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Efficacy and safety of botulinum toxin in treatment of anismus: A systematic review

World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第3期7卷 453-462页

作者： Sameh Hany Emile Hossam Ayman Elfeki Hosam Ghazy Elbanna mohamed youssef Waleed Thabet Tito M Abd El-Hamed Basem Said Ahmed Lotfy General Surgery Department Colorectal Surgery Unit Mansoura Faculty of Medicine Mansoura University

AIM: To evaluate the efficacy and safety of botulinum toxin type A(BTX-A) in the management of patients with anismus. METHODS: An organized search of published literature was conducted using electronic databases including: Pub Med/MEDLINE, and Cochrane Central Register of Control ed Trials, also an internet-based search using "Google Scholar" service was conducted. Both comparative and observational studies were included. We excluded irrelevant articles, editorials, case reports, reviews, and meta-analyses. The studies that followed the patients less than 6 mo were excluded. Variables collected were demographic data of the patients, technique of BTX-A injection and number of sessions, short-term and longterm clinical improvement, post-injection changes in electromyography(EMG), defecography, manometry, and balloon expulsion test, and complications recorded after BTX-A ***: Seven studies comprising 189 patients were included in the review. The median age of the patients was 41.2 years and female-to-male ratio was 1.3:1. The median dose of BTX-A injected per procedure was 100 IU(range, 20-100 IU). Lateral injection was done in five trails and combined lateral and posterior injections in two trials. Three studies used endorectal ultrasonographyguided technique, one study used EMG-guided technique,whereas the remaining three studies used manual palpation with the index finger. The median percentage of patients who reported initial improvement of symptoms was 77.4%(range 37.5%-86.7%), this percentage declined to a median of 46%(range 25%-100%) at 4 mo after injection of BTX-A. Rates of improvement evaluated by balloon expulsion test, EMG, and defecography ranged between(37.5%-80%),(54%-86.7%), and(25%-86.6%), respectively. Fourteen(7.4%) patients developed complications after injection of BTX-A. Complication rates across the studies ranged from 0% to 22.6%. CONCLUSION: Initial satisfactory improvement of symptoms after BTX-A injection remarkably deteriorate

关键词： Botulinum toxin Botulinum toxin type A Botox Anismus Puborectalis syndrome Efficacy

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Multivariate Deep Learning Approach for Electric Vehicle Speed Forecasting

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Big Data Mining and Analytics 2021年第1期4卷 56-64页

作者： youssef Nait Malek Mehdi Najib mohamed Bakhouya Mohammed Essaaidi LERMA Lab College of Engineering and ArchitectureInternational University of RabatSala Al Jadida 11100Morocco ENSIAS Mohamed V UniversityAgdal Rabat 10112Morocco TICLab College of Engineering and ArchitectureInternational University of RabatSala Al Jadida 11100Morocco LERMA Lab College of EngineeringInternational University of RabatSala Al Jadida 11100Morocco

Speed forecasting has numerous applications in intelligent transport systems’design and control,especially for safety and road efficiency *** the field of electromobility,it represents the most dynamic parameter for efficient online in-vehicle energy ***,vehicles’speed forecasting is a challenging task,because its estimation is closely related to various features,which can be classified into two categories,endogenous and exogenous *** features represent electric vehicles’characteristics,whereas exogenous ones represent its surrounding context,such as traffic,weather,and road *** this paper,a speed forecasting method based on the Long Short-Term Memory(LSTM)is *** LSTM model training is performed upon a dataset collected from a traffic simulator based on real-world data representing urban *** proposed models are generated for univariate and multivariate scenarios and are assessed in terms of accuracy for speed *** results show that the multivariate model outperforms the univariate model for short-and long-term forecasting.

