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Incidence and prevention of venous thromboembolism in acutely ill hospitalized elderly Chinese

Chinese Medical Journal 2011年第3期124卷 335-340页

作者： LI Xiao-ying FAN Jin CHENG you-qin WANG Yan YAO Chen ZHONG Nan-shan Department of Geriatric Cardiology Chinese People's Liberation Army General Hospital Beijing 100853 China Beijing University People's Hospital Beijing 100044 China Guangzhou Institute of Respiratory Disease GuangzhouGuangdong 510120 China

Background As the third most frequent cardiovascular disease, venous thromboembolism （VTE） remains a major cause of morbidity and mortality in hospitalized patients. The aim of this study was to determine the incidence of VTE and steps for its prevention in acutely ill hospitalized elderly Chinese *** A prospective multi-center study was conducted from June 2006 to November 2007. A total of 607 patientsfrom 40 research centers in China were enrolled. Data of the patients＇ baseline characteristics, VTE events and prophylaxis/therapy methods were *** Fifty-nine patients （9.7%） had an objectively confirmed VTE during the 90-day follow-up, of which, 59.3%occurred during the first week and 75% within 14 days. Forty-one patients died （6.6%） during the follow-up, 36.6% died within three weeks. We also found that medical disorders including respiratory failure （16.4%）, acute brain infarction （15.6%）, acute infectious diseases （14.3%）, acute coronary artery syndrome （8.7%） and heart failure （7.6%） play a role in provoking VTE. Only 13.0% of the elderly patients with high risk of VTE used low dose unfractionated heparin, 7.1% used low molecular weight heparin, 5.4% used warfarin,0.3% used graduated compression stockings and none of them used intermittent pneumatic *** Our study showed similar results between our study and western countries in the VTE incidence by day 90 in elderly hospitalized patients with acute medical illness. Great caution must be applied in the care of acutely ill elderly hospitalized patients to deal with the complications of VTE. Application of safe and effective prophylaxes against embolism remains a critical challenge.

关键词： venous thromboembolism deep venous thrombosis pulmonary embolism

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钎焊工艺参数对C/C复合材料/Cu/Mo/TC4钎焊接头微观组织的影响

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材料工程 2012年第8期40卷 78-82页

作者：秦优琼于治水上海工程技术大学材料工程学院上海201620

在钎焊温度为820～940℃,钎焊时间为1～30min的条件下,采用TiZrNiCu钎料、Cu/Mo复合中间层对C/C复合材料和TC4进行了钎焊实验。利用扫描电镜及能谱仪对接头的界面组织进行了研究。结果表明:在较低工艺参数下,Cu/C/C复合材料界面结构为Cu... 详细信息

在钎焊温度为820～940℃,钎焊时间为1～30min的条件下,采用TiZrNiCu钎料、Cu/Mo复合中间层对C/C复合材料和TC4进行了钎焊实验。利用扫描电镜及能谱仪对接头的界面组织进行了研究。结果表明:在较低工艺参数下,Cu/C/C复合材料界面结构为Cu/Cu51Zr14/Ti2(Cu,Ni)+Ti(Cu,Ni)+TiCu+Cu2TiZr/TiC/C/C复合材料。随着工艺参数的提高,TiCu和Cu2TiZr反应相逐渐消失,Ti(Cu,Ni)2新相生成,此时的界面结构为Cu/Cu51Zr14/Ti2(Cu,Ni)+Ti(Cu,Ni)+Ti(Cu,Ni)2/TiC/C/C复合材料。钎焊工艺参数较高时界面结构为Cu/Cu51Zr14/Cu(s.s)+Ti(Cu,Ni)2/TiC/C/C复合材料。随着钎焊温度的增加以及保温时间的延长,界面反应层Cu51Zr14和TiC反应层厚度增加。

关键词： C/C复合材料 TC4 TiZrNiCu钎料 Cu/Mo复合中间层界面组织结构

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Direct differentiation of Lysimachia foenum-graecum Hance for volatile components by ion mobility spectrometry method

Direct differentiation of Lysimachia foenum-graecum Hance fo...

