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Effects of Norepinephrine on Renal Cortical and Medullary Blood Flow in Atherosclerotic Rabbits

Current Medical Science 2022年第6期42卷 1172-1177页

作者： Jia-yu WANG Jie SUN you-bin deng Yu-bo WANG Kun LIU Department of Medical Ultrasound Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Medical Ultrasound Maternal and Child Healthcare Hospital of Hubei ProvinceTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430064China Department of Medical Ultrasound The Third People’s Hospital of Hubei ProvinceWuhan430030China

Objective The aim of this study was to explore the effect of norepinephrine(NE)on renal cortical and medullary blood flow in atherosclerotic rabbits without renal artery *** Atherosclerosis was induced in 21 New Zealand white rabbits by feeding them a cholesterol-rich diet for 16 *** healthy New Zealand white rabbits were randomly selected as *** atherosclerosis induction,standard ultrasonography was performed to confirm that there was no plaque or accelerated flow at the origin of the renal ***-enhanced ultrasound(CEUS)was performed at baseline and during intravenous injection of *** degree of contrast enhancement of renal cortex and medulla after the injection of contrast agents was quantified by calculating the enhanced *** The serum nitric oxide(NO)level in atherosclerotic rabbits was higher than that in healthy rabbits(299.6±152 vs.136.5±49.5,P<0.001).The infusion of NE induced a significant increase in the systolic blood pressure(112±14 mmHg vs.84±9 mmHg,P=0.016)and a significant decrease in the enhanced intensity in renal cortex(17.78±2.07 dB vs.21.19±2.03 dB,P<0.001)and renal medulla(14.87±1.82 dB vs.17.14±1.89 dB,P<0.001)during ***,the enhanced intensity in the cortex and medulla of healthy rabbits after NE infusion showed no significant difference from that at *** NE may reduce renal cortical and medullary blood flow in atherosclerotic rabbits without renal artery stenosis,partly by reducing the serum NO level.

关键词： norepinephrine atherosclerosis contrast-enhanced ultrasound renal blood flow

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Intrinsic Wave Velocity Propagation:A Novel Parameter for Assessing the Effect of Anthracycline Chemotherapy Agents on Cardiac Diastolic Function in Breast Cancer Patients

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Current Medical Science 2023年第6期43卷 1229-1237页

作者： Xiao HUANG Xin-ying FAN Qiao CHENG Jun ZHANG Jie SUN Qiao-ying TANG you-bin deng Xiao-jun BI Department of Medical Ultrasound Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Anthracycline chemotherapeutic agents have significant *** present study emphasized the effect of anthracycline chemotherapy drugs on left ventricular(LV)myocardial stiffness in breast cancer patients by measuring the intrinsic wave velocity propagation(IVP),and evaluating the potential clinical value of IVP in detecting early LV diastolic function *** A total of 68 newly diagnosed breast cancer patients,who were treated with anthracycline-based chemotherapy,were *** echocardiography was performed at baseline(T0),and after 1,2,3,4 and 8 chemotherapeutic cycles(T1,T2,T3,T4 and T5,respectively).Then,the IVP,LV strain parameters[global longitudinal strain(GLS),longitudinal peak strain rate at systole(LSRs),longitudinal peak strain rate at early diastole(LSRe),longitudinal peak strain rate at late diastole(LSRa),and the E/LSRe ratio],and conventional echocardiographic parameters were obtained and further analyzed.A relative reduction of>15%in GLS was considered a marker of early LV subclinical *** Compared to the T0 stage,IVP significantly increased at the T1 ***,there were no significant changes in GLS,LSRs,or LSRe between the T0 and T1 *** parameters significantly decreased from the T2 *** started to significantly decrease at the T5 stage,and the E/LSRe ratio started to significantly increase at the T3 stage(all P<0.05).At the T0 stage,IVP(AUC=0.752,P<0.001)had a good predictive value for LV subclinical dysfunction after *** IVP is a potentially sensitive parameter for the early clinical assessment of anthracycline-related cardiac diastolic impairment.

关键词： breast cancer anthracycline chemotherapy drugs intrinsic wave velocity propagation myocardial stiffness cardiac diastolic function

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Artificial intelligence in medical imaging of the liver

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World Journal of Gastroenterology 2019年第6期25卷 672-682页

作者： Li-Qiang Zhou Jia-Yu Wang Song-Yuan Yu Ge-Ge Wu Qi Wei you-bin deng Xing-Long Wu Xin-Wu Cui Christoph F Dietrich Sino-German Tongji-Caritas Research Center of Ultrasound in Medicine Department of Medical Ultrasound Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Ultrasound Tianyou Hospital Affiliated to Wuhan University of Technology School of Mathematics and Computer Science Wuhan Textitle University Medical Clinic 2 Caritas-Krankenhaus Bad Mergentheim Academic Teaching Hospital of the University of Würzburg

Artificial intelligence(AI), particularly deep learning algorithms, is gaining extensive attention for its excellent performance in image-recognition tasks. They can automatically make a quantitative assessment of complex medical image characteristics and achieve an increased accuracy for diagnosis with higher efficiency. AI is widely used and getting increasingly popular in the medical imaging of the liver, including radiology, ultrasound, and nuclear medicine. AI can assist physicians to make more accurate and reproductive imaging diagnosis and also reduce the physicians' workload. This article illustrates basic technical knowledge about AI, including traditional machine learning and deep learning algorithms, especially convolutional neural networks, and their clinical application in the medical imaging of liver diseases, such as detecting and evaluating focal liver lesions, facilitating treatment, and predicting liver treatment response. We conclude that machine-assisted medical services will be a promising solution for future liver medical care. Lastly, we discuss the challenges and future directions of clinical application of deep learning techniques.

关键词： Liver Imaging Ultrasound Artificial intelligence Machine learning Deep learning

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Artificial intelligence in breast ultrasound

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World Journal of Radiology 2019年第2期11卷 19-26页

作者： Ge-Ge Wu Li-Qiang Zhou Jian-Wei Xu Jia-Yu Wang Qi Wei you-bin deng Xin-Wu Cui Christoph F Dietrich Sino-German Tongji-Caritas Research Center of Ultrasound in Medicine Department of Medical Ultrasound Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Ultrasound The First Affiliated Hospital of Zhengzhou University Medical Clinic 2 Caritas-Krankenhaus Bad Mergentheim Academic Teaching Hospital of the University of Würzburg

Artificial intelligence(AI) is gaining extensive attention for its excellent performance in image-recognition tasks and increasingly applied in breast ultrasound. AI can conduct a quantitative assessment by recognizing imaging information automatically and make more accurate and reproductive imaging diagnosis. Breast cancer is the most commonly diagnosed cancer in women,severely threatening women's health, the early screening of which is closely related to the prognosis of patients. Therefore, utilization of AI in breast cancer screening and detection is of great significance, which can not only save time for radiologists, but also make up for experience and skill deficiency on some beginners. This article illustrates the basic technical knowledge regarding AI in breast ultrasound, including early machine learning algorithms and deep learning algorithms, and their application in the differential diagnosis of benign and malignant masses. At last, we talk about the future perspectives of AI in breast ultrasound.

关键词： Breast Ultrasound Artificial intelligence Machine learning Deep learning

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Review of Design of Process Parameters for Squeeze Casting

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Chinese Journal of Mechanical Engineering 2023年第6期36卷 22-35页

作者： Jianxin deng bin Xie Dongdong you Haibin Huang Guangxi Key Lab of Manufacturing System and Advanced Manufacturing Technology School of Mechanical EngineeringGuangxi UniversityNanning 530003China National Engineering Research Center of Near-Net-Shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510640China

Squeeze casting(SC)is an advanced net manufacturing process with many advantages for which the quality and properties of the manufactured parts depend strongly on the process ***,a universal efficient method for the determination of optimal process parameters is still *** view of the shortcomings and development needs of the current research methods for the setting of SC process parameters,by consulting and analyzing the recent research literature on SC process parameters and using the CiteSpace literature analysis software,manual reading and statistical analysis,the current state and characteristics of the research methods used for the determination of SC process parameters are *** literature data show that the number of pub-lications in the literature related to the design of SC process parameters generally trends upward albeit with signifi-cant *** of the research focus shows that both“mechanical properties”and“microstructure”are the two main subjects in the studies of SC process *** regard to materials,aluminum alloys have been extensively *** methods have been used to obtain SC process parameters:Physical experiments,numeri-cal simulation,modeling optimization,formula calculation,and the use of empirical *** experiments are the main research *** main methods for designing SC process parameters are divided into three categories:Fully experimental methods,optimization methods that involve modeling based on experimental data,and theoreti-cal calculation methods that involve establishing an analytical *** research characteristics and shortcomings of each method were *** simulations and model-based optimization have become the new required *** the development needs and data-driven trends of the SC process,suggestions for the develop-ment of SC process parameter research have been proposed.

