Fabrication of subunit nanovaccines by physical interaction

作     者：CHEN HaoLin LIU Hong LIU LiXin CHEN YongMing CHEN HaoLin;LIU Hong;LIU LiXin;CHEN YongMing

作者机构：School of Materials Science and EngineeringKey Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou510275China Zhuhai Jinan Selenium Source Nanotechnology Co.Ltd.Jinan UniversityZhuhai519000China Laboratory of Biomaterials and Translational MedicineCenter for NanomedicineThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou510630China 

出 版 物：《Science China(Technological Sciences)》 (中国科学（技术科学英文版）)

年 卷 期：2022年第65卷第5期

页      面：989-999页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.22075324,51820105004) the Key Areas Research and Development Program of Guangzhou(Grant No.202007020006) 

主　　题：nanovaccine protein/peptide subunit nanoparticle immunotherapy 

摘      要：Vaccines can improve the quality of human life by preventing the burden of infectious ***,vaccination is becoming a powerful medication for preventing and treating *** vaccines have been developed based on the origin of the ***,we focus on the subunit vaccines whose antigens are proteins or *** advantage of subunit vaccines is safety for recipients;however,the immunogenicity of subunit antigens is relatively *** delivery systems have been applied to improve the immunocompetence of subunit vaccines by targeting lymph nodes,and effectively present antigens to immune ***,adding appropriate molecular adjuvants may strengthen the antigens to elicit immune *** this perspective article,we first elucidate the characteristics of immunity induced by subunit nanovaccines and then summarize the strategies to fabricate subunit nanovaccines with delivering *** we highlight non-covalent interaction to fabricate nanoparticular subunit vaccines.