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中国化学会第22届全国色谱学术报告会及仪器展览会

作者： Jun Shu you qin Ping Cai Shui han Zhang Hunan University of Chinese Medicine Institute of Chinese Materia Medica Hunan Academy of Chinese Medicine

Lysimachia foenum-graecum Hance is the whole grass of the Primulaceae family ,distributed in Hunan,Guangxi,Guangdong,Sichuan,*** has the effects of dispelling cold,avoiding phlegm and other diseases,which is used to treat colds,headaches,sore throats and other symptoms,and its solution and rumbling effect may be related to the volatile oil components in the medicine .

关键词： Lysimachia foenum-graecum Hance volatile components Ion mobility spectrometry

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Cultural differences between China and America reflected in the movie Gua Sha

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海外英语 2019年第8期 213-214,223页

作者：付秦有上海海事大学外国语学院

As cross-cultural communication gains growing popularity in our global world,heavy emphasis has been placed on a better understanding of cultural differences among *** Sha is such a movie that epitomizes the existing cultural differences between China and *** is to firstly make a brief introduction of the plot and then analyze the causes of various cultural conflicts and finally put forward some suggestions to help avoid these conflicts in cross-cultural communication.

关键词： cross-cultural communication cultural differences cultural conflicts gua sha movie

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A discussion on the anomalous threshold enhancement of J/ψ–ψ(3770)couplings and X(6900)peak

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Chinese Physics C 2024年第4期48卷 1-5页

作者：陆业陈畅秦广友郑汉青 Institute of Particle Physics and Key Laboratory of Quark and Lepton Physics(MOE) Central China Normal UniversityWuhan 430079China Department of Physics Peking UniversityBeijing 100871China College of Physics Sichuan UniversityChengdu 610065China

The attractive interaction between J/ψandψ(3770)has to be strong enough if X(6900)is of the molecule *** argue that sinceψ(3770)decays predominantly into a DD^(¯)pair,the interactions between J/ψandψ(3770)may be significantly enhanced owing to the three point DD^(¯)loop *** enhancement originates from the anomalous threshold located at t=−1.288 GeV^(2),whose effect propagates into the s-channel partial wave amplitude in the vicinity of √s≃6.94 *** effect may be helpful in the formation of the X(6900)peak.

关键词： exotic hadrons hadron molecule X(6900)

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首届“女性考古与女性遗产”学术研讨会纪要

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东南文化 2010年第6期 121-122页

作者：彭友琴南京大学历史学系江苏南京210093

为了拓展和发掘考古学及文化遗产学科的研究领域,全面展现有史以来女性、特别是中国女性在人类文化创造过程中的地位和作用,完善历史学、考古学、文化遗产学等相关学科的知识架构和学术体系建构,2010年6月14～16日,南京大学历史学系主... 详细信息

为了拓展和发掘考古学及文化遗产学科的研究领域,全面展现有史以来女性、特别是中国女性在人类文化创造过程中的地位和作用,完善历史学、考古学、文化遗产学等相关学科的知识架构和学术体系建构,2010年6月14～16日,南京大学历史学系主办、南京大学文化与自然遗产研究所举办了首届＂女性考古与女性遗产＂学术研讨会。来自全国各高校及考古文博界的多名专家学者共70余人与会。

关键词：文化遗产学中国女性学术研讨会考古学纪要相关学科南京大学 2010年

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Investigation on chiral capillary columns and their application in separation of enantiomers

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Chinese Journal of Chemistry 1992年第5期10卷 430-433页

作者： ZHOU, Liang-Mo LOU, Xian-Wen LIU, you-qin WANG, qing-Hai ZHU, Dao-Qian Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116012 Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116012

Six chiral diamide stationary phases (CSPs), namely N-(3-carbobenzoxypropionyl)-L- Val-tert-butylamide (CSP-1), N-undecenoyl-L-Val-S-α-phenylethylamide (CSP-2), N-undecenoyl-L- Val-R-α-phenylethylamide (CSP-3), OV-225-L-Val-tert-butylamide (CSP-4), XE-60-L-Val-tert- butylamide (CSP-5) and polycyanoethyl vinyl siloxane-L-Val-tert-butylamide (CSP-6), were inves- tigated and CSP-6 was crosslinked within narrow bore (70 μm) fused silica capillary columns. The separation of amino acid enantiomers on this narrow bore column by gas chromatography (GC) is illustrated.

