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Pyroptosis: mechanisms and diseases

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1233-1253页

作者： Pian Yu Xu Zhang nian liu Ling Tang Cong Peng Xiang Chen The Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunanChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalChangshaHunanChina Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya HospitalChangshaHunanChina Hunan Engineering Research Center of Skin Health and Disease Xiangya HospitalChangshaHunanChina Xiangya Clinical Research Center for Cancer Immunotherapy Central South UniversityChangshaHunanChina

Currently,pyroptosis has received more and more attention because of its association with innate immunity and *** research scope of pyroptosis has expanded with the discovery of the gasdermin family.A great deal of evidence shows that pyroptosis can affect the development of *** relationship between pyroptosis and tumors is diverse in different tissues and genetic *** this review,we provide basic knowledge of pyroptosis,explain the relationship between pyroptosis and tumors,and focus on the significance of pyroptosis in tumor *** addition,we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by *** brief,pyroptosis is a double-edged sword for *** rational use of this dual effect will help us further explore the formation and development of tumors,and provide ideas for patients to develop new drugs based on pyroptosis.

关键词： immunity drugs chemotherapy

QTL Mapping for Adult-Plant Resistance to Stripe Rust in a Common Wheat RIL Population Derived from Chuanmai 32/Chuanyu 12

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Journal of Integrative Agriculture 2012年第11期11卷 1775-1782页

作者： WU Ling XIA Xian-chun ZHENG you-liang ZHANG Zheng-yu ZHU Hua-zhong liu Yong-j ian YANG En-nian LI Shi-zhao HE Zhong-hu Crop Research Institute Sichuan Academy of Agricultural Science Chengdu 610066 P.R. China Institute of Crop Sciences National Wheat Improvement Center/The National Key Facility for Crop Gene Resources and Genetic Improvement Chinese Academy of Agricultural Sciences (CAAS) Beijing 100081 P.R.China Triticeae Research Institute Sichuan Agricultural University Chengdu 611130 P..R. China International Maize and Wheat Improvement Center (CIMMYT) China Office/Chinese Academy of Agricultural Sciences Beijing 100081 P.R China Plant Protection Institute Sichuan Academy of Agricultural Science Chengdu 610066 P.R.China College of Agriculture Siehuan Agricultural University Chengdu 611130 P.R.China

Stripe rust, caused by Puccinia striiformis f. sp. tritici, is a devastating wheat disease worldwide. The Chinese wheat cultivar Chuanmai 32 has shown stable resistance to stripe rust for 10 yr in Sichuan Province, a hotspot for stripe rust epidemics. The objective of the present study was to map quantitative trait loci （QTL） for adult-plant resistance （APR） to stripe rust in a population of 140 recombinant inbred lines （RILs） derived from Chuanmai 32/Chuanyu 12. Field trials were conducted in Chengdu and Yaan, Sichuan, from 2005 to 2008, providing stripe rust reaction data for 6 environments. 797 simple sequence repeat （SSR） markers were screened for association with stripe rust reaction, initially through bulked segregant analysis （BSA）. Based on the mean disease values averaged across environments, the broad-sense heritability of maximum disease severity （MDS） was 0.75. Two QTLs for stripe rust resistance were detected by composite interval mapping （CIM）. They were designated ***-3BL and ***-3BS and explained from 6.6 to 20.1%, respectively, of the phenotypic variance across environments. ***-3BL came from Chuanmai 32; ***-3BS with lower effect was from the susceptible parent Chuanyu 12. Both QTLs appear to be new.

关键词： APR Triticum aestivum microsatellites quanitative trait locus yellow rust

Modeling and Utilization of Biomass-to-syngas for Industrial Multi-energy Systems

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CSEE Journal of Power and Energy Systems 2021年第5期7卷 932-942页

作者： Kuan Zhang Bin Zhou Qiuwei Wu Yijia Cao nian liu Nikolai Voropai Evgeny Barakhtenko College of Electrical and Information Engineering Hunan UniversityChangsha 410082China Center for Electric Power and Energy.Department of Electrical Engineering.Technical University of Denmark.Kgs.Lynghy 28(M)Denmark. State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China. Melentiev Energy Systems Institute of Siberian Branch of the Russian Academy of Sciences IrkutskRussia.

Excessive consumption of fossil fuels in the industry sector has caused hij»h operating costs and severe environmental pollution,advocating a cost-effective and sustainable substitute for fossil fuels.I'his paper proposes an enhanced utilization mechanism of biomass-to-syngas(B2S)to provide various types of steam flows in industrial multi-energy systems(MESs).In this mechanism,the available generations from renewable energy sources(RESs)can be harvested to assist in the biomass gasification in a B2S gasifier for enhancing the syngas yield and its calorific value.A thermodynamic interaction model for B2S is formulated to capture gasification temperature dynamics under high-temperature steam injections and optimally control the thermochemical behaviors of biomass drying,pyrolysis,and gasification.A B2S based energy hub framework with its multienergy coupling matrix is formulated for mapping the input hiomass-wind-solar energy into electricity,syngas,and various types of’steam carriers to satisfy industrial energy cieniands.A hierarchical multi-timeframe dispatch scheme is developed for the energy-efficient conversion and utilization of multi-energy carriers to minimize the system operation *** studies are implemented to demonstrate the superior performance of the proposed methodology on system operational economy and sustainability.

