Effects of chain length and hydrophobicity/charge ratio of AMP on its antimicrobial activity
Effects of chain length and hydrophobicity/charge ratio of AMP on its antimicrobial activity作者机构:Beijing National Laboratory for Molecular Sciences and the Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationState Key Laboratory of Natural and Biomimetic DrugsCollege of Chemistry and Molecular EngineeringSchool of Pharmaceutical SciencesPeking University School of Life Sciences and TechnologyXidian University
出 版 物:《Science China Chemistry》 (中国科学(化学英文版))
年 卷 期:2017年第60卷第3期
页 面:385-395页
核心收录:
学科分类:081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金:supported by the National Natural Science Foundation of China(21574002,21174007) the Beijing Natural Science Foundation(5132015) the Nantong Jianghai Talent Program
主 题:antimicrobial peptides peptide length hydrophobicity/charge ratio
摘 要:Using two series of de novo designed antimicrobial peptides,we studied the effects of peptide length and hydrophobicity/charge(H/C) ratio on the antimicrobial *** these peptides,a correlation was established between their antimicrobial efficacy and the leakage,aggregation,and fusion activities on artificial *** results showed that peptides with an H/C ratio of 1.3,and a length of about half of the membrane thickness caused most potent membrane leakage,and negligible membrane aggregation and *** addition,such peptide also exhibited the highest antimicrobial *** of the hydrophobic and electrostatic interactions showed that the strength,the order and the position of these interactions determined the activities of the peptides on the artificial membrane and thus the antimicrobial *** analyses on the tilt angle of the peptides on the membrane surface indicated that the peptides distorted the membrane in a dynamic mode,instead of being fixed in the membrane at a constant angle.