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Weight loss maintenance after bariatric surgery

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World Journal of Clinical Cases 2023年第18期11卷 4241-4250页

作者： young-Hye cho youngin Lee Jung In choi Sae Rom Lee Sang Yeoup Lee Department of Family Medicine Pusan National University School of MedicineYangsan 50612South Korea Department of Family Medicine Pusan National University Yangsan HospitalYangsan 50612South Korea Family Medicine and Biomedical Research Institute Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Medical Education Pusan National University School of MedicineYangsan 50612South Korea

Metabolic and bariatric surgery(MBS)is an effective treatment for patients with morbid obesity and its ***,many patients experience weight regain(WR)after achieving their nadir *** the definition of WR is challenging as postoperative WR has various *** factors for WR after MBS include anatomical,racial,hormonal,metabolic,behavioral,and psychological factors,and evaluating such factors preoperatively is ***-term regular follow-up and timely treatment by a multidisciplinary team are important because WR after surgery is *** lifestyle interventions that focus on appropriate dietary education,physical activity education or interventions,and behavioral psychological interventions are suggested,more well-designed studies are needed because studies evaluating intervention methods and the effectiveness of WR prevention are *** drugs can be used to prevent and manage patients with WR after MBS;however,more research is needed to determine the timing,duration,and type of anti-obesity drugs used to prevent WR.

关键词： Metabolic and bariatric surgery Weight regain Obesity Roux-en-Y gastric bypass Laparoscopic sleeve gastrectomy

Highly impermeable and flexible silica encapsulation films synthesized by sol-gel process

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Nano Research 2022年第8期15卷 7476-7483页

作者： Si-Hoon Kim Gyeong-seok Hwang Donghwan Koo Dong-Hyun seo Ye-Pil Kwon Hansuek Lee Hyesung Park Eun-chae Jeon Ju-young Kim School of Materials Science and Engineering University of UlsanTechno saneop-ro 55beon-gil 12Ulsan 44776Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)UNIST-gil 50Ulsan 44919Republic of Korea Department of Physics Korea Advanced Institute of Science and Technology(KAIST)Daehak-ro 291Deajeon 34141Republic of Korea Graduate School of Semiconductor Materials and Devices Ulsan National Institute of Science and Technology(UNIST)UNIST-gil 50Ulsan 44919Republic of Korea

Silica thin films synthesized sol–gel process are proposed as flexible encapsulation materials.A sol–gel process provides a dense and stable amorphous silica structure,yielding an extremely high elastic deformation limit of 4.9%and extremely low water vapor transmission rate(WVTR)of 2.90×10^(−4)g/(m^(2)∙day)at 60℃and relative humidity of 85%.The WVTR is not degraded by cyclic bending deformations for the bending radius corresponding to a tensile strain of 3.3%in the silica encapsulation film,implying that the silica thin film is robust against the formation of pinhole-type defects by cyclic bending *** organic solar cells encapsulated with the silica films operate without degradation in power conversion efficiency for 50,000 bending cycles for a bending radius of 6 mm.

关键词： silica thin film sol-gel flexible encapsulation mechanical reliability flexible organic solar cell

Co-administration of ursodeoxycholic acid with rosuvastatin/ezetimibe in a non-alcoholic fatty liver disease model

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Gastroenterology Report 2022年第1期10卷 440-450页

作者： Sang Hyun seo Da Hyun Lee Yu seol Lee Kyung Joo cho Hye Jung Park Hye Won Lee Beom Kyung Kim Jun Yong Park Do young Kim Sang Hoon Ahn Soo Han Bae Seung Up Kim Department of Internal Medicine Graduate School of Medicine ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Yonsei Liver Center Severance HospitalSeoulRepublic of Korea Severance Biomedical Science Institute Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Severance Biomedical Science Institute Yonsei Biomedical Research InstituteYonsei University College of MedicineSeoulRepublic of Korea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoulRepublic of Korea

Background Ursodeoxycholic acid(UDCA),statins,and ezetimibe(EZE)have demonstrated beneficial effects against nonalcoholic fatty liver disease(NAFLD).We investigated the efficacy of the combination of UDCA and the mix of rosuvastatin(RSV)/EZE in the treatment of *** NAFLD mouse models were developed by injecting thioacetamide,fasting,and high-carbohydrate refeeding,highfat diet,and choline-deficient L-amino acid-defined high-fat diet(CDAHFD).Low-dose UDCA(L-UDCA;15 mg/kg)or highdose UDCA(H-UDCA;30 mg/kg)was administered with RSV/*** also employed an in vitro model of NAFLD developed using palmitic acid-treated Hepa1c1c7 *** Co-administration of RSV/EZE with UDCA significantly decreased the collagen accumulation,serum alanine aminotransferase(ALT)levels,and mRNA levels of fibrosis-related markers than those observed in the vehicle group in thioacetamide-treated mice(all P<0.01).In addition,in the group fasted and refed with a high-carbohydrate diet,UDCA/RSV/EZE treatment decreased the number of apoptotic cells and serum ALT levels compared with those observed in the vehicle group(all P<0.05).Subsequently,H-UDCA/RSV/EZE treatment decreased the number of ballooned hepatocytes and stearoyl-CoA desaturase 1(SCD-1)mRNA levels(P=0.027)in the liver of high-fat diet-fed mice compared with those observed in the vehicle *** the CDAHFD-fed mouse model,UDCA/RSV/EZE significantly attenuated collagen accumulation and fibrosis-related markers compared to those observed in the vehicle group(all P<0.05).In addition,UDCA/RSV/EZE treatment significantly restored cell survival and decreased the protein levels of apoptosis-related markers compared to RSV/EZE treatment in palmitic acid-treated Hepa1c1c7 cells(all P<0.05).Conclusion Combination therapy involving UDCA and RSV/EZE may be a novel strategy for potent inhibition of NAFLD progression.

