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A nitroreductase-responsive nanoprobe with homogeneous composition and high loading for preoperative non-invasive tumor imaging and intraoperative guidance

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Chinese Chemical Letters 2024年第7期35卷 313-318页

作者： Jingqi Xin Shupeng Han Meichen Zheng Chenfeng Xu Zhongxi Huang Bin Wang changmin yu Feifei An yu Ren Institute of Medical Engineering Department of BiophysicsSchool of Basic Medical ScienceHealth Science CenterXi'an Jiaotong UniversityXi'an 710061China School of Public Health Health Science CenterXi'an Jiaotong UniversityXi'an 710061China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816China Department of Breast Surgery the First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China

Tumor microenvironment(TME)-activatable probes have been proven to effectively increase signal-tobackground ratios(SBRs)and improve the success rate of complete tumor ***,many fluorescence probes have to be loaded into a nanocarrier for tumor targeted delivery,which consequently encounters poor drug loading,heterogeneous composition and non-encapsulated drug aggregates occurred during nanoformulation ***,a nitroreductase(NTR)-activated“OFF-ON”near-infrared fluorescence nanoprobe,named Nano Bodipy,was synthesized by the spontaneous self-assembling of NTRresponsive dye-polyethylene glycol(PEG)amphiphilic polymer in *** NTR-responsive dye acted as the hydrophobic segment in the amphiphilic polymer,yielding a homogeneous composition and a high loading of 12.2 wt%(according to calculation)in the synthesized Nano *** synthesized Nano Bodipy can efficiently accumulate in tumors via the enhanced permeability and retention(EPR)effect,enabling non-invasive tumor-targeted fluorescence imaging and guiding complete tumor *** the synthesized Nano Bodipy entered the tumor cells,they dissociated and were activated by overexpressed *** the real-time fluorescence guide of Nano Bodipy,complete tumor resection surgery was performed successfully.

关键词： Nitroreductase Tumor diagnosis Intraoperative guidance Self-assembly Nanoprobe

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Glutathione depletion based Pt(Ⅳ) hybrid mesoporous organosilica delivery system to conquer cisplatin chemoresistance: A “one stone three birds” strategy

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Chinese Chemical Letters 2024年第10期 304-311页

作者： Linjie Ju Zhongxi Huang Qian Shen Chan Fu Shuanghe Li Wenjie Duan Chenfeng Xu Weizhen An Zhiqiang Zhai Jifu Wei changmin yu Guoren Zhou Department of Pharmacy Jiangsu Cancer Hospital The Affiliated Cancer Hospital of Nanjing Medical University Jiangsu Institute of Cancer Research Key Laboratory of Flexible Electronics (KLOFE) School of Flexible Electronics (Future Technologies) & Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization College of Resources and Environmental Sciences Nanjing Agricultural University Department of Oncology Jiangsu Cancer Hospital The Affiliated Cancer Hospital of Nanjing Medical University Jiangsu Institute of Cancer Research

The occurrence of acquired resistance to cisplatin （DDP） that induces the toxic drug effects has always been a huge challenge and urgently needs to be resolved in the cancer *** combination of anticancer drugs with different mechanisms can remarkably improve the chemotherapeutic *** that glutathione （GSH） plays as the driving factors in the resistance of DDP,here we have firstly proposed a“three birds,one stone”based nanoplatform to achieve triple synergetic effects simultaneously addressing DDP resistance in non-small cell lung cancer （NSCLC）.Specifically,we initially designed and synthesized a DDP prodrug[Pt（Ⅳ）]bridged silsesquioxane precursor （Pt-Si）.Then Pt-Si and bis[3-（triethoxysilyl）propyl]diselenide （BTESe PD） were integrated into the framework of mesoporous organosilica nanoparticles （MONs） to obtain a nanocarrier MONPt/*** loading with norcantharidin （NCTD） and modifying with the aptamer AS1411 based G-quadruplex （Apt）,the Apt@NCTD@MONPt/Seexhibit impressive tumor homing *** being endocytosed,（Ⅰ） the diselenide and-O-Pt（Ⅳ）-O-rich scaffold can be reduced by the excessive GSH,followed by （Ⅱ） breaking the redox homeostasis via GSH depletion and precise release of the ***,the encapsulated NCTD is also released along with the degradation of the nanocarriers thereby （Ⅲ） achieving the GSH depletion and synergistic anti-tumor effect of NCTD and *** together,we believe this“one stone,three birds”strategy may be a promising paradigm to conquer drug resistance for clinical care.

