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Novel Anti-fouling Strategies of Live and Dead Soft Corals(Sarcophyton trocheliophorum):Combined Physical and Chemical Mechanisms

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Journal of Bionic Engineering 2020年第4期17卷 677-685页

作者： Limei Tian E Jin benli yu Hang sun Yangeng Shang Wei Bing Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun 130022China Weihai Institute for Bionics-Jilin University Weihai 264207China Yantai Ice Wheel Casting Co. LtdYantai 264002China Yantai Ice Wheel Intelligent Machinery Technology Co. LtdYantai 264006China School of Chemistry and Life Science Changchun University of TechnologyChangchun 130012China

At present,biomimetic antifouling research objects are mostly concentrated on the fast-moving marine organism,but the anti-fouling effect of the low-speed or static marine equipment is not *** paper describes the anti-fouling mechanism of soft coral(Sarcophyton trocheliophorum),including the physical defense mechanism and the bactericidal ability of mucus and coral *** a sessile organisms,soft coral lacks escape ***,the study on its antibacterial strategy is significant because it can provide theoretical guidance for static *** showed that the live soft coral would molt in unfriendly environment,and the secreted mucus could defend themselves against fouling ***,Liquid Chromatography-Mass Spectrometry(LC-MS)analysis was conducted to identify the bioactive compounds of the coral powder and *** revealed that both powder and mucus contained a wide variety of toxic components,which had bactericidal ***,at the same concentration,the inhibitory effect of the main components on Gram-negative bacteria was stronger than that on positive *** findings enhance the understanding about the antifouling mechanism of soft coral and provide new ideas for design and prepare novel antifouling strategy to combat biofouling under static condition.

关键词： biomimetic antifouling soft coral antibacterial marine bacteria mucus

NLRP3基因启动子多态性与扩张型心肌病患者临床特征的相关性

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中国医师杂志 2022年第8期24卷 1179-1183页

作者：高爽周瑜孙树印任雪雷王本立韩翔宇济宁医学院临床学院济宁272000 济宁市第一人民医院急诊医学科济宁272011

目的探讨核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)基因启动子区域-30位点单核苷酸多态性(SNP)(rs3738448)G/T与扩张型心肌病(DCM)之间的关系及其相关的危险因素。方法采用病例-对照研究方法,收集137例DCM患者和140例健康对照者。应用... 详细信息

目的探讨核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)基因启动子区域-30位点单核苷酸多态性(SNP)(rs3738448)G/T与扩张型心肌病(DCM)之间的关系及其相关的危险因素。方法采用病例-对照研究方法,收集137例DCM患者和140例健康对照者。应用聚合酶链反应-限制性内切酶片段长度多态性技术结合DNA测序后的序列比对进行数据统计。运用Hardy-Weinberg平衡检验后,应用χ^(2)检验进行相关分析。利用logistic回归对多种危险因素以及该SNP位点与DCM发病进行关联性分析。利用SNPinfo数据库对该SNP影响的转录因子进行预测并分析。结果该SNP位点共检测出GG、GT两种基因型,其基因型分布均符合Hardy-Weinberg平衡(P>0.05),同时在DCM组与对照组间差异有统计学意义(P<0.05)。多因素logistic回归分析显示:平均动脉压、C-反应蛋白、B型脑钠肽是DCM发病的独立危险因素(均P<0.05)。-30(rs3738448)G/T基因型为GT的人群DCM发病率是基因型为GG组的2.243倍(95%CI:1.043~4.827,P<0.05)。在显性、隐性和加性3种不同遗传模式下进行logistic回归分析发现,该SNP显性遗传时与DCM的发生有相关性(OR=0.44,AIC=370.4,BIC=381.3,P<0.05)。结论NLRP3基因启动子区-30(rs3738448)G/T位点与DCM发病有相关性,同时为研究NLRP3基因启动子区多态性提供了群体遗传学资料。