关键词： Electric Vehicle(EV) multivariate Long Short-Term Memory(LSTM) speed forecasting deep learning

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Carbonate rocks resistivity determination using dual and triple porosity conductivity models

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Petroleum 2020年第1期6卷 35-42页

作者： Zeeshan Tariq mohamed Mahmoud Hasan Al-youssef Mohammad Rasheed Khan Department of Petroleum Engineering King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia

The rocks may be classified as Archie rocks or Non-Archie rocks,depending on the link between pore structure and resistivity of the *** carbonate rocks,keeping this factor in view,the applicability of Archie's law tends to be unreasonable and employing Archie's equation will ultimately lead to inaccurate estimates of the water *** investigators have reported models that forms a link between laboratory results and field well logs to determine water saturation in intricate pore *** case of complex systems,Archie's law fails to correctly define the resistivity-index *** addition,it is imperative to carry out investigations at lower saturation values in order to elaborate the non-Archie *** brings the dual and triple porosity conductivity models into the *** these models are essential in defining the considerable changes of the resistivity-index curves,both qualitatively and *** linkage between the two models is depicted electrically in series or in ***,it is possible to have a combination of the two *** a result,the experimental results can be modeled accurately using least *** work presents two models to determine water saturation in carbonate rocks,containing dual and triple porosity *** study also investigates the impact of different influential parameters such as saturation exponents,conductivity ratios,and pore volume fraction of each network systems,on the new ***,the effect of each parameter is individually studied and the sensitivity analysis on the RI curves is produced.A new approach to apply these models is also explained which requires the use of NMR log,mercury injection capillary pressure(MICP)measurement,and simple plotting techniques to determine the water *** proposed new models help petrophysicists to estimate water saturation in Non-Archie rocks,containing double and triple porosity network systems.

关键词： Dual porosity Triple porosity Carbonate rocks Water saturation models

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New Sobolev-Weinstein Spaces and Applications

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Journal of Mathematical Research with Applications 2022年第3期42卷 247-260页

作者： Hassen BEN mohamed youssef BETTAIBI Department of Mathematics Faculty of Sciences Gabes University

In this paper, we consider the generalized Weinstein operator■ we introduce new Sobolev-Weinstein spaces denoted ■associated with the generalized Weinstein operator and we investigate their properties. Next, as appl... 详细信息

关键词： generalized Weinstein operator generalized Weinstein transform sobolev spaces extremal functions reproducing kernels

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Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies

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World Journal of Gastroenterology 2017年第5期23卷 743-750页

作者： youssef Alhmada Denis Selimovic Fadi Murad Sarah-Lilly Hassan youssef Haikel Mossaad Megahed Matthias Hannig mohamed Hassan Department of Pathology University of Mississippi Medical Center Graduate School of Dental Medicine Depart-ment of Restorative DentistryDivision of Oral Health ScienceHokkaido University Clinic of Operative Dentistry Periodontology and Preventive DentistrySaarland University Department of Surgery Tulane University School of Medicine Clinic of Dermatology University Hospital of Aachen Institut National de la Santéet de la RecherchéMédicale Department of Operative Dentistry and Endodontics Dental FacultyUniversity of Strasbourg

In addition to its contributing role in the development of chronic liver diseases, chronic hepatitis C virus (HCV) infection is associated with extrahepatic manifestations, particularly, cutaneous-based disorders including those with pruritus as a symptom. Pruritus is frequently associated with the development of chronic liver diseases such as cholestasis and chronic viral infection, and the accumulation of bile acids in patients’ sera and tissues as a consequence of liver damage is considered the main cause of pruritus. In addition to their role in dietary lipid absorption, bile acids can trigger the activation of specific receptors, such as the G protein-coupled bile acid receptor (GPBA/ TGR5). These types of receptors are known to play a crucial role in the modulation of the systemic actions of bile acids. TGR5 expression in primary sensory neurons triggers the activation of the transient receptor potential vanilloid 1 (TRPV1) leading to the induction of pruritus by an unknown mechanism. Although the pathologic phenomenon of pruritus is common, there is no uniformly effective therapy available. Understanding the mechanisms regulating the occurrence of pruritus together with the conduction of large-scale clinical and evidence-based studies, may help to create a standard treatment protocol. This review focuses on the etiopathogenesis and treatment strategies of pruritus associated with chronic HCV infection.

