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A layered multifunctional framework based on polyacrylonitrile and MOF derivatives for stable lithium metal anode

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Journal of Energy Chemistry 2024年第6期93卷 282-288,I0007页

作者： Fanfan Liu Peng Zuo Jing Li Pengcheng Shi yu shao Linwei Chen Yihong Tan Tao Ma Engineering Research Center of High-frequency Soft Magnetic Materials and Ceramic Powder Materials of Anhui Province School of Chemistry and Material EngineeringChaohu UniversityHefei 238024AnhuiChina Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Pharmacy Anhui University of Chinese MedicineHefei 230012AnhuiChina School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006GuangdongChina Jiujiang DeFu Technology Co. Ltd.Jiujiang 332000JiangxiChina

Composite Li metal anodes based on three-dimensional(3D) porous frameworks have been considered as an effective material for achieving stable Li metal batteries with high energy density.However,uneven Li deposition behavior still occurs at the top of 3D frameworks owing to the local accumulation of Li ions.To promote uniform Li deposition without top dendrite growth,herein,a layered multifunctional framework based on oxidation-treated polyacrylonitrile(OPAN) and metal-organic framework(MOF) derivatives was proposed for rationally regulating the distribution of Li ions flux,nucleation sites,and electrical conductivity.Profiting from these merits,the OPAN/carbon nano fiber-MOF(CMOF) composite framework demonstrated a reversible Li plating/stripping behavior for 500 cycles with a stable Coulombic efficiency of around 99.0% at the current density of 2 mA/cm~2.Besides,such a Li composite anode exhibited a superior cycle lifespan of over 1300 h under a low polarized voltage of 18 mV in symmetrical cells.When the Li composite anode was paired with LiFePO_(4)(LFP) cathode,the obtained full cell exhibited a stable cycling over 500 cycles.Moreover,the COMSOL Multiphysics simulation was conducted to reveal the effects on homogeneous Li ions distribution derived from the above-mentioned OPAN/CMOF framework and electrical insulation/conduction design.These electrochemical and simulated results shed light on the difficulties of designing stable and safe Li metal anode via optimizing the 3D frameworks.

关键词： Lithium metal anode Layered multifunctional framework Ions flux redistribution Electrical insulation/conduction structure Uniform Li deposition

Unconventional 2D Periodic Nanopatterns Based on Block Molecules

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高分子科学:英文版 2023年第10期41卷 1508-1524页

作者： Bo Hou Wen-Bin Zhang yu shao Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry&Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

This review summarizes the self-assembly of block molecules forming unconventional two-dimensional(2D)periodic nanopatterns.Especially,we emphasize the structural evolution from simple columnar phases to complex 2D tiling morphologies in soft materials including block copolymers,liquid crystals,giant molecules,etc.Then,the state-of-the-art nanofabrication technologies for making sophisticated nanostructures with specific functions via combining both bottom-up assembly and top-down lithography-based methods are discussed,highlighting the use of directed self-assembly processes.Finally,we provide our perspective on this area.By further increasing the complexity of block molecules and the designability of lithography,low-dimensional ordered morphologies will be particularly promising for further application in nanotechnology.

关键词： Two-dimensional ordered morphologies Block molecules Directed self-assembly Nanofabrication Tilings and patterns

Development and validation of a model integrating clinical and coronary lesion-based functional assessment for longterm risk prediction in PCI patients

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Journal of Geriatric Cardiology 2024年第1期21卷 44-63页

作者： shao-yu WU Rui ZHANG Sheng yuAN Zhong-Xing CAI Chang-Dong GUAN Tong-Qiang ZOU Li-Hua XIE Ke-Fei DOU State Key Laboratory of Cardiovascular Disease BeijingChina Cardiometabolic Medicine Center Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Catheterization Laboratories Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES To establish a scoring system combining the ACEF score and the quantitative blood flow ratio(QFR) to improve the long-term risk prediction of patients undergoing percutaneous coronary intervention(PCI).METHODS In this population-based cohort study, a total of 46 features, including patient clinical and coronary lesion characteristics, were assessed for analysis through machine learning models. The ACEF-QFR scoring system was developed using 1263consecutive cases of CAD patients after PCI in PANDA Ⅲ trial database. The newly developed score was then validated on the other remaining 542 patients in the cohort.RESULTS In both the Random Forest Model and the Deep Surv Model, age, renal function(creatinine), cardiac function(LVEF)and post-PCI coronary physiological index(QFR) were identified and confirmed to be significant predictive factors for 2-year adverse cardiac events. The ACEF-QFR score was constructed based on the developmental dataset and computed as age(years)/EF(%) + 1(if creatinine ≥ 2.0 mg/d L) + 1(if post-PCI QFR ≤ 0.92). The performance of the ACEF-QFR scoring system was preliminarily evaluated in the developmental dataset, and then further explored in the validation dataset. The ACEF-QFR score showed superior discrimination(C-statistic = 0.651;95% CI: 0.611-0.691, P < 0.05 versus post-PCI physiological index and other commonly used risk scores) and excellent calibration(Hosmer–Lemeshow χ^(2)= 7.070;P = 0.529) for predicting 2-year patient-oriented composite endpoint(POCE). The good prognostic value of the ACEF-QFR score was further validated by multivariable Cox regression and Kaplan–Meier analysis(adjusted HR = 1.89;95% CI: 1.18–3.04;log-rank P < 0.01) after stratified the patients into high-risk group and low-risk group.CONCLUSIONS An improved scoring system combining clinical and coronary lesion-based functional variables(ACEF-QFR)was developed, and its ability for prognostic prediction in patients with PCI was further validated to be significantly better than the post-PCI physiological

