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Role of bile acids in colon carcinogenesis

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World Journal of Clinical Cases 2018年第13期6卷 577-588页

作者： Thi Thinh Nguyen Trong Thuan Ung Nam Ho Kim young do jung Department of Biochemistry Chonnam National University Medical School Department of Nephrology Chonnam National University Medical School

Bile acids(BAs)are cholesterol derivatives synthesized in the liver and then secreted into the intestine for lipid *** are numerous scientific reports describing BAs,especially secondary BAs,as strong carcinogens or promoters of colon ***,BAs act as strong stimulators of colorectal cancer(CRC)initiation by damaging colonic epithelial cells,and inducing reactive oxygen species production,genomic destabilization,apoptosis resistance,and cancer stem cells-like ***,BAs promote CRC progression via multiple mechanisms,including inhibiting apoptosis,enhancing cancer cell proliferation,invasion,and *** are diverse signals involved in the carcinogenesis mechanism of BAs,with a major role of epidermal growth factor receptor,and its down-stream signaling,involving mitogen-activated protein kinase,phosphoinositide 3-kinase/Akt,and nuclear factor kappa-light-chain-enhancer of activated B *** regulate numerous genes including the human leukocyte antigen class I gene,p53,matrix metalloprotease,urokinase plasminogen activator receptor,Cyclin D1,cyclooxygenase-2,interleukin-8,and miRNAs of CRC cells,leading to CRC *** evidence suggests that targeting BAs is an efficacious strategies for CRC prevention and treatment.

关键词： Apoptosis resistance Cancer stemness Bile acids Colorectal cancer Reactive oxygen species Angiogenesis

Helicobacter pylori and interleukin-8 in gastric cancer

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World Journal of Gastroenterology 2013年第45期19卷 8192-8202页

作者： Ko Eun Lee Pham Ngoc Khoi Yong Xia jung Sun Park young Eun Joo Kyung Keun Kim Seok Yong Choi young do jung Research Institute of Medical Sciences Chonnam National University Medical School Gwangju 501-190 South Korea

Helicobacter pylori(***)is a major etiological factor in the development of gastric ***-scale epidemiological studies have confirmed the strong association between *** infection and both cancer development and ***-8(IL-8)is overexpressed in gastric mucosa exposed to *** expression of IL-8 directly correlates with a poor prognosis in gastric ***-8 is *** addition to its potent chemotactic activity,it can induce proliferation and migration of cancer *** this review,we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric *** relationship between IL-8 and *** is *** also summarize the current therapeutics against IL-8 in gastric cancer.

关键词： Helicobacter pylori Interleukin-8 Signals Gastric cancer Therapeutics

Effect of Ca addition on the microstructure and mechanical properties of heat-treated Mg-6.0Zn-1.2Y-0.7Zr alloy

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Journal of Magnesium and Alloys 2021年第5期9卷 1636-1648页

作者： young Gil jung Wonseok Yang Yong Joo Kim Shae.K.Kim young Ok Yoon Hyunkyu Lim do Hyang Kim Advanced Materials and Process R&D Department Korea Institute of Industrial Technology156Gaetbeol-roIncheon 21999Republic of Korea Department of Metallurgical Engineering Yonsei University50Yonsei-roSeoulSeodaemun-gu 03722Republic of Korea

In this study,the effects of Ca addition on the microstructure,thermal properties,and mechanical properties of a Mg-6.0Zn-1.2Y-0.7Zr(ZWK611)alloy at room temperature and 150℃ were *** an increase in the Ca content,the ignition resistance of the ZWK611 alloy improved and the grains became *** as-cast ZWK611 alloy consisted mainly of the dendriticα-Mg matrix and I-phase(Mg_(3)Zn_(6)Y)at the grain *** the other hand,theτ-(Ca_(2)Mg_(6)Zn_(3))and I-phases were formed in the Ca-added ZWK611 *** fraction of theτ-phase increased with an increase in the Ca *** the solid-solution treatment,these phases remained partially at the grain boundaries of the Ca-added ZWK611 alloys and an additional W-phase(Mg_(3)Zn_(3)Y)was *** phases remaining at the grain boundaries restricted the grain growth through the grain boundary pinning *** aging treatment resulted in the formation of MgZn'precipitates in theα-Mg matrix of the *** precipitates were more uniformly distributed in the Ca-added alloys than in the alloys without ***,the heat treatment-induced precipitation improved the tensile and creep properties of the T6-treated *** T6-treated ZWK611+0.7Ca alloy exhibited the best mechanical properties at room temperature and 150℃ among all the tested alloys.

