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Gastro-esophageal reflux disease symptoms are more common in general practice in Japan

World Journal of Gastroenterology 2007年第31期13卷 4219-4223页

作者： Toshiyasu watanabe Yoshihisa Urita Motonobu Sugimoto Kazumasa Miki Division of Gastroenterology and Hepatology Department of Internal Medicine Toho University School of Medicine Omori Hospital Tokyo Japan Division of Gastroenterology and Hepatology Department of Internal Medicine Toho University School of Medicine Omori Hospital Tokyo Japan Department of General Medicine and Emergency Care and Toho University School of Medicine Omori Hospital Tokyo Japan

To accurately assess the prevalence of GERD symptoms in general practice. METHODS： 4139 consecutive patients （2025 men and 2114 women with a mean age of 43 years）, who first attended the Outpatient Department of General Medicine and Emergency Care at Toho University Omori Hospital, were asked to respond to the F-scale questionnaire regardless of their chief complaints. The questionnaire is a self-report instrument, written in a simple and easy-to- understand language, containing 12 questions. RESULTS： Of 4139 subjects, 1554 patients （37.6%） were identified as GERD according to their F-scale score （〉 7）. However, there were only 45 consultations （1.1%） for typical GERD symptoms. Although GERD symptoms are common in adults of all ages, the prevalence of GERD was highest in the 20-29 years age group and the age group 70-79 years had the lowest prevalence for both males and females. CONCLUSION： Although there was a high rote indicating GERD in our primary care population, only 1.1% of outpatients attended our hospital with a chief complaint of GERD symptoms. Since about one-third of GERD patients are affected by atypical symptoms, general physicians need to be cautious about extrapolating these results to patients with a chief complaint other than typical GERD *** T, Urita Y, Sugimoto M, Miki K. Gastro-esophagea reflux disease symptoms are more common in genera practice in Japan. World J Gastroenterol 2007; 13（31） 4219-4223

关键词： Gastroesophageal reflux disease (GERD) F-scale Questionnaire General practice

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General Regulatory Patterns of Plant Mineral Nutrient Depletion as Revealed by serat Quadruple Mutants Disturbed in Cysteine Synthesis

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Molecular Plant 2010年第2期3卷 438-466页

作者： Mutsumi watanabe Hans-Michael Hubberten Kazuki Saito Rainer Hoefgen Graduate School of Pharmaceutical Sciences Chiba University 1-33 Yayoi-cho Inage-ku Chiba 263-8522 Japan Max-Planck-lnstitut fuer Molekulare Pflanzenphysiologie Wissenschaftspark Golm Am Muehlenberg 1 14476 Potsdam-Golm RIKEN Plant Science Center Tsurumi-ku Yokohama 230-0045 Japan

Sulfate is an essential macronutrient for plants. Plants have developed strategies to cope with sulfate deficiency, and other nutrient ion limitations. However, the regulation of these adaptive responses and the coordinating signals that underlie them are still poorly characterized. O-acetylserine （OAS） is a marker metabolite of sulfate starvation and has been speculated to have a signaling function. OAS is synthesized by the enzyme serine acetyltransferase （SERAT）, which is encoded by five distinct genes in Arabidopsis. We investigated quadruple knockout mutants of SERAT that retained only one functional isoform. These mutants displayed symptoms of sulfate starvation. Furthermore, some of them displayed phenotypes typical of prolonged sulfate starvation, in particular, developmental programs associated with senescence or stress responses. Thus, we compared metabolite and transcriptome data from these mutants with N-, P-, K-, and S-depleted plants. This revealed many similarities with general nutrient-depletion-induced senescence （NuDIS）, in- dicating the recruitment of existing regulatory programs for nutrient-starvation responses. Several candidate genes that could be involved in these processes were identified, including transcription factors and other regulatory proteins, as well as the functional categories of their target genes. These results outline components of the regulatory network controlling plant development under sulfate stress, forming a basis for further investigations to elucidate the complete network. In turn, this will advance our broader understanding of plant responses to a range of other nutrient stresses.

关键词： Abiotic/environmental stress ion/metabolite sensing senescence functional genomics Arabidopsis sulfur.

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An Energy Based Dynamic AODV Routing Protocol in Wireless Ad Hoc Networks

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Computers, Materials & Continua 2020年第4期63卷 353-368页

作者： Wuyungerile Li Baoyintu Bing Jia Junxiu Wang Takashi watanabe College of Computer Inner Mongolia UniversityHohhot Inner Mongolia010021China Graduate School of Information Science and Technology Osaka UniversityOsaka565-0871Japan

In recent years,with the rapid development of the Internet and wireless communication technology,wireless Ad hoc networks have received more *** to the limited transmission range and energy of nodes in Ad hoc networks,it is important to establish a reliable and energy-balanced transmission path in Ad hoc *** paper proposes an energy-based dynamic routing protocol based on the existing AODV routing protocol,which has the following two aspects of improvement:(1)In the route discovery process,a node selects a suitable route from the minimum energy consumption route and the energy-balanced route designed in this paper according to a“Mark”bit that representing remaining energy of a node.(2)Based on(1),a route interruption update strategy was proposed to restart the route discovery process when node energy was used *** results demonstrate that compared with AODV and other existing routing protocols,proposed algorithm can reduce network energy consumption and balance node energy,thus extending the network lifetime.

