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Fabrication of subunit nanovaccines by physical interaction

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Science China(Technological Sciences) 2022年第5期65卷 989-999页

作者： chen HaoLin LIU Hong LIU LiXin chen yongming School of Materials Science and Engineering Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou510275China Zhuhai Jinan Selenium Source Nanotechnology Co. Ltd.Jinan UniversityZhuhai519000China Laboratory of Biomaterials and Translational Medicine Center for NanomedicineThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou510630China

Vaccines can improve the quality of human life by preventing the burden of infectious ***,vaccination is becoming a powerful medication for preventing and treating *** vaccines have been developed based on the origin of the ***,we focus on the subunit vaccines whose antigens are proteins or *** advantage of subunit vaccines is safety for recipients;however,the immunogenicity of subunit antigens is relatively *** delivery systems have been applied to improve the immunocompetence of subunit vaccines by targeting lymph nodes,and effectively present antigens to immune ***,adding appropriate molecular adjuvants may strengthen the antigens to elicit immune *** this perspective article,we first elucidate the characteristics of immunity induced by subunit nanovaccines and then summarize the strategies to fabricate subunit nanovaccines with delivering *** we highlight non-covalent interaction to fabricate nanoparticular subunit vaccines.

关键词： nanovaccine protein/peptide subunit nanoparticle immunotherapy

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Layered Double Hydroxide Nanosheets Incorporated Hierarchical Hydrogen Bonding Polymer Networks Coatings

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Nano-Micro Letters 2025年第05期 382-398页

作者： Bifan Guo Yimin He yongming chen Tianci Yang Chaohua Peng Weiang Luo Birong Zeng Yiting Xu Lizong Dai Fujian Provincial Key Laboratory of Fire Retardant Materials College of MaterialsXiamen University Xiamen Key Laboratory of Fire Retardant Materials Xiamen University

In recent decades, annual urban fire incidents, including those involving ancient wooden buildings burned, transportation, and solar panels, have increased, leading to significant loss of human life and property. Addressing this issue without altering the surface morphology or interfering with optical behavior of flammable materials poses a substantial challenge. Herein, we present a transparent, low thickness,ceramifiable nanosystem coating composed of a highly adhesive base(poly（SSS1-co-HEMA1）), nanoscale layered double hydroxide sheets as ceramic precursors, and supramolecular melamine di-borate as an accelerator. We demonstrate that this hybrid coating can transform into a porous,fire-resistant protective layer with a highly thermostable vitreous phase upon exposure to flame/heat source. A nanosystem coating of just ～ 100μm thickness can significantly increase the limiting oxygen index of wood（Pine） to 37.3%, dramatically reduce total heat release by 78.6%, and maintain low smoke toxicity（CITG= 0.016）. Detailed molecular force analysis, combined with a comprehensive examination of the underlying flame-retardant mechanisms, underscores the effectiveness of this coating. This work offers a strategy for creating efficient, environmentally friendly coatings with fire safety applications across various industries.

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Emulsion confined block copolymer self-assembly:Recent progress and prospect

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Nano Research 2023年第1期16卷 564-582页

作者： Yilin Liu Fangfang Ke Yuanchao Li Yi Shi Zhen Zhang yongming chen School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510006China

In the past few decades,significant progress in block copolymer self-assembly has been achieved in many fields,and with the development of nanoscience and nanotechnology,more and more complex situations need block copolymer self-assembly based nanoplatforms having more complex structures for specific multimodal or multiplexed *** the combination of emulsification and self-assembly of the block copolymer,different materials with exotic architectures and functions could be combined within an entity,such as controlled vesicles,Janus particles,and composite particles which are more like ideal *** designs can show their different desired properties depending upon the application situation,including molecular delivery,surfactants,and multicolor *** review will provide a complete summary of the optimization and the synthesis method for the recently designed emulsion confined block copolymer assemblies,and also the challenges and limitations this method faces,and the potential solutions in this field.

