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"Cap and glycosylate"strategy for direct radical functionalization of native sugars

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Science Bulletin 2024年第20期69卷 3163-3165页

作者： Hiroaki matoba Go Hirai Graduate School of Pharmaceutical Sciences Kyushu UniversityFukuoka 812-8582Japan

Glycoconjugates are biologically significant molecules,but their precise role in many biological phenomena remains unclear,largely due to their heterogeneity and complexity,as well as the dynamic enzymatic remodeling/hydrolysis of glycan ***,for mechanistic studies,it is desirable to use metabolically stable mimics of *** this context,S-,Se-,and notably C-linked glycoconjugates have emerged as attractive targets,leading to the development of numerous synthetic methods[1–3].

关键词： sugar hydrolysis attractive

Development of a Method for Assessing Country-Based Flood Risk at the Global Scale

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International Journal of Disaster Risk Science 2022年第1期13卷 87-99页

作者： yoshiyuki Imamura Department of Civil and Environmental Engineering Tokyo Metropolitan University192-0397 HachiojiTokyoJapan

International frameworks such as the Sustainable Development Goals and the Sendai Framework for Disaster Risk Reduction 2015-2030 require the quantification of country-based flood ***,few approaches at the global scale include the three necessary components(hazard,exposure,and vulnerability)for determining disaster risk and are country-based assessments,owing to major challenges such as limited data availability and vulnerability proxy ***,in this study,a method was developed with the following features:Incorporating the hazard,exposure,and vulnerability components;Applicable to the vast majority of countries in the world;Visualizing priority countries and illustrating effective measures and strategies;Clear and easy to understand by leaders and decision makers of international organizations,governments,and other stakeholders;Identifying each country’s challenges and providing guidance on specific issues for more detailed investigation and policy creation;Including more extensive factors compared with past *** Asia and the Pacific,the Flood Risk Index computed by the developed method is compared with the fatality ratio,and the results show that improving flood resilience secures people and society regardless of the magnitude and frequency of *** at the global scale visualizes regional tendencies and indicates that countries closer to the equator have higher flood *** of country-based flood risk based on five indicators demonstrates that the developed method can assist international organizations,governments,and other stakeholders to further examine country-specific conditions and establish and implement policies and strategies toward building a resilient society and achieving international targets.

关键词： Asia and the Pacific Country-based analysis Flood risk index Global scale Vulnerability proxy

Reflection-type holographic disk-type memory using three-dimensional speckle-shift multiplexing

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红外与激光工程 2016年第9期45卷 43-47页

作者： Osamu matoba Graduate School of System Informatics Kobe University

This review presents a reflection-type holographic memory using three-dimensional(3D)speckle-shift multiplexing. First, the schematic of the proposed memory system was described. Then,experimental demonstrations of multiplexing in plane and along the depth direction were presented. The estimated storage capacity of single layer recording was introduced and the maximum storage capacity was discussed. To increase the storage capacity, the multi-layered recording was described. In the multilayered recording, the storage capacity can be increased by appropriate arrangement of holograms in each layer.

关键词：激光雷达成像仿真空间目标在轨

Active surveillance as a practical strategy to differentiate lethal and non-lethal prostate cancer subtypes

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Asian Journal of Andrology 2012年第3期14卷 361-364,I0004页

作者： yoshiyuki Kakehi Department of Urology Kagawa University Faculty of Medicine Kagawa 761-0793 Japan 1

Differentiation between lethal and non-lethal prostate cancer subtypes has become a very important issue in avoiding excessive treatment in an era when prostate-specific antigen （PSA） screening has reduced the rate of prostate cancer deaths by more than 20%. However, it is difficult to determine the patients who may or may not benefit from immediate treatment interventions at the time of the initial diagnosis. The selection of candidate patients who can postpone immediate treatment and undergo follow-ups with a specific surveillance program, or ＇active surveillance,＇ is a practical way to minimize overtreatment. In this review, the benefits and risks of active surveillance are discussed. Future perspectives, including imaging and new biomarkers for improving the outcomes of active surveillance programs, are also discussed.

关键词： active surveillance diagnosis low risk prostate cancer

Making continental crust:The sanukitoid connection

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Chinese Science Bulletin 2008年第11期53卷 1620-1633页

作者： yoshiyuki TATSUMI Institute for Research on Earth Evolution (IFREE) Japan Agency for Marine-Earth Science and Technology (JAMSTEC) Yokosuka 237-0061 Japan

The average continental crust possesses intermediate compositions that typify arc magmatism and as a result it is believed to have been created at ancient convergent plate boundaries. One possible mechanism for intermediate continental crust formation is the direct production of andesitic melts in the upper mantle. Sanukitoids, which characterize the Setouchi volcanic belt, SW Japan, include un-usually high-Mg andesites (HMA). They were generated by slab melting and subsequent melt-mantle interactions under unusual tectonic settings such as where warm lithosphere subducts into hot upper mantle. Such conditions would have existed in the Archean. Hydrous HMA magmas are likely to have solidified within the crust to form HMA plutons, which were then remelted to produce differentiated sanukitoids. At present, generation and differentiation of HMA magmas may be taking place in the Izu-Bonin-Mariana arc-trench system (IBM), because (1) HMA magmatism characterizes the initial stages of the IBM evolution and (2) the IBM middle crust exhibits Vp identical to that of the bulk conti-nental crust. Vp estimates for plutonic rocks with HMA compositions support this. However tonalitic composition for middle-crust-forming rocks cannot be ruled out, suggesting an alternative possibility that the continental crust has been created by differentiation of mantle-derived basaltic magmas.

