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Structural and functional characterization of a novel ShK peptide and its analogue from zoanthids (corals)

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中国药理学与毒理学杂志 2018年第9期32卷 708-709页

作者： GONG Gui-yi LIAO Qi-wen yu-chung tse Simon Ming-yuen LEE University of Macao Macao China South University of Science and Technology of China Shenzhen 518055 China

OBJECTIVE To identify and characterize a novel neuroprotective ShK peptide and its analogue originated from coral *** *** was collected and subjected to transcriptome sequencing at which further bioinformatics analysis had identified a unigene encoding a putative ShK protein candidate,named as ***1 and its rhodamine derivative(PcShK1-RhoB) were synthesized and tested for the neuroprotective effect in 6-OHDA induced Parkinson disease models in vitro and in ***,zebrafish larvae were co-exposed to 6-OHDA and various doses of the peptides;then,dopaminergic(DA) neurons immunoreactivity and locomotion behavior of the zebrafish larvae were ***,PC12 cells were cultured with 6-OHDA in the absence or presence of different concentrations of *** viability was determined by MTT assay while calcium flow in the PC12 cells was monitored by Fluo-4 fluorescent *** Compared with control group,6-OHDA treatment could lead to DA neurons loss and locomotion deficits in PD model of zebrafish larvae(P<0.01).Both PcS hK 1(2.5,5.0 and 7.5 μmol·L^(-1)) and PcS hK 1-RhoB(0.50 and 0.75 μmol·L^(-1)) were found to protect and restore dopaminergic neurons from6-OHDA mediated injury and locomotion deficiency in the PD zebrafish respectively(P<0.01).In addition,PcShK1(2.5 to 20.0 μmol·L^(-1)) and PcShK1-RhoB(0.6 to 2.5 μmol·L^(-1)) effectively prevented against 6-OHDA toxicity in PC12 cells(P<0.01).Further study revealed that they might exert their neuroprotective effects through regulating the calcium *** PcS hK 1 and PcS hK 1-RhoB show neuroprotective effects on 6-OHDA induced PD models,and the underlying protective mechanisms of these peptides probably involve calcium homeostasis regulation.

关键词： transcriptome coral P. caribaeoru neuroprotective zebrafish calcium homeostasis

Ras suppressor protein（RSU-1） inhibits LET-60 activity to promote egg laying in Caenorhabditis elegans

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Ras suppressor protein（RSU-1） inhibits LET-60 activity to ...

第五届中国秀丽线虫大会

作者： Xinyan Wang Huang Shuai yu chung tse Southern University of Science and Technology

＜正＞The egg laying process in Caenorhabditis elegans is stimulated by providing synaptic input to regulate the contraction and relaxation of vulval *** egg-laying behavior in *** is an excellent model for the study ...

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秀丽隐杆线虫在高校遗传学实验中的应用

遗传 2017年第8期39卷 763-768页

作者：马小英赵颖岚贾方兴宋亚坤谢宇聪南方科技大学生物系深圳518000

秀丽隐杆线虫(Caenorhabditiselegans)是模式生物中的重要成员之一,因其实验成本低,实验周期短,非常适宜用于高校的遗传学实验教学中。线虫在实验教学中的使用,一方面可以有效地丰富高校实验教学的内容,另一方面也可以很好地激发学生的... 详细信息

秀丽隐杆线虫(Caenorhabditiselegans)是模式生物中的重要成员之一,因其实验成本低,实验周期短,非常适宜用于高校的遗传学实验教学中。线虫在实验教学中的使用,一方面可以有效地丰富高校实验教学的内容,另一方面也可以很好地激发学生的学习兴趣。本文介绍了线虫在遗传学实验教学中的应用实例,如生活周期观察、单因子杂交、单核苷酸多态性研究、RNA干扰(RNAi)实验等;对实验设置、操作要求、实验相关准备工作等进行了较为细致的描述,为线虫在高校遗传学实验教学中的应用提供了详实案例,可为线虫在高校遗传学实验或其他相关实验课程如细胞生物学实验、模式生物与发育生物学实验中的应用提供参考。

关键词：线虫实验教学遗传学实验

A novel coordinated control for NZEB clusters to minimize their connected grid overvoltage risks

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Building Simulation 2022年第10期15卷 1831-1848页

作者： Yelin Zhang Norman chung Fai tse Haoshan Ren Yongjun Sun Division of Building Science and Technology City University of Hong KongKowloonHong KongChina

