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Detection and treatment of synchronous lesions in colorectal cancer: The clinical implication of perioperative colonoscopy

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World Journal of Gastroenterology 2007年第30期13卷 4108-4111页

作者： Min Sun Kim young jin park Department of Surgery Dongguk University International Hospital Dongguk University School of Medicine Goyang Korea Department of Surgery Ilsanpaik Hospital Inje University School of Medicine Goyang Korea

AIM： To evaluate the clinical significance of preand intra-operative colonoscopy for the detection of synchronous lesions in colon cancer.METHODS： Two hundred and sixty-five pre-operative and 51 intra-operative colonoscopic evaluations were performed in 316 colorectal cancer patients who underwent curative resection from January 2001 to June 2006. The incidence and characteristics of synchronous lesions and their influence on surgery were evaluated.RESULTS： Two hundred and eighty-two synchronous lesions were detected in 124 （39.2%） of 316 patients including all lesions regardless of their histologic type. True adenomatous polyps were found in 91 （28.8%） of 326 patients, and 27 （5.4% of all patients） patients had synchronous colon cancers. The preoperative identification of synchronous lesions altered the planned surgery in 37 （14.0%） of 265 patients. In 18 patients among the surgically removed cases, the lesions were removed by extending the resection range. Further segmental resection or polypectomy through enterotomy was necessary in 29 patients. Nineteen （37.2%） of 52 intraoperative colonoscopy cases had synchronous lesions. Additional surgical procedures including segmental bowel resection and polypectomy with enterotomy were necessary in 7 （23.7%） of 52 intraoperative colonoscopy cases to remove the lesions.CONCLUSION： Synchronous colorectal polyps or cancer are frequent and their preoperative detection is important for optimal surgical planning and treatment. Intraoperative colonoscopy is a useful option in cases where a preoperative colonoscopy is not feasible.

关键词： Colon cancer Synchronous colon polyp Intraoperative colonoscopy

A Furan-Substituted Polymeric Hole-Transporting Material for Energy Level Regulation and Less Planarity in Colloidal Quantum Dot Solar Cells

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Energy & Environmental Materials 2023年第5期6卷 340-346页

作者： Jun woo Lee Duck Hoon Lee younghoon Kim jin young park Hyung Ryul You Taiho park Minjun Kim Jongmin Choi Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)77 Cheongam-RoNam-GuPohang Gyeongbuk 37673Korea Department of Chemical and Environmental Engineering Yale UniversityNew Haven CT 06511USA Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Korea Department of Chemistry Kookmin UniversitySeoul 02707Korea RIKEN Center for Emergent Matter Science(CEMS) 2-1 HirosawaWako Saitama 351-0198Japan

For efficient colloidal quantum dot(CQD)solar cells(CQD-SCs),thiol-passivated p-type CQDs are generally used as a hole-transporting material(HTM);however,there are issues with the control of optoelectrical properties,low thiol passivation rate,and poor morphology with a power conversion efficiency(PCE)of approximately 11%.Although polymeric HTMs have been introduced to address these issues,maximizing efficiency and achieving green-solvent processability and thermal stability for commercialization is ***,we synthesize a novel benzodifuran(BDF)-based HTM(asy-ranPBTBDF)showing an electron-deficient state,low steric hindrance,and low planarity compared to those of a typical benzodithiophene(BDT)-based HTM(asy-ranPBTBDT).BDF properties lead to deep high occupied molecular orbital(HOMO)levels,closeπ-πstacking,excellent solubility,and amorphous properties related to efficiency,green-solvent processability,and thermal *** these benefits,the asy-ranPBTBDF-based CQD-SC showed enhanced open-circuit voltage(Voc)(0.65 V)and PCE(13.29%)compared to those of the asy-ranPBTBDT-based device(0.63 V and 12.22%)in toxic processes with *** asy-ranPBTBDF-based CQD-SC showed a PCE of 12.51%in a green-solvent process with 2-methylanisole and improved thermal stability at 80℃(83.8%retaining after 24 h)owing to less lateral crystallization than the asy-ranPBTBDT-based device(60.8%retaining after 24 h).