关键词：赞岐状岩大陆壳地质学地质运动

Updated results from the European Randomized Study of Prostate-Specific Antigen （PSA） Screening for Prostate Cancer： are Asian countries encouraged to promote PSA screening？

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Asian Journal of Andrology 2012年第4期14卷 522-524页

作者： Mikio Sugimoto yoshiyuki Kakehi Department of Urology Kagawa University Faculty of Medicine Kita-gun Kagawa 761-0793 Japan

An updated result of European Randomized Screening Trial for Prostate Cancer encourages Asian countries to proceed prostate-specific antigen （PSA） screening for early detection. On the other hand, the issue of overtreatment is emerging as a serious problem. Active surveillance （AS） should be more prevalent than now to avoid overtreatment for patients with favourablerisk prostate cancer （PCa） detected by PSA test.

关键词： Disease genetics Dyslipidaemias Endocrine system and metabolic diseases Therapeutics

Transmission of hepatitis C virus: Self-limiting hepatitis or chronic hepatitis?

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World Journal of Gastroenterology 2013年第41期19卷 6957-6961页

作者： Takafumi Saito yoshiyuki Ueno Department of Gastroenterology Yamagata University School of MedicineYamagata 990-9585Japan

It has been suggested that hepatitis C virus(HCV)is selectively transmitted to a new host as an infectious clone from multiple HCV variants(quasispecies)in the *** individuals with HCV infection develop chronic hepatitis,but approximately 15%-40%of them clear the virus spontaneously and the hepatitis is resolved in a self-limiting manner in the acute phase of *** difference in the outcome of acute hepatitis C is attributable to both viral characteristics and genetic regulation of *** particular,the evolutionary dynamics of the infecting virus and host genetic polymorphisms pertaining mainly to the immune system,including polymorphisms in the region of the Interleukin 28B gene encoding interferon-λ-3,are associated with susceptibility to HCV infection.

关键词： Hepatitis C Spontaneous clearance Interleukin 28B Single nucleotide polymorphism Interferon-λ

Study on compound ultra-precision alignment technique

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仪器仪表学报 2007年第10期28卷 1741-1745页

作者： Zhang Jinlong Yang Ankang Liu Jingnan yoshiyuki Uchidas College of Electrical and Automatic Engineering Nanjing Normal Univ. Nanjing 210042 China Automation College Southeast Univ. Nanjing 210096 China Department of lnformation Network Engineering Aichi Institute of Technology Toyoda 470-0392 Japan

A nano-displacement measurement system with duo-gratings is analyzed by using optics theory,a math- ematic model for the system is established,and the characteristic of laser Moirésignals is studied through CAD simu- *** improve signal sensitivity and positioning accuracy,two methods of precision positioning are brought for- ward:differential Moirépositioning method and modified Moirépositioning method.A compound control system for precision positioning is set up by combining these 2 Moiréalignment methods,in which the modified Moiréalignment technique is used for coarse alignment and the differential Moiréalignment technique is used for fine alignment,and the system obtains positioning accuracy of±10 nm in±500μm positioning range with shot response time.

关键词：信号超精密排列技术纳米位移测量系统微分混合排列光学

A combination of tides and nontidal variations in ocean bottom pressure may generate interannual slip fluctuations in the transition zone along a subduction plate interface

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Geodesy and Geodynamics 2023年第1期14卷 43-51页

作者： yoshiyuki Tanaka Hiromu Sakaue Masayuki Kano Suguru Yabe Department of Earth and Planetary Science The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Graduate School of Science Tohoku University6-3Aramaki-aza-aobaAoba-kuSendai980-8578Japan Geological Survey of Japan National Institute of Advanced Industrial Science and Technology(AIST)Tsukuba Central 71-1-1 HigashiTsukubaIbaraki 305-8567Japan

The tidal triggering of earthquakes has been studied for many *** discovery of slow earthquakes in the early 2000s,including slow slip,has urged scientists to investigate the tidal responses of these earthquakes due to their sensitivity to weak stress *** studies have shown that slow earthquakes correlate with diurnal and semidiurnal tides and seasonal variations in surface loads more clearly than ordinary ***,little is known about long-term responses to external *** this paper,based on a widely accepted frictional law for faults,a mechanism is proposed by which nontidal variations in ocean bottom pressure,when combined with tides,pro mote the occurrence of slow *** slow earthquakes accompany a slip on the plate interface,this mechanism allows one to estimate slip modulations.A one-degree-of-freedom slip model is constructed and applied to Ise Bay in the Tonankai region of southwestern Japan,where large-scale ocean mass redistributions have *** model calculated with parameters determined from the observation of tectonic tremors is quantitatively consistent with the slip during 1997-2013 inferred from GNSS data,suggesting that the decrease in the sea-level change in approximately 2006 could cause the accele ration of a slip observed after *** result implies that the decreases in sea level in approximately 1996 and 2014 could also cause subsequent slip *** three slip acceleration periods temporally coincide with the increases in background seismicity in a shallower portion of the plate *** changes in seismicity are common to shallow earthquakes in the Tokai area,and a similar model can reproduce *** studies are expected to reveal causality between shallow earthquakes and long-term slip fluctuations based on modeling that considers changes in the frictional property along the plate interface.

关键词： Tides Ocean bottom pressure Slow earthquake Seismicity Kuroshio current