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磁分离技术和纳米金比色法用于嗜碱性粒细胞活化试验研究

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材料导报 2024年第9期38卷 249-255页

作者：王迎迎刘永欣沈倩付婵余昌敏东南大学附属中大医院南京210009 南京工业大学柔性电子(未来技术)学院南京210009

嗜碱性粒细胞活化试验是一种安全、高效的诊断过敏疾病技术,成为临床体外诊断过敏疾病的主要方法之一。目前,嗜碱性粒细胞活化试验主要是利用流式细胞术对细胞进行检测,这种方法通常存在检测时间长、操作繁琐和成本高等缺点。针对这些问... 详细信息

嗜碱性粒细胞活化试验是一种安全、高效的诊断过敏疾病技术,成为临床体外诊断过敏疾病的主要方法之一。目前,嗜碱性粒细胞活化试验主要是利用流式细胞术对细胞进行检测,这种方法通常存在检测时间长、操作繁琐和成本高等缺点。针对这些问题,本研究开发了一种表面修饰HLA-DR抗体的磁珠分离体系,将其与过敏患者的外周血共孵育5 min后,利用磁性分离技术,筛选出表面含有HLA-DR标记物的细胞。测试结果表明,筛选后的嗜碱性粒细胞在全血中的细胞占比从0.2%提升到11.5%,嗜碱性粒细胞活化试验检测灵敏性得到了有效提高。进一步地,本研究构建了CD63适配体修饰的金纳米粒子检测体系,利用CD63适配体特异性识别活化后的嗜碱性粒细胞表面的CD63抗体,使金纳米粒子在嗜碱性粒细胞表面聚集,溶液颜色由红色转变为蓝紫色,实现对激活的嗜碱性粒细胞可视化比色检测,为临床开展嗜碱性粒细胞活化试验提供了新的方法。

关键词：比色法金纳米粒子嗜碱性粒细胞激活实验磁分离适配体

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Dimorphism in Calceola sandalina (Linneé, 1771)

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Science China Earth Sciences 2007年第12期50卷 1761-1766页

作者： yu changmin Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences NIGPAS Nanjing 210008 China

Based on studying the ontogenetic development of Calceola sandalina in the Early Devonian yukiang Formation from Guangxi Zhuang Autonomous Region, South China, it is for the first time to issue the evidence indicating the existence of sexual dimorphism in Calceola sandalina. The new discovery will add important data on sexual dimorphism throughout the non-colonial fossil metazoan, and it also may throw lights on studying the taxonomy and phylogeny of Calceola sandalina and its relevant taxa.

关键词： biocoenosis, benthonics, sexual dimorphism, bimodal variation, metazoans, ecomorphs, brood pouches

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New Data on the Age of the yukiang (yujiang) Formation at Liujing, Guangxi, South China

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Acta Geologica Sinica(English Edition) 2017年第4期91卷 1438-1447页

作者： LU Jianfeng QIE Wenku yu changmin CHEN Xiuqin Nanjing Institute of Geology andPalaeontology Chinese Academy of Sciences Nanjing 210008 China Key Laboratory of Economic Stratigraphy and Palaeogeography Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences Nanjing 210008 China

The age of the yukiang （yujiang） Formation has been shrouded in controversy for more than 75 years. New investigation at the Liujing section, Hengxian County, Guangxi, has revealed a conodont sequence assignable to two Early Devonian conodont zonations： the Eognathodus kindlei？-Polygnathus pireneae Zone and the Polygnathus nothoperbonus Zone from oldest to youngest. The Gaoling and Mahuangling members of the Nahkaoling （Nagaoling） Formation and the overlying Xiayiling Member and lower part of the Shizhou Member of the yukiang Formation are proven to belong to the Pragian Eognathodus kindlei？-Polygnathus pireneae Zone. The co-occurrence of Polygnathus pireneae and Pol. sokolovi in the lower part of the Shizhou Member demonstrates that this interval can be approximately correlated with the uppermost part of the Polygnathus pireneae Zone. However, precise level identification of the Pragian-Emsian Boundary （PEB） in the Liujing section remains dfficult due to the scarcity of suitable limestone samples for conodont analysis from the middle and upper parts of the Shizhou Member. The Daliancun and Liujing members of the yukiang Formation and the lower part of the overlying Moding Formation are assigned to the Polygnathus nothoperbonus Zone with the nominal species of this biozone ranging from the bottom of the Daliancun Member to the lower part of the Moding Formation.

