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World Journal of Gastroenterology 2007年第45期13卷 6112-6114页

作者： Jun-Seok Park Sung-Bum Kang Duck-Woo kim Na-young kim Kyoung-Ho Lee young-hoon kim Department of Surgery Chung-Ang University Hospital Seoul National University Bundang Hospital Seongnam-si Gyeonggi-do 463-707 Korea Department of Surgery Seoul National University Bundang Hospital Seongnam-si Gyeonggi-do 463-707 Korea Department of Internal Medicine Seoul National University Bundang Hospital Seongnam-si Gyeonggi-do 463-707 Korea Department of Diagnostic Radiology Seoul National University Bundang Hospital

There are no reports regarding perforation of the colorectum induced by anorectal manometry. We report two cases of colorectal perforation that occurred during manometry in the patients undergoing restorative proctectomy for distal rectal cancer. In the first patient, computed tomography showed an extraperitoneal perforation in the pelvic cavity and a rupture of the rectal wall. A localized perforation into the retroperitoneum was managed conservatively. In the second patient, a 3 cm linear colon rupture was detected above the anastomotic site. A primary closure of the perforated colon and proximal ileostomy were conducted, but the patient died 2 wk later. We hypothesize that the perforation induced by anorectal manometry may be associated with the relative weakening of the proximal bowel wall due to anastomosis, decreased compliance, and abnormal rectal sensation. We suggest that measurement of the maximum tolerable volume should not be routinely performed alter restorative proctectomy for distal rectal cancer.

关键词： Iatrogenic perforation Anorectal manometry Rectal cancer Low anterior resection

Utilizing 3,4-ethylenedioxythiophene(EDOT)-bridged non-fullerene acceptors for efficient organic solar cells

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Journal of Energy Chemistry 2022年第2期31卷 194-204页

作者： Sung Jae Jeon young hoon kim Ie Na kim Nam Gyu Yang Ji Hee Yun Doo Kyung Moon Nano and Information Materials(NIMs)Laboratory Department of Chemical EngineeringKonkuk University120 Neungdong-ro Gwangjin-guSeoul 05029South Korea Department of Academy of Applied Science and Technology Konkuk University120 Neungdong-ro Gwangjin-guSeoul 05029South Korea

A rational design of efficient low-band-gap non-fullerene acceptors(NFAs)for high-performance organic solar cells(OSCs)remains challenging;the main constraint being the decrease in the energy level of the lowest unoccupied molecular orbitals(LUMOs)as the bandgap of A-D-A-type NFAs ***,the short current density(J_(sc))and open-circuit voltage(V_(oc))result in a trade-off relationship,making it difficult to obtain efficient ***,three NFAs(IFL-ED-4 F,IDT-ED-4 F,and IDTT-ED-2 F)were synthesized to address the above-mentioned issue by introducing 3,4-ethylenedioxythiophene(EDOT)as aπ-*** NFAs exhibit relatively low bandgaps(1.67,1.42,and 1.49 eV,respectively)and upshifted LUMO levels(-3.88,-3.84,and-3.81 eV,respectively)compared with most reported low-band-gap ***,the photovoltaic devices based on IDT-ED-4 F blended with a PBDB-T donor polymer showed the best power conversion efficiency(PCE)of 10.4%with a high J_(sc) of 22.1 mA cm^(-2) and Voc of 0.884 V among the examined *** contrast,IDTT-ED-4 F,which was designed with an asymmetric structure of the D-p-A type,showed the lowest efficiency of 1.5%owing to the poor morphology and charge transport properties of the binary ***,when this was introduced as the third component of the PM6:BTP-BO-4 Cl,complementary absorption and cascade energy-level alignment between the two substances could be ***,the IDTT-ED-4 F-based ternary blend device not only improved the Jscand Voc,but also achieved a PCE of 15.2%,which is approximately 5.3%higher than that of the reference device with a minimized energy loss of 0.488 *** addition,the universality of IDTT-ED-2 F as a third component was effectively demonstrated in other photoactive systems,specifically,PM6:BTPe C9 and PTB7-Th:IEICO-4 *** work facilitates a better understanding of the structure–property relationship for utilizing efficient EDOT-bridged NFAs in high-performance OSC applications.