关键词： patients coronary prediction

Cooperative activation of sodium channels for downgrading the energy efficiency in neuronal information processing

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Chinese Physics B 2024年第5期33卷 758-763页

作者：严浩然颜家琦俞连春邵玉峰 School of Physical Science and Technology Lanzhou Center for Theoretical PhysicsLanzhou UniversityLanzhou 730000China Key Laboratory of Theoretical Physics of Gansu Province and Key Laboratory of Quantum Theory and Applications of MoELanzhou UniversityLanzhou 730000China Department of Neuroscience AnatomyHistologyand EmbryologyKey Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical SciencesLanzhou UniversityLanzhou 730000China

The Hodgkin–Huxley model assumes independent ion channel activation,although mutual interactions are common in biological systems.This raises the problem why neurons would favor independent over cooperative channel activation.In this study,we evaluate how cooperative activation of sodium channels affects the neuron’s information processing and energy consumption.Simulations of the stochastic Hodgkin–Huxley model with cooperative activation of sodium channels show that,while cooperative activation enhances neuronal information processing capacity,it greatly increases the neuron’s energy consumption.As a result,cooperative activation of sodium channel degrades the energy efficiency for neuronal information processing.This discovery improves our understanding of the design principles for neural systems,and may provide insights into future designs of the neuromorphic computing devices as well as systematic understanding of pathological mechanisms for neural diseases.

关键词： energy efficiency ion channel noise action potential generation neuronal dynamics

Analysis of fluidized zone in transparent soil under jet induced by pipe leakage

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Water Science and Engineering 2023年第2期16卷 203-210页

作者： Li-jie Jiang Bin Zhang Sai-hua Huang yu shao College of Water Resources and Environmental Engineering Zhejiang University of Water Resources and Electric PowerHangzhou 310018China Key Laboratory for Technology in Rural Water Management of Zhejiang Province Hangzhou 310018China College of Civil Engineering and Architecture Zhejiang UniversityHangzhou 310058China

Jets caused by burst tubes erode the surrounding soil, eventually leading to issues such as ground collapse. It is therefore highly important to study the mechanisms of soil erosion caused by jets after pipeline leakage. To investigate the water-soil interaction mechanisms of pipe leakage, this study used transparent soil and developed a three-dimensional experimental device to observe the fluidization process. Changes in the boundary of the fluidization transition area were investigated, and a formula for calculating the soil damage area was derived. The results showed three different shapes of the fluidized cavity appearing in the fluidization process. The particles initially moved upward and then gradually transitioned into a state of backflow. The effects of particle size, upper load, and porosity on fluidization were also analyzed. It was found that soil with a large particle size and a lower porosity under a heavy upper load can effectively restrain fluidization. Therefore, large-diameter and dense soil can be used as pipe-covering material.

关键词： Water-soil interaction Fluidized cavity Transparent soil Particle image velocimetry Pipe leakage

Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models

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World Journal of Gastroenterology 2024年第9期30卷 1164-1176页

作者： Yan-Li Jiang Juan Li Peng-Fei Zhang Feng-Xian Fan Jie Zou Pin Yang Peng-Fei Wang shao-yu Wang Jing Zhang Department of Magnetic Resonance Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Second Clinical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Gansu Province Clinical Research Center for Functional and Molecular Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Hepatology The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina MR Scientific Marketing Siemens HealthineersXi’an 710065Shaanxi ProvinceChina

BACKGROUND Diffusion-weighted imaging(DWI)has been developed to stage liver fibrosis.However,its diagnostic performance is inconsistent among studies.Therefore,it is worth studying the diagnostic value of various diffusion models for liver fibrosis in one cohort.AIM To evaluate the clinical potential of six diffusion-weighted models in liver fibrosis staging and compare their diagnostic performances.METHODS This prospective study enrolled 59 patients suspected of liver disease and scheduled for liver biopsy and 17 healthy participants.All participants underwent multi-b value DWI.The main DWI-derived parameters included Mono-apparent diffusion coefficient(ADC)from mono-exponential DWI,intravoxel incoherent motion model-derived true diffusion coefficient(IVIM-D),diffusion kurtosis imaging-derived apparent diffusivity(DKI-MD),stretched exponential model-derived distributed diffusion coefficient(SEM-DDC),fractional order calculus(FROC)model-derived diffusion coefficient(FROC-D)and FROC model-derived microstructural quantity(FROC-μ),and continuous-time random-walk(CTRW)model-derived anomalous diffusion coefficient(CTRW-D)and CTRW model-derived temporal diffusion heterogeneity index(CTRW-α).The correlations between DWI-derived parameters and fibrosis stages and the parameters’diagnostic efficacy in detecting significant fibrosis(SF)were assessed and compared.RESULTS CTRW-D(r=-0.356),CTRW-α(r=-0.297),DKI-MD(r=-0.297),FROC-D(r=-0.350),FROC-μ(r=-0.321),IVIM-D(r=-0.251),Mono-ADC(r=-0.362),and SEM-DDC(r=-0.263)were significantly correlated with fibrosis stages.The areas under the ROC curves(AUCs)of the combined index of the six models for distinguishing SF(0.697-0.747)were higher than each of the parameters alone(0.524-0.719).The DWI models’ability to detect SF was similar.The combined index of CTRW model parameters had the highest AUC(0.747).CONCLUSION The DWI models were similarly valuable in distinguishing SF in patients with liver disease.The combined index of CTRW parameters had the highest AUC.