关键词： emulsion block copolymer confined volume self-assembly exotic architectures

A method for online detection and lifespan evaluation of light sources

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Optoelectronics Letters 2023年第11期19卷 693-697页

作者： YU Kanghua chen Huacai ZHU Zhouhong HU Jinzhao chen yongming College of Optical and Electronic Technology China Jiliang UniversityHangzhou310018China

Light emitting diode(LED) light source degradation detection and lifetime evaluation usually use the data of light flux change as a basis,but the process of light flux measurement is complicated and tedious,requiring the use of an integrating sphere,and cannot be performed *** is unfriendly to the detection of machine vision light sources used in production *** address this problem,this paper proposes and designs a method for online detection and lifetime evaluation of light sources by using a mini spectrometer to detect the intensity of light sources online,and evaluates the light degradation and lifetime of light sources based on the changes in light intensity during *** determines whether the light source needs to be adjusted or replaced,avoiding misjudgment or missed judgment in production detection due to light source *** experiment was conducted on LED under high-temperature accelerated *** light intensity data after aging was fitted by an acceleration and life evaluation model,and the fitting result showed that the error of life evaluation by this method was 8.37%.As a comparison,this paper also detects the changes in light flux of light sources during the experiment,and the average error between the decay of light intensity and the decay of light flux was only 0.102%.It has been validated that the error in evaluating the lifetime of light sources using this method is 10.71%,and the accuracy of the evaluation is about 90%.The results show that the method is accurate,reliable,and can be used as a basis for online detection and evaluation of LED light source degradation.

关键词： lifetime fitted integrating

Di-PEGylated insulin:A long-acting insulin conjugate with superior safety in reducing hypoglycemic events

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2761-2772页

作者： Zhipeng Zeng Runcheng Tan Shi chen Haolin chen Zhijia Liu Lixin Liu Mingqiang Li yongming chen Laboratory of Biomaterials and Translational Medicine Center for NanomedicineThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China School of Materials Science and Engineering Center of Functional BiomaterialsKey Laboratory of Polymeric Composite Materials and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China

Although the discovery of insulin 100 years ago revolutionized the treatment of diabetes,its therapeutic potential is compromised by its short half-life and narrow therapeutic *** long-acting insulin analogs,such as insulin-polymer conjugates,are mainly used to improve pharmacokinetics by reducing renal ***,these conjugates are synthesized without sacrificing the bioactivity of insulin,thus retaining the narrow therapeutic index of native insulin,and exceeding the efficacious dose still leads to ***,we report a kind of di-PEGylated insulin that can simultaneously reduce renal clearance and receptor-mediated *** impairing the binding affinity to the receptor and the activation of the receptor,di-PEGylated insulin not only further prolongs the half-life of insulin compared to classical mono-PEGylated insulin but most importantly,increases its maximum tolerated dose *** target of long-term glycemic management in vivo has been achieved through improved pharmacokinetics and a high *** work represents an essential step towards long-acting insulin medication with superior safety in reducing hypoglycemic events.

关键词： Diabetes Insulin Therapeutic index Hypoglycemia PEGylation Receptor-mediated clearance Half-life Diabetic nephropathy

Optical resolution ability of optically active poly(N-diphenylmethyl maleimide)

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Chinese Science Bulletin 1998年第3期43卷 220-223页

作者： Weihong Liu Lianhe Shao yongming chen Chuanfu chen Guoquan Liu Fu Xi Chinese Acad Sci Inst Chem Beijing 100080 Peoples R China

A new optically active polymer, (+)poly(N_diphenylmethyl maleimide), was coated on macroporous silica gel and used as a chiral stationary phase for high performance liquid chromatographic resolution of enantiomers. The chiral polymer showed efficient resolution ability to some polar racemates, and eleven pairs of racemates are resolved effectively.

关键词： optical resolution chiral stationary phase high performance liquid chromatography N_diphenylmethyl maleimide optically active polymer.

