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An efficient and facile procedure for synthesis of octyl polyglucoside

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Chinese Chemical Letters 2007年第10期18卷 1173-1175页

作者： Ying Wu Jiu Gao yu xiao fei Ma Jian She Zhang Department of Chemistry School of Science Tianjin University Tianjin 300072 China

Nonionic surfactant alkyl polyglucoside （APG） was prepared by direct glycosidation of alkyl alcohol with glucose in the presence of sulfate acid-silica gel （H2SO4/SiO2） as solid acidic catalyst. The quantity of catalyst was only of 1 wt%, based on the glucose, and the conversion of glucose was close to 100% at 110 ℃ in 1.5 h. The product was characterized by FT-IR, mass and ^1H NMR spectra. The degree of polymerization （DP） of the glucose in the product was 1.37, and critical micelle concentration （CMC） of product was only 0.0104 wt%.

关键词： Alkyl polyglucoside Sulfate acid-silica gel Solid acidic Catalyst

Synthesis of aliphatic amidediol and used as a novel mixed plasticizer for thermoplastic starch

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Chinese Chemical Letters 2008年第4期19卷 395-398页

作者： Jian She Zhang Jiu Gao yu Ying Wu xiao fei Ma School of Science Tianjin UniversityTianjin 300072PR China

In this paper,aliphatic amidediol was synthesized and mixed with glycerol used as a plasticizer for preparing thermoplastic starch（AGPTPS）.The yield of aliphatic amidediol was 91%.FF-IR expressed that the mixture of aliphatic amidediol and glycerol formed stronger and stable hydrogen bond with starch molecules compared to the native *** scanning electron microscope（SEM）native cornstarch granules were proved to transfer to a homogeneous continuous *** being stored for a period time at room temperature,the mechanical properties of AGPTPS were also *** a mixed plasticizer,aliphatic amidediol and glycerol would be practical to extend TPS application scopes.

关键词： Thermoplastic starch Aliphatic amidediol Glycerol Plasticizer

Biomaterial‑based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration

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Military Medical Research 2025年第1期12卷 96-120页

作者： Ying-Ying Li Shuai-fei Ji xiao-Bing Fu yu-Feng Jiang xiao-Yan Sun Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department Chinese PLA General Hospital and PLA Medical CollegePLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin InjuryRepair and RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048China Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048China 2Department of Tissue Regeneration and Wound RepairChinese PLA General HospitalBeijing 100853China

Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages,ultimately impairing its normal physiological *** evidence underscores the potential of targeted modulation of mechanical cues to enhance skin regeneration,promoting scarless repair by influencing the extracellular microenvironment and driving the phenotypic *** field of skin repair and skin appendage regeneration has witnessed remarkable advancements in the utilization of biomaterials with distinct physical ***,a comprehensive understanding of the underlying mechanisms remains somewhat elusive,limiting the broader application of these *** this review,we present two promising biomaterial-based mechanical approaches aimed at bolstering the regenerative capacity of compromised *** first approach involves leveraging biomaterials with specific biophysical properties to create an optimal scarless environment that supports cellular activities essential for *** second approach centers on harnessing mechanical forces exerted by biomaterials to enhance cellular plasticity,facilitating efficient cellular reprogramming and,consequently,promoting the regeneration of skin *** summary,the manipulation of mechanical cues using biomaterial-based strategies holds significant promise as a supplementary approach for achieving scarless wound healing,coupled with the restoration of multiple skin appendage functions.

关键词： Scarless Wound healing Biomaterials Mechanical cues Skin appendages

Adsorption and Desorption of Ammonium in Wetland Soils Subject to Freeze-Thaw Cycles

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Pedosphere 2011年第2期21卷 251-258页

作者： yu xiao-fei ZHANG yu-Xia ZOU yuan-Chun ZHAO Hong-Mei LU Xian-Guo WANG Guo-Ping Northeast Institute of Geography and Agroecology Chinese Academy of Sciences Changehun 130012 (China) Graduate University of Chinese Academy of Sciences Beijing 100049 (China)

Nitrogen （N） cycling in boreal peatland ecosystems may be influenced in important ways by freeze-thaw cycles （FTCs）. Adsorption and desorption of ammonium ions （NH4＋） were examined in a controlled laboratory experiment for soils sampled from palustrine wetland, riverine wetland, and farmland reclaimed from natural wetland in response to the number of FTCs. The results indicate that freeze-thaw significantly increased the adsorption capacity of NH： and reduced the desorption potential of NH4＋ in the wetland soils. There were significant differences in the NH4＋ adsorption amount between the soils with and without freeze-thaw treatment. The adsorption amount of NH4＋ increased with increasing FTCs. The palustrine wetland soil had a greater adsorption capacity and a weaker desorption potential of NH4＋ than the riverine wetland soil because of the significantly higher clay content and cation exchange capacity （CEC） of the riverine wetland soil. Because of the altered soil physical and chemical properties and hydroperiods, the adsorption capacity of NH4＋ was smaller in the farmland soil than in the wetland soils, while the desorption potential of the farmland soil was higher than that of the wetland soils. Thus, wetland reclamation would decrease adsorption capacity and increase desorption potential of NH4＋, which could result in N loss from the farmland soil. FTCs might mitigate N loss from soils and reduce the risk of water pollution in downstream ecosystems.