关键词： non-alcoholic fatty liver disease non-alcoholic steatohepatitis ursodeoxycholic acid rosuvastatin ezetimibe

Pyogenic liver abscess secondary to gastric perforation of an ingested toothpick:A case report

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世界临床病例杂志 2023年第23期11卷 5622-5627页

作者： Yeshong Park Ho-seong Han Yoo-seok Yoon Jai young cho Boram Lee Mee young Kang Jinju Kim Hae Won Lee Department of Surgery Seoul National University Bundang HospitalSeongnam-si 13620South Korea

BACKGROUND Liver abscess due to foreign body-induced gastrointestinal tract perforation is a rare event that could be misdiagnosed due to low *** than 100 cases have been reported to *** SUMMARY We report a case of a 53-year old female patient with pyogenic liver abscess secondary to ingestion of a toothpick with penetration through the lesser curvature of the *** patient presented with persistent epigastric *** computed tomography demonstrated the presence of a linear radiopaque object associated with abscess formation in the left liver *** changes in the lesser curvature of the stomach indicated gastric wall penetration by the *** the abscess was refractory to antibiotic treatment,laparoscopic liver resection was performed to remove the foreign body and adjacent liver *** surgery,symptoms fully resolved without any *** This rare case demonstrates the importance of considering foreign body penetration as a cause of pyogenic liver abscess,particularly in abscesses of unknown origin that are resistant to antibiotic *** suspicion,early diagnosis,and prompt removal of the foreign body could lead to improved outcomes in these patients.

关键词： Foreign body ingestion Liver abscess Pyogenic liver abscess Liver resection Case report

Robotic versus laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: A propensity score-matched analysis

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 154-159页

作者： Dakyum Shin Jaewoo Kwon Jae Hoon Lee seo young Park Yejong Park Woohyung Lee Ki Byung Song Dae Wook Hwang Song Cheol Kim Division of Hepato-Biliary and Pancreatic Surgery Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine88 Olympic-ro 43-gilSongpa-guSeoul 05505Korea Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of Medicine29 Saemunan-roJongno-guSeoul 03181Korea Department of Statistics and Data Science Korea National Open University86 Daehak-roJongno-guSeoul 03087Korea

Background: Minimally invasive surgery is becoming increasingly popular in the field of pancreatic surgery. However, there are few studies of robotic distal pancreatectomy(RDP) for pancreatic ductal adenocarcinoma(PDAC). This study aimed to investigate the efficacy and feasibility of RDP for PDAC. Methods: Patients who underwent RDP or laparoscopic distal pancreatectomy(LDP) for PDAC between January 2015 and September 2020 were reviewed. Propensity score matching analyses were performed. Results: Of the 335 patients included in the study, 24 underwent RDP and 311 underwent LDP. A total of 21 RDP patients were matched 1:1 with LDP patients. RDP was associated with longer operative time(209.7 vs. 163.2 min;P = 0.003), lower open conversion rate(0% vs. 4.8%;P < 0.001), higher cost(15 722 vs. 12 699 dollars;P = 0.003), and a higher rate of achievement of an R0 resection margin(90.5% vs. 61.9%;P = 0.042). However, postoperative pancreatic fistula grade B or C showed no significant intergroup difference(9.5% vs. 9.5%). The median disease-free survival(34.5 vs. 17.3 months;P = 0.588) and overall survival(37.7 vs. 21.9 months;P = 0.171) were comparable between the groups. Conclusions: RDP is associated with longer operative time, a higher cost of surgery, and a higher likelihood of achieving R0 margins than LDP.