关键词： Liver fibrosis Magnetic resonance imaging Diffusion-weighted magnetic resonance Liver biopsy Significant fibrosis

PD-1 inhibitor in combination with fruquintinib therapy for initial unresectable colorectal cancer:A case report

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World Journal of Clinical Cases 2022年第14期10卷 4669-4675页

作者： Hong-Qiang Zhang Chang-Zhi Huang Jing-yu Wu Zhen-Ling Wang yu shao Zan Fu Department of General Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND PD-1 inhibitors in combination with fruquintinib have not previously been reported as neoadjuvant therapy for patients with colorectal cancer.In this case report,the combination of a PD-1 inhibitor and fruquintinib demonstrated good efficacy in patients with MSI-H colorectal cancer.CASE SUMMARY The patient was a young man in his 30s who had MSI-H type colon cancer.The patient underwent four cycles of neoadjuvant therapy with a PD-1 inhibitor combined with fruquintinib before surgery,resulting in regression of the mass and a successful surgery.CONCLUSION Some patients with colorectal cancer have the MSI-H type,and the first-line chemotherapy regimen is not effective.However,PD-1 monoclonal antibody immunotherapy has a good therapeutic effect,which can be improved by combination therapy with fruquintinib.We recommend that patients with a history of colon or rectal cancer receive universal MSI testing;then,neoadjuvant therapy should be used.

关键词： Colorectal cancer Neoadjuvant PD-1 inhibitors Fruquintinib MSI-H Case report

Selecting an Appropriate Experimental Animal Model for Cholangiocarcinoma Research

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 700-710页

作者： Man Li Xueli Zhou Wei Wang Baoan Ji yu shao Qianyu Du Jinghao Yao Yan Yang Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhuiChina Depart-ment of Cancer Biology Mayo ClinicJacksonvilleFloridaUSA

Cholangiocarcinoma(CCA)is a highly aggressive biliary tree malignancy with intrahepatic and extra-hepatic sub-types that differ in molecular pathogeneses,epidemiology,clinical manifestations,treatment,and prognosis.The over-all prognosis and patient survival remains poor because of lack of early diagnosis and effective treatments.Preclini-cal in vivo studies have become increasingly paramount as they are helpful not only for the study of the fundamental molecular mechanisms of CCA but also for developing novel and effective therapeutic approaches of this fatal cancer.Recent advancements in cell and molecular biology have made it possible to mimic the pathogenicity of human CCA in chemical-mechanical,infection-induced inflammatory,implantation,and genetically engineered animal models.This review is intended to help investigators understand the particular strengths and weaknesses of the currently used in vivo animal models of human CCA and their related mod-eling techniques to aid in the selection of the one that is the best for their research needs.

关键词： Cholangiocarcinoma Heterogeneity Animal model Genetically engineered model Cancer cell of origin

Fractal Growth of Giant Amphiphiles in Langmuir-Blodgett Films

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Chinese Journal of Polymer Science 2022年第6期40卷 556-566页

作者： Wei-Jie Wang Xian Xu yu shao Jian-Wen Liao Han-Xin Jian Bing Xue Shu-Guang Yang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620China Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Fractal structures have attracted considerable scientific interest,and fractal geometry is an effective tool to study the complicated structure and dynamic processes,such as dilation symmetry of disorder structure,percolation,gelation,and metal-insulator transition.Here,we summarized our findings of fractal growth of giant amphiphiles in Langmuir-Blodgett(LB)film.Giant amphiphiles composed of polyhedral oligomeric silsesquioxanes(POSS)derivatives and poly(ethylene oxide)(PEO),with structural diversities of POSS head modification,POSS head number,PEO chain length,are precisely synthesized.The effect of molecular structures and operation parameters on the fractal growth patterns are discussed,in addition,other fractal growth patterns in LB films and in Langmuir films are included,aiming to understand the basic molecular principle of fractal growth in LB system.

关键词： Fractal growth Langmuir-Blodgett(LB)film Langmuir film Giant amphiphiles Poly(ethylene oxide)(PEO)crystallization