关键词： colloidal quantum dot green-solvent photovoltaics semiconducting polymers stability

Duodenal obstruction following acute pancreatitis caused by a large duodenal diverticular bezoar

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World Journal of Gastroenterology 2012年第38期18卷 5485-5488页

作者： Ji Hun Kim Jae Hyuck Chang Sung Min Nam Mi Jeong Lee Il Ho Maeng jin young park Yun Sun Im Tae Ho Kim Il young park Sok Won Han Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul 137-701 South Korea Department of Surgery College of Medicine The Catholic University of Korea Seoul 137-701 South Korea

Bezoars are concretions of indigestible materials in the gastrointestinal tract. It generally develops in patients with previous gastric surgery or patients with delayed gastric emptying. Cases of periampullary duodenal divericular bezoar are rare. Clinical manifestations by a bezoar vary from no symptom to acute abdominal syndrome depending on the location of the bezoar. Biliary obstruction or acute pancreatitis caused by a bezoar has been rarely reported. Small bowel obstruction by a bezoar is also rare, but it is a complication that requires surgery. This is a case of acute pancreatitis and subsequent duodenal obstruction caused by a large duodenal bezoar migrating from a periampullary diverticulum to the duodenal lumen, which mimicked pancreatic abscess or microperforation on abdominal computerized tomography. The patient underwent surgical removal of the bezoar and recovered completely.

关键词： Bezoar Diverticulum Pancreatitis Duodenal obstruction

Antiproliferative and apoptosis-inducing potential of 3β-hydroxy-△5-steroidal congeners purified from the soft coral Dendronephthya putteri

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Journal of Oceanology and Limnology 2019年第4期37卷 1382-1392页

作者： Thilina U. JAYAWARDENA Won Woo LEE I. P. Shanura FERNANDO K. K. Asanka SANJEEWA Lei WANG Tee Gee LEE young jin park Chang-ik KO You-jin JEON Department of Marine Life Sciences Jeju National University Jeju 690-756 Republic of Korea Department of Hotel Cooking Nutrition Jeonnam Provincial College Jeollanam-do Republic of Korea Department of Family Medicine College of Medicine Dong-A University Busan 602-715 Republic of Korea Choung Ryong Fisheries Co. Ltd. 7825 Iljudong-ro Namwon-eup Seogwipo-si Jeju-do Republic of Korea

The exploration and identification of antiproliferative phytochemicals have received increased attention in medicinal chemistry. In particular, research focused on the toxicology of marine natural products has increased in recent years. Terpenoids, among many secondary metabolites, have been demonstrated to act as effective anticancer agents. Soft corals, a group of marine invertebrates, produce a variety of terpenoids with biofunctional properties. The current study presents the extraction, purification, and identification of sterol congeners from the soft coral Dendronephthya putteri. The method involves 50% chloroform-methanol extraction, polar column fractionation, and analysis through GC-MSn. Dose-dependent antiproliferative activity was observed within the sterol-rich fraction (DPCMH 2-4), which consisted of 3β-hydroxy-Δ5-steroidal congeners. This fraction inhibited the growth of HL-60 and MCF-7 cells with IC50 values of 25.27±1.43 and 22.81±0.15 μg/mL, respectively. Apoptotic body formation, DNA damage, cell cycle arrest, and apoptotic cell signaling pathway activation were also observed, reinforcing the dose-dependent antiproliferative and apoptosis-inducing activity of 3β-hydroxy-Δ5-steroidal congeners. To our knowledge, this is the first report of anticancer agent identification from the soft coral D. putteri. Based on the observations, these steroidal congeners are promising candidates for the development of anticancer drugs.