关键词： Non-fullerene acceptor 3,4-ethylenedioxythiophene Organic solar cell π-bridge π-spacer

Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第26期18卷 3426-3434页

作者： Yang Hyun Baek Kyoung Tae kim Sung Wook Lee Jin Sook Jeong Byeong Ho Park Kyung Jin Nam Jin Han Cho young hoon kim young hoon Roh Hyung Sik Lee young Min Choi Sang young Han Department of Internal Medicine Dong-A University College of MedicineBusan 602-103South Korea Department of Pathology Dong-A University College of MedicineBusan 602-103South Korea Department of Radiology Dong-A University College of MedicineBusan 602-103South Korea Department of Surgery Dong-A University College of MedicineBusan 602-103South Korea Department of Radiation Oncology Dong-A University College of MedicineBusan 602-103South Korea

AIM:To investigate the efficacy of hepatic arterial infusion chemotherapy(HAIC) using floxuridine(FUDR) in patients with advanced hepatocellular carcinoma(HCC) confined to the ***:Thirty-four patients who had advanced HCC with unresectability or unsuccessful previous therapy in the absence of extrahepatic metastasis were treated with intra-arterial FUDR chemotherapy at ourhospital between March 2005 and May *** the 34 patients,9 patients were classified as Child class C,and 18 patients had portal vein tumor thrombus(PVTT).One course of chemotherapy consisted of continuous infusion of FUDR(0.3 mg/kg during day 1-14) and dexamethasone(10 mg on day 1,4,7 and 11),and this treatment was repeated every 28 ***:Two patients(5.9%) displayed a complete response,and 12 patients(35.3%) had a partial *** tumor control rate was 61.8%.The median overall survival times were 15.3 mo,12.4 mo and 4.3 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0392).The progression-free survival was 12.9 mo,7.7 mo and 2.6 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0443).The cumulative survival differed significantly according to the Child-Pugh classification and the presence of *** addition to hepatic reserve capacity and PVTT,the extent of HCC was an independent factor in determining a poor *** most common adverse reactions to HAIC were mucositis,diarrhea and peptic ulcer disease,but most of these complications were improved by medical treatment and/or a delay of ***:The present study demonstrates that intra-arterial FUDR chemotherapy is a safe and effective treatment for advanced HCC that is recalcitrant to other therapeutic modalities,even in patients with advanced cirrhosis.

关键词： Hepatic arterial infusion chemotherapy Floxuridine Advanced hepatocellular carcinoma Child-Pugh classification Portal vein tumor thrombus

Segmented tomographic evaluation of structural degradation of carbon support in proton exchange membrane fuel cells

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Journal of Energy Chemistry 2022年第11期31卷 359-367,I0010页

作者： Jung A.Hong Min-Hyoung Jung Sung Yong Cho Eun-Byeol Park Daehee Yang young-hoon kim Sang-Hyeok Yang Woo-Sung Jang Jae Hyuck Jang Hyo June Lee Sungchul Lee Hu young Jeong young-Min kim Department of Energy Science Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Fuel Cell Core Parts Development Cell Hyundai Mobis Co.Ltd.Uiwang 16082Republic of Korea Electron Microscopy&Spectroscopy Team Korea Basic Science Institute(KBSI)Daejeon 34133Republic of Korea Graduate School of Semiconductor Materials and Devices Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

The variation of the three-dimensional(3D)structure of the membrane electrode of a fuel cell during proton exchange cycling involves the corrosion/compaction of the carbon *** increasing degradation of the carbon structure continuously reduces the electrocatalytic performance of proton exchange membrane fuel cells(PEM-FCs).This phenomenon can be explained by performing 3D tomographic analysis at the ***,conventional tomographic approaches which present limited experimental feasibility,cannot perform such evaluation and have not provided sufficient structural information with statistical significance thus ***,a reliable methodology is required for the 3D geometrical evaluation of the carbon ***,we propose a segmented tomographic approach which employs pore network analysis that enables the visualization of the geometrical parameters corresponding to the porous carbon structure at a high *** approach can be utilized to evaluate the 3D structural degradation of the porous carbon structure after cycling in terms of local surface area,pore size distribution,and their 3D *** geometrical parameters of the carbon body were demonstrated to be substantially reduced owing to the cycling-induced *** information enables a deeper understanding of the degradation phenomenon of carbon supports and can contribute to the development of stable PEM-FC electrodes.

