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Utilization of One Novel Microbial Esterase WDEst9 in the Kinetic Resolution of (5)-Methyl 2-chloropropionate and (5)-Ethyl 2-chloropropionate

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Chemical Research in Chinese Universities 2019年第5期35卷 830-836页

作者： WANG Yilong xu yongkai ZHANG Yun SUN Aijun HU Yunfeng CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301P.R.China Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301P.R.China Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014P.R.China

One novel microbial esterase WDEst9 from Dactylosporangium aurantiacum subsp. Hamdenensis NRRL 18085 was functionally characterized and the results demonstrated that the enantio-preference of WDEst9 was opposite to that of three other microbial esterases(BSE01701, PHE14 and Bae02030) in the kinetic resolution of racemic methyl lactate. We further investigated the potential of esterase WDEst9 in the kinetic resolution of both (±)-methyl 2-chloropropionate and (±)-ethyl 2-chioropropionate. The enantio-preference of WDEst9 was also interestingly opposite to that of esterases EST 12-7 and EstC10, and generated (S)-methyl 2-chloropropionate and (S)-ethyl 2-chloropropionate with high enantiomeric excess(both e.e.>98%) and high yield after many iterations of process optimization. Through genome mining, microbial esterase WDEst9 was characterized to be a novel esterase which may provide valuable complementary enantio-selectivity and possesses very good potential in the kinetic resolution of high value-added chiral chemicals.

关键词： Biocatalysis Novel esterase Asymmetric hydrolysis Complementary enantio-preference (5)-Methyl 2-chloropropionate (S)-Ethyl 2-chloropropionate

Clinical study of Sichong Tablet on prevention of lower extremities arteriosclerosis disease peripheral arterial in-stent restenosis

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China Medical Abstracts(Internal Medicine) 2020年第2期37卷 66-67页

作者： xu yongkai Dept Peripheral Vase Affil HospShandong TCM UnivJinan 250014

Objective To investigate the clinical efficacy and mechanism of Sichong Tablet(SCT)on prevention of lower extremities arteriosclerosis disease(LEAD)peripheral arterial in-stent restenosis(ISR).Methods Totally 60 LEAD ... 详细信息

关键词： prevention arterial Tablet

Characterization ofanovel deep-seamicrobial esterase EstC 10 and its use in the generation o f(R)-methyl 2-chloropropionate

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Journal of Oceanology and Limnology 2018年第2期36卷 473-482页

作者： GONG Yanhui MA Sanmei WANG Yongfei xu yongkai SUN Aijun ZHANG Yun HU Yunfeng Key Laboratory of Tropical Marine Bio-Resources and Ecology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China Guangdong Key Laboratory of Marine Materia Mediea South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China Department ofBiotechnology Jinan University Guangzhou 510632 China Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014 China South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center Guangzhou 510275 China

A novel esterase EstC10 from Bacillus sp. CX01 isolated from the deep sea of the Western Pacific Ocean and the functionalities of EstC 10 was characterized. At present, the reports about the kinetic resolution ofracemic methyl 2-chloropropionate were quite rare. So we developed deep-sea microbial esterase EstC10 as a novel biocatalyst in the kinetic resolution of racemic methyl 2-chloropropionate and generate （R）-methyl 2-chloropropionate with high enantiomeric excess （〉99%） after the optimization of process parameters such as pH, temperature, organic co-solvents, surfactants, substrate concentration and reaction time. Notably, the optimal substrate concentration （80 mmol/L） of esterase EstC10 was higher than the kinetic resolution of another esterase, Estl2-7 （50 mmoFL）. The novel microbial esterase EstC10 identified from the deep sea was a promising green biocatalyst in the generation of （R）-methyl 2-chloropropionate as well of many other valuable chiral chemicals in industry.

关键词： biocatalysis deep-sea microorganisms novel esterase kinetic resolution (R)-methyl 2-chloropropionate

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节理对爆炸应力波能量影响研究

建筑结构 2023年第S2期53卷 2389-2393页

作者：徐永恺合肥工业大学合肥230000

天然岩体中存在着大量的节理裂隙,这些裂隙对爆炸应力波能量的传播起到隔断减振的作用。基于ANSYS/LS-DYAN数值模拟软件,建立线弹性单条节理岩石爆破数值模型,研究节理性质对爆炸能量产生的影响。研究发现:节理厚度D越大,透射能量比K_(T... 详细信息

