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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan yu xiao-Li Li xiao-Ting Sun Li-Ting Wang xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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汽车牌照图像的预处理研究

沈阳工业大学学报 2002年第2期24卷 121-124页

作者：徐全生于霞梁乐彬沈阳工业大学信息科学与工程学院辽宁沈阳110023

讨论了平滑和二值化方法,提出一种改进的适合汽车牌照图像自身特点的去噪及二值化方法.该方法将平滑和二值化结合起来,对螺丝钉、大污点、牌照边框、字符分割不当等引起的噪声非常有效,为正确的特征抽取提供了保证.

关键词：图像预处理车牌识别文字识别汽车牌照智能交通交通管理

High-level representation sketch for video event retrieval

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Science China(Information Sciences) 2016年第7期59卷 158-172页

作者： yu ZHANG xiaowu CHEN liang LIN Changqun xia Dongqing ZOU State Key Laboratory of Virtual Reality Technology and Systems School of Compute Science and EngineeringBeihang University School of Advanced Computing Sun Yat-Sen University

Representing video events is an essential step for a wide range of visual applications. In this paper,we propose the event sketch, a high-level event representation, to depict the dynamic properties of video events composed of actions of semantic objects. We show that this representation can facilitate a novel sketch based video retrieval(SBVR) system, which has not been considered before to the best of our knowledge. In this system, users are allowed to draw the evolutions(e.g. spatiotemporal layouts and behaviors of semantic objects)on a board, and retrieve the events whose semantic objects have the similar evolutions from a database. To do this, event sketches are constructed on both the user queries and database videos, and compared under a novel graph-matching scheme based on data-driven Monta Carlo Markov chain(DDMCMC). To test our approach, we collect a novel dataset of goal events in real soccer videos, which consists actions of multiple players and shows large variability in the evolution process of the events. Experiments on this dataset and the publicly available dataset CAVIAR demonstrated the effectiveness of the proposed approach.

关键词： video retrieval event representation event sketch drawing board distance function relevance feedback DDMCMC

An Improved Calculation of Nonlinear Stopping Power of an Electron Gas for Slow Hydrogen Ions

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Chinese Physics Letters 1996年第11期13卷 825-828页

作者： MU yu-guang xia yue-yuan MEI liang-mo Department of Physics Shandong UniversityJinan 250100

The stopping power of an electron gas for hydrogen ions is calculated based on the full self-consistent nonlinear density-functional *** different configurations of hydrogen ions are considered and a criterion to test the validity of the self-consistent calculation is *** of calculation with available experimental data shows good agreement.

关键词： hydrogen Electron calculation

开鲁坳陷钱家店铀矿床铀的赋存状态及铀矿形成时代研究

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铀矿地质 2005年第4期21卷 213-218页

作者：张明瑜郑纪伟田时丰夏毓亮刘汉彬辽河石油勘探局通辽铀矿辽宁盘锦124010 核工业北京地质研究院北京100029

本文对开鲁坳陷钱家店铀矿床铀的存在形式及铀矿成矿作用进行了研究。钱家店铀矿床矿石中铀的存在形式有铀矿物、吸附铀及含铀矿物,其中以铀矿物和吸附铀形式为主。U6+/U4+比值为0.266～1.116,平均为0.761。铀矿石中铀在各种粒级碎屑中... 详细信息

本文对开鲁坳陷钱家店铀矿床铀的存在形式及铀矿成矿作用进行了研究。钱家店铀矿床矿石中铀的存在形式有铀矿物、吸附铀及含铀矿物,其中以铀矿物和吸附铀形式为主。U6+/U4+比值为0.266～1.116,平均为0.761。铀矿石中铀在各种粒级碎屑中均有分布,但集中分布在0.1～0.25mm粒级中,铀分布率27.89%～76.98%,平均为46.55%。钱家店砂岩型铀矿床UPb等时线年龄为53±3Ma和7±0Ma。

关键词：钱家店铀矿床铀的赋存状态铀矿形成时代 U-Pb等时线

SplitPass： A Mutually Distrusting Two-Party Password Manager

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Journal of Computer Science & Technology 2018年第1期33卷 98-115页

作者： yu-Tao Liu Dong Du yu-Bin xia Hai-Bo Chen Bin-yu Zang Zhenkai liang Institute of Parallel and Distributed Systems Shanghai Jiao Tong University Shanghai 200240 China School of Computing National University of Singapore Singapore 117417 Singapore