关键词： Electron tomography Fuel cell Proton exchange membrane Membrane electrode assembly Carbon corrosion

Interleukin-2 gene-encoded stromal cells inhibit the growth of metastatic cholangiocarcinomas

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World Journal of Gastroenterology 2006年第12期12卷 1889-1894页

作者： Myung-Hwankim Sang Soo Lee Sung Koo Lee Seung-Gyu Lee Chul-Won Suh Gyung-Yub Gong Jung-Sun Park young-hoon kim Sang-Hee kim Department of Gastroenterology University of Ulsan College of MedicineAsan Medical CenterSeoulKorea Department of Surgery University of Ulsan College of MedicineAsan Medical CenterSeoulKorea Department of Oncology University of Ulsan College of MedicineAsan Medical CenterSeoul Korea Department of Pathology University of Ulsan College of MedicineAsan Medical CenterSeoulKorea Asan Institute for Life Sciences.Seoul Korea

AIM： To demonstrate bone marrow stromal cells （BMSCs） can be used as an attractive target for genetic modification in the treatment of malignant diseases. METHODS： Using a hamster model of biliary cancer, we investigated the therapeutic effects of interleukin-2 （IL-2） gene-modified BHSCs. Syrian golden hamsters were injected via the femoral vein with 5×10^5 cells of the KIGB-5 biliary cancer cell line （n=20）. One week later, the hamsters were injected intraperitoneally with BMSCs containing Ad/hIL-2 and Ad/△E1, unmodified BHSCs, or RPHI only （control） and observed for 12 wk （n=5/each group）. RESULTS： All hamsters treated with BMSCs containing Ad/hIL-2 survived with no evidence of the disease during this period. In contrast, hamsters in the other three groups showed disseminated metastases involving the lungs as eady as 4 wk.CONCLUSION： Ad/IL-2 therapy is effective in the treatment of biliary cancer.

关键词： Bone marrow stromal cell Adenovirus/hIL-2 Biliary cancer

Sex-based differences in histology,staging,and prognosis among 2983 gastric cancer surgery patients

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World Journal of Gastroenterology 2022年第9期28卷 933-947页

作者： Yonghoon Choi Nayoung kim Ki Wook kim Hyeong Ho Jo Jaehyung Park Hyuk Yoon Cheol Min Shin young Soo Park Dong Ho Lee Hyeon Jeong Oh Hye Seung Lee young Suk Park Sang-hoon Ahn Yun-Suhk Suh Do Joong Park Hyung-Ho kim Ji-Won kim Jin Won kim Keun-Wook Lee Won Chang Ji hoonPark Yoon Jin Lee Kyoung Ho Lee young hoon kim Department ofInternal Medicine Seoul National University Bundang HospitalSeongnam 13620South Korea Nayoung Department of Internal Medicine Seoul National University College of MedicineSeoul 03080South Korea Department of Pathology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Pathology Seoul National University College of MedicineSeoul 03080South Korea Department of Surgery Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Surgery Seoul National University College of MedicineSeoul 03080South Korea Department of Radiology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Radiology Seoul National University College of MedicineSeoul 03080South Korea

BACKGROUND Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer(GC).AIM To analyze the differences in GC characteristics according to sex in patients who underwent surgical treatment for *** A total of 2983 patients diagnosed with gastric adenocarcinoma who received surgical treatment at the Seoul National University Bundang Hospital between 2003 and 2017 were *** clinicopathological characteristics, histologic type of GC, overall and GC-specific survival rates, and associated risk factors were *** Among the 2983 patients, 2005(67.2%) and 978(32.8%) were males and females, *** average age of the female group(59.36 years) was significantly younger than that of the male group(61.66 years;P younger than 60 years of age, with a significantly higher proportion of diffuse-type cancer than in the male *** of sex, diffuse-type GC was more common in younger patients, and the proportion of intestinal-type GC increased with *** overall survival rate was significantly higher in females(P < 0.001).However, this difference disappeared for GC-specific survival(P = 0.168), except for the poor GC-specific survival rate in advanced-stage cancer(stage Ⅲ or above) in females(P = 0.045).The risk factors for GC-related mortality were older age, upper location of GC, and diffuse-or mixed-type *** terms of comorbidities, more males died from diseases other than GC, including other malignancies such as lung cancer, hepatocellular carcinoma, and pancreatic cancer, and respiratory diseases such as interstitial lung disease and chronic obstructive pulmonary disease, while there were relatively more cardiovascular or cerebrovascular deaths in *** Sex-based differences in GC were