Combinatorial synthesis of redox-responsive cationic polypeptoids for intracellular protein delivery application

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Science China Chemistry 2020年第11期63卷 1619-1625页

作者： Zhicheng Le Tong Xiao Zhijia Liu Xingliang Liu Hong Liu Lixin Liu yongming chen School of Materials Science and Engineering Key Laboratory of Polymeric Composite and Functional Materials of Ministry of EducationGD Research Center for Functional Biomaterials Engineering and TechnologySun Yat-sen UniversityGuangzhou 510275China

Biologics play an essential role in treating various indications from cancers to the metabolic diseases,while the current development of new classes of intracellular-acting protein drugs is still hindered because of high molecular mass and overall hydrophilicity of proteins creating extremely poor permeability across cell ***,there remains an unmet need to develop safe,potent approaches to augment intracellular protein delivery ***,we described a facile multicomponent reaction system for generating a small library of redox-responsive cationic polypeptoids with high *** co-assembly of optimized polymer with protein leads to the formation of compacted nanocomplexes with smaller size and high encapsulation efficiency,thus improving cellular internalization via the macropinocytosis and/or caveolae-mediated endocytosis *** endo-lysosomal escape,the nanocomplexes can be disassociated to efficiently release cargo proteins into the cytosol,owing to the intracellular glutathione(GSH)-triggered rapid cleavage of disulfide bonds in polymers *** a result,we screened a promising platform reagent for efficient cytosolic protein delivery application.

关键词： multicomponent reaction cationic polypeptoid redox-responsive intracellular delivery protein

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建设项目电子档案元数据应用、问题及策略

中国建设信息化 2025年第3期 58-61页

作者：金松邱媛陈永明彭源新深圳市城市建设档案馆国家档案局重点实验室广州市微柏软件股份有限公司

本文以XML文件和关系型数据库为例,探讨元数据的多种表现形式和管理方式。通过数据管理、电子档案和建设项目三个层面的论述深入阐述建设项目电子档案元数据的特点和应用。结合现行标准和深圳典型案例经验,分析建设项目电子档案元数据... 详细信息

本文以XML文件和关系型数据库为例,探讨元数据的多种表现形式和管理方式。通过数据管理、电子档案和建设项目三个层面的论述深入阐述建设项目电子档案元数据的特点和应用。结合现行标准和深圳典型案例经验,分析建设项目电子档案元数据在实际应用中存在的问题,如复杂性、困难性和缺乏主动性,并提出了应对策略。通过这些探讨和分析,为建设项目电子档案元数据的管理和应用提供有益的参考。

关键词：建设项目电子档案元数据数据管理

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Synthesis of novel hierarchical porous polymers with a nanowire-interconnected network structure from core-shell polymer nanoobjects

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Science China Chemistry 2017年第8期60卷 1084-1089页

作者： yeru liang yingbo ruan junlong huang bo peng chen-yang liu ruowen fu mingqiu zhang yongming chen dingcai wu Materials Science Institute Key Laboratory for Polymeric Composite ＆ Functional Material of Ministry of Education Guangdong Provincial Key Laboratory for High Performance Polymeric Composites School of Chemistry Sun Yat-sen University Guangzhou 510275 China aCAS Key Laboratory of Engineering Plasties Institute of Chemistry Chinese Academy of Sciences Be!jing 100190 China School of Materials Science and Engineering Sun Yat-sen University Guangzhou 510275 China

Design and fabrication of the micro/nanostructures of the network units is a critical issue for porous nanonetwork structured materials. Significant progress has been attained in construction of the network units with zero-dimensional spherical ***, owing to the limitations of synthetic methods, construction of porous building blocks in one dimension featuring high aspect ratios for porous nanonetwork structured polymer(PNSP) remains largely unexplored. Here we present the successful design and preparation of PNSP with a novel type of one-dimensional network unit, i.e., microporous heterogeneous nanowire. Well-defined core-shell polymer nanoobjects prepared from a gelable block copolymer, poly(3-(triethoxysilyl)propyl methacrylate)-block-polystyrene are employed as building blocks, and facilely transformed into PNSP via hypercrosslinking of polystyrene shell. The as-prepared PNSP exhibits unique three-dimensional hierarchical nanonetwork morphologies with large surface area. These findings could provide a new avenue for fabrication of unique well-defined PNSP, and thus generate valuable breakthroughs in many applications.

关键词： hierarchical porous polymer nanonetwork structure one-dimensional network unit hypercrosslinking microporous heterogeneous nanowire