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Sarcopenia is associated with Framingham risk score in the Korean population： Korean National Health and Nutrition Examination Survey （KNHANES） 2010-2011

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Journal of Geriatric Cardiology 2015年第4期12卷 366-372页

作者： chae-Hwa Byeon Kee-young Kang Se-Hun Kang Eun-Jin Bae Department of Family Medicine DaeDong Hospital Myeongnyun-dong Dongnae-gu Busan South Korea

Background Sarcopenia is a risk factor for metabolic disorders and cardiovascular disease, but the association between sarcopenia and cardiovascular risk factors according to age and obesity status in the general population remains unknown. We thus investigated these associations in the Korean population. Methods We included 8,958 and 8,518 subjects from the fifth Korean National Health and Nutrition Examination Survey （KNHANES）（from 2010 and 2011, respectively）. the study was restricted to participants 〉 20 years old who had completed the health examination survey, including whole body dual-energy X-ray absorptiometry scans. After exclusion, 7,366 subjects （3,188 men, 4,178 women） were included in our final analysis. Age was categorized according to three age groups （20-39, 40-59, mad 〉 60 years）, and subjects were catego- rized according to their sarcopenic and obesity status. Cardiovascular risk was assessed with Framingham risk score （FRS）. Results the sarco- penic obese group had a higher FRS than the non-sarcopenic obese group, which had a higher FRS than the non-sarcopenic non-obese group. Age-wise, the 20-39 year-old group showed a non-significant association between sarcopenia and FRS. In the 40-59 year-old group, regardless of obesity status, sarcopenic subjects had a higher FRS than non-sarcopenic subjects. In the 〉 60 year-old group, sarcopenic subjects had a higher FRS than non-sarcopenic subjects for the non-obese group. Conclusions Sarcopenia was associated with cardiovascular disease and may be an early predictor of its susceptibility in both elderly and middle-aged subjects. thus, management of sarcopenia is necessary to prevent cardiovascu- lar disease.

关键词： Age Cardiovascular disease Cardiovascular risk factor Framingham risk score Sarcopenia

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Effects of acupuncture stimulation on brain activation induced by cue-elicited alcohol craving

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Neural Regeneration Research 2022年第5期17卷 1059-1064页

作者： Hyeok Gyu Kwon Seong Hun Choi Joon Ho Seo chae Ha Yang Mi young Lee Department of Physical therapy College of Health ScienceEulji UniversityGyeonggiRepublic of Korea Department of Anatomy and Histology College of Oriental MedicineDaegu Haany UniversityGyeongsanRepublic of Korea Department of Rehabilitation Gyeongbuk Regional Rehabilitation HospitalGyeongsanRepublic of Korea Department of Physiology College of Korean MedicineDaegu Haany UniversityDaeguRepublic of Korea Department of Physical therapy College of Biomedical ScienceDaegu Haany UniversityGyeongsanRepublic of Korea

Acupuncture has been shown to be effective on alcohol use ***,the underlying mechanism remains poorly *** investigate the effects of Shenmen(Ht7)acupoint on brain activation induced by cue-elicited alcohol craving,30 right-handed healthy light to moderate alcohol drinkers were recruited from the *** were randomly assigned to undergo acupuncture either at Ht7(experimental acupoint,n=15)or Jingqu(LU8,control acupoint,n=15)*** randomized controlled study was performed in Daegu Haany University and Daegu-Gyeongbuk Medical Innovation Foundation,Republic of *** and data collection were conducted from December 2018 to May *** results showed that after acupuncture at Ht7 acupoint,the activation of orbitofrontal cortex and dorsolateral prefrontal cortex was greatly increased,while the activation of dorsolateral prefrontal cortex was obviously reduced,and subject's craving for alcohol was reduced when he/she seeing alcohol-related video clips involving various alcohols(beer,wine,or soju)or drinking *** at Ht7 more greatly reduced subject's alcohol cravings than acupuncture at LU8 *** findings suggest that acupuncture can improve the self-control of mild to moderate social drinkers through the activation of the orbitofrontal cortex and dorsolateral prefrontal cortex,thereby reducing the craving for *** study protocol was approved by the Institutional Review Board of Daegu Haany University Korean Medicine Hospital,Republic of Korea(approval ***-D-18026-PRO-02)on November 30,2018.