关键词： Hepatitis C virus Pruritus Cholestasis Autotoxin Lysophosphatidic acid PI3 kinase

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Correlation between DKK-1 Level and Bone Density Status in Children on Maintenance Haemodialysis

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Open Journal of Nephrology（肾脏病） 2024年第1期 48页

作者： Manal Abd El-Salam Marwa mohamed Anwar Rasha Mahmoud Gouda Naglaa Abou El Fattah Nadia youssef Riad

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Chemical compounds as well as antioxidant and litholytic activities of Arbutus unedo L. leaves against calcium oxalate stones

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Journal of Integrative Medicine 2019年第6期17卷 430-437页

作者： Rabie Kachkoul Tarik Squalli Housseini mohamed Mohim Radouane El Habbani youssef Miyah Anissa Lahrichi Laboratory of Biochemistry Faculty of Medicine and PharmacyUniversity Sidi Mohammed Ben AbdellahBP 1893FezMorocco Faculty of Science and Technology University Sidi Mohammed Ben AbdellahBP 2202FezMorocco Laboratory of Molecular Bases in Human Pathology and Therapeutic Tools Faculty of Medicine and PharmacyUniversity Sidi Mohammed Ben AbdellahBP 1893FezMorocco Department of Nephrology University Hospital HassanⅡBP 1835AtlasFezMorocco

Objective: The present study aimed to quantify and identify the bioactive compounds of the Arbutus unedo L. leaves in order to evaluate both their antioxidant properties and litholytic activities against calcium oxalate ***: This survey was carried out using hydroalcoholic extract(***) and infusion(***) of A. unedo leaves. The quantification of phenolic compounds, flavonoids, flavonols and anthocyanins was done by spectrophotometric methods and identification of chemical components was performed by ultraperformance liquid chromatography with photodiode array and electrospray ionization tandem mass spectrometry. Antioxidant activity was measured using the 1,1-diphenyl-2-picrylhydrazyl(DPPH)method and by the ferric reducing/antioxidant power(FRAP) assay. Litholytic activity of *** and *** was studied using a special model that resembles circuitry of the urinary ***: *** showed greater antioxidant efficacy than ***(P < 0.05). Its higher efficiency was shown via the values of median inhibitory concentration, which was close to(76.14 ± 0.91) mg/mL for *** versus(202.64 ± 5.77) lg/mL for *** using the DPPH method, and(53.77 ± 0.81) lg/mL for *** versus(236.86 ± 31.90) lg/mL for ***, using FRAP method. *** exhibited significantly higher litholytic activity compared to ***(P < 0.05), with dissolution values of 31.03% ± 0.63% versus 14.55% ± 0.65%, ***: Overall, the results suggest that the A. unedo is rich in bioactive compounds, and possesses antioxidant and litholitic abilities that are worthy of further study.

关键词： Antioxidant activity Arbutus unedo L Litholytic activity Phenolic compounds Liquid chromatography Photodiode array Electrospray ionization tandem Mass spectrometry

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Behavior of raft on settlement reducing piles:Experimental model study

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Journal of Rock Mechanics and Geotechnical Engineering 2013年第5期5卷 389-399页

作者： Basuony El-Garhy Ahmed Abdel Galil Abdel-Fattah youssef mohamed Abo Raia Civil Engineering Department Faculty of Engineering Minufiya University

An experimental program is conducted on model piled rafts in sand *** experimental program is aimed to investigate the behavior of raft on settlement reducing *** testing program includes tests on models of single pile,unpiled rafts and rafts on 1,4,9,or 16 *** model piles beneath the rafts are closed ended displacement piles installed by *** lengths of piles are used in the experiments to represent slenderness ratio,L/D,of 20,30 and 50,*** dimensions of the model rafts are 30 cm×30 cm with different thickness of 0.5 cm,1.0 cm or 1.5 *** raft-soil stiffness ratios of the model rafts ranging from 0.39 to 10.56 cover flexible to very stiff *** improvement in the ultimate bearing capacity is represented by the load improvement ratio,LIR,and the reductions in average settlement and differential settlement are represented by the settlement ratio,SR,and the differential settlement ratio,DSR,*** effects of the number of settlement reducing piles,raft relative stiffness,and the slenderness ratio of piles on the load improvement ratio,settlement ratio and differential settlement ratio are presented and *** results of the tests show the effectiveness of using piles as settlement reduction measure with the *** the number of settlement reducing piles increases,the load improvement ratio increases and the differential settlement ratio decreases.