关键词： Ad hoc networks routing protocol energy network lifetime

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Effect of Injection Position on In-Flight Melting Behavior of Granular Alkali-Free Glass Raw Material in 12-Phase AC Arc Plasma

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Plasma Science and Technology 2009年第6期11卷 699-703页

作者：姚耀春 K.YATSUDA T.watanabe T.YANO National Engineering Laboratory of Vacuum Metallurgy Kunming University of Science and Technology Department of Environmental Chemistry and Engineering Tokyo Institute of TechnologyYokohama 226-8502Japan Department of Chemistry and Materials Science Tokyo Institute of TechnologyTokyo 152-8550Japan

An innovative in-flight glass melting technology with a multi-phase AC arc plasma was developed to save energy and reduce emissions for the glass industry. The effect of the injection position on the in-flight melting behavior of granulated powders was investigated. Results show that the injection position has a strong effect on the melting behavior of alkali-free glass raw material. With the increase in injection distance, the vitrification, decomposition, and particle shrinkage of initial powders are improved. Longer injection distance causes much energy to transfer to particles due to a longer residence time of powder in the high temperature zone. The high vitrification and decomposition degrees indicate that the new in-flight melting technology with 12-phase AC arc can substantially reduce the melting and refining time for glass production.

关键词： 12-phase AC arc plasma in-flight melting technology heat transfer glass production

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早稻田大学国际文学馆（村上春树图书馆）

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城市环境设计 2024年第1期147卷 116-123页

作者：渡边启太渡部悠川澄·小林研二写真事务所

我们将早稻田大学校园内的4号楼改建为新的村上春树图书馆，成为一条穿过原有建筑的“木隧道”。木隧道超越了时间和空间，我们将村上春树小说中连接不同维度的“隧道”转译为建筑空间。我们通过将外墙重新漆成白色涂装和原来的建筑，...

我们将早稻田大学校园内的4号楼改建为新的村上春树图书馆，成为一条穿过原有建筑的“木隧道”。木隧道超越了时间和空间，我们将村上春树小说中连接不同维度的“隧道”转译为建筑空间。我们通过将外墙重新漆成白色涂装和原来的建筑，强调了新建的三维木屏风雨棚。雨棚作为隧道入口的指示，也代表了维度之间的边界。这条木制隧道纵向贯穿了原有的楼板，同时用作书架、剧院和演讲厅。20世纪是混凝土的时代，混凝土具有“坚硬”和“冰冷”的特性。相比之下，对于这个图书馆，我们想象了一条隧道，通过使用细腻柔软的木材来保护我们、培育梦想。

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Saturated hydraulic conductivity of compacted bentonite-sand mixtures before and after gas migration in artificial seawater

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第1期15卷 216-226页

作者： Yasutaka watanabe Shingo Yokoyama Misato Shimbashi Yoichi Yamamoto Takahiro Goto Sustainable System Research Laboratory Central Research Institute of Electric Power IndustryChibaJapan Science and Technology Department Nuclear Waste Management Organization of JapanTokyoJapan

To understand the self-healing property of an engineered barrier for radioactive waste disposal,the hydraulic conductivity of compacted bentoniteesand mixtures saturated with artificial seawater(SW)before and after gas migration was ***-and Ca-bentonites were mixed with fine sand at a ratio of 70%bentonite in dry *** aspects were considered during the experiment:the hydraulic conductivity of the specimen that was resaturated after gas migration and the distribution of water content immediately after gas migration to study gas migration *** gas migrated through the entire cross-section of the specimen,and gas breakthrough occurred in the equilibrium swelling pressure range ***,the gas flow rate reached a sufficient large value when the gas pressure was approximately twice the equilibrium axial pressure(the sum of swelling and confining pressures),which excluded the back *** the gas migration pathway was not visible when the specimen was observed immediately after gas migration,the water content distribution showed that several parts of the specimen with lower water content were connected in the direction of gas *** resaturation,the change in permeability was within a limited rangedtwo to three times larger than that before gas migration for each type of bentonite in *** slight change suggests that gas migration creates a pore structure that cannot be sealed via crystalline swelling of montmorillonite in SW,even if highly compacted bentonite is used under a constant-volume condition.

