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CsOH catalyzed aerobic oxidative synthesis of p-quinols from multi-alkyl phenols under mild conditions

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Science China Chemistry 2015年第8期58卷 1334-1339页

作者： yu-feng liang Kai Wu Zhiqing Liu Xiaoyang Wang yujie liang Chenjiang Liu Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University The Key Laboratory of Oil and Gas Fine Chemicals Ministry of Education & Xinjiang Uygur Autonomous Region Xinjiang University

p-Quinols are ubiquitous structural motifs of various natural products and pharmaceutical compounds,and versatile building blocks in synthetic *** reported methods for the synthesis of p-quinol require stoichiometric amounts of *** oxygen is considered as an ideal oxidant due to its natural,inexpensive,and environmentally friendly *** the ongoing research of C–H bond hydroxylation,we found that multi-alkyl phenols could react with molecular oxygen under mild ***,we describe an efficient oxidative de-aromatization of multi-alkyl phenols to p-quinols.1 atm of molecular oxygen was used as the *** multi-alkyl phenols could react smoothly at room *** labeling experiment was also performed,and the result proved that the oxygen atom in the produced hydroxyl group is from molecular oxygen.

关键词： p-quinol molecular oxygen de-aromatization carbanion cesium hydroxide

Micro-acting Force in Boundary Layer in Low-Permeability Porous Media

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Chinese Physics Letters 2011年第2期28卷 148-151页

作者： feng yu-liang ZHANG yuan JI Bing-yu MU Wen-Zhi Automation Department Nanjing University of Science and TechnologyNanjing 210094 Earth Science Institute Northeast Petroleum UniversityDaqing 163318 Daqing Oilfield Exploration and Development Institute Daqing 163712 SINOPEC Exploration and Production Research Institute Beijing 100083

There are lots of reasons to restrict a low-permeability oil layer to enhance the recovery *** on the research results of non-Darcy flow,microfiow of water drive and micro-acting force in low permeability porous media are studied by establishing the expression of fluid viscosity *** calculation shows that under the condition of L/S interaction,the radial velocity distribution near the solid wall changes obviously,and the curve form changes from convex to *** tinier the capillary radius is,the stronger the L/S interaction *** larger the n value is,more obviously the flowing velocity *** results will help people to deal with improving recovery factor of low permeability reservoir,and understanding the fluid How behavior in blood capillary.

关键词： capillary radius establishing

Metal-Free 12-Catalyzed Highly Selective Dehydrogenative Coupling of Alcohols and Cyclohexenones

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Chinese Journal of Chemistry 2018年第3期36卷 233-240页

作者： yu-feng liang Yizhi yuan Tao Shen Song Song Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Rd. 38 Beijing 100191 China State Key Laboratory of Elemento-Organic Chemistry Nankai University Weijin Road 94 Tianjin 300071 China

The l2 catalyzed highly selective oxidatve condensation of cydohexenones and alcohols for the synthesis of aryl atkyl ethers has been described. DMSO is employed as the mild terminal oxidant. This novel methodology offers a metal-free reaction condition, operational simplicity and broad substrate scope to afford valuable products from inexpensive reagents. Various meta-substituted aromatic ethers which are hardly synthesized from the reported methods requiring meta-substituted phenols, are efficiently prepared by the present protocol.

关键词： metal-free dehydrogenative coupling oxidation selectivity alcohols

Synthesis of a dendritic estrogen cluster:A potential tool for studies of nuclear versus extranuclear pathways of estrogen actions

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Chinese Chemical Letters 2012年第12期23卷 1319-1322页

作者： Jian Chen Hu Zheng Yan Song yu feng liang Qing Rong Qi Functional Food(Drug) Laboratory Institute of Agro-Product Processing Science and TechnologySichuan Academy of Agricultural Science Key Laboratory of Drug-Targeting and Drug-Delivery Systems of the Ministry of Education Department of Medicinal ChemistryWest China School of PharmacySichuan University

A novel estrogen dendrimer has been synthesized through a combination of divergent and convergent approaches in 9 practical steps and in good yields. It was characterized and confirmed by elemental analysis, FT-IR, MS, 1H NMR, 13C NMR. The dendrimer contains 16 estrone units and is potentially a useful tool for the studies of estrogen actions.

关键词： Estrogen dendrimer Synthesis Nuclear and extranuclear Receptor

Different approaches for treating myopic choroidal neovascularization:a network Meta-analysis

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2105-2116页

作者： Ya-Jun Wu yu-liang feng Jia-Song Yang Hua Fan Wen-Sheng Li Aier School of Ophthalmology Central South UniversityChangsha 410000Hunan ProvinceChina Department of Ophthalmology Shanghai Aier Eye HospitalShanghai 200235China Shanghai Aier Eye Institute Shanghai 200235China

AIM:To evaluate the efficacy of intravitreal injection of anti-vascular endothelial growth factor(anti-VEGF),photodynamic therapy(PDT),and laser treatment(LT)for anatomical and functional improvement in myopic choroidal neovascularization(mCNV)***:Two researchers independently searched PubMed,Cochrane Library,Web of Science,and other databases to screen studies comparing best-corrected vision acuity(BCVA)and foveal center thickness(FCT)changes after mCNV ***-treatment chorioretinal atrophy(CRA)is a secondary outcome *** retrieval time limit is from the database construction to January 30,***:A total of 1072 eyes in 16 articles were *** the RCTs,intravitreal bevacizumab(IVB)and intravitreal ranibizumab(IVR)were superior to PDT(MD=0.18,95%CI:0.02,0.40,MD=0.18,95%CI:0.01,0.42)in improving BCVA of mCNV patients(P<0.05).The relative effectiveness in improving BCVA,from high to low,appeared to be IVR,intravitreal aflibercept(IVA),IVB,LT,PDT,and sham first followed by IVA(Sham/IVA).While improving the FCT from high to low was IVA,IVR,IVB,*** retrospective studies,the results of BCVA after long-term treatment showed that all the therapeutic effects from high to low was IVA,intravitreal conbercept(IVC),IVR,IVB,IVB/IVR,PDT with IVB/IVR,*** effect of improving FCT was IVA,IVR,IVC,PDT,and IVB from high to *** in the effects of improving CRA,the IVB appeared to be higher than IVR,while the PDT was the smallest,but none of the differences in the results were statistically ***:Anti-VEGF has the best effect on longterm vision improvement in mCNV patients,using IVB or IVR alone to treat mCNV may be better than IVB or IVR combined with *** is no significant difference in the improvement of visual acuity,macular edema,and CRA in mCNV patients treated with any different anti-VEGF drugs.