关键词： conodonts Nahkaoling Formation yukiang Formation Liujing section Pragian Emsian

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A Comprehensive Evaluation on the Devonian-Carboniferous Boundary Stratotype Candidate Section in Nanbiancun, Guilin, Guangxi

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Acta Geologica Sinica(English Edition) 1990年第1期64卷 69-79页

作者： yu changmin Nanjing Institute of Geology and Palaeontology, Academia Sinica 2This paper is extracted from some relevant chapters of a monograph. The authors who wrote the monograph are: yu changmin Ruan Yiping Xu Hankui Wang Shangqi Zhu Zhaoling Mu Xinan Wang Keliang Yin Bao' an Li Zhengliang Li Yukuan Guo Shuying Yao Zhaogui He Guiying Zhang Yue'e Lu Hongjin Huang Zhicheng Zhu Sizhao Yang Jiedong Wang Yinxi Ye Sujuan and Xu Tongchun.

This paper presents a comprehensive evaluation on the Devonian-Carboniferous Boundary (DCB) sectionin Nanbiancun. Guilin. Guangxi on the basis of Palaeontological, biostratigraphical and sedimentarypetrological studies as well as microfacies analysis. REE and trace element analysis and isotopic dating. The DCB at this section conforms to the definition of this boundary and essentially measure up the criteriaand conditions for selection of the boundary stratotype. Up to 14 fossil groups are contained in the section. Thesection presents a general biostratigraphical framework with multispecies fossils zones, assemblage zones andmultiple groups of fossils and has latent preponderant conditions for magnetostratigraphic andchronostratigraphic studies. The boundary and point occur in a persistent and continuous monofacialcarbonate succession. and the section is located in a tourist city with convenient communication, where variousfacies of DCB sections are developed. allowing the correlation within a small area. So it is an ideal candidateboundary stratotype.

关键词： Guilin Guangxi A Comprehensive Evaluation on the Devonian-Carboniferous Boundary Stratotype Candidate Section in Nanbiancun

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金纳米粒子的表面修饰及生物应用进展

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化学通报 2024年第6期87卷 642-651页

作者：赵陈泷沈倩黄众熙陈泽娜杨乃娣余昌敏南京工业大学柔性电子(未来技术)学院南京210009

近年来纳米材料被广泛应用于生物医学、航空航天和精细化工等领域。构成纳米材料的纳米粒子具有小尺寸效应、表面效应和宏观量子隧道效应等性质。其中金纳米粒子(AuNPs)由于其独特的荧光特性、良好的生物相容性和表面等离子共振等性质,... 详细信息

近年来纳米材料被广泛应用于生物医学、航空航天和精细化工等领域。构成纳米材料的纳米粒子具有小尺寸效应、表面效应和宏观量子隧道效应等性质。其中金纳米粒子(AuNPs)由于其独特的荧光特性、良好的生物相容性和表面等离子共振等性质,被广大科研人员深入研究。然而,目前AuNPs仍存在水分散性差、肾清除效率低和量子发射产率低等问题,限制了其广泛应用。因此,研究者对AuNPs表面进行多样化修饰,从而能有效克服上述缺点。本文就目前主流配体表面修饰AuNPs的研究进展进行总结,着重介绍了功能化AuNPs在生物成像、生物检测、生物治疗三方面的应用,最后对AuNPs的临床治疗机制的探索以及商业化的应用进行了展望,希望能为相关领域的研究者们提供新思路。

关键词：金纳米粒子表面修饰生物应用

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Recent progress in small molecule fluorescent probes for nitroreductase

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Chinese Chemical Letters 2018年第10期29卷 1451-1455页

作者： Wenjing Qin Chenchen Xu Yanfei Zhao changmin yu Sheng Shen Lin Li Wei Huang Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM)Nanjing Tech University (NanjingTech)Nanjing 211816 China Department of Sports Medicine and Adult Reconstructive Surgery Drum Tower HospitalSchool of MedicineNanjing UniversityNanjing 210008 China

