Association of body mass index with serum alanine aminotransferase in Chinese adolescents:a school-based cross-sectional study

作     者：Zan Ding Jing Zhang Chang-Yu Deng Ying-Bin You Hua Zhou 

作者机构：Institute of Low Carb MedicineBaoan Central Hospital of Shenzhenthe Fifth Affiliated Hospital of Shenzhen UniversityShenzhenGuangdongP.R.China Department of NursingBaoan Central Hospital of Shenzhenthe Fifth Affiliated Hospital of Shenzhen UniversityShenzhenGuangdongP.R.China Department of Preventive MedicineShantou University Medical CollegeShantouGuangdongP.R.China 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2020年第8卷第2期

页      面：119-124,I0002页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by the Baoan District Medical and Health Basic Research Project[grant number:2018JD088] 

主　　题：adolescent alanine aminotransferase association body mass index cut-off point 

摘      要：Background:Numerous studies have consistently demonstrated that high body mass index(BMI)is related to elevated serum alanine aminotransferase(ALT)among adults,but little is known about the association regarding adolescents,especially in *** this study,we aimed to investigate the association between BMI and ALT activity among Chinese ***:A school-based cross-sectional study was performed among nine high schools in Shenzhen,China between February 2017 and June 2018.A generalized linear-regression model adjusting for age and gender was conducted,and bivariate correlation analysis between ALT and BMI was also ***:A total of 7,271 adolescents aged from 9 years to 17 years were ***,weight,BMI,and ALT were higher among boys than among girls(all P0.001).The mean(standard deviation)of serum ALT levels was 14.26(14.77)U/*** the entire BMI range,the BMIALT correlation was stronger for boys(Spearman’s r=0.396,P0.001)and adolescents of 14 years17 years(r=0.356,P0.001)than for girls(r=0.203,P0.001)and adolescents of 9 years13 years(r=0.221,P0.001),*** ALT increased rapidly and followed a linear pattern from the point of BMI20.5 kg/m^(2),and each increase of 1 kg/m^(2)in BMI range above 20.5 kg/m^(2)was averagely correlated with an increase of 2.71 U/L in ALT levels(P0.001).Conclusions:We found a significant BMIALT *** at 20.5 kg/m^(2)may be a cut-off for evaluating serum ***27.1 kg/m^(2)for boys and24.9 kg/m^(2)for girls were linked to an elevated ALT activity for Shenzhen adolescents.