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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo wang Tingli Yuan Tianjie Lyu Ling Zhang Meng wang Zhiying He yongjun wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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Residual recurrence risk of ischaemic cerebrovascular events: concept, classification and implications

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Stroke & Vascular Neurology 2021年第2期6卷 155-157页

作者： yongjun wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina

INTRODUCTION Patients with stroke still have substantial residual risk of stroke recurrence in spite of therapies following the guidelines.1 In addition to traditional vascular risk factors,conditions such as chronic inflammation,poor quality of care and variable response to standard therapy may contribute to the residual risk of stroke recurrence.2-4 There-fore,it is important to understand and clas-sify the sources of residual risk to improve the prevention of stroke recurrence in patients already have a stroke.

关键词： prevention inflammation Patients

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Hydrographic Characteristics and Oceanic Heat Flux in the Upper Arctic Ocean over the Alpha Ridge Observed by the DTOP Platform in 2018 and 2021

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Journal of Ocean University of China 2024年第2期23卷 304-316页

作者： wang yongjun LI Tao College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdao 266100China Frontier Science Center for Deep Ocean Multispheres and Earth System(FDOMES) and Physical Oceanography Laboratory Ocean University of ChinaQingdao 266100China Laoshan Laboratory Qingdao 266237China

In 2018 and 2021,the Drift-Towing Ocean Profilers(DTOP)provided extensive temperature and salinity data on the upper 120m ocean through their drifts over the Alpha Ridge north of the Canada *** thickness and temperature maximum of Alaska Coastal Water(ACW)ranged from 20m to 40m and-1.5℃to-0.8℃,respectively,and the salinity generally maintained from 30.2 to *** with World Ocean Atlas 2018’s climatology manifested a 40m-thick and warm ACW roughly ex-ceeding the temperature maximum by 0.4–0.5℃in June–August *** anomalously warm ACW was highly related to the ex-pansion of the Beaufort Gyre in the negative Arctic Oscillation *** summer,the under-ice oceanic heat flux F_(w)^(OHF)was elevated,with a maximum value of above 25Wm^(-2).F_(w)^(OHF)was typically low in the freezing season,with an average value of 1.2Wm^(-2).The estimates of upward heat flux contributed by ACW to the sea ice bottom F_(w)^(OHF)were in the range of 3–4Wm^(-2)in June–August 2021,when ACW contained a heat content of more than 80MJm^(-2).The heat loss over this period was driven by a weak stratification upon the ACW layer associated with a surface mixed layer(SML)approaching the ACW *** autumn,F_(w)^(OHF)was reduced(<2 Wm^(-2))except during rare events when it elevated F_(w)^(OHF)*** addition,the intensive and widespread Ekman suction,which created a violent upwelling north of the Canada Basin,was largely responsible for the substantial cooling and thinning of the ACW layer in the summer of 2021.

关键词： Arctic Ocean oceanic heat flux Alaska Coastal Water Alpha Ridge

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Blood Biomarkers in Minor Stroke and Transient Ischemic Attack

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Neuroscience Bulletin 2016年第5期32卷 463-468页

作者： Jiejie Li yongjun wang Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China China National Clinical Research Center for Neurological Diseases Beijing 100050 China Center of Stroke Beijing Institute for Brain DisordersBeijing 100050 China Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Beijing 100050 China

Minor stroke and transient ischemic attack（TIA）are common disorders with a high rate of subsequent disabling stroke, so the early recognition and management of minor stroke and TIA is of great importance. At the moment, the diagnosis of these disorders is based on neurologic deficits in a stroke-clinician＇s examination of the patient, supplemented by the results of acute brain ***, high variability in TIA diagnosis has been reported between physicians, even trained vascular neurologists, and image-based diagnostic confirmation is not always readily available. Some patients still have ischemic events despite sustained standard secondary preventive therapy. Blood biomarkers are promising to aid in the diagnosis, risk stratification, and individual treatment of minor stroke and TIA. Some studies are being conducted in this field. This mini-review aims to highlight potential biomarkers for diagnosis and those helpful in predicting the risk of future stroke and the selection of treatment.