关键词：心肌病,扩张型 NOD样受体蛋白3 多态性,单核苷酸

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有源光纤环形腔滤波器优化

量子电子学报 2001年第2期18卷 114-119页

作者：俞本立钱景仁罗家童杨瀛海孙志培安徽大学物理系合肥230039 中国科技大学电子工程与信息科学系合肥230027

本文引入输入光线宽因子，利用多光束干涉理论，给出了有源光纤环形腔滤波器输出光谱密度等公式．利用这些公式可以对腔的结构和参数方便地进行理论分析和优化设计．当使该有源滤波器工作在锁定状态时，可得到窄线宽光输出．

关键词：有源滤波器有源光纤优化环形腔滤波器

PGC-1α基因Gly482Ser多态性与2型糖尿病发病的相关性研究

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大连医科大学学报 2009年第3期31卷 295-298页

作者：回圆敕关玉峰李政孙崴张霞张萍苏本利大连医科大学附属第二医院内分泌科辽宁大连116027 普兰店市中心医院泌尿内科辽宁普兰店116200

[目的]研究过氧化物酶体增殖物激活受体γ共活化物-1α(PGC-1α)Gly482Ser基因多态性与2型糖尿病发病的相关性。[方法]选取大连居住的汉族人2型糖尿病病人(DM)140例和非糖尿病对照(NC)88人;用聚合酶链反应(PCR)-限制性内切酶技术检测PG... 详细信息

[目的]研究过氧化物酶体增殖物激活受体γ共活化物-1α(PGC-1α)Gly482Ser基因多态性与2型糖尿病发病的相关性。[方法]选取大连居住的汉族人2型糖尿病病人(DM)140例和非糖尿病对照(NC)88人;用聚合酶链反应(PCR)-限制性内切酶技术检测PGC-1αGly482Ser基因型。[结果]DM组Ser/Ser基因型分与NC组比较差异有显著性意义(χ2=10.969,P=0.004),按性别分层后男性DM组与NC组比较差异无显著性意义(χ2=3.601,P=0.165),而女性DM组与NC组比较差异有显著性意义(χ2=11.02,P=0.004)。在NC组和DM组,随Ser等危基因增加,空腹C肽和2 h C肽呈逐渐降低趋势,但只有Ser/Ser与Gly/Gly两基因型之间相比差异有显著性意义(P0.05)。[结论]PGC-1 Gly482Ser多态性可能与女性2型糖尿病的发病相关,Ser/Ser型携带者C肽水平更低。

关键词： 2型糖尿病过氧化物酶体增殖物激活受体γ辅激活因子-1α 遗传/多态性

Strong interlayer coupling in phosphorene/graphene van der Waals heterostructure： A first-principles investigation

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Frontiers of physics 2018年第2期13卷 167-174页

作者： Xue-Rong Hu Ji-Ming Zheng Zhao-yu Ren Institute of Photonics Photo-technology National Key Laboratory of Photoelectric Technology and Functional Materials (Culture Base) National Photoelectric Technology and Functional Materials Application of Science and Technology International Cooperation Base Northwest University Xi'an 710069 China

Based on first-principles calculations within the framework of density functional theory, we study the electronic properties of phosphorene/graphene heterostructures. Band gaps with different sizes are observed in the heterostructure, and charges transfer from graphene to phosphorene, causing the Fermi level of the heterostructure to shift downward with respect to the Dirac point of graphene. Significantly, strong coupling between two layers is discovered in the band spectrum even though it has a van der Waals heterostructure. A tight-binding Hamiltonian model is used to reveal that the resonance of the Bloch states between the phosphorene and graphene layers in certain K points combines with the symmetry matching between band states, which explains the reason for the strong coupling in such heterostructures. This work may enhance the understanding of interlayer interaction and composition mechanisms in van der Waals heterostructures consisting of two-dimensional layered nanomaterials, and may indicate potential reference information for nanoelectronic and optoelectronic applications.

关键词： strong coupling vdW heterostructure DFT calculations tight-binding Hamiltonian model