关键词： Biomass energy microgrid multi-energy systems renewable energy sources syngas

建筑材料课程思政元素的挖掘、设计及融入教学实践研究

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科教文汇 2025年第1期 100-105页

作者：王婷郭红军刘梦溪杨柳年立辉江苏建筑职业技术学院江苏徐州221116

落实立德树人根本任务,课程思政建设不可或缺。近年来,国家接连颁布多项加强高校课程思政建设的指导意见。该文聚焦建筑材料课程,剖析其特点与课程思政建设的必要性,深入阐释如何依据课程内容挖掘思政元素,并列举与知识点对应的思政元... 详细信息

落实立德树人根本任务,课程思政建设不可或缺。近年来,国家接连颁布多项加强高校课程思政建设的指导意见。该文聚焦建筑材料课程,剖析其特点与课程思政建设的必要性,深入阐释如何依据课程内容挖掘思政元素,并列举与知识点对应的思政元素及目标。结合思政内容对该课程进行课程思政的整体教学设计,并举例说明了如何开展相关教学实践以及如何进行课程思政教学效果评价,以期为其他专业课的课程思政建设提供思路。

关键词：建筑材料课程思政课堂教学教学设计教学评价

Esophageal superficial adenosquamous carcinoma resected by endoscopic submucosal dissection:A rare case report

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World Journal of Clinical Cases 2021年第6期9卷 1336-1342页

作者： Guan-Yi liu Ji-Xin Zhang Long Rong Wei-Dong nian Bi-Xiao nian Yuan Tian Endoscopy Center Peking University First HospitalBeijing 100032China Department of Pathology Peking University First HospitalBeijing 100032China

BACKGROUND Adenosquamous carcinoma(ASC),which is comprised of squamous cell carcinoma(SCC)and adenocarcinoma elements,is a rare histological type of esophageal *** reports have focused on the endoscopic findings and the effectiveness of the endoscopic treatment of early *** SUMMARY A 77-year-old man underwent esophagogastroduodenoscopy for heartburn.A flat lesion with an uneven and slightly elevated central portion was found in the distal *** endoscopy with narrow-band imaging showed a well-demarcated brownish area with dendritically branched abnormal vessels and highly irregular intrapapillary capillary loops.A histopathological diagnosis of SCC was obtained by endoscopic *** ultrasonography revealed a hypoechoic mass confined to the mucosa *** lesion was suspected to be SCC with invasion into the muscularis *** lesion was resected en bloc by endoscopic submucosal dissection and histologically diagnosed as esophageal ASC limited within the muscularis mucosa,which was completely resected without lymphovascular or neural *** SCC element was the predominant *** adenocarcinoma element formed ductal and nested structures distributed in a focal *** patient underwent only endoscopic submucosal dissection and has been under annual endoscopic and radiographic surveillance for 3 years without *** For early ASC confined within the mucosal layer,complete endoscopic resection might also be a curative treatment.

关键词： Adenosquamous carcinoma Esophageal neoplasms Endoscopy Narrow band imaging Endoscopic submucosal dissection Case report

Application of electromagnetic metallurgy in continuous casting: A review

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Progress in Natural Science:Materials International 2024年第1期34卷 1-11页

作者： Jiale Li Yi nian Xiang liu youcheng Zong Xinyu Tang Chaojie Zhang Liqiang Zhang The Intelligent Metallurgy Research Institute School of Metallurgical Engineering Anhui University of Technology

The standards within the global steel industry are constantly advancing, necessitating increasingly rigorous quality control protocols during the continuous casting process. Central to the challenges faced in this domain are persistent defects such as central segregation, V-shaped segregation, and center porosity, which significantly impede the production of high-caliber steel products. The discipline of electromagnetic metallurgy has emerged as a critical solution in reducing these defects, thereby enhancing the efficiency and stability of continuous casting operations. Its demonstrated effectiveness has led to its widespread implementation across global and domestic steel production industries. This paper aims to deliver a comprehensive examination of electromagnetic metallurgy's impact on the final stages of solidification in continuous casting, along with its contributions to the heating and purification processes within the tundish. Additionally, it will explore the potential advancements and applications of this technology in the evolving sphere of continuous casting.