关键词： Dendronephthya putteri soft coral antiproliferative agent HL-60 MCF-7 apoptosis steroidal congeners

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雪花秀的中国市场拓展战略研究

雪花秀的中国市场拓展战略研究

作者： jin young park 浙江工商大学

学位级别：硕士

Recently,the Chinese market has been receiving attention from around the world for the growth of its economy and the increase in national *** Chinese cosmetics market is also becoming the largest market in the world with its huge *** cosmetics companies have been successful since they *** market in the early 1990 s and now South Korea is China’s second largest cosmetic *** the Korean Wave,Korean cosmetics companies benefited from largely positive reception from Chinese consumers including Amore *** analyzing how Amore Pacific successfully introduces and establishes Sulwhasoo in China,this study will examined the current market situation of the Chinese cosmetic industry and identified the characteristics unique to Chinese consumers,along with the interpretation of the current market presences and potentials for growth in Chinese market and based on this insights compare Amore Pacific’s strategy in China is explored using SWOT,STP and Marketing 4Ps *** analysis,it possible to compare the differences in strategies associated with different sub-brands in Amore Pacific’s *** addition,this study will examine Amore Pacific’s "new-retail" strategy,including e-commerce and offline store experiences to that cater to a younger generation of consumers that are coming into *** this study will propose some suggestions that address the identified concerns,solutions that are relevant in particular for cosmetics companies wishing to establish a presence in China.

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hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer

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World Journal of Gastroenterology 2003年第5期9卷 956-960页

作者： Jae-Il Kim young-jin park Ki-Hong Kim Ji-Il Kim Byung-Joo Song Meung-Soo Lee Chul-Num Kim Seok-Hyo Chang Department of Surgery Ilsan Paik HospitalInje University College of Medicine.2240Daehwa-dongIlsan-guKoyang shiKyunggido 412-270Korea

AIM:To determine the association of hOGG1 (8-oxoguanine glycosylase I,OGG1) polymorphism of Ser326Cys substitution with colon cancer risk and possible interaction with known environmental risk factors. METHODS:A case-control study with 125 colon cancer cases and 247 controls was conducted, RESULTS:There was no major difference in Ser326Cys genotype distribution between cases and *** meat intake tended to increase the odds ratio for colon cancer with an OR of 1.72 (95 % confidence interval;CI=1.12-2.76). Such tendency was more prominent in Cys/Cys carriers (OR=4.31,95 % CI=1.64-11.48),but meat intake was not a significant risk factor for colon cancer in Ser/Ser or Ser/ Cys *** OR for colon cancer was elevated with marginal significance in smokers who were Cys/Cys carriers (OR=2.75,95 % CI=1.07-7.53) but not in Ser/Ser or Ser/ Cys carriers. CONCLUSION:These results suggest that the hOGG1 Ser326Cys polymorphism is probably not a major contributor to individual colon cancer susceptibility overall,but the Cys/ Cys genotype may alter the impact of some environmental factors on colon cancer development.

关键词： Base Sequence Case-Control Studies Colonic Neoplasms DNA DNA-Formamidopyrimidine Glycosylase Diet Female Genotype Humans Male Meat Middle Aged N-Glycosyl Hydrolases Odds Ratio Polymorphism, Genetic Risk Factors Smoking

Migration routes and differences in migration strategies of Whooper Swans between spring and autumn

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Avian Research 2023年第3期14卷 345-353页

作者： Ji-Yeon Lee Hyung-Kyu Nam jin-young park Seung-Gu Kang Nyambayar Batbayar Dong-Won Kim Jae-Woong Hwang Otgonbayar Tsend Tseveenmyadag Natsagdorj Jugdernamjil Nergui Tuvshintugs Sukhbaatar Wee-Haeng Hur Jeong-Chil Yoo The Korea Institute of Ornithology and Department of Biology Graduate SchoolKyung Hee University26 Kyungheedae-roDongdaemun-guSeoul02447Republic of Korea National Institute of Biological Resources 42 Hwangyeong-roSeo-guIncheon22689Republic of Korea Endangered Species Research Center National Institute of EcologyYeongyang36351Republic of Korea Wildlife Sciences and Conservation Center of Mongolia Union BuildingB-701UNESCO str.Ulaanbaatar14210Mongolia