关键词： Bentonite Gas migration Hydraulic conductivity Seawater(SW) Self-healing

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Proposal of Walking to Prevent a Fall of a Planetary Exploration Legged Rover Using Effect of Loose Soil Caused by a Propagation of Vibration

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Journal of Artificial Intelligence and Technology 2021年第3期1卷 153-165页

作者： Tomohiro watanabe Kojiro Iizuka Graduate School of Engineering and Science Shibaura Institute of TechnologySaitama City 337-8570Japan Department of Systems and Engineering and Science Shibaura Institute of TechnologySaitama City 337-8570Japan

In this study,a walking method that prevents a fall of the planetary exploration-legged rover is *** the proposed walking method,the leg is sunk by giving vibration to the *** posture of the rover is changed to prevent a fall of the rover by sinking the ***,the relationship between the kind of vibration and the subsidence of the leg is *** this experimental result,the leg is shown to be easy to sink to the ground by giving ***,the larger the vibratory force is,the easier the leg sinks to the ***,the legged testbed walks on the loose ground with a slope using the proposed walking *** this experimental result,the testbed is difficult to fall down when it uses the proposed ***,the angle of a slope that the testbed can walk becomes large by using the proposed walking.

关键词： planetary exploration legged rover fall prevention loose ground vibration

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Japan's experience of energy saving and business model for low-carbon economy

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Chinese Journal of Population,Resources and Environment 2013年第4期11卷 288-298页

作者： Satoshi watanabe Makoto Nishimura Graduate School of Economics Nagoya University

The purpose of this paper is to clarify the questions concerning stimulation of the innovation and the diffusion of energy saving or *** do so,this paper explains using two cases of Japan-energy saving innovation after the Oil Shock and the eco points *** the case after the oil shock,we explain the energy saving trend after the Oil Shock and the factors *** we put forward the business model for the low-carbon ***,we analyze the case of the eco points system from 2009-2011 in Japan and explain the significance of the business model for diffusion of the low-carbon products.

关键词： energy saving innovation eco-point system business model low-carbon economy Japan

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Newly emerging standard chemotherapies for gastric cancer and clinical potential in elderly patients

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World Journal of Gastrointestinal Oncology 2009年第1期1卷 47-54页

作者： Shinichi Sakuramoto Keishi Yamashita Masahiko watanabe Department of Surgery Kitasato University Hospsital

With the increase in average life expectancy,the rate of occurrence of gastric cancer in elderly patients is also *** many clinical trials have been conducted to examine the effect of chemotherapy treatment on gastric cancer,age limits for eligible subjects have prevented the establishment of standards for chemotherapy in elderly patients with gastric *** of March 2009,evidence-based standard chemotherapy regimens were *** the Western world,debates centered on the ECF(Epirubicin/cisplatin/5FU) or DCF(Docetaxel/cisplatin/5-FU) regimens based on the phase □ randomized controlled trial at the Royal Marsden Hospital(RMH) or the V325 study,*** JCOG9912 and SPIRITS trials emerged from Japan indicating attractive regimens that include S-1 for advanced gastric cancer *** these active anticancer drugs,the trials that studied the eff icacy of adjuvant therapies or surgical approaches,such as the Int-116/MAGIC/ACTS-GC trials,have actually succeeded in demonstrating the benefits of adjuvant therapies in gastric cancer *** cases of gastric cancer in elderly patients,treatment policies should consider these studies while analyzing not only the therapeutic effects but also drug toxicity,individual general health conditions,and social factors to select treatments that emphasize quality of life.

关键词： Gastric cancer Elderly patients Chemotherapy Regimen comparison

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Liquid biopsy leads to a paradigm shift in the treatment of pancreatic cancer

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World Journal of Gastroenterology 2022年第46期28卷 6478-6496页

作者： Fumiaki watanabe Koichi Suzuki Hiroshi Noda Toshiki Rikiyama Department of Surgery Saitama Medical CenterJichi Medical UniversitySaitama 330-8503Japan

Pancreatic ductal adenocarcinoma(PDAC)is one of the most *** 5-year survival rate is very *** recent induction of neoadjuvant chemotherapy and improvements in chemotherapy for patients with pancreatic cancer have resulted in improved survival ***,the prognosis of pancreatic cancer is still *** dramatically improve the prognosis,we need to develop more tools for early diagnosis,treatment selection,disease monitoring,and response rate ***,liquid biopsy(circulating free DNA,circulating tumor DNA,circulating tumor cells,exosomes,and microRNAs)has caught the attention of many researchers as a new biomarker that is minimally invasive,confers low-risk,and displays an overall state of the ***,liquid biopsy does not employ the traditional difficulties of obtaining tumor samples from patients with advanced PDAC to investigate their molecular biological *** addition,it allows for long-term monitoring of the molecular profile of tumor *** could help in identifying tumor-specific alterations that use the target structure for tailor-made *** this review,we highlighted the latest discoveries and advances in liquid biopsy technology in pancreatic cancer research and showed how it can be applied in clinical practice.

关键词： Pancreatic cancer Cell-free DNA Circulating tumor DNA Circulating tumor cells Exosomes MicroRNAs

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