Using a password manager is known to be more convenient and secure than not using one, on the assmnption that the password manager itself is safe. However recent studies show that most popular password managers have security vulnerabilities that may be fooled to leak passwords without users＇ awareness. In this paper, we propose a new password manager, SplitPass, which vertically separates both the storage and access of passwords into two mutually distrusting parties. During login, all the parties will collaborate to send their password shares to the web server, but none of these parties will ever have the complete password, which significantly raises the bar of a successful attack to compromise all of tile parties. To retain transparency to existing applications and web servers, SplitPass seamlessly splits the secure sockets layer （SSL） and transport layer security （TCP） sessions to process on all parties, and makes the joining of two password shares transparent to the web servers. We have implemented SplitPass using an Android phone and a cloud assistant and evaluated it using 100 apps from top free apps in the Android official market. The evaluation shows that SplitPass securely protects users＇ passwords, while incurring little performance overhead and power consumption.

关键词： password manager privacy protection mobile-cloud system

地浸砂岩型铀矿床铀-镭平衡系数研究及其地质意义

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铀矿地质 2013年第2期29卷 93-98页

作者：夏毓亮修群业韩军李林强郑纪伟核工业北京地质研究院北京100029 辽河油田新能源开发公司辽宁盘锦124001

对地浸砂岩型铀矿床中矿化砂岩和非矿化砂岩、矿化泥岩和非矿化泥岩样品进行了系统的铀-镭平衡系数研究,惊奇地发现矿化砂岩和矿化泥岩都普遍偏铀,非矿化砂岩和非矿化泥岩都普遍偏镭,而且矿化泥岩比矿化砂岩更偏铀,非矿化泥岩比非矿化... 详细信息

对地浸砂岩型铀矿床中矿化砂岩和非矿化砂岩、矿化泥岩和非矿化泥岩样品进行了系统的铀-镭平衡系数研究,惊奇地发现矿化砂岩和矿化泥岩都普遍偏铀,非矿化砂岩和非矿化泥岩都普遍偏镭,而且矿化泥岩比矿化砂岩更偏铀,非矿化泥岩比非矿化砂岩更偏镭。表明泥岩类岩石在铀成矿的地质时期内是具有渗透性的,非矿化泥岩和非矿化砂岩可以为铀成矿提供重要的铀源。

关键词：地浸砂岩型铀矿铀-镭平衡系数渗透性成矿铀源

Substitution Reactions by Azide and Thiocyanide Anions in Room Temperature Ionic Liquids

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Chinese Chemical Letters 2003年第3期14卷 239-242页

作者： yu xia LI Wei liang BAO Zhi Ming WANG Department of Chemistry Zhejiang UniversityXi Xi CampusHangzhou 310028

Conducted in the ionic liquids, activated and inactivated halides, acyl chlorides, tosylate, and bezotriazolyl acylates were converted to corresponding azide and thiocyanide compounds in high yields under mild conditi... 详细信息

关键词： Room temperature ionic liquids azide thiocyanide substitution reactions.

Effects of chain length and hydrophobicity/charge ratio of AMP on its antimicrobial activity

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Science China Chemistry 2017年第3期60卷 385-395页

作者： Qiuhong yu Zhengxi Zhang Jianbo Sun yuqiong xia Quan Du Dehai liang Beijing National Laboratory for Molecular Sciences and the Key Laboratory of Polymer Chemistry and Physics of Ministry of Education State Key Laboratory of Natural and Biomimetic DrugsCollege of Chemistry and Molecular EngineeringSchool of Pharmaceutical SciencesPeking University School of Life Sciences and Technology Xidian University

Using two series of de novo designed antimicrobial peptides,we studied the effects of peptide length and hydrophobicity/charge(H/C) ratio on the antimicrobial *** these peptides,a correlation was established between their antimicrobial efficacy and the leakage,aggregation,and fusion activities on artificial *** results showed that peptides with an H/C ratio of 1.3,and a length of about half of the membrane thickness caused most potent membrane leakage,and negligible membrane aggregation and *** addition,such peptide also exhibited the highest antimicrobial *** of the hydrophobic and electrostatic interactions showed that the strength,the order and the position of these interactions determined the activities of the peptides on the artificial membrane and thus the antimicrobial *** analyses on the tilt angle of the peptides on the membrane surface indicated that the peptides distorted the membrane in a dynamic mode,instead of being fixed in the membrane at a constant angle.

关键词： antimicrobial peptides peptide length hydrophobicity/charge ratio