关键词： Gastric cancer Histology Prognosis Sex difference Survival

Advantageous properties of halide perovskite quantum dots towards energy-efficient sustainable applications

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Green Energy & Environment 2024年第6期9卷 949-965页

作者： Qian Zhao Shuo Wang young-hoon kim Shekhar Mondal Qingqing Miao Simiao Li Danya Liu Miao Wang Yaxin Zhai Jianbo Gao Abhijit Hazarika Guo-Ran Li School of Materials Science and Engineering Nankai UniversityTianjin300350China Department of Energy Engineering Hanyang UniversitySeoul04763Republic of Korea Polymers and Functional Materials Division CSIR-Indian Institute of Chemical TechnologyUppal RoadTarnakHyderabad500007India Institute of Process Engineering Chinese Academy of SciencesBeijing100190China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of PhysicsHunan Normal UniversityChangshHunan410081China Department of Chemistry Brock University1812 Sir Isaac WaySt CatharinesOntarioCanada

As lead halide perovskite(LHP)semiconductors have shown tremendous promise in many application fields,and particularly made strong impact in the solar photovoltaic area,low dimensional quantum dot forms of these perovskites are showing the potential to make distinct marks in the fields of electronics,optoelectronics and *** so-called perovskite quantum dots(PQDs)not only possess the most important features of LHP materials,i.e.,the unusual high defect tolerance,but also demonstrate clear quantum size effects,along with exhibiting desirable optoelectronic properties such as near perfect photoluminescent quantum yield,multiple exciton generation and slow hot-carrier ***,we review the advantageous properties of these nanoscale perovskites and survey the prospects for diverse applications which include lightemitting devices,solar cells,photocatalysts,lasers,detectors and memristors,emphasizing the distinct superiorities as well as the challenges.

关键词： Perovskite quantum dot Light-emitting Detector Laser Solar cell

Effect of botulinum toxin type A on the cervical sympathetic trunk in chronic relapsing inflammatory optic neuropathy

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Chinese Medical Journal 2021年第22期134卷 2771-2772页

作者： Ji Yeong kim Yong Ho Lee young hoon kim Department of Anesthesiology and Pain Medicine Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

To the Editor:Optic neuritis(ON)usually ends with one episode,but recurs in 3%to 5%of *** recurrent patients,those that emerge negative from multiple sclerosis or neuromyelitis optica(NMO)workup are diagnosed with chronic relapsing inflammatory optic neuropathy(CRION).This disease group,first named by Kidd et al,[1]refers to a clinical situation in which inflammatory optic nerve inflammation on both sides occurs repeatedly and worsens when steroids or immu-nosuppressants are *** diagnosis is important in this group because the risk of blindness is significant,and as such,treatment is focused on preserving ***,because a significant number of CRION patients suffer from ocular pain,alleviation of pain should not be overlooked.

关键词： neuropathy diagnosis inflammation

Spontaneous Absorption of a Lumbar Epidural Hematoma after Interlaminar Epidural Steroid Injection in a Patient with Spinal Stenosis： Close Observation as a Treatment Strategy

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Chinese Medical Journal 2018年第1期131卷 117-118页

作者： Soo Hyang kim Yun Joung Han young hoon kim Jae Min Lee Yoo Mi kim Hue Jung Park Department of Anesthesiology and Pain Medicine College of Medicine Seoul St. Mary's Hospital The Catholic University of Korea Seoul 06591 Korea

To the Editor： A lumbar epidural block is used to treat patients with a herniated intervertebral disc, spinal stenosis, or lumbosacral radiculopathy. This approach reduces radicular pain by decreasing inflammation of nerve roots through epidural corticosteroid injection. Patients with moderate-to-severe spinal stenosis who taking various anticoagulant agents have more risk for epidural hematoma.

关键词： Spontaneous Absorption a Lumbar Epidural Hematoma after Interlaminar

Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee kim Rudolph ETanzi Se hoon Choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin