Helicobacter pylori and interleukin-8 in gastric cancer

作     者：Ko Eun Lee Pham Ngoc Khoi Yong Xia Jung Sun Park Young Eun Joo Kyung Keun Kim Seok Yong Choi Young Do Jung 

作者机构：Research Institute of Medical Sciences Chonnam National University Medical School Gwangju 501-190 South Korea 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第45期

页      面：8192-8202页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by A research grant,No.0720570,from the National Cancer Center,by the National Research Foundation of Korea(NRF)grant,Basic Research Program,No.2010-0009910 MRCfor Gene Regulation,No.2011-0030132 funded by the Korea government(MSIP) 

主　　题：Helicobacter pylori Interleukin-8 Signals Gastric cancer Therapeutics 

摘      要：Helicobacter pylori(***)is a major etiological factor in the development of gastric ***-scale epidemiological studies have confirmed the strong association between *** infection and both cancer development and ***-8(IL-8)is overexpressed in gastric mucosa exposed to *** expression of IL-8 directly correlates with a poor prognosis in gastric ***-8 is *** addition to its potent chemotactic activity,it can induce proliferation and migration of cancer *** this review,we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric *** relationship between IL-8 and *** is *** also summarize the current therapeutics against IL-8 in gastric cancer.