天然岩体中存在着大量的节理裂隙,这些裂隙对爆炸应力波能量的传播起到隔断减振的作用。基于ANSYS/LS-DYAN数值模拟软件,建立线弹性单条节理岩石爆破数值模型,研究节理性质对爆炸能量产生的影响。研究发现:节理厚度D越大,透射能量比K_(T)逐渐减小并趋于稳定,而反射能量比K_(R)则逐渐增大并趋于稳定;节理距爆源距离L越远,透射能量比K_(T)逐渐增大并趋于稳定,反射能量比K_(R)逐渐较小并趋于稳定;节理角度θ越来越大,透射能量比K_(T)逐渐增大并趋于1,反射能量比K_(R)逐渐较小并趋于0。当节理填充不同材料时,填充材料与岩石物理性质相差越大,对爆炸应力波能量反射能力越强,应力波越难透射过节理;节理填充相同材料时,节理厚度越大,对爆炸应力波的反射能力也越强。

关键词：岩石爆破节理性质爆破能量数值模拟

Defects and morphology engineering for constructing V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S nanotube heterojunction arrays toward efficient bifunctional electrocatalyst for overall water splitting

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Journal of Energy Chemistry 2024年第7期94卷 29-40页

作者： Wenyuan Sun Alan Meng Lei Wang Guicun Li Jinfeng Cui yongkai Sun Zhenjiang Li College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042ShandongChina Key Laboratory of Optic-electric Sensing and Analytical Chemistryfor Life Science MOE College of Chemistry and Molecular EngineeringQingdao Universityof Science and TechnologyQingdao 266042ShandongChina College of Environment and Safety Engineering Qingdao University of Science and TechnologyQingdao 266042ShandongChina Qingdao Huanghai University Qingdao 266000ShandongChina College of Electromechanical Engineering Qingdao University of Science and TechnologyQingdao 266061ShandongChina

The development of highly active,stable and inexpensive electrocatalysts for hydrogen production by defects and morphology engineering remains a great ***,S vacancies-rich Ni_(3)S_(2)@Cu_(2)S nan-otube heterojunction arrays were in-situ grown on copper foam(V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S NHAs/CF)for efficient electrocatalytic overall water *** the merits of nanotube arrays and efficient electronic mod-ulation drived by the OD vacancy defect and 2D heterojunction defect,the resultant V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S NHAs/CF electrocatalyst exhibits excellent electrocatalytic activity with a low overpotential of 47 mV for the hydrogen evolution reaction(HER)at 10 mA cm^(-2) current density,and 263 mV for the oxygen evolution reaction(OER)at 50 mA cm^(-2) current density,as well as a cell voltage of 1.48 V at 10 mA cm^(-2).Moreover,the nanotube heterojunction arrays endows V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S NHAs/CF with outstanding stability in long-term catalytic processes,as confirmed by the continuous chronopotentiom-etry tests at current densities of 10 mA cm^(-2) for 100 h.

关键词： Nanotubearrays Heterojunction Vacancy Bifunctional electrocatalyst Overall water splitting

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周围血管疾病中医瘀毒病因论

世界科学技术-中医药现代化 2020年第9期22卷 3318-3322页

作者：许永楷温雅山东中医药大学附属医院济南250014 山东中医药大学中医学院济南250355

周围血管疾病包括:动脉性疾病、静脉性疾病和淋巴管性疾病3大类。临床实践中发现,周围血管疾病是血瘀证疾病。随着病程进展,久瘀成毒,瘀毒互结,具有病程缠绵、难治、难愈的特点。陈柏楠教授认为瘀毒是血瘀病机的延伸,瘀毒症候群是周围... 详细信息

周围血管疾病包括:动脉性疾病、静脉性疾病和淋巴管性疾病3大类。临床实践中发现,周围血管疾病是血瘀证疾病。随着病程进展,久瘀成毒,瘀毒互结,具有病程缠绵、难治、难愈的特点。陈柏楠教授认为瘀毒是血瘀病机的延伸,瘀毒症候群是周围血管疾病血瘀后期的重要表现。瘀可化毒,毒可致瘀,瘀毒互结,病势缠绵,难消难愈;瘀毒日久变生急难重症。因此我们需重视瘀毒证治,瘀毒同治,应用清热解毒、活血化瘀类药物,使瘀祛毒清,恢复健康。

关键词：周围血管疾病血瘀瘀毒

Food-Borne Poisoning Accident from Amanitin Toxin in Wild Mushrooms—Xingtai City,Hebei Province,China,2023

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China CDC weekly 2024年第3期6卷 56-59页