关键词： Mg-Zn-Y alloys Heat-treatment Precipitate Mechanical properties Thermal analysis

Transient involuntary movement disorder after spinal anesthesia: A case report

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World Journal of Clinical Cases 2021年第26期9卷 7917-7922页

作者： Giyoung Yun Eunsoo Kim Wangseok do young-Hoon jung Hyun-Ju Lee Yesul Kim Department of Anesthesia and Pain Medicine Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Anesthesia and Pain Medicine Pusan National UniversitySchool of MedicineYangsan 50612South Korea

BACKGROUND Spinal anesthesia is commonly used for various *** many complications occur after induction of spinal anesthesia,involuntary movement is an extremely rare *** SUMMARY Herein,we report the case of a 54-year-old healthy male patient who experienced involuntary movements after intrathecal injection of local *** patient had undergone metal implant removal surgery in both the lower extremities;7 h after intrathecal hyperbaric bupivacaine administration,involuntary raising of the left leg began to occur every 2 *** the movement disorder appeared,the patient was conscious and *** other specific symptoms were noted in the physical examination conducted immediately after the involuntary leg raising started;moreover,the patient's motor and sensory assessments were *** symptom gradually *** hours after the symptom first occurred,its frequency decreased to approximately once every three *** days postoperatively,the symptoms had completely disappeared without *** Anesthesiologists should be aware that movement disorders can occur after spinal anesthesia and be able to identify the cause,such as electrolyte imbalance or epilepsy,since immediate action may be required for ***,it is crucial to know that involuntary movement that develop following spinal anesthesia is mostly self-limiting and may not require additional costly examinations.

关键词： Movement disorder Spinal anesthesia Bupivacaine Dexmedetomidine Case report

Fabrication of periodically aligned vertical singlecrystalline anatase TiO2 nanotubes with perfect hexagonal open-ends using chemical capping materials

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Nano Research 2014年第1期7卷 104-109页

作者： Hui Song Kyubong Jo Bock young jung Gun young jung School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju Republic of Korea Department of Chemistry and Interdisciplinary Program of Integrated Biotechnology Sogang University Seoul Republic of Korea Department of General Dentistry College of Dentistry Yonsei University Seoul Republic of Korea

A vertically aligned anatase TiO2 （A-TiO2） nanotube array has been fabricated by coating a ZnO nanorod （NR） template with a TiO2 precursor solution. After coating, the ZnO NR cores were selectively etched in an acidic environment to form TiO2 nanotubes （NTs）. More specifically, after growing the ZnO NRs via a hydrothermal method, one drop of the TiO2 precursor solution was cast to coat the ZnO NRs, the tops of which were previously covered with chemical capping materials by electrostatic interaction, and then the sample was sintered. Finally, the sample was immersed in an acidic solution resulting in selective etching of the ZnO NR cores. Thus, only TiO2 NTs remained on the substrate. The capping material is effectively used to create a perfect, hexagonal open-ended TiO2 NT array, which interestingly extends onset absorption towards the visible region.

关键词： TiO2 nanotubes chemical capping material ZnO nanorod template laser interferencelithography

Diagnosis and management of ophthalmic zoster sine herpete accompanied by cervical spine disc protrusion:A case report

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World Journal of Clinical Cases 2021年第25期9卷 7588-7592页

作者： Giyoung Yun Eunsoo Kim Jiseok Baik Wangseok do young-Hoon jung Chang-Min You Department of Anesthesia and Pain Medicine Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Anesthesia and Pain Medicine Pusan National UniversitySchool of MedicineYangsan 50612South Korea

BACKGROUND Zoster sine herpete(ZSH)can be misdiagnosed because there are no typical vesicular eruptions characterized by a dermatomal ***,incorrect treatment due to a misdiagnosis can lead to severe pain and fatal *** SUMMARY A 75-year-old woman complained of sudden onset right shoulder pain and atypical *** 18 d,sudden hearing loss occurred in the left *** serology tests conducted after the onset of hearing loss,varicella-zoster virus IgM was *** had no history of a rash or *** the suspicion of ZSH,antiviral treatment and stellate ganglion block were administered four times,and the pain was effectively *** Early diagnosis and treatment of ZSH can help not only by reducing pain but also by preventing fatal complications.