关键词： acupuncture addiction alcohol brain activation craving cue functional MRI Shenmen(Ht7)acupoint

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Collapse behavior evaluation of hybrid thin-walled member by stacking condition

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transactions of Nonferrous Metals Society of China 2011年第A1期21卷 135-140页

作者： Kil-Sung LEE Hyeon-Kyeong SEO Yong-June YANG Woo-chae HWANG Kwang-Hee IM In-young YANG R&D Center Dacc LTD. 948-13 Dunsan-ri Bongdong-eup Wanju-gun Jeonbuk 565-902 Korea Departments of Advanced Parts and Materials Engineering Graduate School Chosun University Department of Automotive Engineering Woosuk University Departments of Mechanical Design Engineering Chosun University

the recent trend of vehicle design aims at crash safety and environmentally-friendly aspect. For the crash safety aspect, the energy absorbing members should absorb collision energy sufficiently but for the environmentally-friendly aspect, the vehicle structure must be light weight in order to improve the fuel efficiency and reduce the tail gas emission. therefore, the light weight of vehicle must be achieved in a securing safety status of crash. An aluminum or carbon fiber reinforced plastics (CFRP) is representative one of the light-weight materials. Based on the respective collapse behavior of aluminum and CFRP member, the collapse behavior of hybrid thin-walled member was evaluated. the hybrid members were manufactured by wrapping CFRP prepreg sheets outside the aluminum hollow members in the autoclave. Because the CFRP is an anisotropic material whose mechanical properties, such as strength and elasticity, change with its stacking condition, the effects of the stacking condition on the collapse behavior evaluation of the hybrid thin-walled member were tested. the collapse mode and energy absorption capability of the hybrid thin-walled member were analyzed with the change of the fiber orientation angle and interface number.

关键词： collapse behavior aluminum and CFRP hybrid thin-walled member stacking condition

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Debris Flow in Metropolitan Area - 2011 Seoul Debris Flow

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Journal of Mountain Science 2013年第2期10卷 199-206页

作者： Chan-young YUNE Yun-Ki chae Joongcheol PAIK Gihong KIM Seung-Woo LEE Heung-Seok SEO Department of Civil Engineering Gangneung-Wonju National University Department of Civil Engineering Gangneung-Wonju National UniversityGangneungSouth Korea Department of Construction Engineering Gangneung Yeongdong College

A large number of debris flows occurred simultaneously at around 8:30 to 8:50 *** July 27,2011,at the center of Seoul,*** area is located in the southern part of Seoul and is a densely populated *** a result of the debris flow event,16 people were killed,30 houses were buried,and 116 houses were damaged around Umyeon Mountain,a relatively small mountain with a height of 312.6 *** the debris flow event,field investigations on the initiation and transportation zones of debris flows have been carried *** data were collected from the automatic weather stations(AWSs) which are operated by the Korea Meteorological Administration(KMA).Video files recorded by residents were also acquired and used to analyze the flow characteristics of the debris *** investigation shows that about 40 debris flows occurred around Umyeon Mountain and most of the debris flows were initiated by small slope *** effects of the precipitation that triggered the debris flows were analyzed as well.A landslide hazard map which considers slope gradient and aspect,strength of soil,hazard record,rainfall conditions,and vegetation,was constructed and compared with the initiation zones of debris flows.

关键词： Debris flows Field investigation Rainfall Flow characteristics Hazard map

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Hepatocellular carcinoma in Budd-Chiari syndrome:A single center experience with long-term follow-up in South Korea

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World Journal of Gastroenterology 2012年第16期18卷 1946-1952页

作者： Hana Park Jin young Yoon Kyeong Hye Park Do young Kim Sang Hoon Ahn Kwang-Hyub Han chae Yoon Chon Jun Yong Park Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea Institute of Gastroenterology Yonsei University College of MedicineSeoul 120-752South Korea Liver Cirrhosis Clinical Research Center Seoul 120-752South Korea Brain South Korea 21 Project for Medical Science Seoul 120-752South Korea

AIM:to evaluate long-term clinical course of BuddChiari syndrome(BCS) and predictive factors associated with the development of hepatocellular carcinoma(HCC) and ***:We analyzed 67 patients with BCS between June 1988 and May *** diagnosis of BCS was confirmed by hepatic venous outflow obstruction shown on abdominal ultrasound sonography,computed tomography,magnetic resonance imaging,or *** median follow-up period was 103 ± 156 [interquartile range(IQR)] ***:the median age of the patients was 47 ± 16(IQR) *** diagnosis,54 patients had cirrhosis,25(37.3%) Child-Pugh class A,23(34.3%) Child-Pugh class B,and six(9.0%) patients Child-Pugh class *** the follow-up period,HCC was developed in 17 patients,and the annual incidence of HCC in patients with BCS was 2.8%.Patients in HCC group(n = 17) had higher hepatic venous pressure gradient(HVPG) than those in non-HCC group(n = 50)(21 ± 12 mmHg vs 14 ± 7 mmHg,P = 0.019).the survival rate of BCS patients was 86.2% for 5 years,73.8% for 10 years,and 61.2% for 15 *** patients with BCS and HCC,survival was 79% for 5 years,43.1% for 10 years,and 21.5% for 15 ***:the incidence of HCC in patients with BCS was similar to that in patients with other etiologic cirrhosis in South *** HVPG is expected to provide additional information for predicting HCC development in BCS patients.