关键词： Raft Settlement reducing piles Piled raft Model tests Sand soil

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Anti-inflammatory and analgesic properties of Moroccan medicinal plants:Phytochemistry,in vitro and in vivo investigations,mechanism insights,clinical evidences and perspectives

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Journal of Pharmaceutical Analysis 2022年第1期12卷 35-57页

作者： Abdelhakim Bouyahya Fatima-Ezzahrae Guaouguaou Nasreddine El Omari Naoual El Menyiy Abdelaali Balahbib mohamed El-Shazly youssef Bakri Laboratory of Human Pathologies Biology Department of BiologyFaculty of Sciencesand Genomic Center of Human PathologiesFaculty of Medicine and PharmacyMohammed Ⅴ University in Rabat4014Morocco Mohammed Ⅴ University in Rabat LPCMIOMaterials Science Center(MSC)Ecole Normale SuperieureRabat1014Morocco Laboratory of Histology Embryology and CytogeneticFaculty of Medicine and PharmacyMohammed Ⅴ University in Rabat10100Morocco Department of Biology Faculty of Sciences Dhar El MahrazUniversity Sidi Mohamed Ben AbdellahFez30003Morocco Laboratory of Zoology and General Biology Faculty of SciencesMohammed Ⅴ University in RabatRabat1014Morocco Department of Pharmacognosy Faculty of PharmacyAin-Shams UniversityCairo11566Egypt Department of Pharmaceutical Biology Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt

Moroccan medicinal plants exhibit several pharmacological properties such as antimicrobial,anticancer,antidiabetic,analgesic,and anti-inflammatory effects,which are related to the presence of numerous bioactive compounds,including phenolic acids,flavonoids,and *** the present review,we systematically evaluate previously published reports on the anti-inflammatory and analgesic effects of Moroccan medicinal *** in vitro investigations revealed that Moroccan medicinal plants inhibit several enzymes related to inflammatory processes,whereas in vivo studies noted significant anti-inflammatory and analgesic effects as demonstrated using different experimental *** bioactive compounds exhibiting in vitro and in vivo anti-inflammatory and analgesic effects,with diverse mechanisms of action,have been *** plants and their bioactive compounds reveal specific secondary metabolites that possess important anti-inflammatory effects in clinical *** review proposes the potential applications of Moroccan medicinal plants as sources of anti-inflammatory and analgesic agents.

关键词： Inflammation Medicinal plants Bioactive compounds Anti-inflammatory Analgesic

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CactiViT:Image-based smartphone application and transformer network for diagnosis of cactus cochineal

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Artificial Intelligence in Agriculture 2023年第3期9卷 12-21页

作者： Anas Berka Adel Hafiane youssef Es-Saady mohamed El Hajji Raphaël Canals Rachid Bouharroud IRF-SIC Laboratory Ibnou Zohr UniversityBP 8106—Cite DakhlaAgadir 80000Morocco INSA CVL University of OrleansPRISME LaboratoryEA 4229Bourges 18022France Regional Center for Agricultural Research of Agadir National Institute of Agricultural ResearchAvenue EnnasrPoB 415 Rabat PrincipaleRabat 10090Morocco

The cactus is a plant that grows in many rural areas,widely used as a hedge,and has multiple benefits through the manufacture of various cosmetics and other ***,this crop has been suffering for some time from the attack of the carmine scaleDactylopius opuntia(Hemiptera:Dactylopiidae).The infestation can spread rapidly if not treated in the early *** solutions consist of regular field checks by the naked eyes carried out by *** major difficulty is the lack of experts to check all fields,especially in remote *** addition,this requires time and *** the need for a system that can categorize the health level of cacti *** date,deep learning models used to categorize plant diseases from images have not addressed the mealy bug infestation of cacti because computer vision has not sufficiently addressed this *** there is no public dataset and smartphones are commonly used as tools to take pictures,it might then be conceivable for farmers to use them to categorize the infection level of their *** this work,we developed a system called CactiVIT that instantly determines the health status of cacti using the Visual image Transformer(ViT)*** also provided a new image dataset of cochineal infested cacti.1 Finally,we developed a mobile application that delivers the classification results directly to farmers about the infestation in their fields by showing the probabilities related to each *** study compares the existing models on the new dataset and presents the results *** VIT-B-16 model reveals an approved performance in the literature and in our experiments,in which it achieved 88.73%overall accuracy with an average of+2.61%compared to other convolutional neural network(CNN)models that we evaluated under similar conditions.

关键词： Cactus Cochineal Smartphones Classification VIT Deep learning

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