关键词： CSP Investigation on chiral capillary columns and their application in separation of enantiomers

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Clinical significance of chromosomal abnormalities detected by interphase fluorescence in situ hybridization in newly diagnosed multiple myeloma patients

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Chinese Medical Journal 2011年第19期124卷 2981-2985页

作者： HU Yu CHEN Lei SUN Chun-yan SHE Xiao-mei AI Li-sha qin you Institute of Hematology Union Hospital Tongji Medical CollegeHuazhong University of Science and Technology Wuhan Hubei 430022 China

Background Chromosome 13q14 deletion （del13q14）, chromosome 1q21 gain （amp1q21） and chromosome 17p13 deletion （del17p13） are the most frequent chromosomal aberrations in multiple myeloma （MM）. They play an important role in prognosis. The aim of this study was to investigate the clinical significance of the chromosomal changes in Chinese MM *** Interphase fluorescence in situ hybridization （FISH） on bone marrow （BM） cells was performed in 72 enrolled MM patients. Relationships between chromosomal abnormalities and clinical features, response to therapies and prognosis were *** As a result of interphase FISH, 77.8% （56/72） patients had chromosome changes. The incidences of each probe were RB1 51.4% （37/72）, D13S319 47.2% （34/72）, 1q21 45.8% （33/72） and p53 22.2% （12/72）. Osteolytic lesion,BM plasma cells index, serum calcium and serum M component were significantly correlated to del13q14. BM plasma cells and hemoglobin were correlated to amp1q21. Serum lactate dehydrogenase （LDH） was correlated with *** with del13q14 treated with bortezomib had a notably higher overall response rate than the patients treated with traditional chemotherapies （93% vs. 65%, P=0.048）. Patients carrying amp1q21 or/and del17p13 did not achieve satisfactory response to bortezomib. The median progression-free survival （PFS） for patients with amp1q21 was 5 months and patients without amp1q21 got 9-month PFS （P=0.001）. The median PFS for patients with del13q14 was 5 months （vs. 8 months, P=0.026）. The median PFS for patients with del17p13 was 3 months （vs. 8 months, P=0.002）.Patients with β2-microglobulin 〉5.5 mg/L also had a worse outcome, whose median PFS was 5 months （vs. 8 months,P=0.016）.Conclusions The prevalence of chromosomal abnormalities of MM patients was similar in Chinese and Caucasian people. Genetic changes were associated with patients＇ responses to therapies and prognosis.

关键词： multiply myeloma fluorescence in situ hybridization cytogenetics prognosis progression free survival

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Pien Tze Huang(片仔癀) Overcomes Doxorubicin Resistance and Inhibits Epithelial-Mesenchymal Transition in MCF-7/ADR Cells

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Chinese Journal of Integrative Medicine 2019年第8期25卷 598-603页

作者： CHEN Xi QI Fei SHEN A-ling CHU Jian-feng Thomas Joseph Sferra CHEN you-qin PENG Jun Academy of Integrative Medicine Fujian University of Traditional Chinese Medicine Fuzhou (350122)China Department of Oncology Fuzhou General Hospital of Nanjing Military Command Fuzhou (350003)China Fujian Key Laboratory of Integrative Medicine on Geriatric Fujian University of Traditional Chinese Medicine Fuzhou (350122)China School of Medicine Case Western Reserve University Cleveland OH (44106) USA