关键词： Budd-Chiari syndrome Hepatocellular carcinoma Prognosis

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Synthesis of hexagonal boron nitrides by chemical vapor deposition and their use as single photon emitters

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Nano Materials Science 2021年第3期3卷 291-312页

作者： Hongwei Liu chae young You Jingwei Li Patrick Ryan Galligan Jiawen You Zhenjing Liu Yuting Cai Zhengtang Luo Department of Chemical and Biological Engineering the Hong Kong University of Science and TechnologyClear Water BayKowloon999077Hong Kong

two-dimensional(2D)hexagonal boron nitride(hBN),due to its extraordinary thermal,chemical,and optical properties,has arisen as an enticing material for the research community to explore for various applications,including the use of site defects in hBN as single photon emitters(SPEs).In this review,we systematically summarize recent advanced strategies towards the controllable synthesis of 2D hBN using chemical vapor deposition,towards a full control of the domain size,orientation,morphology,layer number,and stacking order,***,we review the underlying mechanisms for single photon emission(SPE)in hBN and methods to selectively generate and tune the ***(e.g.,carbon substituted defects)are discussed for the potential use as emission *** finally give an outlook of future challenges and opportunities on desirable hBN synthesis and further investigation of SPEs in hBN,targeting to utilize hBN as single photon emitters in an industrial scale.

关键词： hBN CVD Controllable synthesis Single photon emission

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Loose-fit graphitic encapsulation of silicon nanowire for one-dimensional Si anode design

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Journal of Materials Science & technology 2017年第10期33卷 1120-1127页

作者： Seh-Yoon Lim Sudong chae Su-Ho Jung Yuhwan Hyeon Wonseok Jang Won-Sub Yoon Jae-young Choi Dongmok Whang School of Advanced Materials Science and Engineering SKKU Advanced Institute of Nanotechnology Sungkyunkwan University Suwon 440-746 South Korea Department of Energy Sdence Sungkyunkwan University Suwon 440-746 South Korea

Silicon nanowires（SiNWs） encapsulated with graphene-like carbon sheath（GS） having a void space in between（SiNW@V@GS） are demonstrated for the improved electrochemical performance of Si anode in lithium ion battery. the Si NW@V@GS structure was synthesized by a scalable fabrication method including four successive reactions： metal-catalyzed CVD growth of Si NWs, controlled thermal oxidation, and deposition of the graphitic layer, to form Si NW@SiO2@GS and additional chemical etching of sacrificial SiO2 layer between Si NWs and carbon sheath. During the synthetic process, the thickness of the void spacing was controlled by adjusting the oxidation-dependent process. the well-controlled void space and crystalline graphitic carbon sheath of the SiNW@V@GS structure enable good reversible capacity of1444 m Ahg^（-1） and cycling stability of 85% over 150 cycles.

关键词： Lithium ion battery Silicon nanowire Graphene Void spacing Anode

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Efficacy of cap-assisted endoscopy for routine examining the ampulla of Vater

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World Journal of Gastroenterology 2013年第13期19卷 2037-2043页

作者： young Rak Choi Joung-Ho Han young Shim Cho Hye-Suk Han Hee Bok chae Seon Mee Park Sei Jin Youn Department of Internal Medicine College of MedicineChungbuk National University

AIM: to determine the efficacy of a cap-assisted endoscopy (CAE) to completely visualize the ampulla of Vater (AV) in patients failed by conventional endoscopy. MEtHODS: A prospective study was conducted on 120 patients > 20 years of ages who visited the Health Promotion Center of Chungbuk National University Hospital for conscious sedation esophagogastroduodenoscopy (EGD) as a screening test from July to October, 2011. First, forward-viewing endoscopy was performed with reasonable effort using a push and pull method. We considered complete visualization of the AV when we could observe the entire AV including the orifice clearly, and reported the observation as complete or incomplete (partial or not found at all). Second, in cases of complete failure of the observation, an additional AV examination was conducted by attaching a short cap (D-201-10704, Olympus Medical Systems, tokyo, Japan) to the tip of a forward-viewing endoscope. third, if the second method failed, we replaced the short cap with a long cap (MH-593, Olympus Medical Systems) and performed a re-examination of the AV. RESULtS: Conventional endoscopy achieved complete visualization of the AV in 97 of the 120 patients (80.8%) but was not achieved in 23 patients (19.2%). Age (mean ± SD) and gender [male (%)] were not significantly different between the complete observation and the incomplete observation groups. Additional short CAE was performed in patients in whom we could not completely visualize the AV. this group included 13 patients (10.9%) with partial observation of the AV and 10 (8.3%) in which the AV was not found. Short CAE permitted a complete observation of the AV in 21 of the 23 patients (91.3%). Patients in whom visualization of the AV failed with short CAE had satisfactory outcomes by replacing the short cap with a long cap. the additional time for CAE took an average of 141 ± 88 s. there were no complications and no significant mucosal trauma. CONCLUSION: CAE is safe to use as a salvage me