The increasing applications of net-zero energy buildings (NZEBs) will lead to more frequent and larger energy interactions with the connected power grid, thereby being able to result in severe grid overvoltage risks. Control optimization has been proven effective to reduce such risks. Existing controls have oversimplified the overvoltage quantification by simply using the aggregated power exchanges to represent the connected grid overvoltages. Ignoring the complex voltage influences among the grid nodes, such oversimplification can easily result in low-accuracy impact evaluations of the NZEB-grid energy interactions, thereby causing non-optimal/unsatisfying overvoltage mitigations. Therefore, this study proposes a novel coordinated control method in which a power-distribution-network model has been adopted for more accurate overvoltage quantification. Meanwhile, the battery operations of individual NZEBs are iteratively coordinated using a sequential optimization approach for achieving the global optimum with substantially reduced computation complexity. For verifications, the proposed coordinated control has been systematically compared with an uncoordinated control and a conventional coordinated control in grid overvoltage minimization. The study results show that the overvoltage improvements can reach 23.5% and 12.3% compared with the uncoordinated control and the conventional coordinated control, respectively. The reasons behind the improvements have also been analyzed in detail. The proposed coordinated control can be used in practice to improve NZEB-clusters’ grid friendliness.

关键词： net-zero energy building coordinated control optimization,genetic algorithm overvoltage quantification grid friendliness

Counting Isomorphism Classes of Pointed Hyperelliptic Curves of Genus 4 over Finite Fields with Even Characteristic

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Acta Mathematica Sinica,English Series 2010年第6期26卷 1019-1054页

作者： Huah CHU Ying Pu DENG tse-chung YANG Department of Mathematics National Taiwan University Taipei Taiwan Key Laboratory of Mathematics Mechanization Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 P. R. China and State Key Laboratory of Information Security Graduate University of Chinese Academy of Sciences Beijing 100049 P. R. China

This paper is devoted to counting the number of isomorphism classes of pointed hyperelliptic curves over finite fields. We deal with the genus 4 case and the finite fields are of even characteristics. The number of isomorphism classes is computed and the explicit formulae are given. This number can be represented as a polynomial in q of degree 7, where q is the order of the finite field. The result can be used in the classification problems and it is useful for further studies of hyperelliptic curve cryptosystems, e.g. it is of interest for research on implementing the arithmetics of curves of low genus for cryptographic purposes. It could also be of interest for point counting problems; both on moduli spaces of curves, and on finding the maximal number of points that a pointed hyperelliptic curve over a given finite field may have.

关键词： hypereUiptic curves hyperelliptic curve cryptosystems Jacobians isomorphism classes stabilizer

An uncommon source of upper gastrointestinal bleeding:epiphrenic esophageal diverticulum

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Gastroenterology Report 2017年第4期5卷 313-315,I0003页

作者： chung Sang tse Neil D.Parikh Department of Internal Medicine Mayo ClinicRochesterMNUSA Division of Gastroenterology Department of Internal MedicineYale School of MedicineNew HavenCTUSA

Esophageal diverticula are rare findings that have an estimated incidence of 1 per 500000 people per year,even though acute upper gastrointestinal bleeding is a relatively common medical emergency with an incidence of up to 150 per 100000 people per year and a mortality rate of 7-14%.An 83-year-old man presented with hematemesis and *** upper endoscopy revealed an esophageal diverticulum,within which was an adherent *** of the clot identified a bleeding vessel within the diverticulum;this was successfully clipped and hemostasis was *** the best of our knowledge,this is the first case report of a bleeding epiphrenic esophageal diverticulum that was successfully managed endoscopically with hemostatic clips *** rare,our case serves as a reminder that bleeding epiphrenic esophageal diverticula can present as massive upper gastrointestinal bleeding and urgent endoscopic therapy can be life-saving.

关键词： upper gastrointestinal bleed epiphrenic esophageal diverticulum esophago-gastroduodenoscopy

Glucose Oxidase/Polypyrrole Biosensor Fabricated by Galvanostatic Electropolymerization Accompanied with a Potential Jumping

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稀有金属材料与工程 2006年第A03期35卷 277-281页

作者： yuh-Ming Uangl Hung-Te chung tse-Chuan Chou Department of Chemical Engineering WuFeng Institute of TechnologyChiayiTaiwan62153China Dpartment of Chemical Engineering National Cheng Kung UniversityTainanTaiwan70101China