Long-distance migratory birds travel more rapidly in spring than in autumn,as they face temporal breeding ***,several species travel slower in spring owing to environmental influences,such as food availability and wind *** trackers were attached to 17 Whooper Swans(Cygnus cygnus) inhabiting northeastern Mongolia,to determine their migration routes and stopover sites in spring and *** between spring and autumn migrations,migration-influencing parameters,and the effect of spring stopover site temperatures were *** swans completed perfect tours between their wintering and breeding sites,and these data were used for *** migration lasted 57 days,with 49.2 days spent at 3.7 stopover *** migration lasted 21.5 days,with 17.5 days spent at 1.0 stopover ***,the swans traveled more rapidly in autumn than in *** distance,number of stopovers,migration speed,and straightness were important migration determinants in both spring and *** distance,stopover duration,number of stopovers,daily travel speed,travel duration,and migration speed differed significantly between spring and *** spring migration,the temperature at the current stopover sites and that at the future stopover sites displayed significant variations(t=1585.8,df=631.6,p <0.001).These findings are critical for the conservation and management of Whooper Swans and their key habitats in East Asian regions,and the data are anticipated to make a particularly significant contribution toward developing detailed management plans for the conservation of their key habitats.

关键词： Key stopover sites Migration characteristics Migration route Migration strategy Tracking Whooper Swan

Newly developed autoimmune cholangitis without relapse of autoimmune pancreatitis after discontinuing prednisolone

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World Journal of Gastroenterology 2012年第41期18卷 5990-5993页

作者： Ji Hun Kim Jae Hyuck Chang Sung Min Nam Mi Jeong Lee Il Ho Maeng jin young park Yun Sun Im Tae Ho Kim Chang Whan Kim Sok Won Han Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

A 57-year-old man presented with a 2-wk history of painless jaundice and weight Iossl He had a large ill- defined enhancing mass-like lesion in the uncinate pro- cess of the pancreas with stricture of the distal common bile duct. Aspiration cytology of the pancreatic mass demonstrated inflammatory cells without evidence of malignancy. Total serum immunoglobulin G level was slightly elevated, but IgG4 level was normal. After the 2-wk 40 mg prednisolone trial, the patient＇s symptoms and bilirubin level improved significantly. A follow-up computed tomography （CT） scan showed a dramatic resolution of the pancreatic lesion. A low dose steroid was continued. After six months he self-discontinued prednisolone for 3 wk, and was presented with jaundice again. ACT scan showed newly developed intrahepatic biliary dilatation and marked concentric wall thickening of the common hepatic duct and the proximal common bile duct without pancreatic aggravation. The patient＇ s IgG4 level was elevated to 2.51 g/L. Prednisolone was started again, after which his serum bilirubin level became normal and the thickening of the bile duct was resolved. This case suggests that autoimmune pancre- atitis can progress to other organs that are not involved at the initial diagnosis, even with sustained pancreatic remission.

关键词： Autoimmune disease Pancreatitis Cholan-gitis Prednisolone

Establishment and characterization of four human hepatocellular carcinoma cell lines containing hepatitis B virus DNA

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World Journal of Gastroenterology 1999年第4期5卷 17-23页

作者： Jae Ho Lee 1, Ja Lok Ku 1, young jin park 1,2 , Kuhn Uk Lee 2, Woo Ho Kim 3 and Jae Gahb park 1,2

AIM To investigate the characteristics of newly established four hepatocellular carcinoma cell lines (SNU 739, SNU 761, SNU 878 and SNU 886) from Korean hepatocellular cancer patients. METHODS Morphologic and genetic studies were done. RESULTS All four lines grew as a monolayer with an adherent pattern, and their doubling times ranged from 20 to 29 hours. The viability rate was relatively high (88%-94%). Neither mycoplasmal nor bacterial contamination was present. The lines showed different patterns in fingerprinting analysis. The hepatitis B virus (HBV) DNA was integrated in the genomes of all four lines, and in all of them HBx, HBc and HBs transcripts were detected by reverse transcriptase PCR methods. Among the three cell lines used as control (Hep 3B, SK Hep1 and Hep G2), only Hep 3B showed HBx expression, and this line was used as a HBV integrated control. The RNA of albumin was detected in three lines (SNU 761, SNU 878 and SNU 886), that of transferrin in two lines (SNU 878, SNU 886), and that of IGF Ⅱ was detected in none of the cell lines. CONCLUSION These well characterized cell lines may be very useful for studying the biology of hepatocellular carcinoma in association with the hepatitis B virus.

关键词： carcinoma, hepatocellular liver neoplasms hepatitis B virus hepatitis x antigen cell line