关键词： Zoster sine herpete Ophthalmic pain Burning pain Ultrasound-guided stellate ganglion block Case report

Nontarget screening using passive air and water sampling with a level Ⅱ fugacity model to identify unregulated environmental contaminants

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Journal of Environmental Sciences 2017年第12期29卷 84-91页

作者： In-young Chung Yu-Mi Park Hyun-Jeoung Lee Hyuk Kim dong-Hoon Kim Il-Gyu Kim Sang-Min Kim young-Sun do Kwang-Seol Seok jung-Hwan Kwon Chemical Research Division Environmental Health Research Department National Institute of Environmental ResearchIncheon Division of Environmental Science and Ecological Engineering Korea University

It is thought that there are many unregulated anthropogenic chemicals in the *** risk assessment of chemicals, it is essential to estimate the predicted environmental concentrations. As an effort of identifying residual organic contaminants in air and water in Korea, nontarget screening using two-dimensional gas chromatography time-of-flight mass spectrometry（GC × GC-TOFMS） was conducted at 10 sites using polyurethane foam passive air sampler and at 6 sites using polydimethyl siloxane（PDMS） passive water sampler in three different seasons in 2014. More than 600 chemical peaks were identified satisfying the identification criteria in air and water samples, respectively, providing a list for further investigation. Chemical substances with reported national emission rates in2014（n = 149） were also screened for potential existence in the environment using a level Ⅱ fugacity model. Most of chemical substances classified as not detectable were not identified with detection frequency greater than 20% by nontarget screening, indicating that a simple equilibrium model has a strong potential to be used to exclude chemicals that are not likely to remain in the environment after emissions from targeted monitoring.

关键词： Nontarget screening GC × GC-TOFMS Passive sampling Pollutant release and transfer register(PRTR) Fugacity model

Chemical surface tuning of zinc metal anode toward stable,dendrite-less aqueous zinc-ion batteries

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Journal of Energy Chemistry 2023年第11期86卷 1-8,I0001页

作者： Pranav Kulkarni Sun-Sik Kim Hyun young jung Department of Energy Engineering Gyeongsang National UniversityJinju-siGyeongnam 52725South Korea Department of Energy System Engineering Gyeongsang National UniversityJinju-siGyeongnam 52725South Korea

The commercialization of Zn batteries is confronted with urgent challenges in the metal anode,such as dendrite formation,capacity loss,and cracking or ***,surface interfacial engineering of the Zn anode is introduced for achieving safety and dendritic-free cycling for high-performance aqueous Zn batteries through a simple but highly effective chemical etching-substitution *** chemical modification induces a rough peak-valley surface with a thin fluorine-rich interfacial layer on the Zn anode surface,which regulates the growth orientation via guiding uniform Zn plating/stripping,significantly enhances accessibility to aqueous electrolytes and improves wettability by reducing surface *** a result,such a synergetic surface effect enables uniform Zn plating/stripping with low polarization of 29 m V at a current density of 0.5 m A cm^(-2) with stable cyclic performance up to 1000 ***,a full cell composed of a fluorine-substituted Zn anode coupled with aβ-MnO_(2)or Ba-V_(6)O_(13)cathode demonstrates improved capacity retention to 1000 cycles compared to the pristine-Zn *** proposed valley deposition model provides the practical direction of surface-modified interfacial chemistries for improving the electrochemical properties of multivalent metal anodes via surface tuning.

关键词： Dendrite free Peak-Valley surface Zinc-ion batteries Surface modification Fluorinated interface

Hydrogen sulfide controls peripheral nerve degeneration and regeneration:a novel therapeutic strategy for peripheral demyelinating disorders or nerve degenerative diseases

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Neural Regeneration Research 2014年第24期9卷 2119-2121页

作者： Junyang jung Na young Jeong Department of Anatomy and Neurobiology School of Medicine Biomedical Science Institution Kyung Hee University Department of Anatomy and Cell Biology College of Medicine Dong-A University

After peripheral nerve injury, the process of Wallerian degeneration is initiated in the distal stump of injured nerves. Wallerian degeneration in peripheral nerves involves axonal degeneration and degradation of the myelin sheath in Schwann cells. This provides the necessary conditions for axonal regeneration and remyelination. After nerve injury, macrophages are also recruited to the distal nerve stump and, together with Schwann cells, play a role in the clearance of myelin debris.

关键词： Hydrogen sulfide controls peripheral nerve degeneration and regeneration Figure