A galvanostatic glucose oxidase (GOD_x)/polypyrrole (Ppy) biosensor fabricated through a potential jumping process was *** spite of the instantaneous voltage jumping from 0.95 V to 1.7 V versus Ag/AgCl in the galvanostatic polymerization of pyrrole with commercial GOD_x,this GOD_x enzyme still could be successfully bundled with polypyrrole (Ppy).And,the results also confirmed that this glucose sensor not only possessed of better sensitivity to glucose than that fabricated from potentiometry or mild voltage elevating galvanometry for the similar preparing conditions but also exhibited two-week long-term ***,the kinetic data of Michalis constant (K_m) and Maximum current (I_m) for the optimized sensor were *** discovery this electro-modification process may disclose a novel method for fabricating the other enzyme biosensors.

关键词： conformation conducting galvanostatic dentritic jumping

Surgical intervention for acute pancreatitis in the COVID-19 era

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World Journal of Clinical Cases 2022年第31期10卷 11292-11298页

作者： yu-Jang Su tse-Hao Chen Toxicology Division Emergency DepartmentMacKay Memorial HospitalTaipei 10449Taiwan Department of Medicine MacKay Medical CollegeNew Taipei 252Taiwan Department of Nursing Yuanpei University of Medical TechnologyHsinChu 300Taiwan Department of Nursing MacKay Junior College of MedicineNursingand ManagementNew Taipei 25245Taiwan Emergency Medicine MacKay Memorial HospitalTaipei 10449Taiwan

Approximately 15%-19%of patients with severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)infections develop gastrointestinal *** pancreatitis(AP)has been reported in 0.1%of patients with coronavirus disease 2019(COVID-19).Biliary AP was most common(78.4%)before the COVID-19 pandemic;idiopathic AP is most common in patients with COVID-19(up to 57.1%).The number of emergency department presentations decreased by 23.3%during the pandemic and many governments made national recommendations to delay nonurgent endoscopic procedures,leading to decrements of 22%in combined esophagogastroduodenoscopy(EGD)and colonoscopy and 20%in EGD after the COVID-19 *** symptoms and signs of COVID-19-related AP are fever(63%),abdominal pain(58%),respiratory symptoms(40%),nausea and vomiting(39%),and headache(4%).Approximately 5-10%of patients develop necrotizing or hemorrhagic AP,and patients who required surgical intervention had a higher mortality *** to 2019,the rates of elective surgery decreased by 41.8%in 2020;including cholecystectomy(40.1%decrease)and pancreas(111.1%decrease).Surgical volumes also decreased by 18.7%in 2020;device-assisted laparoscopic and robot-assisted procedures reduced by 45.4%and 61.9%during the COVID-19 Lockdown in 2020.

关键词： 2019-nCoV Complications COVID-19 Pancreatitis Surgery

Is necrosectomy obsolete for infected necrotizing pancreatitis? Is a paradigm shift needed?

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World Journal of Gastroenterology 2014年第45期20卷 16925-16934页

作者： yu-chung Chang Department of Surgery Chung Shan Medical University Hospital College of Medicine Chung Shan Medical University

In 1886,Senn stated that removing necrotic pancreatic and peripancreatic tissue would benefit patients with severe acute *** then,necrosectomy has been a mainstay of surgical procedures for infected necrotizing pancreatitis(NP).No published report has successfully questioned the role of ***,however,increasing evidence shows good outcomes when treating walled-off necrotizing pancreatitis without a *** literature concerning NP published primarily after 2000 was reviewed;it demonstrates the feasibility of a paradigm *** majority(75%)of minimally invasive necrosectomies show higher completion rates:between 80%and 100%.Transluminal endoscopic necrosectomy has shown remarkable results when combined with percutaneous drainage or a metallic *** morbidities range from 40%to 92%.Single-digit mortality rates have been achieved with transluminal endoscopic necrosectomy,but not with video-assisted retroperitoneal necrosectomy *** procedures without necrosectomy have evolved from percutaneous drainage to transluminal endoscopic drainage with or without percutaneous endoscopic gastrostomy access for laparoscopic *** series have reached higher success rates of 79%-93%,and even 100%,using transcystic multiple drainage *** is becoming evident that transluminal endoscopic drainage treatment of walledoff NP without a necrosectomy is *** further refinement of the drainage procedures,a paradigm shift from necrosectomy to drainage is inevitable.

关键词： Delay until liquefaction Infected necrotizing pancreatitis Minimally invasive treatment Transluminal endoscopic drainage/necrosectomy Walled-off pancreatic necrosis