关键词： Minor stroke TIA Biomarker Prognosis Diagnosis Gene Protein

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Localization of nitric oxide synthase in the developing gonads of amphioxus Branchiostoma belcheri tsingtauense

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Acta Oceanologica Sinica 2005年第5期24卷 120-126页

作者： wang yongjun ZHANG Shicui Department of Marine Biology Ocean University of China Qingdao 266003 China Department of Fishery Nantong Agricultural College Nantong 226007 China

The localization of nitric oxide synthases （NOS） is dealed with in the developing gonads of amphioxus Branchiostoma belcheri tsingtauense. It was found by NADPH-diaphorase staining that （1） NOS activity was present in the nuclear membranes of germinal vesicles during the entire period ofoocyte development; （2） NOS was localized in both the nuclear membranes and the perinuclear region of cytoplasm in the vitellogenetic oocytes; （3） NOS was relocated in the cortical layer in the mature egg; （4） NOS activity was present in spermatocytes, but not in the spermatogonia in the middle of October; （5） NOS was detected in both spermatozoa and spermatids as well as spermatocytes during the breeding season. This is the first report on the distribution pattern of NOS in the developing gonads in protochordates. These results suggest a role for NOS in the functioning of the nuclear membranes and yolk synthesis during oogenesis and in cell division and differentiation during spermatogenesis.

关键词： amphioxus Branchiostoma nitric oxide synthase gonad localization

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Correlation of hypoxia-inducible factor-1 alpha and erythropoietin protein and mRNA to cerebral ischemic tolerance in a focal ischemia/reperfusion model using the twice suture method

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Neural Regeneration Research 2009年第11期4卷 846-852页

作者： Renliang Zhao yongjun wang Department of Neurology Beijing Tiantan Hospital Capital University of Medical Sciences Beijing 100050 China Department of Neurology Affiliated Hospital of Medical College Qingdao University Qingdao 266003 Shandong Province China

BACKGROUND： Numerous studies have shown that transient ischemic preconditioning induces cerebral ischemic tolerance. However, the underlying mechanisms of endogenous protection following ischemic preconditioning remain unclear. OBJECTIVE： To dynamically measure erythropoietin and hypoxia-inducible factor-1α （HIF-1α） mRNA and protein expression at various times following preconditioning, and to investigate effects of erythropoietin and HIF-1α on cerebral ischemic tolerance in a model of focal ischemia/reperfusion established using the twice suture method. DESIGN, TIME AND SETTING： The randomized, controlled study was performed at the Institute of Anatomy, Medical College, Qingdao University, China from March 2006 to March 2007. MATERIALS： Rabbit anti-rat HIF-1α monoclonal antibody and biotinylated goat anti-rabbit IgG （Boster, China）, rabbit anti-rat erythropoietin monoclonal antibody （Santa Cruz Biotechnology, USA）, and one-step RT-PCR kit （Qiagen, Germany） were used in this study. METHODS： A total of 99 healthy, male, Wistar rats were randomly assigned to three groups： sham surgery （n = 9）, non-ischemic preconditioning （n = 45）, and ischemic preconditioning （n = 45）. In the ischemic preconditioning group, rat models of pre-ischemia-reperfusion-ischemia-reperfusion were established by occluding the left middle cerebral artery using the twice suture method. In the non-ischemic preconditioning group, pre-ischemia was replaced by sham surgery. Subsequently, the ischemic preconditioning and non-ischemic preconditioning groups were equally divided into five subgroups according to time of first reperfusion, including 1-, 3-, 7-, 14-, and 21-day subgroups. The sham surgery group received the sham surgery twice. MAIN OUTCOME MEASURES： HIF-la and erythropoietin protein expression was measured in the cerebral cortex, corpus striatum, and hippocampus of the ischemic hemisphere. HIF-1α and erythropoietin mRNA expression were determined in the frontal and parietal cortex of the

关键词： ischemic tolerance ischemic preconditioning cerebral ischemia rat hypoxia-inducible factor-1α erythropoietin

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Rapid transfer alignment for SINS of carrier craft

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Journal of Systems Engineering and Electronics 2013年第2期24卷 303-308页

作者： Jingshuo Xu yongjun wang Zhicai Xiao Qingdao Campus of Naval Aeronautical and Astronautical University Department of Control Engineering Naval Aeronautical and Astronautical University

In order to improve the survival ability and rapid response ability of the carrier craft,a new rapid transfer alignment method of the strapdown inertial navigation system（SINS） on a rocking base is put *** the method,the aircraft carrier does not need any form of ***,interfering motions such as rolling,pitching,and yawing motions caused by sea waves are effectively ***,the deck flexure deformation model is ***,the state space model of transfer alignment is ***,the feasibility of this method is validated by the *** results show that the misalignment angle error can be estimated and reach an anticipated precision-0.2 mrad in 5 s,while the deck deformation angle error can be estimated and reach a better precision- 0.1 mrad in 20 s.

关键词： strapdown inertial navigation system(SINS) transfer alignment carrier aircraft carrier moored.