关键词： Squeeze casting Process parameter design Process parameter optimization Data-driven Neural network Research method analysis Literature analysis CiteSpace

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Ultrahigh spatiotemporal resolution beam signal reconstruction with bunch phase compensation

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Nuclear Science and Techniques 2024年第5期35卷 99-108页

作者： you-Ming deng Yong-bin Leng Xing-Yi Xu Jian Chen Yi-Mei Zhou Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of the Chinese Academy of Sciences Beijing 100049China Shanghai Synchrotron Radiation Facility Chinese Academy of SciencesShanghai 201204China University of Science and Technology of China Hefei 230026China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China

Various electromagnetic signals are excited by the beam in the acceleration and beam-diagnostic elements of a particle *** is important to obtain time-domain waveforms of these signals with high temporal resolution for research,such as the study of beam–cavity interactions and bunch-by-bunch parameter ***,a signal reconstruction algorithm with ultrahigh spatiotemporal resolution and bunch phase compensation based on equivalent sampling is proposed in this *** with traditional equivalent sampling,the use of phase compensation and setting the bunch signal zero-crossing point as the time reference can construct a more accurate reconstructed *** basic principles of the method,simulation,and experimental comparison are also *** on the beam test platform of the Shanghai Synchrotron Radiation Facility(SSRF)and the method of experimental verification,the factors that affect the reconstructed signal quality are analyzed and discussed,including the depth of the sampled data,quantization noise of analog-to-digital converter,beam transverse oscillation,and longitudinal *** results of the beam experiments show that under the user operation conditions of the SSRF,a beam excitation signal with an amplitude uncertainty of 2%can be reconstructed.

关键词： Turn-by-turn bunch phase compensation technique Equivalent sampling Signal reconstruction algorithm Ultrahigh spatiotemporal resolution SSRF

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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin bin Mingming Zhao Jun Liu Jianrong Yang Demao deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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Association of body mass index with serum alanine aminotransferase in Chinese adolescents:a school-based cross-sectional study

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Gastroenterology Report 2020年第2期8卷 119-124,I0002页

作者： Zan Ding Jing Zhang Chang-Yu deng Ying-bin you Hua Zhou Institute of Low Carb Medicine Baoan Central Hospital of Shenzhenthe Fifth Affiliated Hospital of Shenzhen UniversityShenzhenGuangdongP.R.China Department of Nursing Baoan Central Hospital of Shenzhenthe Fifth Affiliated Hospital of Shenzhen UniversityShenzhenGuangdongP.R.China Department of Preventive Medicine Shantou University Medical CollegeShantouGuangdongP.R.China

Background:Numerous studies have consistently demonstrated that high body mass index(BMI)is related to elevated serum alanine aminotransferase(ALT)among adults,but little is known about the association regarding adolescents,especially in *** this study,we aimed to investigate the association between BMI and ALT activity among Chinese ***:A school-based cross-sectional study was performed among nine high schools in Shenzhen,China between February 2017 and June 2018.A generalized linear-regression model adjusting for age and gender was conducted,and bivariate correlation analysis between ALT and BMI was also ***:A total of 7,271 adolescents aged from 9 years to 17 years were ***,weight,BMI,and ALT were higher among boys than among girls(all P<0.001).The mean(standard deviation)of serum ALT levels was 14.26(14.77)U/*** the entire BMI range,the BMIALT correlation was stronger for boys(Spearman’s r=0.396,P<0.001)and adolescents of 14 years17 years(r=0.356,P<0.001)than for girls(r=0.203,P<0.001)and adolescents of 9 years13 years(r=0.221,P<0.001),*** ALT increased rapidly and followed a linear pattern from the point of BMI20.5 kg/m^(2),and each increase of 1 kg/m^(2)in BMI range above 20.5 kg/m^(2)was averagely correlated with an increase of 2.71 U/L in ALT levels(P<0.001).Conclusions:We found a significant BMIALT *** at 20.5 kg/m^(2)may be a cut-off for evaluating serum ***27.1 kg/m^(2)for boys and24.9 kg/m^(2)for girls were linked to an elevated ALT activity for Shenzhen adolescents.

关键词： adolescent alanine aminotransferase association body mass index cut-off point

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Determination of the Weibull parameters from the mean value and the coefficient of variation of the measured strength for brittle ceramics

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Journal of Advanced Ceramics 2017年第2期6卷 149-156页

作者： bin deng Danyu JIANG Department of the Prosthodontics Chinese PLA General Hospital Beijing 100853 China Analysis and Testing Center for Inorganic Materials State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Shanghai 200050 China

Accurate estimation of Weibull parameters is an important issue for the characterization of the strength variability of brittle ceramics with Weibull *** this paper,a simple method was established for the determination of the Weibull parameters,Weibull modulus m and scale parameter σ0,based on Monte Carlo *** was shown that an unbiased estimation for Weibull modulus can be yielded directly from the coefficient of variation of the considered strength ***,using the yielded Weibull estimator and the mean value of the strength in the considered sample,the scale parameter σ0 can also be estimated accurately.

关键词： Weibull distribution Weibull parameters strength variability unbiased estimation coefficient of variation

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