关键词： myopic choroidal neovascularization aflibercept bevacizumab conbercept laser treatment ranibizumab photodynamic therapy

Bioinformatic Analysis of BBTV Satellite DNA in Hainan

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Virologica Sinica 2011年第4期26卷 279-284页

作者： Nai-tong yu Tuan-cheng feng yu-liang Zhang Jian-hua Wang Zhi-xin Liu Institute of Tropical Bioscience and Biotechnology CA TAS Haikou 571101 China

Banana bunchy top virus (BBTV),family Nanaviridae,genus Babuvirus,is a single stranded DNA virus (ssDNA) that causes banana bunchy top disease (BBTD) in banana *** is the most common and most destructive of all viruses in these plants and is widespread throughout the Asia-Pacific *** this study we isolated,cloned and sequenced a BBTV sample from Hainan Island,*** results from sequencing and bioinformatics analysis indicate this isolate represents a satellite DNA component with 12 DNA sequences *** also predicted the physical and chemical properties,structure,signal peptide,phosphorylation,secondary structure,tertiary structure and functional domains of its encoding protein,and compare them with the corresponding quantities in the replication initiation protein of BBTV DNA1.

关键词： Banana bunchy top virus Satellite Prediction

Organocatalytic enantioselective construction of bicyclic γ-butrolactones

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Chinese Chemical Letters 2023年第7期34卷 122-126页

作者： Qiang Zhang Jingxiang Pang Tian-Zhang Wang feng Chen Minghao Shen Tianyu Li Yongshuai Chai yu-feng liang Jie Sun Zhushuang Bai School of Pharmacy and Pharmaceutical Science&Institute of Materia Medica Shandong First Medical University&Shandong Academy of Medical SciencesNHC Key Laboratory of biotechnology drug(Shandong Academy of Medical Sciences)Key Lab for Rare&Uncommon Diseases of Shandong ProvinceJi'nan 250117China School of Chemistry and Chemical Engineering Shandong UniversityJi'nan 250100China

An enantioselective organo-catalyzed reaction of furanones with α,β-unsaturated ketones has been established herein, which provides an efficient access to chiral bicyclic γ-butyrolactones in good yields, enantioselectivities and diastereoselectivities. Further transformations of product are demonstrated. A diamine mediated catalytic cycle is proposed.

关键词： Organocatalyst Asymmetric synthesis Bicyclicγ-butyrolactone Diamine Cyclization

Nickel-catalyzed reductive formylation of aryl halides via formyl radical

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Chinese Chemical Letters 2024年第12期35卷 476-481页

作者： Xiao-Bo Liu Ren-Ming Liu Xiao-Di Bao Hua-Jian Xu Qi Zhang yu-feng liang School of Food and Biological Engineering School of Chemistry and Chemical EngineeringAnhui Province Key Laboratory of Advance Catalytic Materials and Reaction EngineeringHefei University of Technology School of Chemistry and Chemical Engineering Shandong University Institute of Industry&Equipment Technology Hefei University of Technology

Aromatic aldehydes are the most fundamentally important compounds used in organic *** development of new synthetic methods for introduction of a formyl group into an organic scaffold is highly *** this report,a nickel-catalyzed reductive coupling between aryl halides and α–chloro N-methoxyphthalimide has been documented for the synthesis of a diverse array of aromatic *** of mild reductive coupling conditions,excellent functional group tolerance,especially for substrates containing free-OH and-NH2,was *** to the simple operation mode,a large library of aromatic aldehydes can be quickly constructed by this ***,the present protocol is amenable for late-stage functionalization of bioactive compound.A combined computational and experimental investigation suggested the reaction may undergo a reaction mechanism of active Ni（I） catalyst formation and the formation of key formyl radical intermediate under zinc reductive conditions.

关键词： Nickel Formylation Radical SET Reductive coupling

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干细胞再生和修复心肌的现状与挑战

生理科学进展 2015年第2期46卷 87-93页

作者：冯宇亮余细勇广东省心血管病研究所广东省人民医院广东省医学科学院华南理工大学医学院广州510080

心肌梗死的发病率日益增加,但目前标准疗法的效果不尽如人意。因此,人们不断探索新的治疗手段。近年来,干细胞被认为是再生和修复心肌的重要来源之一,已有多种类型的干细胞被证明具有向心肌分化的能力。目前,全球范围内已有数千名心梗... 详细信息

心肌梗死的发病率日益增加,但目前标准疗法的效果不尽如人意。因此,人们不断探索新的治疗手段。近年来,干细胞被认为是再生和修复心肌的重要来源之一,已有多种类型的干细胞被证明具有向心肌分化的能力。目前,全球范围内已有数千名心梗患者接受自体干细胞治疗,但结果喜忧参半。本文将就当前干细胞在心肌再生和修复的研究进展进行综述并提出尚待解决的重要问题。

关键词：干细胞心肌梗死再生修复