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Study of Pickering emulsions stabilized by mixed particles of silica and calcite

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Particuology 2010年第4期8卷 390-393页

作者： Sha wang yongjun He Yong Zou Department of Applied Chemistry Xi'an University of Science and Technology Xi'an 710054 China

Picketing emulsions were prepared using mixed particles of silica and calcite as emulsifiers. The effects of the silica content in the mixed particles on the stability and the drop size of the Picketing emulsions were investigated. The results showed that the Picketing emulsions were of the oil-in-water type. With increasing silica content in the mixed partides, the stability and the drop size of the Pickering emulsions decreased. Larger silica particles had more influence on the stability of the emulsions, while smaller ones had more influence on the drop size of the emulsions. The effect of the silica particles on the emulsions was attributed to their adsorptive behavior at the oil-water interfaces of the Picketing emulsions.

关键词： Calcite Silica Mixed panicles Pickering emulsions Stability

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Changes in serum cellular adhesion molecule and matrix metalloproteinase-9 levels in patients with cerebral infarction following hyperbaric oxygen therapy A case and intergroup control study

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Neural Regeneration Research 2008年第11期3卷 1245-1248页

作者： Renliang Zhao Chunxia wang yongjun wang Department of Neurology the Affiliated Hospital of Medical College Qingdao University Qingdao 266003 Shandong Province China Department of Neurology Beijing Tiantan Hospital Capital University of Medical Sciences Beijing 100050 China Qingdao Mental Health Center Qingdao 266034 Shandong Province China

BACKGROUND： Animal studies have confirmed that hyperbaric oxygen （HBO） therapy can reduce matrix metalloproteinase activity and blood brain barrier permeability, thereby exhibiting neuroprotective effects. However, at present, consensus does not exist in terms of its clinical efficacy. OBJECTIVE： To validate the significance of changes in serum cellular adhesion molecule and MMP-9 levels in patients with cerebral infarction following HBO therapy. DESIGN, TIME AND SETTING： This randomized, controlled, neurobiochemical study was performed at the Department of Neurology, Affiliated Hospital of Qingdao University Medical College between December 2002 and March 2006. PARTICIPANTS： A total of 112 patients with acute cerebral infarction of internal carotid artery, comprising 64 males and 48 females, averaging （67 ±11） years, were recruited and randomized to a HBO group （n = 50） and a routine treatment group （n = 62）. An additional 30 gender- and age-matched normal subjects, consisting of 17 males and 13 females, averaging （63 ± 9） years, were enrolled as control subjects. METHODS： The routine treatment group received routine drug treatment and rehabilitation exercise. HBO treatment was additionally performed in the HBO group, once a day, for a total of 10 days. MAIN OUTCOME MEASURES： Serum levels of soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, soluble E-selectin, and matrix metalloproteinase-9 were detected by enzyme linked immunosorbent assay. RESULTS： Upon admission, serum levels of soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, soluble E-selectin, and matrix metalloproteinase-9 were significantly increased in patients with cerebral infarction, compared with control subjects （P 〈 0.01）. Following HBO and routine treatments, serum levels of the above-mentioned indices were significantly reduced in the HBO and routine treatment groups （P 〈 0.01）. Moreover, greater efficacy was observed in the HBO group

关键词： cerebral infarction E-selectin hyperbaric oxygen intercellular adhesion molecule matrix metalloproteinase-9 vascular cell adhesion molecule

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Information diffusion network inferring and pathway tracking

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Science China(Information Sciences) 2015年第9期58卷 135-149页

作者： ZHOU DongHao HAN WenBao wang yongjun YUAN BaoDi College of Computer National University of Defense Technology State Key Laboratory of Mathematical Engineering and Advanced Computing College of Computer Science and Technology Fudan University

Network diffusion, such as spread of ideas, rumors, contagious disease, or a new type of behaviors, is one of the fundamental processes within networks. Designing effective strategies for influence spread maximization, rumor spread minimization, or epidemic immunization has attracted considerable research attention. However, a key challenge is that many times we can only observe the trace of contagion spreading across network, but the underlying network structure is unknown and the transmission rates between node pairs are unclear to us. In this paper, given the observed information cascades, we aim to address two problems:diffusion network structure inferring and information diffusion pathways tracking. We propose a novel probabilistic model called Network Inferring from Multidimensional Features of Cascades(NIMFC) which takes into account heterogeneous features, including temporal and topological features of cascades, node attributes, and information content, to infer the latent network structure and transmission rates of edges. Also, based on the inferred network structure, we may track diffusion pathways of a cascade in social networks. We use blocked coordinate descent method to learn a sparse estimation of the latent network. Our proposed model NIMFC is evaluated both on large synthetic and real-world data sets, and experimental results show that our method significantly outperforms state-of-the-art models both in terms of recovering the latent network structure and information pathway tracking.

关键词： diffusion network network inferring information pathway tracking temporal feature node attributes topological feature informatio

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