关键词： Ampulla of Vater Conventional endoscopy Cap-assisted endoscopy Screening test Complete observation

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High-frequency magnetic stimulation attenuates beta-amyloid protein 1-42 neurotoxicity in organotypic hippocampal slices

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Neural Regeneration Research 2010年第18期5卷 1365-1372页

作者： Don-Kyu Kim young Chul Yoon Soo Ahn chae Kyung Mook Seo tai Ryoon Han Si-Hyun Kang Department of Physical Medicine and Rehabilitation Chung-Ang University College of Medicine Department of Neurology Chung-Ang University College of Medicine Department of Pediatrics Chung-Ang University College of Medicine Department of Physical Medicine and Rehabilitation Seoul National University

Repetitive transcranial magnetic stimulation （rtMS） has been utilized as a therapeutic tool for neurodegenerative disorders including Alzheimer＇s disease. However, the precise mechanisms of its clinical effects remain unknown. β-amyloid （Aβ） exhibits direct neurotoxic effects and is closely related to neuronal degeneration in Alzheimer＇s disease. therefore, it has been hypothesized that the neuroprotective effects of rtMS are related to the mechanisms of protection against Aβ neurotoxicity. Organotypic hippocampal slices were prepared from 8-day old, Sprague Dawley rats. the tissue slices were exposed to 100 μmol/L Al3142 since day 12 in vitro with and without high-frequency （20 Hz） magnetic stimulation. Magnetic stimulation efficacy was evaluated by measuring neuronal nuclei （NeuN） protein expression and by observing cultures following propidium iodide fluorescence staining and bromodeoxyuridine （BrdU） immunohistochemistry. Lactate dehydrogenase activity was detected in the culture media to evaluate hippocampal neuronal damage. Our results demonstrated that high-frequency magnetic stimulation significantly reversed the reduction of NeuN protein expression because of Aβ1-42 exposure （P 〈 0.05） and significantly reduced the number of damaged cells in the hippocampal slices （P 〈 0.05）. However, lactate dehydrogenase levels and anti-BrdU staining results did not reveal any statistical differences these findings indicate that high-frequency magnetic stimulation might have protective effect on hippocampal neurons from Aβ1-42 neurotoxicity.

关键词： organotypic hippocampus amyloid beta-protein magnetic stimulation nerve degeneration/metabolism nerve degeneration/pathology organ culture techniques rats, Sprague Dawiey

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Effects of ethanol on the tonicity of corporal tissue and the intracellular Ca^2＋ concentration of human corporal smooth muscle cells

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Asian Journal of Andrology 2010年第6期12卷 890-898页

作者： Sung Chul Kam Mee Ree chae Ji young Kim Seol Ho Choo Deok Hyun Han Sung Won Lee Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 Korea

Heavy alcohol consumption is associated with an increased risk of erectile dysfunction （ED）; however, the acute effects of ethanol （EtOH） on penile tissue are not fully understood. We sought to investigate the effects of EtOH on corporal tissue tonicity, as well as the intracellular Ca^2＋ concentration （[Ca^2＋]i） and potassium channel activity of corporal smooth muscle. Strips of corpus cavernosum （CC） from rabbits were mounted in organ baths for isometric tension studies. Electrical field stimulation （EFS） was applied to strips precontracted with 10 μmol L^-1 phenylephrine as a control. EtOH was then added to the organ bath and incubated before EFS. the [Ca^2＋]i levels were monitored by the ratio of fura-2 fluorescence intensities using the fura-2 loading method. Single-channel and whole-cell currents were recorded by the conventional patch-clamp technique in short-term cultured smooth muscle cells from human CC tissue. the corpus cavernosal relaxant response of EFS was decreased in proportion to the concentration of EtOH. EtOH induced a sustained increase in [Ca^2＋]i in a dose-dependent manner, Extracellular application of EtOH significantly increased whole-cell K^＋ currents in a concentration-dependent manner （P 〈 0.05）. EtOH also increased the open probability in cell-attached patches; however, in inside-out patches, the application of EtOH to the intracellular aspect of the patches induced slight inhibition of Ca^2＋-activated potassium channel （KCa） activity. EtOH caused a dose-dependent increase in cavemosal tension by alterations to [Ca^2＋]i. Although EtOH did not affect KCa channels directly, it increased the channel activity by increasing [Ca^2＋]i. the increased corpus cavemosal tone caused by EtOH might be one of the mechanisms of ED after heavy drinking.

关键词： alcohol Ca^2+-activated potassium channel corporal smooth muscle penile erection

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