Selecting an Appropriate Experimental Animal Model for Cholangiocarcinoma Research
作者机构：Department of Medical OncologyThe First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhuiChina Depart-ment of Cancer BiologyMayo ClinicJacksonvilleFloridaUSA
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2022年第10卷第4期
页 面：700-710页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the Outstanding Young Talents Program in Higher Education Institutions of Anhui Province(No.gxfx2017066) the 512 Talent Cultivation Plan of Bengbu Medical College(No.by51202208) the internal grants from both Distinguished Young Scholars Science Foundation(No.2019byyfyjq02) General New Technology Project(No.2020144)of the First Affiliated Hospital of Bengbu Medical College Baoan Ji is supported by the NCI-funded Mayo Clinic SPORE in Hepatobiliary Cancer(P50 CA210964)
主 题：Cholangiocarcinoma Heterogeneity Animal model Genetically engineered model Cancer cell of origin
摘 要：Cholangiocarcinoma(CCA)is a highly aggressive biliary tree malignancy with intrahepatic and extra-hepatic sub-types that differ in molecular pathogeneses,epidemiology,clinical manifestations,treatment,and *** over-all prognosis and patient survival remains poor because of lack of early diagnosis and effective ***-cal in vivo studies have become increasingly paramount as they are helpful not only for the study of the fundamental molecular mechanisms of CCA but also for developing novel and effective therapeutic approaches of this fatal *** advancements in cell and molecular biology have made it possible to mimic the pathogenicity of human CCA in chemical-mechanical,infection-induced inflammatory,implantation,and genetically engineered animal *** review is intended to help investigators understand the particular strengths and weaknesses of the currently used in vivo animal models of human CCA and their related mod-eling techniques to aid in the selection of the one that is the best for their research needs.
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