Objective: To evaluate the effect of Pien Tze Huang (片仔癀, PZH) on breast cancer chemo resistance and related epithelial-mesenchymal transition (EMT) and investigate the underlying mechanisms. Methods: 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay was used to determine the cell viability. Adriamycin (ADR) staining observed by fluorescence microscope was performed to detect the accumulation of ADR. Transwell assay was used to analyze the cell migration and invasion. Western-blot was performed to detect the protein expression of related genes. Results: MCF-7/ADR cells were resistant to ADR treatment, and PZH treatment inhibited the viability of MCF-7/ADR cells in a dose-dependent manner. PZH treatment also increased the intercellular accumulation of ADR and down-regulated the expression of ABCG2 and ABCB1 in MCF-7/ADR cells (P<0.05). In addition, PZH treatment inhibited EMT, migration and invasion of MCF-7/ADR cells (P<0.05). Moreover, PZH suppressed activation of transforming growth factor β 1 (TGF-β) signaling in MCF-7/ADR cells (P<0.05). Conclusion: PZH treatment can effectively overcome chemoresistance via down-regulating ABCG2, ABCB1 and inhibit EMT in ADR resistant human breast cancer cells via suppression of the TGF-β 1 pathway.

关键词： Pien Tze Huang Chinese medicine breast cancer chemoresistance epithelial-mesenchymal transition

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Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice

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World Journal of Gastroenterology 2012年第47期18卷 7079-7086页

作者： qing-E Tian Huan-De Li Miao Yan Hua-Lin Cai qin-you Tan Wen-Yuan Zhang School of Pharmaceutical Sciences Central South University Xiangtan Central Hospital Clinical Pharmacy and Pharmacology Research Institute the Second Xiangya HospitalCentral South University

AIM:To investigate the adjunct anticancer effect of Astragalus polysaccharides in H22 tumor-bearing ***:To establish a solid tumor model,5.0 × 10 6 /mL H22 hepatoma cells were inoculated subcutaneously into the right armpit region of Kunming mice(6-12 wk old,18-22 g).When the tumors reached a size of 100 mm 3,the animals were treated as indicated,and the mice were randomly assigned to seven groups(n = 10 each).After ten days of treatment,blood samples were collected from mouse eyes,and serum was harvested by *** were sacrificed,and the whole body,tumor,spleen and thymus were weighed *** rate of tumor inhibition and organ indexes were *** expression levels of serum cytokines,P-glycoprotein(P-GP) and multidrug resistance(MDR) 1 mRNA in tumor tissues were detected using enzyme-linked immunosorbent assay,Western blotting,and quantitative myeloid-derived suppressor cells reverse transcription-polymerase chain reaction,***:The tumor inhibition rates in the treatment groups of Adriamycin(ADM) + Astragalus polysaccharides(APS)(50 mg/kg),ADM + APS(100 mg/kg),and ADM + APS(200 mg/kg) were significantly higher than in the ADM group(72.88% vs 60.36%,P = 0.013;73.40% vs 60.36%,P = 0.010;77.57% vs 60.36%,P = 0.001).The spleen indexes of the above groups were also significantly higher than in the ADM group(0.65 ± 0.22 vs 0.39 ± 0.17,P = 0.023;0.62 ± 0.34 vs 0.39 ± 0.17,P = 0.022;0.67 ± 0.20 vs 0.39 ± 0.17,P = 0.012),and the thymus indexes of the ADM + APS(100 mg/kg) and ADM + APS(200 mg/kg) groups were significantly higher than in the ADM group(0.20 ± 0.06 vs 0.13 ± 0.04,P = 0.029;0.47 ± 0.12 vs 0.13 ± 0.04,P = 0.000).APS was found to exert a synergistic antitumor effect with ADM and to alleviate the decrease in the sizes of the spleen and thymus induced by *** expression of interleukin-1α(IL-1α),IL-2,IL-6,and tumor necrosis factor-α(TNF-α) was significantly higher in the ADM + APS(50 mg/kg),ADM + APS(100 mg/kg)

关键词： Astragalus polysaccharides Tumor inhibition rate Cytokines P-glycoprotein Adjunct anticancer

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