关键词： Minimally invasive surgery Robotic distal pancreatectomy Laparoscopic distal pancreatectomy Pancreatic ductal adenocarcinoma Propensity score matching

Three-dimensional free view reconstruction in axially distributed image sensing

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Chinese Optics Letters 2017年第8期15卷 40-43页

作者： chang-taek seo shin-won kang myungjin cho 3d display components support center gumi electronics and information technology research instituteGumi-siGyeongsangbuk-do 730-853Korea school of electronics engineering college of it engineeringkyungpook national universityDaegu 702-701Korea department of electrical electronicand control engineeringiitchankyong national university327 Chungang-roAnseong-siGyonggi-do 456-749Korea

Three-dimensional （3D） acquisition has been the most important technique for augmented reality or virtual reality industries. Stereo vision can obtain 3D infor- mation of objects using disparity between two images captured by a stereo camera. However, due to lack of per- spectives for 3D objects in this technique, accurate 3D information may not be generated and the number of viewing points is limited. By contrast, multi-view or super multi-view imaging techniques can obtain more accurate 3D information because they use multiple cameras for pickup of 3D objects so that more perspec- tives and viewing points of 3D objects can be recorded.

关键词： view free Three-dimensional free view reconstruction in axially distributed image sensing

The balance between efficient anti-inflammatory treatment and neuronal regeneration in the olfactory epithelium

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Neural Regeneration Research 2018年第10期13卷 1711-1714页

作者： seo young Chang Isaias Glezer Department of Biochemistry Escola Paulista de MedicinaUniversidade Federal de SAo Paulo

The sense of smell is important for human quality of life. This sophisticated sensorial system relies on the detection of odorant molecules that engage receptors expressed in the cilia of dedicated neurons that constitute the olfactory epithelium（OE）. Importantly, the OE is a highly active site of adult neurogenesis where short-lived neurons are efficiently replenished, even after massive neuronal cell loss. It is suggested that the degree of olfactory function recovery after OE injury may depend on the nature of the lesion（traumatic, chemical, infectious or inflammatory）, as well on the velocity of cellular regeneration. Topical steroidal anti-inflammatory drugs, such as glucocorticoids, are routinely prescribed for treating upper airway inflammatory conditions, such as chronic rhinosinusitis. While the therapeutic strategy aims to minimize the inflammatory damage and dysfunction to nasal air conduction, new evidences raise concerns if such drugs may impair neuronal regeneration in the OE. In consequence, new directions are necessary in terms of drug development or prescription, in order to preserve olfactory function through lifelong repeated episodes of chronic inflammation in the upper respiratory tract. Here we discuss mechanisms involved in glucocorticoid deleterious effects to OE regeneration and possible therapeutic alternatives considering relevant side effects.

关键词： anti-inflammatory drugs corticosteroids hyposmia inflammation rhinosinusitis olfactory epithelium sensory neurons cell proliferation

Adenosine monophosphate enhances callus regeneration competence for de novo plant organogenesis

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Molecular Plant 2023年第12期16卷 1867-1870页

作者： Hong Gil Lee seo young Jang Eun Yee Jie Seung Hee choi Ok-Sun Park Soon Hyung Bae Hyun-Soon Kim Suk Weon Kim Geum-Sook Hwang Pil Joon seo Department of Chemistry Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Integrated Metabolomics Research Group Western Seoul CenterKorea Basic Science InstituteSeoul 03759Korea Biological Resource Center Korea Research Institute of Bioscience and BiotechnologyJeongeup56212Korea Plant Systems Engineering Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Korea College of Pharmacy Chung-Ang UniversitySeoul 06974Korea

Dear Editor,Plant tissue culture involves callus formation and de novo shoot ***,explants from differentiated tissues are used to generate a pluripotent cell mass,called callus,on auxin-rich callus-inducing medium(CIM),followed by shoot regeneration on cytokinin-rich shoot-inducing medium(SiM).Callus results from division of pericycle-like cells(Atta et al.,2009;Sugimoto et al.,2010);its cellular identity resembles that of lateral root primordia(Atta et al.,2009;Sugimoto et al.,2010).Callus acquires cellular pluripotency by forming root stem cell niches on CIM(Sugimoto et al.,2010)。

关键词： Adenosine callus

A 360-Degree Panoramic Image Inpainting Network Using a Cube Map

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Computers, Materials & Continua 2021年第1期66卷 213-228页

作者： seo Woo Han Doug young Suh Department of Electronic Engineering Kyung Hee UniversityYoungin17104South Korea

Inpainting has been continuously studied in the field of computer *** artificial intelligence technology developed,deep learning technology was introduced in inpainting research,helping to improve ***,the input target of an inpainting algorithm using deep learning has been studied from a single image to a ***,deep learning-based inpainting technology for panoramic images has not been actively *** propose a 360-degree panoramic image inpainting method using generative adversarial networks(GANs).The proposed network inputs a 360-degree equirectangular format panoramic image converts it into a cube map format,which has relatively little distortion and uses it as a training *** the cube map format is used,the correlation of the six sides of the cube map should be ***,all faces of the cube map are used as input for the whole discriminative network,and each face of the cube map is used as input for the slice discriminative network to determine the authenticity of the generated *** proposed network performed qualitatively better than existing single-image inpainting algorithms and baseline algorithms.

关键词： Panoramic image image inpainting cube map generative adversarial networks