作者： Baopu Lv Liang Liu Hao Xiao Qingbing Meng Rui Zhang Yaqing An Yingli Jin Yu Ma Hengbo Gao yongkai Li Qian He Yutao Zhang Changqing Liu Xiaoyan Luo Xiaomin xu Fenshuang Zheng Yingping Tian Hongshun Zhang Dongqi Yao Emergency Department The Second Hospital of Hebei Medical UniversityShijiazhuang CityHebei ProvinceChina National Institute of Occupational Health and Poison Control Chinese Centre for Disease Control and PreventionBeijingChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang CityHebei ProvinceChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Emergency Department The Affiliated Hospital of Yunnan UniversityKunming CityYunnan ProvinceChina

What is already known about this topic?Fatal poisonings caused by wild mushrooms containing amanita toxins pose a significant threat in the southern regions of *** toxins primarily induce gastrointestinal symptoms initially,which are then followed by potentially life-threatening acute liver *** is added by this report?This report contributes to the existing knowledge on these cases of poisoning by documenting the second occurrences in Hebei Province and the first occurrences in Xingtai *** individuals reported consuming wild mushrooms from the same origin,and laboratory tests confirmed the presence ofα-amanitin in their blood *** are the implications for public health practice?This underscores the risk associated with the collection and consumption of amanita toxin-containing mushrooms in *** is important to note that the identification of toxic and non-toxic mushrooms should not solely rely on personal experience or appearance.

关键词： Hebei consuming initially

Enantioselective Resolution of (±)-l-Phenylethyl Acetate by Using the Whole Cells of Deep-sea Bacterium Bacillus sp. DL-2

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Chemical Research in Chinese Universities 2019年第5期35卷 792-798页

作者： DONG Lu xu yongkai ZHANG Yun SUN Aijun HU Yunfeng CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301P.R.China Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014P.R.China

Bacillus sp. DL-2 was isolated from the deep sea of the Western Pacific and further utilized as novel biocatalysts to efficiently asymmetrically hydrolyze (±)-1-phenylethyl acetate. After the optimization of hydrolytic reactions, chiral chemicals (R)1-phenylethanol and (S)-l-phenylethyl acetate were obtained with high optical purities (96% and 99.8%, respectively). Our research is about the asymmeric hydrolysis of (±)-1-phenylethyl acetate using whole-cell biocatalysts. In addition, the optical purity of (S)-l-phenylethyl acetate generated through the kinetic resolution of (±)-1-phenylethyl acetate using the whole-cells of Bacillus sp. DL-2 was the highest report so far. Using the whole cells of deep sea bacterium Bacillus sp. DL-2 as the biocatalysts is an enviromnentally friendly method and will play critical roles in industrial asymmetric synthesis.

关键词： Deep-sea microorganism Whole-cell biocatalyst Asymmetric hydrolysis (R)-1-Phenylethanol (S)-1-Phenylethyl acetate

Single crystal growth and characterization of 166-type magnetic kagome metals

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Chinese Physics B 2024年第9期33卷 145-150页

作者： Huangyu Wu Jinjin Liu yongkai Li Peng Zhu Liu Yang Fuhong Chen Deng Hu Zhiwei Wang Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic Systems Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Zhuhai 519000China Material Science Center Yangtze Delta Region Academy of Beijing Institute of TechnologyJiaxing 314011China

Kagome magnets were predicted to be a good platform to investigate correlated topology band structure,Chern quantum phase,and geometrical frustration due to their unique lattice *** we reported single crystal growth of 166-type kagome magnetic materials,including HfMn_(6)Sn_(6),ZrMn_(6)Sn_(6),GdMn_(6)Sn_(6)and GdV_(6)Sn_(6),by using the flux method with Sn as the *** them,HfMn_(6)Sn_(6)and ZrMn_(6)Sn_(6)single crystals were grown for the first time.X-ray diffraction measurements reveal that all four samples crystallize in HfFe6Ge6-type hexagonal structure with space group P6/*** samples show metallic behavior from temperature dependence of resistivity measurements,and the dominant carrier is hole,except for GdV6Sn6 which is electron *** samples have magnetic order with different transition temperatures,HfMn_(6)Sn_(6),ZrMn_(6)Sn_(6)and GdV_(6)Sn_(6)are antiferromagnetic with TN of 541 K,466 K and 4 K respectively,while GdMn_(6)Sn_(6)is ferrimagnetic with the critical temperature of about 470 *** study will enrich the research platform of magnetic kagome materials and help explore the novel quantum phenomena in these interesting *** dataset of specific crystal structure parameters for HfMn_(6)Sn_(6)are available in Science Data Bank,with the link.

关键词： kagome metal single crystal growth crystal structure physical property