Nitroreductase（NTR） is a member of flavin-containing enzymes that exists widely in bacteria. Hypoxia,which is a characteristic of locally advanced solid tumors, resulting from an imbalance between oxygen consumption and supply, can result in NTR overexpression. Using either nicotinamide adenine dinucleotide（NADH） or nicotinamide adenine dinucleotide phosphate（NADPH） as a source of reducing equivalents, NTR can catalyze the reduction of nitroaromatic compounds to the corresponding *** on this reduction mechanism, NTR can be applied not only in the bioremediation and degradation of organic nitrogen compounds, but also in the development of NTR-targeted fluorescent probes to detect the hypoxic status of cancer cells. This review aims to provide a summary of the progress in fluorescent probes for NTR in recent years and elucidate the main fluorescent mechanisms that have been applied to design probes.

关键词： Probe Fluorescence Nitroreductase Small molecule probes

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Red carbon dots as label-free two-photon fluorescent nanoprobes for imaging of formaldehyde in living cells and zebrafishes

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Chinese Chemical Letters 2020年第3期31卷 759-763页

作者： Hong Wang Jing Wei Chonghua Zhang yuan Zhang yubin Zhang Lin Li changmin yu Peisheng Zhang Jian Chen Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education Hunan Provincial Key Laboratory of Controllable Preparationand Functional Application of Fine PolymersHunan Provincial Key Lab of Advanced Materials for New Energy Storage and ConversionHunan Province College KeyLaboratory of QSAR/QSPRSchool of Chemistry and Chemical EngineeringHunan University of Science and TechnologyXiangtan 411201China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211800China State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640China

Direct,in situ selective detection of intracellular formaldehyde(FA)is of great significance for understanding its function in FA-related ***,red carbon dots(RCD)are reported as label-free two-photon fluorescent nanoprobes for detecting and imaging of *** addition of FA,the-NH2 groups of RCD could quickly and specially react with aldehydes to form Schiff base and then the strong fluorescence of RCD with blue-shift emission is recovery due to the destruction of the hydrogen bond interaction between RCD and *** addition,the nanoprobes exhibit outsta nding photo stability,rapid response(<1 min),high sensitivity(~9.9μmol/L)and excellent selectivity toward FA over other aldehyde group ***,owing to the good cell-membrane permeability and biocompatibility,as well as the large two-photon absorption cross-section,the as-prepared RCD can be used as label-free nanoprobes for selectively detecting and imaging FA in living cells and zebrafishes through one-photon and two-photon ***,RCD could stain the tissue of zebrafishes at depths interval of up to 240μm under two-photon *** research implied that RCD are promising tools for directly and in situ imaging FA in vivo,thus providing critical insights into FA-related pathophysiological processes.

关键词： Carbon dots(CDs) Two-photon excitation Formaldehyde(FA) Intracellular imaging Zebrafishes

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Mitochondria-targeted fluorescent probe based on vibration-induced emission for real-time monitoring mitophagy-specific viscosity dynamic

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Chinese Chemical Letters 2020年第11期31卷 2897-2902页

作者： Shuangxi Wang Bicong Zhou Na Wang changmin yu Naidi Yang Jian Chen Qiong Wu Chengwu Zhang Lin Li Wei Huang Key Laboratory of Flexible Electronics(KLOFE)&•Institute of Advanced Materials(1AM) Nanjing Tech University(NanjingTech)Nanjing 211800China Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)Xi'an 710072China Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers Hunan University of Science and TechnologyXiangtan 411201China

Directly monitoring mitophagy-specific viscosity dynamic in living cells is of great significance but remains ***,this study reported a novel mitochondria-targeted fluorescent probe DPACDY based on vibration-induced emission(VIE)for monitoring viscosity changes during mitochondrial *** probe contained N,N’-diphenyl-dihydrodibenzo[a,c]phenazine(DPAC)as the VIE core and two positively charged pyridinium moieties for mitochondria *** the ambient viscosity increased,the vibration of DPAC-DY could be hindered,and subsequently resulting in the enhancement of fluorescence *** vitro and intracellular experiments indicated that the probe DPAC-DY showed highly sensitive response to viscosity due to VIE ***,by virtue of this probe,in situ and real-time visualization of the specific viscosity dynamics during the mitochondrial autophagy process was ***,this work provides a novel strategy for VIE-based viscosity response sensors applied to specific organelles and offers a platform for in-depth study of mitochondrial viscosity-related diseases.

关键词： Vibration-induced emission Autophagy Viscosity Fluorescence detection

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