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Interleukin-2 gene-encoded stromal cells inhibit the growth of metastatic cholangiocarcinomas

Interleukin-2 gene-encoded stromal cells inhibit the growth of metastatic cholangiocarcinomas

作     者:Myung-HwanKim Sang Soo Lee Sung Koo Lee Seung-Gyu Lee Chul-Won Suh Gyung-Yub Gong Jung-Sun Park Young-Hoon Kim Sang-Hee Kim 

作者机构:Department of GastroenterologyUniversity of Ulsan College of MedicineAsan Medical CenterSeoulKorea Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoulKorea Department of OncologyUniversity of Ulsan College of MedicineAsan Medical CenterSeoul Korea Department of PathologyUniversity of Ulsan College of MedicineAsan Medical CenterSeoulKorea Asan Institute for Life Sciences.SeoulKorea 

出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))

年 卷 期:2006年第12卷第12期

页      面:1889-1894页

核心收录:

学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基  金:Supported by The Asan Institute for Life Sciences of South Korea No.2003-013 

主  题:Bone marrow stromal cell Adenovirus/hIL-2 Biliary cancer 

摘      要:AIM: To demonstrate bone marrow stromal cells (BMSCs) can be used as an attractive target for genetic modification in the treatment of malignant diseases. METHODS: Using a hamster model of biliary cancer, we investigated the therapeutic effects of interleukin-2 (IL-2) gene-modified BHSCs. Syrian golden hamsters were injected via the femoral vein with 5×10^5 cells of the KIGB-5 biliary cancer cell line (n=20). One week later, the hamsters were injected intraperitoneally with BMSCs containing Ad/hIL-2 and Ad/△E1, unmodified BHSCs, or RPHI only (control) and observed for 12 wk (n=5/each group). RESULTS: All hamsters treated with BMSCs containing Ad/hIL-2 survived with no evidence of the disease during this period. In contrast, hamsters in the other three groups showed disseminated metastases involving the lungs as eady as 4 wk. CONCLUSION: Ad/IL-2 therapy is effective in the treatment of biliary cancer.

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