关键词： cation exchange capacity clay content farmland hydroperiod N loss

Sodium-dependent glucose transporter 2 inhibitors improve heart function in patients with type 2 diabetes and heart failure

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World Journal of Cardiology 2025年第1期17卷 110-117页

作者： Yi-fei Zhang yu-Xiang Liu Wu-xiao Yang Department of Cardiology Shanxi Provincial People's HospitalShanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina Department of Nephrology Shanxi Provincial People's HospitalShanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina

This article discusses the study by GrubićRotkvićet al on the mechanisms of action of sodium-glucose cotransporter 2 inhibitors(SGLT2i)in patients with type 2 diabetes mellitus(T2DM)and heart failure(HF).T2DM and HF are highly comorbid,with a significantly increased prevalence of HF in patients with ***2i exhibit potential in reducing hospitalization rates for HF and cardiovascular mortality through multiple mechanisms,including improving blood glucose control,promoting urinary sodium excretion,reducing sympathetic nervous system activity,lowering both preload and afterload on the heart,alleviating inflammation and oxidative stress,enhancing endothelial function,improving myocardial energy metabolism,and stabilizing cardiac ion *** research and clinical practice will help optimize the use of SGLT2i in HF patients.

关键词： Sodium-glucose cotransporter 2 inhibitors Type 2 diabetes mellitus Heart failure Diabetic cardiomyopathy Cardiovascular disease

Insulin autoantibodies,D-dimer and microalbuminuria:A crosssectional,case-control study of type 2 diabetes

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World Journal of Diabetes 2025年第2期16卷 38-46页

作者： Lin-Shan Zhang Peng yu fei Yao Zhi-Qiang Lu xiao-Mu Li Hong Chen Department of Endocrinology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Endocrinology Shanghai Geriatric Medical CenterShanghai 201104China Department of Endocrinology Fuzhou Hospital of Traditional Chinese MedicineFuzhou 350000Fujian ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM)often leads to vascular complications,such as *** role of insulin autoantibodies(IAA)and their interaction with D-dimer in this context remains *** To investigate the characteristics of IAA and its effect on albuminuria in T2DM *** We retrospectively analyzed clinical data from 115 T2DM patients with positive IAA induced by exogenous insulin,and 115 age-and sex-matched IAA-negative T2DM patients as *** scores were calculated using multivariate logistic *** variables were selected using the least absolute shrinkage and selection operator(LASSO)*** constructed a prediction model and analyzed the association between IAA and albuminuria based on demographic and laboratory *** The IAA-positive group had significantly higher D-dimer levels[0.30(0.19-0.55)mg/L vs 0.21(0.19-0.33)mg/L,P=0.008]and plasma insulin levels[39.1(12.0-102.7)μU/mL vs 9.8(5.5-17.6)μU/mL,P0.5 g/L)was 2.88(95%confidence interval:1.17-7.07)in the IAA-positive group(P interaction<0.05).CONCLUSION D-dimer elevation is an independent risk factor for abnormal albuminuria and interacts with IAA in the development of abnormal albuminuria in T2DM patients.

关键词： Insulin autoantibody Microalbuminuria D-dimer Type 2 diabetes

圆柱壳在水下爆炸载荷下的流-固耦合响应分析

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振动与冲击 2007年第7期26卷 125-128页

作者：余晓菲刘土光余宏坤华中科技大学船舶与海洋工程系武汉430074 中国西南电子设备研究所成都610036

研究了无限域流场中两端简支圆柱壳受球形炸药爆炸冲击载荷作用的响应特性。运用Hamilton变分原理,推导出了考虑流固耦合作用圆柱壳受水下爆炸冲击载荷作用的运动方程,并分别展开成Fourier级数的形式,最后在时域上差分离散,用Galerkin... 详细信息

研究了无限域流场中两端简支圆柱壳受球形炸药爆炸冲击载荷作用的响应特性。运用Hamilton变分原理,推导出了考虑流固耦合作用圆柱壳受水下爆炸冲击载荷作用的运动方程,并分别展开成Fourier级数的形式,最后在时域上差分离散,用Galerkin方法求解,得到了在水下爆炸冲击载荷下圆柱壳的响应分析。文章着重就圆柱壳在迎爆面和背爆面的不同位置的变形位移和变形速度进行了对比分析,同时还比较了流体动压力对结构响应的影响。并将分析结果与有限元计算软件***计算结果比较,验证了算法的可靠性。

关键词：圆柱壳水下爆炸响应流固耦合 Galerkin方法 MSC.DYTRAN

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan yu xiao-Li Li xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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高速冲击下薄壁组合结构吸能特性研究

爆炸与冲击 2006年第5期26卷 395-403页

作者：张涛刘土光肖汉林余晓菲华中科技大学交通学院湖北武汉430074

研究了高速冲击下组合薄壁结构的吸能特性。采用显式动力有限元方法模拟薄壁结构在轴向冲击下的动态屈曲并分析其吸能特性,通过在结构上增加诱导缺陷和提出新型组合截面来提高其抗冲击吸能性能。同时对多种模型对比分析,研究了不同诱导... 详细信息

研究了高速冲击下组合薄壁结构的吸能特性。采用显式动力有限元方法模拟薄壁结构在轴向冲击下的动态屈曲并分析其吸能特性,通过在结构上增加诱导缺陷和提出新型组合截面来提高其抗冲击吸能性能。同时对多种模型对比分析,研究了不同诱导缺陷、截面形式对吸能特性的影响,以得到最优化的结构。

关键词：固体力学吸能冲击薄壁结构诱导缺陷