关键词： continuous casting Quality control Final electromagnetic stirring Induction heating Electromagnetic purification

Association Between Polymorphisms of DNA Repair Gene XRCC1 and DNA Damage in Asbestos-Exposed Workers

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Biomedical and Environmental Sciences 2006年第3期19卷 232-238页

作者： XIAO-HONG ZHAO CUANG JIA YONG-QUAN liu SHAO-WEI liu LEI YAN YU JIN nian liu Beijing Key Laboratory of Bioactive Substances and Functional Foods Be（jing Union University Beijing 100083 China Department of Occupational and Environmental Health Sciences School of Public Health Peking University Beijing 100083 China Institue of Haidian Health Inspection and Supervision Beijing 100080 China

Objective To compare the asbestos-induced DNA damage and repair capacities of DNA damage between 104 asbestosexposed workers and 101 control workers in Qingdao City of China and to investigate the possible association between polymorphisms in codon 399 of XRCC1 and susceptibility to asbestosis. Methods DNA damage levels in peripheral blood lymphocytes were determined by comet assay, and XRCC1 genetic polymorphisms of DNA samples from 51 asbestosis cases and 53 non-asbestosis workers with a similar asbestos exposure history were analyzed by PCR/RFLP. Results The basal comet scores （3.95±2.95） were significantly higher in asbestos-exposed workers than in control workers （0.10±0.28）. After 1 h H2O2 stimulation, DNA damage of lymphocytes exhibited different increases. After a 4 h repair period, the comet scores were 50.98±19.53 in asbestos-exposed workers and 18.32±12.04 in controls. The residual DNA damage （RD） was significantly greater （P〈0.01） in asbestos-exposed workers （35.62%） than in controls （27.75%）. XRCC1 genetic polymorphism in 104 asbestos-exposed workers was not associated with increased risk of asbestosis. But compared with polymorphisms in the DNA repair gene XRCC1 （polymorphisms in codon 399） and the DNA damage induced by asbestos, the comet scores in asbestosis cases with Gin/Gin, Gln/Arg, and Arg/Arg were 40.26±18.94, 38.03±28.22, and 32.01±11.65, respectively, which were higher than those in non-asbestosis workers with the same genotypes （25.58±11.08, 37.08±14.74, and 29.38±10.15）. There were significant differences in the comet scores between asbestosis cases and non-asbestosis workers with Gin/Gin by Student＇s t-test （P〈0.05 or 0.01）. The comet scores were higher in asbestosis workers with Gin/Gin than in those with Arg/Arg and in non-asbestosis workers exposed to asbestos, but without statistically significant difference. Conclusions Exposure to asbestos may be related to DNA damage or the capacity of cells to repair H2O2-induced DNA damage. DNA re

关键词： Asbestos Asbestosis DNA damage XRCC 1 DNA repair Polymorphisms Comet assays

Synthesis and Thermal Stability of Antimony Tris (Thioethyl Stearate) for PVC

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Journal of Central South University 2000年第3期12卷 146-148页

作者： liu you nian,WANG Chun jiang,SHU Wan gen,ZENG Dong ming,Chen Qi yuan (College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China) College of Chemistry and Chemical Engineering Central South University Changsha China

A novel type of thermal stabilizer-antimony tris (thioethyl stearate) (ATS) was synthsized. Its thermal stability was measured by heat-aging oven test when incorporated into PVC. ATS was synthesized from stearic acid, antimony trioxide and 2-mercaptoethanol in two steps. The reaction conditions of synthesis were optimized through orthogonal test. Experimental results show that the molar ratio of stearic acid and antimony tris (2-hydroxyethylthiolate) was 1.2, adding 0.6%tetra-n-butyl titanate as catalyst and xylene as azeotropic solvent, heating and refluxing for about 4 h, and the yield of ATS is 83.9%. The thermal stability time is about 40 min(at 200 °C) when added 2phr(per hundred resin) in PVC. The thermal stability of ATS is better than that of Ca-Zn complex and basic lead stabilizers, and equal to that of dibutyltin dilaurate.

关键词： thermal stabilizer antimony thiolate synthesis thermal stability

Applications and prospects of functional oligosaccharides in pig nutrition:A review

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Animal Nutrition 2023年第2期13卷 206-215页

作者： nian liu Haibo Shen Fan Zhang Xiang liu Qinrui Xiao Qian Jiang Bie Tan Xiaokang Ma College of Animal Science and Technology Hunan Agricultural UniversityChangsha410128China

Oligosaccharides are low molecular weight carbohydrates between monosaccharides and poly-saccharides,which consist of 2 to 20 monosaccharides linked by glycosidic *** have the effects of promoting growth,regulating immunity,improving the structure of intestinal flora,and are anti-inflammatory and *** the comprehensive implementation of the antibiotic prohibition policy in China,oligosaccharides as new green feed additive have been paid more ***-charides can be divided into the following 2 categories according to their digestive characteristics:one is easy to be absorbed by the intestine,called common oligosaccharides,such as sucrose and maltose oligosaccharide;the other is difficult to be absorbed by the intestine and has special physiological functions,called functional *** common functional oligosaccharides include mannan oligosaccharides(MOS),fructo-oligosaccharides(FOS),chitosan oligosaccharides(COS),xylo-oligosaccharides(XOS)and so *** this paper,we review the types and sources of functional oligo-saccharides,their application in pig nutrition,and the factors limiting their efficacy in recent *** review provides the theoretical basis for further research of functional oligosaccharides,and the future application of alternative antibiotics in pig industry.

关键词： Functional oligosaccharides Pig nutrition Growth performance Intestinal health Antioxidants Immune performance