induced colitis nuclear factor erythroid 2-related factor 2

Epoxidation of styrene catalyzed by manganese (Ⅲ) porphyrins supported on chloromethylated polystyrene resin bearing crown ether groups

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Chinese Journal of Chemistry 1996年第4期14卷 303-309页

作者： YOU, Jing-Song XIAO, You-Fa yu, Xiao-qi cheng, Ai-Xia LAN, Zhong-WeiDepartment of Chemistry, Sichuan University, chengdu, Sichuan 610064, China

Metalloporphyrins and crown ether groups were simultaneously supported on chloromethylated polystyrene resin to produce a series of polymer-supported catalysts. The synthesis of these catalysts has been studied. The influence of pH, concentrations of NaOCl and phase transfer catalysts on the epoxidation of styrene catalyzed by these catalysts has also been investigated. The experimental results show that manganese(Ⅲ) porphyrin bound to chloromethylated polystyrene which bears crown ether groups is effective catalysts for the epoxidation of styrene by sodium hypochlorite. The introduction of crown ether groups increases the catalytic efficiency of supported metalloporphyrins. The kinetics of epoxidation catalyzed by supported manganese(Ⅲ) porphyrins obeys Michaelis-Menten equation-the characteristic of enzyme-driven reaction.

关键词： Epoxidation crown ether manganese(Ⅲ) porphyrin styrene

Network analysis of adolescent non-suicidal self-injury subgroups identified through latent profile analysis

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World Journal of Psychiatry 2024年第12期14卷 1936-1946页

作者： Wei Yang Kun Lian yu-qi cheng Xiu-Feng Xu Xin-Cen Duan Xu You Department of Psychiatry The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Department of Neurosurgery The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina Department of Psychiatry Zhongshan Hospital Affiliated to Fudan UniversityShanghai 201100China Department of Psychiatry Honghe Second People's HospitalHonghe 651400Yunnan ProvinceChina

BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents and frequently cooccurs with *** the distinct patterns of NSSI behaviors,along with their associated risk and protective factors,is crucial for developing effective *** To classify NSSI behaviors and examine interactions between risk and resilience factors in Chinese *** A cross-sectional study involving 3967 Chinese students(51.7%female,mean age 13.58±2.24 years)who completed questionnaires on parenting styles,bullying,childhood maltreatment,depression,resilience,and *** profile analysis(LPA)was used to identify NSSI subtypes,and network analysis explored interactions between risk and resilience *** Three NSSI subtypes were identified:NSSI with depression(18.8%),NSSI without depression(12.3%),and neither(68.9%).Bullying was the central risk factor across subtypes,while emotional control and family support were key protective *** analyses showed significant differences between groups(P<0.001).CONCLUSION This study identified three NSSI subtypes among Chinese *** emerged as a central risk factor,while emotional control and family support were key protective *** these areas may help reduce NSSI behaviors in this population.

关键词： Non-suicidal self-injury Adolescent Network analysis Latent profile analysis Resilience

Preparation and Characterization ofPerhydroxycucurbit[6]uril-Bonded Silica Stationary Phasefor Hydrophilic-Interaction Chromatography

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Preparation and Characterization ofPerhydroxycucurbit[6]uril...

Cucurbit[7]uril: A Novel Additive for theSeparation of several Nitrobenzenes byCapillary Electrophoresis

中国化学会全国第十二届大环第四届超分子化学学术讨论会

作者： Liu Si-Min Xu Li Feng yu-qi Wu cheng-Tai (Department of Chemistry Wuhan University Wuhan 430072)

＜正＞ For the first time, perhydroxylcucurbit[6]uril was grafted to silica gel as a hydrophilic-interaction chromatographic stationary phase. The retention mechanism of alkaloids on the stationary phase was discussed. The results indicate that the stationary phase behaves as a hydrophilic-interaction chromatographic packing. And several alkaloids were separated on the stationary phase.

关键词： Hydrophilic-interaction Perhydroxylcucurbituril Alkaloids

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Cucurbit[7]uril: A Novel Additive for theSeparation of sever...

Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

中国化学会全国第十二届大环第四届超分子化学学术讨论会

作者： Liu Si-min Wei Fang Feng yu-qi Wu cheng-tai (Department of Chemistry Wuhan University Wuhan 430072)

＜正＞ The use of a novel macrocyclic molecule, cucurbit[7]uril （CB[7]）, as an additive in capillary electrophoresis （CE） for the separation of several neutral nitrobenzenes was reported. The results showed that CB[7] exhibited good selectivity for the nitrobenzenes and their successful separation was obtained under optimum condition.

关键词： Cucurbituril Nitrobenzenes Capillary electrophoresis

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World Journal of Clinical Cases 2025年第4期13卷 18-27页

作者： cheng-cheng Wei yu-qing Huang cheng-Hong yu Department of Cardiology Tongxiang First People's HospitalTongxiang 314500Zhejiang ProvinceChina Department of Cardiology Guangdong Cardiovascular InstituteGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained *** To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive *** Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of *** changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal *** examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%*** The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the *** the course of a mean follow-up of 4.8 years,143 ischemic strokes *** normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et *** changed and ischemic stroke WJCC https://*** 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),*** In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.

关键词： Longitudinal change Hypertension Dyslipidemia Lipid profile Ischemic stroke

平稳随机激励下耦合Newmark滑移系统的可靠性分析

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计算力学学报 2014年第5期31卷 578-583页

作者：邓学晶林倩亓玉成邹德高中国石油大学(华东)工程力学系青岛266555 大连理工大学土木水利学院大连116024

基于随机激励的离散形式,对耦合Newmark系统的动力可靠度问题进行解析分析。平稳随机激励下,耦合Newmark系统初始滑移极限状态方程可以写成n个标准正态随机变量的显式线性函数,并能给出可靠度指标的理论解。对于以相对滑移量为临界状态... 详细信息

基于随机激励的离散形式,对耦合Newmark系统的动力可靠度问题进行解析分析。平稳随机激励下,耦合Newmark系统初始滑移极限状态方程可以写成n个标准正态随机变量的显式线性函数,并能给出可靠度指标的理论解。对于以相对滑移量为临界状态的情况,极限状态方程是n个标准正态随机变量的隐式函数,可借助静力可靠度方法进行求解。算例表明,系统初始滑移的设计点激励是以潜在滑动体自振频率为主频,振幅渐增的谐振时程;后者的失效概率与摩擦系数成非线性关系,存在合适的摩擦系数使失效概率最小。

关键词：动力可靠度地震永久位移滑动位移随机振动